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Measurement of mechanical properties of cells based on their internal structures

Research Project

Project/Area Number 15086209
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionNagoya Institute of Technology

Principal Investigator

MATSUMOTO Takeo  Nagoya Institute of Technology, Grad Sch Eng, Professor (30209639)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Hiroshi  Osaka Univ, Grad Sch Eng Sci, Assoc. Professor (00263228)
NAGAYAMA Kazuaki  Nagoya Inst Tech, Grad Sch Eng, Research Associate (10359763)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥40,000,000 (Direct Cost: ¥40,000,000)
Fiscal Year 2006: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2005: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2004: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2003: ¥20,400,000 (Direct Cost: ¥20,400,000)
KeywordsBiomechanics / Cell mechanics / Cytoskeleton / Organelle / Vasuclar Smooth Muscle Cells / Mechanical Adaptation
Research Abstract

Relationship linking mechanical properties of cells and their cytoskeletons are important in mechanotransduction. In this study, we measured quasi-static tensile properties and stress relaxation responses mainly of smooth muscle cells (SMCs) freshly isolated from aortic walls (FSMCs) and those cultured following isolation (CSMCs) with micro tensile testers to know the effects of the disruption of actin filaments (AF) or microtubules (MT). Their 3D microstructures were observed with a cell rotation system. Following results were obtained:
1. FSMCs were stiffer in their longitudinal direction in which AFs align, and the stiffness of CSMCs decreased by 60% following AF disruption, indicating that AFs play dominant roles in their tensile properties.
2. Stress relaxation response of CSMCs could be expressed with the combination of fast exponential decay with a time constant of〜1 min and slow decay with a time constant of 〜1 h, and the AF disruption caused significant change in the slow decay.
3. We established a method to stretch cells maintaining their shape on substrate and found that the stiffness of CSMCs decreased by 70 and 30% following AF and MT disruption, respectively. MTs may play significant roles in the tensile properties of SMCs.
4. We successfully observed with the cell rotation system that AFs aligned helically in the FSMCs and that nucleus of CSMCs buckled when the cells were detached from substrate and shrank.
5. Local stiffness measured with an atomic force microscope increased following MT disruption in CSMCs. Whole-cell stiffness of cultured fibroblasts did not change following MT disruption, but decreased significantly by〜75% following AF disruption.
These results indicate that not only AFs but also MTs have significant effects on cell mechanical properties, but the degree of contribution of MTs depends on the cell types and mode of deformation.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (65 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (37 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Book (7 results) Patent(Industrial Property Rights) (1 results) Publications (7 results)

  • [Journal Article] Matsumoto : Actin filaments affect on not only elasticity but also late viscous response in stress relaxation of single isolated aortic smooth muscle cells (Possible effect of active reorganization of actin filaments)2007

    • Author(s)
      Nagayama K
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 93-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Novel Micro Tensile Tester with Feed-back Control for Viscoelastic Analysis of Single Isolated Smooth Muscle Cells2007

    • Author(s)
      Nagayama K
    • Journal Title

      Medical Engineering & Physics 29

      Pages: 620-628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Actin filaments affect on not only elasticity but also late viscous response in stress relaxation of single isolated aortic smooth muscle cells(Possible effect of active reorganization of actin filaments)2007

    • Author(s)
      K. Nagayama
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 93-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A novel micro tensile tester with feed-back control for viscoelastic analysis of single isolated smooth muscle cells2007

    • Author(s)
      K. Nagayama
    • Journal Title

      Medical Engineering and Physics 29

      Pages: 620-628

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2007

    • Author(s)
      H. Wada
    • Journal Title

      World Scientific, Singapore 4

      Pages: 14-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A Novel Micro Tensile Tester with Feed-back Control for Viscoelastic nalysis of Single Isolated Smooth Muscle Cells2007

    • Author(s)
      Nagayama K
    • Journal Title

      Medical Engineering & Physics 29・5

      Pages: 620-628

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tensile properties of cultured aortic smooth muscle cells obtained in a quasi-in situtensile test with thermoresponsive gelatin2006

    • Author(s)
      Nagayama K
    • Journal Title

      Journal of Biomechanical Science and Engineering 1

      Pages: 256-267

    • NAID

      130000079548

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of actin filament distribution on tensile properties of smooth muscle cell sobtained from rat thoracic aortas2006

