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Studies on the Regulatory Mechanism of Neuronal Death: Isolation of Novel Factors and Title of Preparation of Model of Neurodegenerative Disease.

Research Project

Project/Area Number 15109002
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

NOMURA Yasuyuki  Hokkaido University, Graduate School of Medicine, Invited Researcher, 大学院医学研究科, 招聘教員 (00034041)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Ryosuke  Kyoto University, Graduate School of Medicine, Professor, 大学院医学研究科, 教授 (90216771)
OKUMA Yasunobu  Chiba Institute of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (20127939)
UEHARA Takashi  Hokkaido University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院薬学研究院, 助教授 (00261321)
KANEKO Masayuki  Chiba Institute of Science, Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 講師 (10322827)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥112,190,000 (Direct Cost: ¥86,300,000、Indirect Cost: ¥25,890,000)
Fiscal Year 2006: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2005: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2004: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2003: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Keywordsnitric oxide (NO) / ER stress / protein disulfide isomerase (PDI) / nitrosylation / neurodegenerative disease / parkin / Pael receptor (Pael-R) / transgenic mouse / パーキン / アポトーシス / カスパーゼ / 内在性抵抗因子 / 小胞体関連タンパク質分解 / ユビキチン / プロテアソーム / GMEB1 / ニューロン / グリア / ストレス / 小胞体 / ERAD / 脳虚血 / ユビキチンリガーゼ
Research Abstract

Protein-disulphide isomerase (PDI), which exists in endoplasmic reticulum (ER), and assists in the maturation and transport of unfolded secretory proteins. PDI has two domains that function as independent active sites with homology to the small, redox-active protein thioredoxin. We demonstrated that PDI was S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function. NO-induced S-nitrosylation of PDI inhibited its enzymatic activity, leads to the accumulation of polyubiquitinated proteins, and activates the unfolded protein response. Furthermore, we showed in brains manifesting sporadic Parkinson's or Alzheimer's disease, that PDI is S-nitrosylated. Thus, PDI prevents neurotoxicity associated with ER stress and protein misfolding, but NO blocks this protective effect in neurodegenerative disorders through the S-nitrosylation of PDI.
Upregulation of Parkin associated endothelin-receptor like receptor (Pael-R) in the ubiquitin-protein ligase Parkin deficient mice leads to death of dopaminergic neurons. The cell death in these animals was protected or aggaravated in upregulated or deficient mice of the ER chaperone ORP150 (150 kDa oxygen-regulated protein), respectively. We interbreed Pael-R-upregulated and Parkin knockout mice. In the mice, we observed ER-stress in the brain, selective cell death of catecholaminergic neurons in the substantia nigra and the locus ceruleus, and deficiency of mitochondria complex I. These data suggest a model in which ER-and dopamine-related stress are major contributors to decreased viability of dopaminergic neurons in a setting relevant to Parkinson's disease.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (149 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (136 results) Book (4 results) Patent(Industrial Property Rights) (3 results) Publications (6 results)

  • [Journal Article] Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression.2007

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Europ. J. Pharmacol. 554

      Pages: 8-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pael Receptor Induces Death of Dopaminergic Neurons in the Substantia Nigra via Endoplasmic Reticulum Stress and Dopamine Toxicity, which is Enhanced under Condition of Parkin Inactivation.2007

    • Author(s)
      Kitao, Y. et al.
    • Journal Title

      Hum. Mol. Genet. 16

      Pages: 50-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).2007

    • Author(s)
      Kuzuya, A. et al.
    • Journal Title

      J. Neurosci. Res. 85

      Pages: 153-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion.2007

    • Author(s)
      Ohtani, R. et al.
    • Journal Title

      Brain Res. 1135

      Pages: 195-200

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.2007

    • Author(s)
      Kawamoto, Y. et al.
    • Journal Title

      Brain Res. 1136

      Pages: 219-227

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.2007

    • Author(s)
      Inden, M. et al.
    • Journal Title

      J. Neurochem. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairement of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8.2007

    • Author(s)
      Tomobe, K. et al.
    • Journal Title

      Brain res. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS.2007

    • Author(s)
      Yamashita, H. et al.
    • Journal Title

      J. Neurochem. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in {alpha}-synucleinopathy brains.2007

    • Author(s)
      Murakami, T. et al.
    • Journal Title

      J. Neurol. Neurosurg. Psychiatry (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cell type-specific upregulation of parkin in response to ER stress.2007

