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The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering

Research Project

Project/Area Number 15109010
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

TAKIGAWA Masaharu  Okayama University, Grand. Sch. Med. Dent. & Pharm. Sci, Prof (20112063)

Co-Investigator(Kenkyū-buntansha) KUBOTA Satoshi  Okayama Univ., Grad. Sch. Med. Dent. & Pharm. Sci, Assoc. Prof (90221936)
HATTORI Takako  Okayama Univ., Grad. Sch. Med. Dent. & Pharm. Sci, Assist. Prof (00228488)
NISHIDA Takashi  Okayama Univ., Grad. Sch. Med. Dent. & Pharm. Sci, Assist. Prof (30322233)
YAMAMOTO Teruko  Tohoku University, Graduate School of Dentistry, Professor (00127250)
TABATA Yasuhiko  Kyoto University, Institute for Frontier Medical Sciences, Professor (50211371)
青山 絵理子  岡山大学, 歯学部, 教務員 (10432650)
山合 友一朗  岡山大学, 大学院医歯薬学総合研究科, 助手 (00158057)
椋代 義樹  岡山大学, 歯学部, 教務員 (50325099)
小守 壽文  長崎大学, 医歯薬学総合研究科, 教授 (00252677)
中西 徹  岡山大学, 大学院・医歯学総合研究科, 助教授 (30243463)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥103,870,000 (Direct Cost: ¥79,900,000、Indirect Cost: ¥23,970,000)
Fiscal Year 2006: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2005: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2004: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2003: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
KeywordsCTGF / CCN2 / regeneration / regenerin / hard tissue / binding molecule / regulation of gene expression / signal transduction / mutant animal / 間葉系幹細胞 / 血管 / 受容体 / 遺伝子発現 / 歯根膜 / 結合蛋白 / CCN22 / CCNファミリー / 骨 / 軟骨 / 骨髄間葉系幹細胞 / 結合組織成長因子(CTGF) / CTGF遺伝子ノックアウトマウス / ゼラチンハイドロゲル
Research Abstract

1. Using wild type and/or mutant animals, we found that in addition to endochondral ossification in growth plate, CTGF/CCN2 was involved in secondary ossification center formation, intramembranous ossification, formation of periodontal ligament and articular and auricular cartilages, distraction osteogenesis and repair of tooth extraction socket. In vivo administration of CTGF/CCN2 with gelatin hydrogel into the artificial defect of articular cartilage and bone resulted in repair of these tissues, respectively. Taken together with the finding that platelets contained much CTGF/CCN2, these findings indicate that CTGF/CCN2 functions as a regeneration factor "regenerin".
2. We developed CTGF/CCN2 domain-specific antibodies and domain-specific ELISA systems. The function and signal transduction pathway of each domain was different depending on types of cells, such as chondrocytes and endothelial cells. CT domain of CTGF/CCN2 promoted adhesion of mesenchymal stem cells on hydroxyapatite plates, suggesting a possible application for bone regeneration with a combination of CTGF/CCN2 and hydroxyapatite.
3. A cis-element in 3'-untranslation region (3'-UTR) of CTGF/CCN2 mRNA, which was involved in destabilization of its mRNA, and a protein, which bound to the element, were found in chondrocytes. The biding between them changed in reverse relation to the process of chondrocyte differentiation. A hypoxia-inducible protein, which stabilized CTGF/CCN2 mRNA by binding to its 3'-UTR was also detected.
4. CTGF/CCN2 bound to perlecan, aggrecan and fibronectin, indicating its retention in extracellular matrix. CTGF/CCN2 had collaborative action with M-CSF on cartilage. Low density lipoprotein-related protein I was one of the receptors for CTGF/CCN2 in chondrocytes. Concerning signal transduction pathway of CTGF/CCN2 in chondrocytes, PKC was found as an upstream mediator of ERK and p38MAPK. JNK was involved in cell proliferation. PI3K and PKB were found to be involved in calcification.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (174 results)

All 2008 2007 2006 2005 2004 2003 Other

All Journal Article (138 results) (of which Peer Reviewed: 43 results) Book (24 results) Publications (12 results)

  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008

    • Author(s)
      Eguchi, T., et. al.
    • Journal Title

      Mol. Cell. Biol. 28

      Pages: 2391-2413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.2008

    • Author(s)
      Kawaki, H., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 366(2)

      Pages: 450-456

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008

    • Author(s)
      Ono, M., et. al.
    • Journal Title

      Cell Transplantation 17

      Pages: 231-240

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatinhydrogel. Tissue Engineering2008

    • Author(s)
      Kikuchi, T., et. al.
    • Journal Title

      Tissue Engineering

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008

    • Author(s)
      Eguchi, T., et. al.
    • Journal Title

      Mol. Cell. Biol 28

      Pages: 2391-2413

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functional requirement of CCN2 for intramembranous bone formation in embryonic mice2008

    • Author(s)
      Kawaki, H., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 366(2)

      Pages: 450-456

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family 2/Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes2008

    • Author(s)
      Fujisawa, T., et. al.
    • Journal Title

      Osteoarthritis and Cartilage (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel2008

    • Author(s)
      Kikuchi, T., et. al.
    • Journal Title

      Tissue Engineering (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family proteins and angiogenesis: from embryo to adulthood.2007

    • Author(s)
      Kubota, S. and Takigawa, M.
    • Journal Title

      Angiogenesis. 10(1)

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes2007

    • Author(s)
      Yanagita, T., et. al.
    • Journal Title

      FEBSJ. 274(7)

      Pages: 1655-1665

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN22007

    • Author(s)
      Ono, M., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 357(1)

      Pages: 20-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Increased connective tissue growth factor relative to brain natriuretic Peptide as a determinant of myocardial fibrosis2007

    • Author(s)
      Koitabashi, N., et. al.
    • Journal Title

      Hypertension 49(5)

      Pages: 1120-1127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Different transcriptional strategies for ccn2/ctgf gene induction betweenhuman chondrocytic and breast cancer cell lines2007

    • Author(s)
      Eguchi, T., et. al.
    • Journal Title

      Biochimie 89(3)

      Pages: 278-288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A functional polymorphism in the 5'UTR of GDF5 is associated with susceptibility to osteoarthritis2007

    • Author(s)
      Miyamoto, Y., et. al.
    • Journal Title

      Nat. Genet. 39

      Pages: 529-533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation2007

    • Author(s)
      Oka, M., et. al.
    • Journal Title

      J, Histochem, Cytochem, 55

      Pages: 1245-1255

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Report on fourth international work shop on the CCN family of Genes2007

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      J. Cell Commun. Signal. 1

      Pages: 59-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family 2/Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes2007

    • Author(s)
      Fujisawa, T., et. al.
    • Journal Title

      Osteoarthritis and Cartilage

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of CCN2/CTGF/Hcs242007

    • Author(s)
      Kubota, S. and Takigawa, M.
    • Journal Title

      bone growth. In Internal Review of Cytology, Vol. 257(K.W.Jeon ed.), Academic Press(Amsterdam)

      Pages: 1-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family proteins and angiogenesis : from embryo to adulthood2007

    • Author(s)
      Kubota, S., Takigawa, M
    • Journal Title

      Angiogenesis (invited review) 10(1)

      Pages: 1-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes2007

    • Author(s)
      Yanagita, T., et. al.
    • Journal Title

      FEES J 274(7)

      Pages: 1655-1665

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN22007

    • Author(s)
      Ono M., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 357(1)

      Pages: 20-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines2007

    • Author(s)
      Eguchi, T., et. al.
    • Journal Title

      Biochimie 89(3)

      Pages: 278-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis2007

    • Author(s)
      Miyamoto, Y., et. al.
    • Journal Title

      Nat. Genet 39

      Pages: 529-533

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation2007

    • Author(s)
      Oka, M., et. al.
    • Journal Title

      J. Histochem. Cytochem 55

      Pages: 1245-1255

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Report on fourth international workshop on the CCN family of genes2007

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      J. Cell. Commun. Signal 1

      Pages: 59-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family proteins and angiogenesis : from embryo to adulthood.2007

    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      Angiogenesis 10(1)

      Pages: 1-11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CCN22007

    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      UCSD/Nature Molecular Pages

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A functional polymorphism in the 5'-UTR of growth differentiation factor 5 (GDF5) is associated with susceptibility to osteoarthritis in Asian populations.2007

    • Author(s)
      Miyamoto Y et al.
    • Journal Title

      Nature Genetics in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Report on the fourth international workshop on the CCN family of genes.2007

    • Author(s)
      Kubota S et al.
    • Journal Title

      J. Cell Commun. Signal. in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes.2007

    • Author(s)
      Yanagita T et al.
    • Journal Title

      FEBS J. in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Promotion of Attachment of Human Bone Marrow Stromal Cells by CCN2.2007

    • Author(s)
      Ono M et al.
    • Journal Title

      Biophys. Biochem. Res. Commun. in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.2007

    • Author(s)
      Koitabashi N et al.
    • Journal Title

      Hypertension in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.2007

    • Author(s)
      Eguchi T et al.
    • Journal Title

      Biochimie in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.2006

    • Author(s)
      Kondo, S., et. al.
    • Journal Title

      Oncogene 25(7)

      Pages: 1099-1110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF)in human endothelial cells.2006

    • Author(s)
      Kondo, S., et. al.
    • Journal Title

      Molecular Cancer Therapeutics 5

      Pages: 129-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes2006

    • Author(s)
      Yosimichi, G., et. al.
    • Journal Title

      Bone 38

      Pages: 853-863

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes integrin αβ12006

    • Author(s)
      Hoshijima M., et. al.
    • Journal Title

      FEBS Lett. 580(5)

      Pages: 1376-1382

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dexamethasone induced connective tissue growth factor expression inrenal tugbular epithelial cells in a mouse strain-specific manner.2006

    • Author(s)
      Okada, H., et. al.
    • Journal Title

      Am. J. Pathol. 168(2)

      Pages: 737-743

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 軟骨組織の発生分化とCCNファミリー遺伝子2006

    • Author(s)
      久保田 聡、滝川正春
    • Journal Title

      Clin. Calcium 16(3)

      Pages: 486-492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of LRP1, a CCN2 receptor, in chondrocytes2006

    • Author(s)
      Kawata, K., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 345(2)

      Pages: 552-559

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture2006

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      Biochimie 88(12)

      Pages: 1973-1981

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer.2006

    • Author(s)
      Shimo, T., et. al.
    • Journal Title

      J. Bone Miner. Res. 21

      Pages: 1045-1059

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression and regulation of an anti-sense RNA transcript from human connective tissue growth factor gene in human cells2006

    • Author(s)
      Kondo, S., et. al.
    • Journal Title

      Asian J. Oral Mallilofa. Surg. 18

      Pages: 172-179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparable response of ccnl with ccn2 genes upon arthritis : An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines2006

    • Author(s)
      Moritani, N.H., et. al.
    • Journal Title

      Cell Commun.Signal 3(1)

      Pages: 6-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells2006

    • Author(s)
      Kondo, S., et. al.
    • Journal Title

      Oncogene 25(7)

      Pages: 1099-1110

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial2006

    • Author(s)
      Kondo, S., et. al.
    • Journal Title

      Mol. Cancer Then 5

      Pages: 129-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Roles of PKC, PI3K and INK in multiple transduction of CCN2/CTGF signals in chondrocytes2006

    • Author(s)
      Yosimichi, G., et. al.
    • Journal Title

      Bone 38

      Pages: 853-863

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes integrin α5β12006

    • Author(s)
      Hoshijima, M., et. al.
    • Journal Title

      FEBS Lett. 580(5)

      Pages: 1376-1382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dexamethasone induced connective tissue growth factor expression in renal tugbular epithelial cells in a mouse strain-specific manner2006

    • Author(s)
      Okada, H., et. al.
    • Journal Title

      Am. J. Pathol 168(2)

      Pages: 737-743

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family genes in the development and differentiation of cartilage tissues2006

    • Author(s)
      Kubota, S., Takigawa, M
    • Journal Title

      Clin. Calium (without peer review) 130

      Pages: 486-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of LRP1, a CCN2 receptor, in chondrocytes2006

    • Author(s)
      Kawata, K., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 345(2)

      Pages: 552-559

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in cultue2006

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      Biochimie 88(12)

      Pages: 1973-1981

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer2006

    • Author(s)
      Shimo, T., et. al.
    • Journal Title

      J. Bone Miner. Res 21

      Pages: 1045-1059

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression and regulation of an anti-sense RNA transcript from human connective tissue growth factor gene in human cells2006

    • Author(s)
      Kondo, S., et. al.
    • Journal Title

      Asian J. Oral Mallilofa. Surg 18

      Pages: 172-179

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes on cultue.2006

    • Author(s)
      Kubota S et al.
    • Journal Title

      Biochimie 88

      Pages: 1773-81

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pathogenic role of connective tissue growth factor (CCN2/CTGF) in osteolytic metastasis of breast cancer.2006

    • Author(s)
      Shimo T et al.
    • Journal Title

      J. Bone Miner. Res. 21

      Pages: 1045-1059

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.2006

    • Author(s)
      Yoshimichi G et al.
    • Journal Title

      Bone 38

      Pages: 853-863

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dexamethasone induced connective tissue growth factor expression in renal tugbular epithelial cells in a mouse strain-specific manner.2006

    • Author(s)
      Okada H et al.
    • Journal Title

      Am. J. Pathol. 168(2)

