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移植腎へのHGF遺伝子導入の臨床研究

Research Project

Project/Area Number 15109009
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

奥山 明彦  大阪大学, 医学系研究科, 教授 (20093388)

Co-Investigator(Kenkyū-buntansha) 高原 史郎  大阪大学, 医学系研究科, 寄附講座教授 (70179547)
今井 圓裕  大阪大学, 医学系研究科, 講師 (00223305)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2004: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2003: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
KeywordsHepatocyte Growth Factor / 遺伝子治療 / electropotation法 / 腎移植 / 慢性拒絶反応 / 線維化 / 大動物 / 長期生着 / 腎臓移植 / 臓器保存 / Hepatocyte Growth Facto / electroporation法
Research Abstract

研究実績の概要
(1)ブタ腎へのelectroporatign法によるHGF遺伝子直接導入(安全性試験):平成15年度報告に記載した安全性試験の結果を論文投稿し、追加実験(病理診断とPCR法による長期遺伝子発現の有無の確認)を要求され、実施した。再投稿し受理された(Gene Therapy : in press)
(2)ブタ腎へのHGF直接投与による有効性および安全性試験:大阪大学医学部附属病院・遺伝子治療臨床研究審査委員会から要求された追加実験有効性試験は終了。

Report

(2 results)
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (12 results)

All 2004 Other

All Journal Article (8 results) Publications (4 results)

  • [Journal Article] Comprehensive examination of gene expression associated with long-term stable graft acceptance2004

    • Author(s)
      H.Zhang
    • Journal Title

      Clin Transplant 18

      Pages: 70-78

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Direct HGF gene transfer into kidney suppressed cyclosporine A nephropathy.2004

    • Author(s)
      Yazawa Y
    • Journal Title

      Nephrol Dial Transplant 19

      Pages: 1-5

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity.2004

    • Author(s)
      Mizui M
    • Journal Title

      Kidney Int 65

      Pages: 2041-2053

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin.2004

    • Author(s)
      Nakajima H
    • Journal Title

      J Am Soc Nephrol 15

      Pages: 276-285

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Exploring RNA Interference as a Therapeutic Strategy for Renal Disease.

    • Author(s)
      Takabatake Y
    • Journal Title

      Gene Therapy in press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Actions of a Rho Signaling Inhibitor, Y-27632, Against Progression in a Mouse Model of Hepatocellular Carcinoma

    • Author(s)
      F.Xue
    • Journal Title

      Gastroenterology in press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Rapid recovery from liver injury in hepatectomized rat by naked HGF gene transfer

    • Author(s)
      Kobayashi, S
    • Journal Title

      Hepatology in press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Electroporation-mediated HGF gene transfection protected the kidney against graft injury.

    • Author(s)
      Isaka, Y
    • Journal Title

      Gene Therapy in press

    • Related Report
      2004 Annual Research Report
  • [Publications] S.Kobayashi, K.Dono, T.Tanaka, S.Takahara, et al.: "Gene transfer into the liver by plasmid injection into the portal vein combined with electroporation"J Gene Med. 5. 201-208 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] F.Xue, T.Takahara, Y.Yata, Y.Kuwabara, E.Shinno, K.Nonome, M.Minemura, S.Takahara: "Hepatocyte growth factor gene therapy accelerates regeneration in cirrhotic mouse livers after hepatectomy"GUT. 52. 694-700 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Yazawa, Y.Isaka, S.Takahara, E.Imai, et al.: "Direct HGF gene transfer into kidney suppressed cyclosporine A nephropathy."Nephrol Dial Transplant. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Kobayashi, K.Dono, T.Tanaka, T.Kato, H.Nagano, K.Umeshita, et al.: "Rapid recovery from liver injury in hepatectomized rat by naked HGF gene transfer with in vivo electoroporation"Hepatology. (In press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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