    • Author(s)
      Wang, H. et al.
    • Journal Title

      ARS Forum (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibitory effect of 4-(2-aminoethyl)- benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression.2007

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Europ. J. Pharmacol. 554

      Pages: 8-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression.2007

    • Author(s)
      Hosoi, T., et al.
    • Journal Title

      Europ. J. Pharmacol 554

      Pages: 8-11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pael Receptor Induces Death of Dopaminergic Neurons in the Substantia Nigra via Endoplasmic Reticulum Stress and Dopamine Toxicity, which is Enhanced under Condition of Parkin Inactivation.2007

    • Author(s)
      Kitao, Y., et al.
    • Journal Title

      Hum. Mol. Genet. 16

      Pages: 50-60

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impairment of CREB phosphorylation in the hippocampal CAl region of the senescence-accelerated mouse (SAM) P8.2007

    • Author(s)
      Tomobe, K., et al.
    • Journal Title

      Brain Res. 1141

      Pages: 214-217

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzene sulfonyl fluoride-responsive serine protease.2007

    • Author(s)
      Hosoi, T., et al.
    • Journal Title

      Cell Res. 17

      Pages: 184-186

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cell type-specific upregulation of parkin in response to ER stress.2007

    • Author(s)
      Wang, H., et al.
    • Journal Title

      ARS Forum (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in {alpha}-synucleinopathy brains.2007

    • Author(s)
      Murakami, T., et al.
    • Journal Title

      J. Neurol. Neurosurg. Psychiatry (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS.2007

    • Author(s)
      Yamashita, H., et al.
    • Journal Title

      J. Neurochem. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.2007

    • Author(s)
      Kawamoto, Y., et al.
    • Journal Title

      Brain Res. 1136

      Pages: 219-227

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion.2007

    • Author(s)
      Ohtani, R., et al.
    • Journal Title

      Brain Res. 1135

      Pages: 195-200

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).2007

    • Author(s)
      Kuzuya, A., et al.
    • Journal Title

      J. Neurosci. Res. 85

      Pages: 153-165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells.2006

    • Author(s)
      Hyoda, K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 340

      Pages: 286-290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells.2006

    • Author(s)
      Hayashi, N. et al.
    • Journal Title

      Neurosci. Lett. 397

      Pages: 5-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.2006

    • Author(s)
      Tsuruma, K. et al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 11397-11404

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dual inhibition of protein phosphatase-1/2A and calpain rescues nerve growth factor-differentiated PC12 cells from oxygen-glucose deprivation-induced cell death.2006

    • Author(s)
      Nakajima, T. et al.
    • Journal Title

      J. Neurosci. Res. 83

      Pages: 459-468

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior.2006

    • Author(s)
      Nomura, M. et al.
    • Journal Title

      Psychopharmacology 187

      Pages: 30-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.2006

    • Author(s)
      Kubota, K. et al.
    • Journal Title

      J. Neurochem. 97

      Pages: 1259-1268

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.2006

    • Author(s)
      Omura, T. et al.
    • Journal Title

      J. Neurochem. 99

      Pages: 1456-1469

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 2-Aminopurine inhibits leptin receptor signal transduction.2006

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Europ. J. Pharmacol. 553

      Pages: 61-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in Allium species.2006

    • Author(s)
      Nishimura, H. et al.
    • Journal Title

      BioFactors 26

      Pages: 135-146

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration.2006

    • Author(s)
      Uehara, T. et al.
    • Journal Title

      Nature 441

      Pages: 513-517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chromogranin-mediated Secretion of Superoxide Dismutase Mutants as a Novel Pathogenic Pathway for ALS.2006

    • Author(s)
      Urushitani, M. et al.
    • Journal Title

      Nature Neurosci. 9

      Pages: 108-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.2006

    • Author(s)
      Rezgaoui, M. et al.
    • Journal Title

      J. Cell Sci. 119

      Pages: 542-549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Localization of Id2 mRNA in the adult mouse brain.2006

    • Author(s)
      Kitajima, K. et al.
    • Journal Title

      Brain Res. 1073-1074

      Pages: 93-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals.2006

    • Author(s)
      Misawa, H. et al.
    • Journal Title

      Neurobiol. Dis. 23

      Pages: 169-177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI : A case report.2006