      Pages: 737-743

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Possible role of LRP1, a CCN2 receptor, in chondrocytes.2006

    • Author(s)
      Kawata K et al.
    • Journal Title

      Biochem Biophys Res Commun. 345(2)

      Pages: 552-559

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression and regulation of an anti-sense RNA transcripts from human connective tissue growth factor gene in human cells.2006

    • Author(s)
      Kondo S et al.
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery 18

      Pages: 172-179

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.2006

    • Author(s)
      Kondo, S et al.
    • Journal Title

      Oncogene 25(7)

      Pages: 1099-1110

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor (VEGF) in human endothelial cells.2006

    • Author(s)
      Kondo, S et al.
    • Journal Title

      Molecular Cancer Therapeutics 5(1)

      Pages: 129-137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes integrin alpha5beta1.2006

    • Author(s)
      Hoshijima M et al.
    • Journal Title

      FEBS Lett. 580(5)

      Pages: 1376-1382

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 軟骨組織の発生分化とCCNファミリー遺伝子2006

    • Author(s)
      久保田聡, 滝川正春
    • Journal Title

      Clinical Calcium 16

      Pages: 486-492

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.2006

    • Author(s)
      Yosimichi G et al.
    • Journal Title

      Bone (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of chicken ccn2 gene by interaction between RNA cis-element and trans-factor during differentiation of chondrocytes2005

    • Author(s)
      Mukudai, Y., et. al.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 3166-3177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor expressed in tubular epithelium plays apivotal role in renal fibrogenesis2005

    • Author(s)
      Okada, H.et. al.
    • Journal Title

      J. Am. Soc. Nephrol. 16(1)

      Pages: 133-143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes:possible regenerative roles in articular cartilage metabolism2005

    • Author(s)
      Nakao, K., et. al.
    • Journal Title

      Bone 36

      Pages: 884-892

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfal-null mutant in late stage of mouse embryonic development2005

    • Author(s)
      Yamaai, T., et. al.
    • Journal Title

      Bone 23

      Pages: 280-288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines.2005

    • Author(s)
      Moritani, N.H., et. al.
    • Journal Title

      Cell Commun. Signal. 3(1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transcriptional repression by the cis-acting element of structure-anchored repression (CAESAR) of human ctgf/ccn2 mRNA2005

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      FEBS Lett 579

      Pages: 3751-3758

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose2005

    • Author(s)
      Kobayashi, T., et. al.
    • Journal Title

      Clin Exp Nephrol. 9(2)

      Pages: 114-121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.2005

    • Author(s)
      Asano, M., et. al.
    • Journal Title

      Cell Commun Signal. Oct5;3(1)

      Pages: 11-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Increased Levels of CTGF mRNA Expression in a Murine Model of Allergic Airway Inflammation2005

    • Author(s)
      Mei Piao H., et. al.
    • Journal Title

      Allergology International 54

      Pages: 107-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CCNファミリー:その構造と機能2005

    • Author(s)
      滝川正春
    • Journal Title

      細胞 37

      Pages: 462-465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Roles of CCN2/CTGF2005

    • Author(s)
      Takigawa, M., et. al.
    • Journal Title

      the control of growth and regeneration. In CN Proteins: A New Family of Cell Growth and Differentiation Regulators (Perbal B.& Takigawa M.eds.), Imperial College Press, London

      Pages: 101-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CTGF/Hcs24/CCN2 as a regeneration factor("regenerin")acting on various types of mesenchymal cells. In Progress2005

    • Author(s)
      Takigawa, M.
    • Journal Title

      Stem Cell Research(ColumbusF, ed), Nova Science, Hauppauge, NY

      Pages: 19-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regulation of chicken ccn2 gene by interaction between RNA cis-element and trans-factor during differentiation of chondrocytes2005

    • Author(s)
      Mukudai, Y., et. al.
    • Journal Title

      J. Biol. Chem 280

      Pages: 3166-3177

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis2005

    • Author(s)
      Okada, H., et. al.
    • Journal Title

      J. Am. Soc. Nephrol 16(1)

      Pages: 133-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes : possible regenerative roles in articular cartilage metabolism2005

    • Author(s)
      Nakao, K., et. al.
    • Journal Title

      Bone 36

      Pages: 884-892

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfal-null mutant in late stage of mouse embryonic development2005

    • Author(s)
      Yamaai, T., et. al.
    • Journal Title

      J. Bone Miner. Metab 23

      Pages: 280-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose2005

    • Author(s)
      Kobayashi, T., et. al.
    • Journal Title

      Clin. Exp. Nephrol 9(2)

      Pages: 114-121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived relic2005