    • Author(s)
      Nagayama K
    • Journal Title

      Journal of Biomechanics 39

      Pages: 293-301

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of cyclic strain on the orientation of cultured macrophages2006

    • Author(s)
      Miyazaki H
    • Journal Title

      Journal of Biomechanical Science and Engineering 1

      Pages: 268-279

    • NAID

      130000079549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tensile properties of cultured aortic smooth muscle cells obtained in a quasi-in situ tensile test with thermoresponsive gelatin2006

    • Author(s)
      K. Nagayama
    • Journal Title

      Journal of Biomechanical Science and Engineering 1

      Pages: 256-267

    • NAID

      130000079548

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of actin filament distribution on tensile properties of smooth muscle cells obtained from rat thoracic aortas2006

    • Author(s)
      K. Nagayama
    • Journal Title

      Journal of Biomechanics 39

      Pages: 293-301

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of cyclic strain on the orientation of cultured macrophages2006

    • Author(s)
      H. Miyazaki
    • Journal Title

      Journal of Biomechanical Science and Engineering 1

      Pages: 268-279

    • NAID

      130000079549

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2006

    • Author(s)
      H. Wada
    • Journal Title

      World Scientific, Singapore 2

      Pages: 16-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 血管壁の実験バイオメカニクス : マクロからミクロへ2006

    • Author(s)
      松本 健郎
    • Journal Title

      脈管学 46・6

      Pages: 749-757

    • NAID

      10018473170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mechanical Analysis of Aortic Wall Considering Microscopic Structure2006

    • Author(s)
      Matsumoto T
    • Journal Title

      Proceedings of Human Biomechanics 2006

      Pages: 32-41

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tensile properties of cultured aortic smooth muscle cells obtained in a quasi-in situ tensile test with thermoresponsive gelatin2006

    • Author(s)
      Nagayama K
    • Journal Title

      Journal of Biomechanical Science and Engineering 1・1

      Pages: 256-267

    • NAID

      130000079548

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of cyclic strain on the orientation of cultured macrophages2006

    • Author(s)
      Miyazaki H
    • Journal Title

      Journal of Biomechanical Science and Engineering 1・1

      Pages: 268-279

    • NAID

      130000079549

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of Actin Filaments on the Viscoelastic Properties of Aortic Smooth Muscle Cells2006

    • Author(s)
      Nagayama K
    • Journal Title

      Proceedings of 15th International Conference on Mechanics in Medicine and Biology

      Pages: 435-438

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of Actin Filament Distribution on Tensile Properties of Smooth Muscle Cells Obtained from Rat Thoracic Aortas2006

    • Author(s)
      Nagayama K
    • Journal Title

      J Biomechanics 39・2

      Pages: 293-301

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Observation of cell shortening and dynamic changes of actin filaments during cell detachment from thermoresponsive-gelatin-coated substrate2005

    • Author(s)
      Nagayama K
    • Journal Title

      JSME International Journal, Series C 48

      Pages: 411-418

    • NAID

      110004826659

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Observation of cell shortening and dynamic changes of actin filaments during cell detachment from thermoresponsive-gelatin-coated substrate2005

    • Author(s)
      K. Nagayama
    • Journal Title

      JSME International Journal, Series C 48

      Pages: 411-418

    • NAID

      110004826659

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2005

    • Author(s)
      H. Wada
    • Journal Title

      World Scientific, Singapore 1

      Pages: 16-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Observation of Cell Shortening and Dynamic Changes of Actin Filaments during Cell Detachment from Thermoresponsive-Gelatin-Coated Substrate2005

    • Author(s)
      Nagayama K
    • Journal Title

      JSME Int J Ser C 48・4

      Pages: 411-418

    • NAID

      110004826659

    • Related Report
      2005 Annual Research Report
  • [Journal Article] In vivo mechanical properties of thoracic aortic aneurysmal wall estimated from in vitro biaxial tensile test2005

    • Author(s)
      Fukui T
    • Journal Title

      Bio-medical Materials and Engineering 15・4

      Pages: 295-305

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pipette Aspiration Method for the Measurement of Nonlinear and Anisotropic mechanical Properties of Blood Vessel Walls under Biaxial Stretch2005

    • Author(s)
      Ohashi T
    • Journal Title

      J Biomechanics 38・11

      Pages: 2248-2256

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Flow-induced Changes in Dimensions and Mechanical Properties of Rabbit Common Carotid Arteries2005