    • Author(s)
      Mitsueda-Ono, T. et al.
    • Journal Title

      J. Neurol. Sci. 247

      Pages: 109-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Generators and temporal succession of giant somatosensory evoked potentials in cortical reflex myoclonus : Epicortical recording from sensorimotor cortex.2006

    • Author(s)
      Hitomi, T. et al.
    • Journal Title

      Clin. Neurophysiol. 117

      Pages: 1481-1486

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).2006

    • Author(s)
      Arai, R. et al.
    • Journal Title

      Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62

      Pages: 330-334

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.2006

    • Author(s)
      Shirakashi, Y. et al.
    • Journal Title

      Acta Neuropathol. (Berl) 112

      Pages: 681-689

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents.2006

    • Author(s)
      Nakaji, K. et al.
    • Journal Title

      Stroke 37

      Pages: 2816-2823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Heterogeneous epileptogenicity and cortical function within malformations of cortical development : A case report.2006

    • Author(s)
      Kinoshita, M. et al.
    • Journal Title

      J. Neurol. Sci. 251

      Pages: 129-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration.2006

    • Author(s)
      Uehara, T., et al.
    • Journal Title

      Nature 441

      Pages: 513-517

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A ubiquitin ligase HRDl promotes the degradation of Pael receptor, a substrate of Parkin.2006

    • Author(s)
      Omura, T., et al.
    • Journal Title

      J. Neurochem 99

      Pages: 1456-1469

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells.2006

    • Author(s)
      Hayashi, N., et al.
    • Journal Title

      Neurosci. Lett 397

      Pages: 5-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 2-Aminopurine inhibits leptin receptor signal transduction.2006

    • Author(s)
      Hosoi, T., et al.
    • Journal Title

      Europ. J. Pharmacol 553

      Pages: 61-66

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in Allium species.2006

    • Author(s)
      Nishimura, H., et al.
    • Journal Title

      Biofactors 26

      Pages: 135-146

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior.2006

    • Author(s)
      Nomura, M., et al.
    • Journal Title

      Psychopharmacology (Berl) 187

      Pages: 30-35

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.2006

    • Author(s)
      Kubota, K., et al.
    • Journal Title

      J. Neurochem 97

      Pages: 1259-1268

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Leptin and its receptor mechanisms involved in the brain immune system.2006

    • Author(s)
      Okuma, Y., et al.
    • Journal Title

      Nippon Yakurigaku Zasshi 127

      Pages: 25-31

    • NAID

      10017495043

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.2006

    • Author(s)
      Tsuruma, K., et al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 11397-11404

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heterogeneous epileptogenicity and cortical function within malformations of cortical development : A case report.2006

    • Author(s)
      Kinoshita, M., et al.
    • Journal Title

      J. Neurol. Sci. 251

      Pages: 129-133

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents.2006

    • Author(s)
      Nakaji, K., et al.
    • Journal Title

      Stroke 37

      Pages: 2816-2823

    • Related Report
      2006 Annual Research Report
  • [Journal Article] alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.2006

    • Author(s)
      Shirakashi, Y., et al.
    • Journal Title

      Acta Neuropathol. (Berl) 112

      Pages: 681-689

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).2006

    • Author(s)
      Arai, R., et al.
    • Journal Title

      Acta Crystallograph Sect. F Struct. Biol. Cryst. Commun. 62

      Pages: 330-334

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Generators and temporal succession of giant somatosensory evoked potentials in cortical reflex myoclonus : Epicortical recording from sensorimotor cortex.2006

    • Author(s)
      Hitomi, T., et al.
    • Journal Title

      Clin. Neurophysiol 117

      Pages: 1481-1486

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI.2006

    • Author(s)
      Mitsueda-Ono, T., et al.
    • Journal Title

      J. Neurol. Sci. 247

      Pages: 109-111

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals.2006

    • Author(s)
      Misawa, H., et al.
    • Journal Title

      Neurobiol. Dis. 23

      Pages: 169-177

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury2006

    • Author(s)
      Tsuruma, K.et al.
    • Journal Title

      J.Biol.Chem. (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.2006

    • Author(s)
      Kubota, K.et al.
    • Journal Title

      J.Neurochem. (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic analysis of learning and memory deficits in senescence-accelerated mouse (SAM).2005