    • Author(s)
      Asano, M., et. al.
    • Journal Title

      Cell Commun. Signal 3(1)

      Pages: 11-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased levels of CTGF mRNA expression in a murine model of allergic airway inflammation2005

    • Author(s)
      Mei, Piao, H., et. al.
    • Journal Title

      Allergology International 54

      Pages: 107-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The CCN family : Structures and functions (in Japanese)2005

    • Author(s)
      Takigawa, M
    • Journal Title

      Saibou (without peer review) 34

      Pages: 462-465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis.2005

    • Author(s)
      Okada H et al.
    • Journal Title

      J.Am.Soc.Nephrol. 16(1)

      Pages: 133-143

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative transfactor during differentiation of chondrocytes.2005

    • Author(s)
      Mukudai Y et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 3166-3177

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Connective tissue growth factor causes persistent proa2(I) collagen gene expression induced by transforming growth factor-b in a mouse fibrosis model.2005

    • Author(s)
      Chujo S et al.
    • Journal Title

      J.Cell.Physiol. 203

      Pages: 477-456

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparable response of ccn1 with ccn2 genes upon arthritis : An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines.2005

    • Author(s)
      Moritani NH et al.
    • Journal Title

      Cell Commun Signal.(E-pub journal) 3(1)

      Pages: 6-6

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant in late stage of mouse embryonic development.2005

    • Author(s)
      Yamaai et al.
    • Journal Title

      J.Bone Miner.Metab. 23

      Pages: 280-288

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes : possible regeneration roles in articular cartilage metabolism.2005

    • Author(s)
      Nakao K et al.
    • Journal Title

      Bone 36

      Pages: 884-892

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose.2005

    • Author(s)
      Kobayashi T et al.
    • Journal Title

      Clin Exp Nephrol. 9(2)

      Pages: 114-121

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transcriptional repression by the cis-acting element of structure-anchored repression (CAESAR) of human ctgf/ccn2 mRNA.2005

    • Author(s)
      Kubota S et al.
    • Journal Title

      FEBS Lett. 579

      Pages: 3751-3758

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.2005

    • Author(s)
      Asano M et al.
    • Journal Title

      Cell Commun Signal.(E-pub Jurnal) 3(1)

      Pages: 11-11

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative transfactor during differentiation of chondrocytes.2005

    • Author(s)
      Mukudai, Y. et al.
    • Journal Title

      J.Biol.Chem. 280(5)

      Pages: 3166-3177

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes : possible regeneration roles in articular cartilage metabolism.2005

    • Author(s)
      Nakao, K. et al.
    • Journal Title

      Bone (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfal-null mutant in late stage of mouse embryonic development.2005

    • Author(s)
      Yamaai, T. et al.
    • Journal Title

      J.Bone Miner.Metab. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CCNファミリー:その構造と機能2005

    • Author(s)
      滝川正春
    • Journal Title

      細胞 (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.2004

    • Author(s)
      Yokoi, H., et. al.
    • Journal Title

      J. Am. Soc. Nephrol. 15

      Pages: 1430-1440

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocyte2004

    • Author(s)
      Minato, M., et. al.
    • Journal Title

      J. Biochem. 135

      Pages: 347-354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor)2004

    • Author(s)
      Nishida, T., et. al.
    • Journal Title

      J. Bone Miner. Res. 19

      Pages: 1308-1319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24/CCN2) during distraction osteogenesis.2004

    • Author(s)
      Kadota, H. et al.
    • Journal Title

      J. Bone Miner. Metab. 22(4)

      Pages: 293-302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.2004

    • Author(s)
      Kaji T., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 322

      Pages: 22-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression and localization of Connective tissue growth factor (CTGF/Hcs24/CCN2) by chondrocytes in osteoarthritic cartilage.2004

    • Author(s)
      Omoto, S., et. al.
    • Journal Title

      Osteoarthirtis and Cartilage 12(10)

      Pages: 771-778

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets.2004

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      J. Biochem. 136

      Pages: 279-282

    • NAID

      10016201865

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CCNファミリー2004

    • Author(s)
      滝川正春
    • Journal Title

      Molecular Medicine 41

      Pages: 756-758

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis2004

    • Author(s)
      Yokoi, H., et. al.
    • Journal Title

      J. Am. Soc. Nephrol 15

      Pages: 1430-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Module-specific antibodies against human connective tissue growth factor : Utility for structural and functional analysis of the factor as related to chondrocytes2004