    • Author(s)
      Matsumoto T
    • Journal Title

      JSME Int J Ser C 48・4

      Pages: 477-483

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of Actin Filament Distribution on Tensile Properties of Smooth Muscle Cells Obtained from Rat Thoracic Aortas2005

    • Author(s)
      Nagayama K
    • Journal Title

      J Biomechanics (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanical anisotropy of rat aortic smooth muscle cells decreases with their contraction : Possible effect of actin filament orientation2004

    • Author(s)
      Nagayama K
    • Journal Title

      JSME International Journal, Series C 47

      Pages: 985-991

    • NAID

      110004820827

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mechanical anisotropy of rat aortic smooth muscle cells decreases with their contraction : Possible effect of actin filament orientation2004

    • Author(s)
      K. Nagayama
    • Journal Title

      JSME International Journal, Series C 47

      Pages: 985-991

    • NAID

      110004820827

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Atomic Force Microscopy : Methods and Protocols in Biomedical applications2004

    • Author(s)
      P. C. Braga
    • Journal Title

      Humana Press

      Pages: 307-313

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Residual Stress and Strain in the Lamellar Unit of the Porcine Aorta : Experiment and Analysis2004

    • Author(s)
      Matsumoto T
    • Journal Title

      J Biomechanics 37・6

      Pages: 807-815

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Microscopic Residual Stress Caused by the Mechanical Heterogeneity in the Lamellar Unit of the Porcine Thoracic Aortic Wall2004

    • Author(s)
      Matsumoto T
    • Journal Title

      JSME Int J Ser A 47・3

      Pages: 341-348

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 細胞の力学特性計測のためのレーザ顕微鏡複合型原子間力顕微鏡(AFM)システムの開発2004

    • Author(s)
      長山 和亮
    • Journal Title

      日本機械学会論文集C編 70・691

      Pages: 128-134

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 細胞用二軸繰返引張機構の開発とこれを用いた血管内皮細胞の力学応答の解析2004

    • Author(s)
      中垣 将
    • Journal Title

      日本機械学会論文集A編 70・694

      Pages: 109-114

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanical Anisotropy of Rat Aortic Smooth Muscle Cells Decreases with Their Contraction : Possible effect of actin filament2004

    • Author(s)
      Nagayama K
    • Journal Title

      JSME Int J, Ser C 47・4

      Pages: 985-991

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tensile properties of fibroblasts and vascular smooth muscle cells2003

    • Author(s)
      Miyazaki H
    • Journal Title

      Biorheology 40

      Pages: 207-212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tensile properties of fibroblasts and vascular smooth muscle cells2003

    • Author(s)
      H. Miyazaki
    • Journal Title

      Biorheology 40

      Pages: 207-212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Determination of mechanical properties of smooth muscle cells from a viewpoint of blood vessel biomechanics (Invited lecture)2006

    • Author(s)
      Matsumoto T
    • Organizer
      3rd Int Sympo on Biomedical Systems Innovation
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-11-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Determination of mechanical properties of smooth muscle cells from a viewpoint of blood vessel biomechanics2006

    • Author(s)
      Matsumoto T
    • Organizer
      3rd Int'l Sympo on Biomed Systems Innovation
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-11-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Observation of Cytoskeleton and Cell Nucleus with 3D Fluorescent Optical Tomography2006

    • Author(s)
      Matsumoto T
    • Organizer
      2006 Biomed Eng Soc Annual Meeting
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2006-10-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of actin filaments and microtubules on tensile properties and internal tension of aortic smooth muscle cells cultured on substrates2006

    • Author(s)
      Nagayama K
    • Organizer
      The Fifth World Congress of Biomechanics
    • Place of Presentation
      Munchen, Germany
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Viscoelastic properties of smooth muscle cells measured with a novel cell tensile testerwith feedback control2005

    • Author(s)
      Matsumoto T
    • Organizer
      Second Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Taipei
    • Year and Date
      2005-11-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Viscoelastic properties of smooth muscle cells measured with a novel cell tensile tester with feedback control2005

    • Author(s)
      Matsumoto T
    • Organizer
      Second Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Taipei
    • Year and Date
      2005-11-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Dynamic behavior of actin filaments in aortic smooth muscle cells during detachment from substrate coated with thermoresponsive gelatin2005