    • Author(s)
      Tomobe, K. et al.
    • Journal Title

      Physiol. Behav. 84

      Pages: 505-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] STAT3 activation and c-FOS expression in the brain following peripheral administration of bacterial DNA.2005

    • Author(s)
      Sako, K. et al.
    • Journal Title

      J. Neuroimmunol. 158

      Pages: 40-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The age-related degeneration of oligodendrocytes in the hippocampus of the senescence-accelerated mouse (SAM) P8 : a quantitative immunohistochemical study.2005

    • Author(s)
      Tanaka, J. et al.
    • Journal Title

      Biol. Pharm. Bull. 28

      Pages: 615-618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8.2005

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Biol. Pharm. Bull. 28

      Pages: 1514-1516

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel pathway for LPS-induced afferent vagus nerve activation : possible role of nodose ganglion.2005

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Auton. Neurosci. 120

      Pages: 104-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Caspase recruitment domain of procaspase-2 could be a target for SUMO-1 modification through Ubc9.2005

    • Author(s)
      Shirakura, H. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 331

      Pages: 1007-1015

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] LPS induces stefin A3 expression in mouse primary cultured glial cells.2005

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Mol. Brain Res. 140

      Pages: 138-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of cyclooxygenase-dependent pathway in contraction of isolated ileum by urotensin II.2005

    • Author(s)
      Horie, S. et al.
    • Journal Title

      Peptides 26

      Pages: 323-329

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells.2005

    • Author(s)
      Fujimuro, M. et al.
    • Journal Title

      Biol. Pharm. Bull. 28

      Pages: 2315-2318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells.2005

    • Author(s)
      Ohkawara, S. et al.
    • Journal Title

      Europ. J. Pharmacol. 525

      Pages: 41-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.2005

    • Author(s)
      Yamamoto, A. et al.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 3390-3399

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.2005

    • Author(s)
      Kim, Y.J.et al.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 21515-21521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.2005

    • Author(s)
      Sekine, K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 330

      Pages: 279-285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and signaling.2005

    • Author(s)
      Yang, Y. et al.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 102

      Pages: 13670-13675

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo evidence of CHIP up-regulation attenuating tau aggregation.2005

    • Author(s)
      Sahara, N. et al.
    • Journal Title

      J. Neurochem. 94

      Pages: 1254-1263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A strapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells.2005

    • Author(s)
      Ohkawara, S. et al.
    • Journal Title

      Europ. J. Pharmacol. 525

      Pages: 41-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Caspase recruitment domain of procaspase-2 could be a target for SUMO-1 modification through Ubc9.2005

    • Author(s)
      Shirakura, H.et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 331

      Pages: 1007-1015

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.2005

    • Author(s)
      Yamamoto, A.et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 3390-3399

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and PI3K/Akt signaling.2005

    • Author(s)
      Yang, Y.et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 102

      Pages: 13670-13675

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.2005

    • Author(s)
      Kim, Y.J.et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 21515-21521

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preconditioning prevents ischemia-induced neuronal death through persistent Akt activation in the penumbra region of the rat brain.2004

    • Author(s)
      Nakajima, T. et al.
    • Journal Title

      J. Vet. Med. Sci. 66

      Pages: 521-527

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in primary mouse cultured glial cells.2004

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Mol. Brain Res. 124

      Pages: 159-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Herbimycin A abrogates NF-κB activation by preferentially interacting with the IKKβ subunit.2004

    • Author(s)
      Ogino, S. et al.
    • Journal Title

      Mol. Pharmacol. 65

      Pages: 1344-1351

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Edaravone protects against cerebral ischemia-induced endoplasmic reticulum dysfunction.2004

    • Author(s)
      Qi, X.et al.
    • Journal Title

      J. Pharmacol. Exp. Therap. 311

      Pages: 388-393

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sodium 4-phenylbutyrate protects against cerebral ischemic injury.2004

    • Author(s)
      Qi, X.et al.
    • Journal Title

      Mol. Pharmacol. 66

      Pages: 899-908

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.2004

    • Author(s)
      Ko, H.S.et al.
    • Journal Title

      FEBS Lett. 566

      Pages: 110-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of murine HRD1 in experimental cerebral ischemia.2004

    • Author(s)
      Qi, X.et al.
    • Journal Title

      Mol. Brain Res. 130

      Pages: 30-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible involvement of pyruvate kinase in acquisition of tolerance to hypoxic stress in glial cells.2004

    • Author(s)
      Shimizu, T. et al.
    • Journal Title

      J. Neurochem. 91

      Pages: 167-175

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bacterial endotoxin induces IL-20 expression in the glial cells.2004

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Mol. Brain Res. 130

      Pages: 23-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Manganese superoxide dismutase is induced by endoplasmic reticulum stress through IRE1-mediated unclear factor (NF)-κ B and AP-1 activation.2004

    • Author(s)
      Kaneko, M. et al.
    • Journal Title

      Biol. Pharm. Bull. 27

      Pages: 1202-1206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of subdiaphragmatic vagotomy on bacterial DNA-induced IL-1 β expression in the mouse hypothalamus.2004

    • Author(s)
      Ono.A.et al.
    • Journal Title

      Brain Res. 1028

      Pages: 233-237

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain.2004

    • Author(s)
      Tsuruma, K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 325

      Pages: 1246-1251

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bacterial endotoxin induces STAT3 activation in the mouse brain.2004

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Brain Res. 1023

      Pages: 48-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The mitochondrial protease Omi-HtrA2 enhances caspase activation through multiple pathways.2004

    • Author(s)
      Suzuki, Y. et al.
    • Journal Title

      Cell Death Differ. 11

      Pages: 208-216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme.2004

    • Author(s)
      Yokota, T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 314

      Pages: 283-291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pael-R is accumulated in Lewy bodies of Parkinson's disease.2004

    • Author(s)
      Murakami, T. et al.
    • Journal Title

      Ann. Neurol. 55

      Pages: 439-442

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.2004

    • Author(s)
      Urushitani, M. et al.
    • Journal Title

      J. Neurochem. 90

      Pages: 231-244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-apoptotic function of API2-MALT1 fusion protein involved in t(11;14)(q21;q21) MALT lymphoma.2004

    • Author(s)
      Hosokawa, Y. et al.
    • Journal Title

      Cancer Res. 64

      Pages: 3452-3457

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differentiation dependent sensitivity to apoptogenic factors in PC12 cells.2004

    • Author(s)
      Vyas, S. et al.
    • Journal Title

      J. Biol. Chem. 279

      Pages: 30983-30993

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.2004

    • Author(s)
      Tateno, M. et al.
    • Journal Title

      Hum. Mol. Genet. 13

      Pages: 2183-2196

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] U-box protein carboxyl terminus of Hsc7O-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.2004

    • Author(s)
      Hatakeyama, S. et al.
    • Journal Title

      J. Neurochem. 91

      Pages: 299-307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Herbimycin A abrogates NF-kB activation by preferentially interacting with the IKKβ subunit.2004

    • Author(s)
      Ogino, S. et al.
    • Journal Title

      Mol. Pharmacol. 65

      Pages: 1344-1351

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.2004

    • Author(s)
      Ko, H.S.et al.
    • Journal Title

      FEB S Lett. 566

      Pages: 110-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Manganese superoxide dismutase is induced by endoplasmic reticulum stress through IRE1-mediated unclear factor (NF)-kB and AP-1 activation.2004

    • Author(s)
      Kaneko, M. et al.
    • Journal Title

      Biol. Pharm. Bull. 27

      Pages: 1202-1206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of subdiaphragmatic vagotomy on bacterial DNA-induced IL-1 β expression in the mouse hypothalamus.2004

    • Author(s)
      Ono, A.et al.
    • Journal Title

      Brain Res. 1028

      Pages: 233-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-apoptotic function of API2-MA LT1 fusion protein involved in t(11;14)(q21;q21) MALT lymphoma.2004

    • Author(s)
      Hosokawa, Y. et al.
    • Journal Title

      Cancer Res. 64

      Pages: 3452-3457

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.2004

    • Author(s)
      Hatakeyama, S. et al.
    • Journal Title

      J. Neurochem. 91

      Pages: 299-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.2004

    • Author(s)
      Ko et al.
    • Journal Title

      FEBS Lett. 566(1-3)