    • Author(s)
      Minato, M., et. al.
    • Journal Title

      J. Biochem 135

      Pages: 347-354

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor)2004

    • Author(s)
      Nishida, T., et. al.
    • Journal Title

      J. Bone Miner. Res 19

      Pages: 1308-1319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of Connective Tissue Growth Factor/Hypertrophic Chondrocyte-Specific Gene Product 24 (CTGF/Hcs24/CCN2) During Distraction Osteogenesis2004

    • Author(s)
      Kadota, H., et. al.
    • Journal Title

      J. Bone Miner. Metab 22(4)

      Pages: 293-302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells2004

    • Author(s)
      Kaji, T., et. al.
    • Journal Title

      Biochem Biophys Res Commun 322

      Pages: 22-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression and localization of Connective tissue growth factor (CTGF/Hcs24/CCN2) by chondrocytes in osteoarthritic cartilage2004

    • Author(s)
      Omoto, S., et. al.
    • Journal Title

      Osteoarthirtis and Cartilage 12(10)

      Pages: 771-778

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abundant retention release of connective tissue growth factor (CTGF/CCN2) by platelets2004

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      J. Biochem 136

      Pages: 279-82

    • NAID

      10016201865

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCN family (in Japanese)2004

    • Author(s)
      Takigawa, M
    • Journal Title

      Mol. Med. (without peer review) 41

      Pages: 756-758

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Module-specific antibodies against human connective tissue growth factor : Utility for structural and functional analysis of the factor as related to chondrocytes.2004

    • Author(s)
      Minato, M. et al.
    • Journal Title

      J.Biochem. 135

      Pages: 347-354

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).2004

    • Author(s)
      Nishida, T. et al.
    • Journal Title

      J.Bone Miner.Res. 19

      Pages: 1308-1319

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of Connective Tissue Growth Factor/Hypertrophic Chondrocyte-Specific Gene Product 24 (CTGF/Hcs24/CCN2) During Distraction Osteogenesis.2004

    • Author(s)
      Kadota, H. et al.
    • Journal Title

      J.Bone Miner.Metab. 22(4)

      Pages: 293-302

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.2004

    • Author(s)
      Kaji, T. et al.
    • Journal Title

      Biochem Biophys Res Commun. 322

      Pages: 22-28

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression and localization of Connective tissue growth factor (CTGF/Hcs24/CCN2) by chondrocytes in osteoarthritic cartilage.2004

    • Author(s)
      Omoto, S. et al.
    • Journal Title

      Osteoarthirtis and Cartilage 12

      Pages: 771-778

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets.2004

    • Author(s)
      Kubota, S. et al.
    • Journal Title

      J.Biochem. 136

      Pages: 279-282

    • NAID

      10016201865

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes2003

    • Author(s)
      Nishida, T., et. al.
    • Journal Title

      J. Cell. Physiol. 196(2)

      Pages: 265-275

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage.2003

    • Author(s)
      Moritani, N. H., et. al.
    • Journal Title

      J. Bone Miner. Metab. 21(4)

      Pages: 205-210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction.2003

    • Author(s)
      Kanyama, M., et. al.
    • Journal Title

      Arch. Oral Biol. 48

      Pages: 723-730

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transcriptional induction of connective tissue growth factor/hypertrophic chondrocyte specific 24 (CTGF/Hcs24) gene by dexamethasone in human chondrocytic cells.2003

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      Bone 33

      Pages: 694-702

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel enzyme-linked immunosorbent assay systems for the quantitative analyses of connective tissue growth factor (CTGF/Hcs24/CCN2): Detection of HTLV-1 tax-induced CTGF from a human carcinoma cell line.2003

    • Author(s)
      Kawaki, H., et. al.
    • Journal Title

      DNA Cell Biol. 22

      Pages: 641-648

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression.2003

    • Author(s)
      Fukunaga, T., et. al.
    • Journal Title

      Bone 33(6)

      Pages: 911-918

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Proposal for a unified CCN nomenclature.2003

    • Author(s)
      Brigstock D.R., et. al.
    • Journal Title

      Mol. Pathol. 56

      Pages: 127-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 成長因子と軟骨細胞2003

    • Author(s)
      久保田聡、滝川正春
    • Journal Title

      腎と骨代謝 16

      Pages: 103-110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes2003

    • Author(s)
      Nishida, T., et. al.
    • Journal Title

      J. Cell. Physiol 196(2)

      Pages: 265-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Interaction of AP-1 and the ctgf gene : a possible driver of chondrocyte hypertrophy in growth cartilage2003

    • Author(s)
      Moritani, N., H., et. al.
    • Journal Title

      J. Bone Miner. Metab 21(4)

      Pages: 205-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Connective Tissue Growth Factor Expressed in Rat Alveolar Bone Regeneration Sites after Tooth Extraction2003