    • Author(s)
      Nagayama K
    • Organizer
      The Second Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2005-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] A cell rotation system for the observation of 3D microstructure of cells2005

    • Author(s)
      Matsumoto T
    • Organizer
      2005 Summer Bioengineering Conference
    • Place of Presentation
      Vail, CO, USA
    • Year and Date
      2005-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Development of a micro tensile tester for viscoelastic analysis of single isolated cells2005

    • Author(s)
      Matsumoto T
    • Organizer
      12th International Congress of Biorheology
    • Place of Presentation
      Chongqing, China
    • Year and Date
      2005-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effect of actin filament orientation on mechanical anisotropy of freshly-isolated vascular smooth muscle cells2005

    • Author(s)
      Nagayama K
    • Organizer
      6th Asian-Pacific Conf on Med&Biol Eng
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2005-04-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effect of the contraction of rat aortic smooth muscle cells on their mechanical anisotropy2004

    • Author(s)
      Nagayama K
    • Organizer
      Biomed Eng Soc 2004 Annual Fall Meeting
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2004-10-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effect of Actin Filament on Tensile Properties of Rat Aortic Smooth Muscle Cells2004

    • Author(s)
      Matsumoto T
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2004-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effect of Actin Filament on Tensile Properties of Rat Aortic Smooth Muscle Cells2004

    • Author(s)
      Matsumoto T
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Osaka
    • Year and Date
      2004-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Biomechanics at Micro- and Nanoscale Levels, vol. IV(分担執筆)2007

    • Author(s)
      Wada H
    • Publisher
      World Scientific
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Biomechanics at Micro- and Nanoscale Levels, vol. II(分担執筆)2006

    • Author(s)
      Wada H
    • Publisher
      World Scientific
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Biomechanics at Micro-and Nanoscale Levels, Vol.II(分担執筆)2006

    • Author(s)
      Matsumoto T
    • Total Pages
      180
    • Publisher
      World Scientific
    • Related Report
      2006 Annual Research Report
  • [Book] Biomechanics at Micro- and Nanoscale Levels, Vol. I(分担執筆)2005

    • Author(s)
      Wada H
    • Publisher
      World Scientific
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Development of a Novel Micro Tensile Tester for Single Isolated Cells and its Application to Viscoelastic Analysis of Aortic Smooth Muscle Cells, Biomechanics at Micro- and Nanoscale Levels, Volume I2005

    • Author(s)
      Matsumoto T
    • Total Pages
      174
    • Publisher
      World Scientific, Singapore
    • Related Report
      2005 Annual Research Report
  • [Book] Atomic Force Microscopy : Methods and Protocols in Biomedical Applications2004

    • Author(s)
      Braga PC
    • Publisher
      Humana Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 構造工学ハンドブック(13.バイオ構造/13.2マクロ構造/13.2.1(b)生体組織構造-血管構造)2004

    • Author(s)
      松本 健郎
    • Total Pages
      1070
    • Publisher
      丸善
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許権2007

    • Inventor(s)
      松本健郎
    • Industrial Property Rights Holder
      松井信行
    • Industrial Property Number
      2007-053508
    • Filing Date
      2007-03-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] Matsumoto T: "Residual Stress and Strain in the Lamellar Unit of the Porcine Aorta : Experiment and Analysis"J Biomechanics. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 長山 和亮: "細胞の力学特性計測のためのレーザ顕微鏡複合型原子間力顕微鏡(AFM)システムの開発"日本機械学会論文集C編. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ozawa H: "Mechanical properties and function of the spinal pia mater"Journal of Neurosurgery : Spine. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松本 健郎: "平滑筋収縮に伴う家兎動脈壁内ひずみ分布の変化 弾性動脈と筋性動脈の比較"日本機械学会論文集A編. 69-677. 37-42 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 杉田 修啓: "軸方向観察による血管壁の局所ひずみ分布計測"日本機械学会論文集A編. 69-677. 43-48 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohashi T: "Rupture Properties of Blood Vessel Walls Measured by Pressure-Imposed Test"JSME International Journal, Series C. 46-4. 1290-1296 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松本 健郎: "構造工学ハンドブック(13.バイオ構造/13.2マクロ構造/13.2.1(b)生体組織構造 血管構造)"丸善. 1070 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2018-03-28  

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