• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Application of High-spin Species Designed by the Studies on Molecule-based on Magnet to MRI ImagingAgents

Research Project

Project/Area Number 15087205
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionKyushu University

Principal Investigator

KOGA Noboru  Kyushu University, Graduate School of Pharmaceutical Sciences, Professor, 大学院薬学研究院, 教授 (60161890)

Co-Investigator(Kenkyū-buntansha) KARASAWA Satoru  Kyushu University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院薬学研究院, 助教授 (80315100)
ASO Mariko  Kyushu University, Graduate School of Pharmaceutical Sciences, Research Associate, 大学院薬学研究院, 助手 (30201891)
AKITA Takeyuki  Kyushu University, Graduate School of Pharmaceutical Sciences, Research Associate, 大学院薬学研究院, 助手 (50294963)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥38,400,000 (Direct Cost: ¥38,400,000)
Fiscal Year 2006: ¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 2005: ¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 2004: ¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 2003: ¥9,600,000 (Direct Cost: ¥9,600,000)
KeywordsStable Radical / MRI Imaging Agent / Molecule-based Magnet / Nuclear Spin Relaxation / Relaxivity / solution / 分子磁性 / 核スピン緩和 / ラジカル / DNA / デンドリマー / 電子スピン / 純粋有機スピン系 / ヘテロスピン系 / 新規MRI造影剤 / 基底三重項種 / 水溶性ラジカル / 高スピン金属錯体 / 高スピン分子 / 核スピン緩和速度 / 常磁性金属イオン
Research Abstract

The molecule for MRI imaging agent requires the high solubility in water and the high relaxivities, r_1 and r_2, of the water proton. One of the factors affecting to the relaxation time of the water proton is the rotational correlation time (τ_R) of the molecule for MRI imaging agent and the relaxivities increase with increasing the τR value. Because the τ_R value is affected by the size of the molecule; τR is proportional to r^3, where r is a radius of the molecule spherical in shape, the molecule with large molecular weight is expected to give high relaxivities. Based on this idea, we performed two approaches, DNA and dendrimer systems. In DNA system, the DNA monomer carrying a stable radical, its oligomer (15mer), and its duplex with a complimentary DNA oligomer were prepared and their relaxivities were investigated by a pulse NMR spectrometry. Obtained values of r_1 and r_2 increased with increasing the molecular weight, as expected. The values of r_1 for a monomer, an oligomer, and a duplex derivatives are 0.25, 0.44, and 0.57 sec^<-1>mM^<-1>, respectively. In water-soluble dendrimer system, sixteen stable radical units could be introduced to the third generation in the amine dendrimer carrying the carboxylic acid moieties by an ion exchange reaction. The value of r_1= 2.28 sec^<-1>mM^<-1> per molecule was obtained. This system is improved by using a hyper-branched polymer (HBP) and the value higher than the one for the Magnevist which is a gadolinium complex and is used in clinical field, is obtained at present stage.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (21 results)

All 2007 2006 2005 2004 Other

All Journal Article (17 results) Publications (4 results)

  • [Journal Article] Magnetic Property of 1 : 2 Mixture of Co(p-tolsal)_2; p-tolsal = N-p-tolylsalicylideniminato, and Cyclic Pentacarbene-pyridine with S = 10/2 in Dilute Frozen Solution2007

    • Author(s)
      Hiroyuki Tobinaga, Madoka Suehiro, Tetsuji Ito, Guangyuan Zhou, Satoru Karasawa, Noboru Koga
    • Journal Title

      Polyhedron In Press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Magnetic Property of 1 : 2 Mixture of Co(p-tolsal)2; p-tolsal = N-p-tolylsalicylideniminato, and Cyclic Pentacarbene-pyridine with S= 10/2 in Dilute Frozen Solution2007

    • Author(s)
      Hiroyuki Tobinaga, Madoka Suehiro, Tetsuji Ito, Guangyuan Zhou, Satoru Karasawa, Noboru Koga
    • Journal Title

      Polyhedron

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Magnetic Property of 1 : 2 Mixture of Co(p-tolsal)_2; p-tolsal = N-p-tolyisalicylideniminato, and Cyclic Pentacarbene-pyridine with S = 10/2 in Dilute Frozen Solution2007

    • Author(s)
      Hiroyuki Tobinaga, Madoka Suehiro, Tetsuji Ito, Guangyuan Zhou, Satoru Karasawa, Noboru Koga
    • Journal Title

      Polyhedron (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Magnetic Properties of 1 : 4 Complexes of Co^(II)X_2 (X = NCO^-, NCS^-, and Br^-) Coordinated with 4-(N-tert-Butylaminoxyl)pyridines : Antiferromagnets in Crystalline States and Single-molecule Magnets in Frozen Solutions2006

    • Author(s)
      Shinji Kanegawa, Satoru Karasawa, Motohiro Nakano, Noboru Koga
    • Journal Title

      Bull. Chem. Soc. Jpn 79

      Pages: 1372-1382

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Magnetic Properties of 1 : 4 Complexes of Co(II)X2(X=NCO-, NCS-, and Br-) Coordinated with 4-(N-tert-Butylaminoxyl)pyridines : Antiferromagnets in Crystalline States and Single-molecule Magnets in Frozen Solutions2006

    • Author(s)
      Shinji Kanegawa, Satoru Karasawa, Motohiro Nakano, Noboru Koga
    • Journal Title