    • Author(s)
      Kanyama, M., et. al.
    • Journal Title

      Arch. Oral Biol 48

      Pages: 723-730

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transcriptional induction of connective tissue growth factor/ hypertrophic chondrocyte specific 24 (CTGF/Hcs24) gene by dexamethasone in human chondrocytic cells2003

    • Author(s)
      Kubota, S., et. al.
    • Journal Title

      Bone 33

      Pages: 694-702

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel enzyme-linked immunosorbent assay systems for the quantitativce analyses of connective tissue growth factor (CTGF/Hcs24/CCN2) : Detection of HTLV-1 tax-induced CTGF from a human carcinoma cell line2003

    • Author(s)
      Kawaki, H., et. al.
    • Journal Title

      DNA Cell Biol 22

      Pages: 641-648

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression2003

    • Author(s)
      Fukunaga, T., et. al.
    • Journal Title

      Bone 33(6)

      Pages: 911-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proposal for a unified CCN nomenclature2003

    • Author(s)
      Brigstock, D.R., et. al.
    • Journal Title

      Mol. Pathol.(without peer review) 56

      Pages: 127-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Grwoth factors and chondrocytes (in Japanese)2003

    • Author(s)
      Kubota, S., Takigawa, M
    • Journal Title

      Kidney Metab. Bone Dis.(without peer review) 16

      Pages: 103-110

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression.2003

    • Author(s)
      Fukunaga, T. et al.
    • Journal Title

      Bone 33(6)

      Pages: 911-918

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Driving the driver : Molecular regulation of ctgf/HCS24/ccn2 that regulates chondrocyte growth and differentiation.2003

    • Author(s)
      Kubota, S. et al.
    • Journal Title

      Recent Res.Develop.Biophys.Biochem. 3(2)

      Pages: 995-1012

    • Related Report
      2004 Annual Research Report
  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth. In Internal Review of Cytology, Vol. 257 (K.W. Jeon ed.)2007

    • Author(s)
      Kubota, S. and Takigawa, M.
    • Publisher
      Academic Press (Amsterdam)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] UCSD-Nature Molecular Pages: CCN2.(online database)2007

    • Author(s)
      Kubota, S. and Takigawa, M.
    • Publisher
      Nature Publishing Group
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth2007

    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In Internal Review of Cytology (review journal), Vol. 257 (K.W. Jeon ed.) Academic Press (Amsterdam)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] CCN22007

    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In UCSD-Nature Molecular Pages (online database)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] International Review of Cytology : A Survey of Cell Biology2007

    • Author(s)
      Kubota S, Takigawa M
    • Total Pages
      41
    • Publisher
      ACDEMIC PRESS
    • Related Report
      2006 Annual Research Report
  • [Book] 軟骨修復-CCN2/CTGF 細胞増殖因子と再生医療2006

    • Author(s)
      久保田聡、滝川正春
    • Publisher
      メディカルレビュー社 大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] CCN Proteins: A New Family of Cell Growth and Differentiation Regulators.2005

    • Author(s)
      Perbal, B. and Takigawa, M. (Editors, 編集)
    • Publisher
      Imperial College Press, London
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] The CCN proteins-The CCN family of proteins: an overview. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators(Perbal B.& Takigawa M.eds.)2005

    • Author(s)
      Perbal, B. and Takigawa, M.
    • Publisher
      Imperial College Press, London
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.)2005

    • Author(s)
      Takigawa, M., et. al.
    • Publisher
      Imperial College Press, London
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells. In Progress in Stem Cell Research (Columbus F, ed)2005

    • Author(s)
      Takigawa, M.
    • Publisher
      Nova Science, Hauppauge, Ny
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] The CCN proteins-A New Family of Cell Growth and Differentiation Regulators (edited book)2005

    • Author(s)
      Perbal, B., Takigawa, M
    • Publisher
      Imperial College Press (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] The CCN proteins-The CCN family of proteins : an overview2005

    • Author(s)
      Perbal, B., Takigawa, M
    • Publisher
      In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.), Imperial College Press (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration2005

    • Author(s)
      Takigawa, M., et. al.
    • Publisher
      In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.), Imperial College Press (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells2005

    • Author(s)
      Takigawa, M
    • Publisher
      In Progress in Stem Cell Research (Columbus F, ed.) Nova Science (Hauppauge, NY)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] CCN Proteins : A New Family of Cell Growth and Differentiation Regulators.2005