      Pages: 110-114

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sodium 4-Phenylbutyrate Protects against Cerebral Ischemic Injury.2004

    • Author(s)
      Qi X et al.
    • Journal Title

      Mol Pharmacol 66(4)

      Pages: 899-908

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bacterial Herbimycin A abrogates NF-κB activation by preferentially interacting with the IKKβ subunit.2004

    • Author(s)
      Ogino et al.
    • Journal Title

      Mol Pharmacol 65(6)

      Pages: 1344-1351

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bacterial endotoxin induces IL-20 expression in the primary cultured glial cells.2004

    • Author(s)
      Hosoi T et al.
    • Journal Title

      Mol Brain Res 130(1/2)

      Pages: 23-29

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Possible involvement of pyruvate kinase in acqusition of tolerance to hypoxic stress in glial cells.2004

    • Author(s)
      Shimizu et al.
    • Journal Title

      J Neurochem 91(1)

      Pages: 167-175

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Edaravone protects against cerebral ischemia-induced endoplasmic reticulum dysfunction.2004

    • Author(s)
      Qi X et al.
    • Journal Title

      J Pharmacol Exp Ther 311(1)

      Pages: 388-393

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells.2003

    • Author(s)
      Nemoto, T. et al.
    • Journal Title

      Europ. J. Pharmacol. 458

      Pages: 17-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The presence and functions of mnscariric receptors in human T cells : The involvement in IL-2 and IL-2 receptor system.2003

    • Author(s)
      Nomura, J. et al.
    • Journal Title

      Life Sci. 72

      Pages: 2121-2126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aβ-induced TNF-α expression and acetylcholine action in mouse glial cells.2003

    • Author(s)
      Nomura, J. et al.
    • Journal Title

      Life Sci. 72

      Pages: 2117-2120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation signal of nuclear factor-κB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2.2003

    • Author(s)
      Kaneko, M. et al.
    • Journal Title

      Biol. Pharm. Bull. 26

      Pages: 931-935

    • NAID

      110003608549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of leptin-induced IL-1β expression by glucocorticoids in the brain.2003

    • Author(s)
      Hosoi, T. et al.
    • Journal Title

      Brain Res. 969

      Pages: 95-101

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Correlation between delayed neuronal cell death and selective decrease in phosphatidylinositol 4-kinase expression in the CA1 subfield of the hippocampus after transient forebrain ischemia.2003

    • Author(s)
      Furuta, Y. et al.
    • Journal Title

      J. Cereb. Blood Flow Metab. 23

      Pages: 962-971

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Age-related alterations in the expression of glial cell line-derived neurotrophic factor in the senescence-accelerated mouse brain.2003

    • Author(s)
      Miyazaki, H. et al.
    • Journal Title

      J. Pharmacol. Sci. 92

      Pages: 28-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cholecystokinin inhibits food intake independent of interleukin-1β expression in the brain.2003

    • Author(s)
      Zhan, L. et al.
    • Journal Title

      Biol. Pharm. Bull. 26

      Pages: 1181-1183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists.2003

    • Author(s)
      Kitamura, Y. et al.
    • Journal Title

      Neruochem. Res. 28

      Pages: 1035-1040

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stress proteins and glial functions : possible therapeutic targets for neurodegenerative disorders.2003

    • Author(s)
      Kitamura, Y. et al.
    • Journal Title

      Pharmacol. Therap. 97

      Pages: 35-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contraction of isolated guinea-pig ileum by urotensin II via activation of ganglionic cholinergic neurons and acetylcholine release.2003

    • Author(s)
      Horie, S. et al.
    • Journal Title

      Neuropharmacology 45

      Pages: 1019-1027

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of interleukin-6 in PC12 cell death induced by MPP^+ and tetrahydroisoquinoline.2003

    • Author(s)
      Shimma, N. et al.
    • Journal Title

      J. Pharmacol. Sci. 93

      Pages: 471-477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.2003

    • Author(s)
      Yang, Y. et al.
    • Journal Title

      Neuron 37

      Pages: 911-924

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] VAChT-Cre.Fast and VAChT-Cre. Slow : Postnatal expression of Cre recombinase in somatomotor neurons with different onset.2003

    • Author(s)
      Misawa, H. et al.
    • Journal Title

      Genesis 37

      Pages: 44-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.2003

    • Author(s)
      Imai, Y. et al.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 51901-51910