      Bull. Chem. Soc. Jpn. 79

      Pages: 1372-1382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Magnetic Properties of 1 : 4 Complexes of Co^<II>X_2 (X=NCO, NCS, and-Br^-) Coordinated with 4-(N-tert-Butylaminoxyl)pyridines : Antiferromagnets in Crystalline States and Single-molecule Magnets in Frozen Solutions2006

    • Author(s)
      Shinji Kanegawa, Satoru Karasawa, Motohiro Nakano, Noboru Koga
    • Journal Title

      Bull. Chem. Soc. Jpn. 79

      Pages: 1372-1382

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecule-Based Magnets in Heterospin Systems2005

    • Author(s)
      Noboru Koga, Satoru Karasawa
    • Journal Title

      Bull. Chem. Soc. Jpn 78

      Pages: 1834-1400

    • NAID

      10019038689

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CRYSTAL STRUCTURES AND MAGNETIC PROPERTIES OF COMPLEXES OF M(NO_3)_2; M = Mn^II, Co^II, Ni^II, AND Cu^II, WITH PYRIDINE LIGANDS CARRYING AN AMINOXYL RADICAL2005

    • Author(s)
      Zhicheng Zhu, Satoru Karasawa, Noboru Koga
    • Journal Title

      Polyhedron 24

      Pages: 2102-2107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Synthesis and EPR studies of 2-N-tert-butylaminoxylpurin derivatives2005

    • Author(s)
      Toshiyuki Kaneko, Mariko Aso, Noboru Koga, Hiroshi Suemune
    • Journal Title

      Org. Lett. 7

      Pages: 303-305

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Crystal Structures and Magnetic Properties of Complexes of M^IICl_2; M = Cu, Ni, and Co, Coordinated with 4-(N-tert-Butyloxyamino)-2-(methoxymethylenyl)pyridine : 2D Magnetic Anisotropy of Aminoxyl-Co Complex in Crystalline State2005

    • Author(s)
      Zhicheng Zhu, Satoru Karasawa, Noboru Koga
    • Journal Title

      Inorg. Chem 44

      Pages: 6004-6011

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecule-Based Magnets in Heterospin Systems2005

    • Author(s)
      Noboru Koga, Satoru Karasawa
    • Journal Title

      Bull. Chem. Soc. Jpn. 78

      Pages: 1834-1400

    • NAID

      10019038689

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CRYSTAL STRUCTURES AND MAGNETIC PROPERTIES OF COMPLEXES OF M(NO3)2; M = MnII, CoII, NiII, AND Cun,WITH PYRIDINE LIGANDS CARRYING AN AMINOXYL RADICAL2005

    • Author(s)
      Zhicheng Zhu, Satoru Karasawa, Noboru Koga
    • Journal Title

      Polyhedron 24

      Pages: 2102-2107

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Crystal Structures and Magnetic Properties of Complexes of MIIC12; M = Cu, Ni, and Co, Coordinated with 4-(N-tert-Butyloxyamino)-2- (methoxymethylenyl)pyridine : 2D Magnetic Anisotropy of Aminoxyl-Co Complex in Crystalline State2005

    • Author(s)
      Zhicheng Zhu, Satoru Karasawa, Noboru Koga
    • Journal Title

      Inorg. Chem. 44

      Pages: 6004-6011

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Synthesis and EPR studies of 2-N-tert-butylaminoxylpurin derivatives2005

    • Author(s)
      Toshiyuki Kaneko, Mariko Aso, Noboru Koga, Hiroshi Suemune
    • Journal Title

      Org.Lett., 7

      Pages: 303-305

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Magnetic properties of dendritic polycarbenes substituted by bulky peripheral groups2005

    • Author(s)
      Takeyuki Akita, Noboru Koga
    • Journal Title

      Polyhedron

      Pages: 2321-2325

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecule-based Magnets in Heterospin Systems2005

    • Author(s)
      Noboru Koga, Satoru Karasawa
    • Journal Title

      Bull.Chem.Soc.Jpn. (In press)

    • NAID

      10019038689

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Magnetic Behavior of Tetrakis[4-(N-tert-butyl-N-oxylamino)pyridine]bis(isocyanato-N)cobalt(II) in Frozen Solution2004

    • Author(s)
      Shinji Kanegawa, Satoru Karasawa, Motohiro Nakano, Noboru Koga
    • Journal Title

      J.Chem.Soc.Chem.Comm. (印刷中)

      Pages: 1750-1751

    • Related Report
      2004 Annual Research Report
  • [Publications] H.Morikawa, S.Karasawa, N.Koga: "Magnetic Property after Irradiation of Tetrakis[4-(a-diazobenzyl)pyridine]copper(II) in a Frozen Solution"Appl.Magn.Reson.. 23・4. 507-515 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Iwasaki, K.Katano, Y.Ohba, S.Karasawa, N.Koga, S.Yamauchi: "On the g Value Shift and Intersystem Crossing in Photo-Excited Radical-Triplet Syslems."Appl.Magn.Reson.. 23・4. 377-391 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Satoru Karasawa, Noboru Koga: "Magnetic behaviors after irradiation of assemblies consisting of bis(hexafluoroacetylacetonato)copper(II) and tetrapyridyl-pentadiazo compounds in frozen solutions"Polyhedron. 22. 1877-1882 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Satoru Karasawa, Guangyuan Zhou, Hiroshi Morikawa, Noboru Koga: "Magnetic Properties of Tetrakis[4-(a-diazobenzyl)pyridine]bis(thiocyanato-N)cobalt(II) in Frozen Solution after Irradiation. Formation of a Single-molecule Magnet in Frozen Solution."J.Am.Chem.Soc.. 125. 13676-13677 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi