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REPRESENTATION OF TIME IN THE BRAIN

Research Project

Project/Area Number 15200031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionJUNTENDO UNIVERSITY

Principal Investigator

KITAZAWA Shigeru  JUNTENDO UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (00251231)

Co-Investigator(Kenkyū-buntansha) NAKAZATO Taizo  , 医学部, 講師 (80155697)
高橋 俊光  , 医学部, 助手 (00250704)
WADA Makoto  , 医学部, 助手 (20407331)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2005: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2004: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2003: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Keywordstemporal order judgment / somatosensory signals / time cognition / fMRI / human / mouse / c-Fos / 高次機能 / c-fos / ラット / 免疫組織化学
Research Abstract

It is known that the brain can resolve the order of two stimuli that are separated in time by as little as 30 ms. However, there is little consensus on how and where such discriminations are made. To elucidate how the brain orders sensory signals, we carried out a series of experiments with human and animal subjects. 1)We previously reported that temporal order judgment of two successive stimuli, delivered to the tips of sticks held in each hand, was altered by crossing the sticks without changing the positions of the hands. The previous report provided evidence for the referral of tactile signals to the tip of an actual tool in hand. In this study, we examined whether the referral occur to the tip, or action point, of a virtual tool for manipulating objects in the virtual reality with reaction force. The results suggest that somatosensory signals can be referred to the action point of a virtual tool that lacks any rigid body connecting the action point and the hand. 2)To elucidate whe … More re and how sensory signals are ordered in the brain, event-related functional magnetic resonance imaging (fMRI) was used while right-handed subjects judged the temporal order of two successive stimuli delivered one to each hand. Greater activation was elicited during the temporal order judgment than during the numerosity judgment in the following areas : bilateral posterior part of the middle temporal gyri (BA 37), bilateral premotor cortices (BA 6), bilateral inferior frontal gyri (BA 44), bilateral inferior parietal cortices (BA 40), and the left primary and secondary somatosensory cortices. The activation in the middle temporal gyri overlapped with the anterior part of the MT/V5.3) To study how somatosensory stimuli are ordered in the mouse brain, c-Fos production was examined in C57BL/6N mice that were trained to judge the order of two air-puff stimuli that were delivered to the right and the left whiskers. c-Fos expression was enhanced bilaterally in the task group as compared to the control group in the primary somatosensory cortex (barrel cortex), the paraventricular thalamic nucleus, the hypothalamus and the retrosplenial agranular cortex. c-Fos expression in the barrel cortex was most evident in the layers II and III, where callosal fibers originate from. Taken together, we infer that temporal order of tactile signals are ordered in time by combining representation of 'motion' in the temporal multimodal areas with the spatial representation of the stimuli in the frontal and parietal cortices. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (36 results)

All 2006 2005 2004 Other

All Journal Article (33 results) Patent(Industrial Property Rights) (1 results) Publications (2 results)

  • [Journal Article] Response to Gilbert : Rhythmicity,randomness and synchrony in climbing fiber signals.2006

    • Author(s)
      Kitazawa S, Wolpert DM.
    • Journal Title

      Trends Neurosci. 29(2)

      Pages: 66-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bayesian calibration of simultaneity in tactile temporal order judgment.2006

    • Author(s)
      Miyazaki M, Yamamoto S, Uchida S, Kitazawa S.
    • Journal Title

      Nat Neurosci. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Response to Gilbert : Rhythmicity, randomness and synchrony in climbing fiber signals.2006

    • Author(s)
      Kitazawa S, Wolpert DM.
    • Journal Title

      Trends Neurosci. 29(2)

      Pages: 66-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Perception of temporal order.2006

    • Author(s)
      Kitazawa S, Wada M
    • Journal Title

      Seitai no Kagaku 57(1)

      Pages: 37-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accelerated recognition of left oblique views of faces.2005

    • Author(s)
      Yamamoto M, Kowatari Y, Ueno S, Yamane S, Kitazawa S.
    • Journal Title

      Exp Brain Res. 161(1)

      Pages: 27-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Temporal order judgment in mice.2005

    • Author(s)
      Wada M, Moizumi S, Kitazawa S.
    • Journal Title

      Behav Brain Res. 157(1)

      Pages: 167-175

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cortical activity in multiple motor areas during sequential finger movements : An application of independent component analysis.2005

    • Author(s)
      Kansaku K, Muraki S, Umeyama S, Nishimori Y, Kochiyama T, Yamane S, Kitazawa S.
    • Journal Title

      Neuroimage 28(3)

      Pages: 669-681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sex difference in language lateralization may be task-dependent.2005

    • Author(s)
      Kitazawa S, Kansaku K.
    • Journal Title

      Brain 128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Referral of tactile sensation to the tips of L-shaped sticks.2005

    • Author(s)
      Yamamoto S, Moizumi S, Kitazawa S.
    • Journal Title

      J Neurophysiol. 93(5)

      Pages: 2856-2863

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rhythmicity,randomness and synchrony in climbing fiber signals.2005

    • Author(s)
      Kitazawa S, Wolpert DM.
    • Journal Title

      Trends Neurosci. 28(11)

      Pages: 611-619

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sex difference in language lateralization may be task-dependent.2005

    • Author(s)
      Kitazawa S, Kansaku K.
    • Journal Title

      Brain 128(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rhythmicity, randomness and synchrony in climbing fiber signals.2005

    • Author(s)
      Kitazawa S, Wolpert DM.
    • Journal Title

      Trends Neurosci. 28(11)

      Pages: 611-619

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Referral of tactile sensation to the tips of L-shaped sticks.2005

    • Author(s)
      Yamamoto, S, Moizumi, S, Kitazawa, S.
    • Journal Title

      J Neurophysiol 93・5

      Pages: 2856-2863

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cortical activity in multiple motor areas during sequential finger movements : an application of independent component analysis.2005

    • Author(s)
      Kansaku, K, Muraki, S, Umeyama, S, Nishimori, Y, Kochiyama, T, Yamane, S, Kitazawa, S.
    • Journal Title

      Neuroimage 28・3

      Pages: 669-681

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sex difference in language lateralization may be task-dependent.2005

    • Author(s)
      Kitazawa S, Kansaku K.
    • Journal Title

      Brain 128・5

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sex difference in language lateralization may be task-dependent.2005

    • Author(s)
      Kitazawa S, Kansaku K.
    • Journal Title

      Brain 128・4(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Temporal order judgment in mice.2005

    • Author(s)
      Wada M, Moizumi S, Kitazawa S.
    • Journal Title

      Behav Brain Res 157・1

      Pages: 167-175

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Accelerated recognition of left oblique views of faces.2005

    • Author(s)
      Yamamoto M, Kowatari Y, Ueno S, Yamane S, Kitazawa S.
    • Journal Title

      Exp Brain Res 161・1

      Pages: 27-33

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Referral of tactile sensation to the tips of L-shaped sticks.2005

    • Author(s)
      Yamamoto S, Moizumi S, Kitazma S.
    • Journal Title

      J Neurophysiol (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of handedness on tactile temporal order judgment.2004

    • Author(s)
      Wada M, Yamamoto S, Kitazawa S.
    • Journal Title

      Neuropsychologia. 42(14)

      Pages: 1887-1895

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dominance of the left oblique view in activating the cortical network for face recognition.2004

    • Author(s)
      Kowatari Y, Yamamoto M, Takahashi T, Kansaku K, Kitazawa S, Ueno S, Yamane S.
    • Journal Title

      Neurosci Res. 50(4)

      Pages: 475-480

    • NAID

      10023902030

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 小脳における運動の最適化.2004

    • Author(s)
      北澤 茂.
    • Journal Title

      順天堂医学 50(1)

      Pages: 26-33

    • NAID

      110006612960

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 触覚の生じる場所-時間順序判断からの示唆-2004

    • Author(s)
      北澤 茂
    • Journal Title

      Jpn J Psychonomic Sci. 23(1)

      Pages: 51-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 言語の起源をめぐって.2004

    • Author(s)
      北澤 茂
    • Journal Title

      科学 74(7)

      Pages: 856-857

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 時間順序の知覚.2004

    • Author(s)
      北澤 茂, 和田 真
    • Journal Title

      科学 74(7)

      Pages: 856-857

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of handedness on tactile temporal order judgment.2004

    • Author(s)
      Wada M, Yamamoto S, Kitazawa S.
    • Journal Title

      Neuropsychologia 42(14)

      Pages: 1887-1895

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dominance of the left oblique view in activating the cortical network for face recognition.2004

    • Author(s)
      Kowatari Y, Yamamoto M, Takahashi T, Kansaku K, Kitazawa S, Ueno S, Yamane S
    • Journal Title

      Neurosci Res. 50(4)

      Pages: 475-480

    • NAID

      10023902030

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Optimization of voluntary movements in the cerebellum.2004

    • Author(s)
      Kitazawa S
    • Journal Title

      Juntendo Medical Journal 50(1)

      Pages: 26-33

    • NAID

      110006612960

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Where tactile sensation takes place2004

    • Author(s)
      Kitazawa S
    • Journal Title

      Jpn J Psychonomic Sci. 23(1)

      Pages: 51-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] On the origin of language.2004

    • Author(s)
      Kitazawa S
    • Journal Title

      Kagaku 74(7)

      Pages: 856-857

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dominance of the left oblique view in activating the cortical network for face recognition.2004

    • Author(s)
      Kowatari Y, Yamamoto M, Takahashi T, Kansaku K, Kitazawa S
    • Journal Title

      Neurosci Res 50・4

      Pages: 475-480

    • NAID

      10023902030

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of handedness on tactile temporal order judgment.2004

    • Author(s)
      Wada M, Yamamoto S, Kitazawa S.
    • Journal Title

      Neuropsychologia 42・14

      Pages: 1887-1895

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Influence of pH on voltammetric measurement of dopamine.

    • Author(s)
      Nakazato T, Kagohashi M, Yoshimi M.
    • Journal Title

      Biogenic Amines (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 染色組織標本の陽性細胞の可視化解析法2006

    • Inventor(s)
      和田 真, 北澤 茂
    • Industrial Property Rights Holder
      学校法人順天堂
    • Industrial Property Number
      2006-013465
    • Filing Date
      2006-01-23
    • Related Report
      2005 Annual Research Report
  • [Publications] 北澤 茂: "小脳と運動:人工小脳計画"順天堂医学. 50・1. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasuhiro Wada: "Acquisition and contextual switching of multiple internal models for different viscous force fields."Neuroscience Research. 46. 319-331 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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