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation signal of nuclear factor-KB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2.2003

    • Author(s)
      Kaneko, M. et al.
    • Journal Title

      Biol. Pharm. Bull. 26

      Pages: 931-935

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cholecystokinin inhibits food intake independent of interleukin-1 β expression in the brain.2003

    • Author(s)
      Zhan, L. et al.
    • Journal Title

      Biol. Pharm. Bull. 26

      Pages: 1181-1183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline.2003

    • Author(s)
      Shimma, N. et al.
    • Journal Title

      J. Pharmacol. Sci. 93

      Pages: 471-477

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] VA ChT-Cre.Fast and VA ChT-Cre.Slow : Postnatal expression of Cre recombinase in somatomotor neurons with different onset.2003

    • Author(s)
      Misawa, H. et al.
    • Journal Title

      Genesis 37

      Pages: 44-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

    • Author(s)
      Inden, M. et al.
    • Journal Title

      J. Neurochem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairement of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8.

    • Author(s)
      Tomobe, K. et al.
    • Journal Title

      Brain res. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS.

    • Author(s)
      Yamashita, H. et al.
    • Journal Title

      J. Neurochem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] PINK1, a gene product of PARK6, accumulates in {alpha}-synucleinopathy brains.

    • Author(s)
      Murakami, T. et al.
    • Journal Title

      J. Neurol. Neurosurg. Psychiatry (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cell type-specific upregulation of parkin in response to ER stress.

    • Author(s)
      Wang, H. et al.
    • Journal Title

      ARS Forum (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 機能形態学総論2007

    • Author(s)
      野村 靖幸
    • Publisher
      化学同人(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 機能形態学総論2007

    • Author(s)
      野村 靖幸
    • Publisher
      化学同人
    • Related Report
      2006 Annual Research Report
  • [Book] 脳の炎症とグリア細胞2005

    • Author(s)
      大熊康修
    • Total Pages
      3
    • Publisher
      Clinical Neuroscience(中外医学社)
    • Related Report
      2005 Annual Research Report
  • [Book] Biochemical changes in the brain of the senescence-accelerated mouse (SAM)P8 and P10 in "The Senescence-Accelerated Mouse (SAM) An Animal model of Senescence(Ed. by Nomura Y, Takeda T, Okuma Y)2004

    • Author(s)
      Nomura Y et al.
    • Total Pages
      448
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 小胞体ストレス関連疾患の予防・治療・診断標的分子としてのKF-12005

    • Inventor(s)
      野村靖幸, 金子雅幸
    • Industrial Property Rights Holder
      大塚製薬株式会社
    • Filing Date
      2005-03-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] APPおよびAβ産生抑制作用蛋白質HRD12005

    • Inventor(s)
      野村靖幸, 金子雅幸
    • Industrial Property Rights Holder
      大塚製薬株式会社
    • Filing Date
      2005-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] APPおよびAβ産生抑制作用蛋白質HRD12004

    • Inventor(s)
      野村 靖幸, 金子 雅幸
    • Industrial Property Rights Holder
      大塚製薬(株)
    • Industrial Property Number
      2004-150456
    • Filing Date
      2004-05-20
    • Related Report
      2004 Annual Research Report
  • [Publications] Furuta et al.: "Correlation between delayed neuronal cell death and selective decrease in phosphatidylinositol 4-kinase expression in the CA1 subfield of the hippocampus after transient forebrain ischemia."Journal of cerebral blood flow and metabolism. 23,8. 962-971 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hosoi et al.: "Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain."Brain Research. 969,1-2. 95-101 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kitamura et al.: "Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists."Neurochemical research. 28,7. 1035-1040 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nomura et al.: "A beta-induced TNF-alpha expression and acetylcholine action in mouse glial cells."Life Science. 72,18-19. 2117-2120 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyazaki et al.: "Age-related alterations in the expression of glial cell line-derived neurotrophic factor in the senescence-accelerated mouse brain."Journal of pharmacological sciences. 92,1. 28-34 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kaneko et al.: "Activation signal of nuclear factor-kappaB in response to endoplasmic reticulumstress is transduced via IRE1 and tumor necrosis factor recepter-associated factor 2."Biological & pharmaceutical bulletin. 26,7. 931-935 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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