    • Author(s)
      Perbal, B., Takigawa, M.(Editors)
    • Total Pages
      311
    • Publisher
      Imperial College Press (London)
    • Related Report
      2005 Annual Research Report
  • [Book] Trend in Stem Cell Research (CTGF/Hcs24・CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells.)2005

    • Author(s)
      Takigawa M (Erik V.Greer.ed.)
    • Total Pages
      245
    • Publisher
      Nova Science (New York)
    • Related Report
      2005 Annual Research Report
  • [Book] The CCN proteins - An Overview. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators2005

    • Author(s)
      Perbal, B., Takigawa, M.
    • Publisher
      Perhal B. & Takigawa M.(eds.), Imperial College Press, London(in press)
    • Related Report
      2004 Annual Research Report
  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration. In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators2005

    • Author(s)
      Takigawa, M. et al.
    • Publisher
      Perbal B. & Takigawa M.(eds.), Imperial College Press, London(in press)
    • Related Report
      2004 Annual Research Report
  • [Book] CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells. In Trends in Stem Cell Research2005

    • Author(s)
      Takigawa, M.
    • Publisher
      Columbus F.(ed), Nova Science, Hauppauge, NY(in press)
    • Related Report
      2004 Annual Research Report
  • [Book] 1.細胞増殖因子を用いた組織再生療法 5)細胞増殖因子を用いた軟骨組織再生療法.遺伝子医学別冊「ドラッグデリバリーシステムDDS技術の新たな展開とその活用法」(田畑 泰彦編)2003

    • Author(s)
      西田 崇, 滝川正春
    • Publisher
      メディカルドウ社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Driving the driver: Molecular regulation of ctgf/HCS24/ccn2 that regulates chondrocyte growth and differentiation.2003

    • Author(s)
      Kubota S and Takigawa M
    • Publisher
      Recent Res. Develop. Biophys. Biochem. 3(part 2)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 1. Tissue regeneration using growth factors. 5) Cartilage regeneration using growth factor (in Japanese)2003

    • Author(s)
      Nishida, T., Takigawa, M
    • Publisher
      In Development and New Application of Drug Delivery System DDS Technology (Tabata Y. ed.) Medical Do (Osaka)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Driving the driver : Molecular regulation of ctgf/HCS24/ccn2 that regulates chondrocyte growth and differentiation2003

    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In Recent Res. Develop. Biophys. Biochem
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Cartilage repair : 10. CTGF(in Japanese)

    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In Growth Factors & Regenerative Medicine (Matsumoto T. & Tabata Y., eds.) Medical Review, (Osaka)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] Nishida, T. et al.: "CTGF/Hcs24,hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation_of_chondrocytes"J.Cell.Physiol.. 196. 265-275 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Moritani, N.H. et al.: "Interaction of AP-1 and the ctgf gene : a possible driver of chondrocyte hypertrophy in growth cartilage"J.Bone Miner.Metab.. 21. 205-210 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanyama, M. et al.: "Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction"Archs.Oral Biol. 40. 723-730 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kubota, S. et al.: "Transcriptional induction of connective tissue growth factor/hypertrophic chondrocyte specific 24(CTGF/Hcs24)gene by dexamethasone in human chondrocytic cells"Bone. 33. 694-702 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawaki, H. et al.: "Novel enzyme-linked Imunosorbent assay systems for the quantitative analysis of connective tissue growth factor(CTGF/Hcs24/CCN2) : Detection of HTLV-I Tax-induced CTGF from a human carcinoma cell line"DNA Cell Biol.. 22. 641-648 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 久保田聡, 滝川正春: "成長因子と軟骨細胞"腎と骨代謝. 16. 103-110 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minato, M et al.: "Module-specific antibodies against human connective tissue growth factor : utility for structural and functional analysis of the factor as related to chondrocyte"J.Biochem.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kadota H. et al.: "Expression of Connective Tissue Growth Factor/Hypertrophic Chondrocyte-Specific Gene Product 24(CTGF/Hcs24/CCN2)During Distraction Osteogenesis"J.Bone Miner.Metab.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishida, T. et al.: "Regeneration of defects in articular cartilage in rat knee joints by CCN2(connective tissue growth factor)"J.Bone Miner.Res.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 滝川正春: "CCN遺伝子ファミリー"Molecular Medicine. 41・6(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 西田 崇, 滝川正春: "ドラッグデリバリーシステム、DDS技術の新たな展開とその活用法"メディカルドウ社. 7 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kubota, S. et al.: "Recent Research Development in Biophysics and Biochemistry"Driving the driver : molecular regulation of CTGF/Hcs24/CCN2 that regulates chondrocyte growth and differentiation(in press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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