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High-performance Stent Technology

Research Project

Project/Area Number 15200038
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUDA Takehisa  KYUSHU UNIVERSITY, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (60142189)

Co-Investigator(Kenkyū-buntansha) KIDOAKI Satoru  KYUSHU UNIVERSITY, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (10336018)
SHIMOKAWA Hiroaki  KYUSHU UNIVERSITY, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (00235681)
内海 裕一  姫路工業大学, 高度産業科学技術研究所, 助教授 (80326298)
服部 正  姫路工業大学, 高度産業科学技術研究所, 教授 (70326297)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2005: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2004: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2003: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Keywordsstent / scaffold / endothelial cell / 内皮前駆細胞 / 光化学
Research Abstract

This study aimed at developing high biocompatible stent technology based on ex vivo cell seeding by combination of cell engineering, matrix engineering and scaffold engineering, by which rapid complete endothelialization on an implanted stent as to fully prevent thrombus formation, thus avoiding stenosis and occlusion, will be achieved. To this end, the authors developed endothelial cell and endothelial progenitor cell, both of which are harvested from autologous tissue or blood, are seeded and cultured to form monolayered tissue on the whole body of stent. As for matrix engineering, vinylated biomolecules include albumin, gelatin and heparin were photopolymerized under visible light-irradiation to form completely cover the stent surface prior to cell seeding. As for scaffold engineering, the authors devised electrospinning method using synthetic biodegradable elastomer (copolymer of lactide and caprolactone) to form a mesh-type cover stent. Bioactive substances such as collagen, heparin and growth factor were also co-electronspun. It is envisaged that the combination of these technologies expectantly enhances the thrombus-free condition which starts immediately after implantation.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (17 results)

All 2005 2004 Other

All Journal Article (12 results) Publications (5 results)

  • [Journal Article] Mesoscopic spatial designs of nano- and micron-Fiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques.2005

    • Author(s)
      S.Kidoaki, I.K.Kwon, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 37-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Electrospun nano- to microfiber fabrics made of biodegradable copolyesters : structural characteristics, mechanical properties and cell adhesion potential.2005

    • Author(s)
      I.K.Kwon, S.Kidoaki, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 3239-3939

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics.2005

    • Author(s)
      T.Matsuda, M.Ihara, H.Inoguchi, K.I1 K.Kwon, K.Takamizawa
    • Journal Title

      J Biomed Mater Res PartA 73A

      Pages: 125-131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mesoscopic spatial designs of nano- and micron-fiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques.2005

    • Author(s)
      S.Kidoaki, I.K.Kwon, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 37-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Electrospun nano- to microfiber fabrics made of biodegradable copolyesters : structural characteristics, mechanical properties and cell adhesion potential.2005

    • Author(s)
      K.Kwon, S.Kidoaki, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 3239-3939

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics.2005

    • Author(s)
      T.Matsuda, M.Ihara, H.Inoguchi, K.Il K.Kwon, K.Takamizawa
    • Journal Title

      J Biomed Mater Res PartA 73A

      Pages: 125-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Mesoscopic spatial designs of nano-and micron-fiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques2005

    • Author(s)
      S.Kidoaki, I.K.Kwon, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 37-46

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Poly(N-isopropylacrylamide)(PNIPAM)-graft gelatin hydrogel surface : interrelationship between microscopic structure and mechanical property of surface regions and cell adhesiveness.2005

    • Author(s)
      S.Ohya, S.Kidoaki, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 3105-3111

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Poly(N-isopropylacrylamide)-grafted gelatin as a thermoresponsive cell-adhesive, mold-releasable material for shape-engineered tissues.2004

    • Author(s)
      T.Matsuda
    • Journal Title

      J.Biomater.Sci.Polymer Wdn Vol.15,No.7

      Pages: 947-955

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Photocurable biodegradable liquid copolymer : synthesis of acrylate-endcapped trimethylene carbonate-based prepolymers, photocuring and hydrolysis.2004

    • Author(s)
      T.Matsuda, I.K.Kwon, S.Kidoaki
    • Journal Title

      Biomacromolecues 5

      Pages: 295-305

    • Related Report
      2004 Annual Research Report
  • [Journal Article] T.Recent progress of vascular graft engineering in Japan. Artificial Organs.2004

    • Author(s)
      Matsuda T
    • Journal Title

      Artificial Organs 28(1)

      Pages: 64-71

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Photo-polymerized microarchitectual constructs prepared by microstereolithography(μSL) using liquid acrylate-end-capped trimethylene carbonate-based prepolymers.2004

    • Author(s)
      I.K.Kwon, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 1675-1684

    • Related Report
      2004 Annual Research Report
  • [Publications] Matsuda T, Nagase J, Ghoda A, Hirano Y, Kidoaki S, Nakayama Y.: "Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity"Biomaterials. 24. 4517-4527 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Gamez E, Ikezaki K, Fukui M, Matsuda T.: "Photoconstructs of nerve guidance prosthesis using photoreactive gelatin as a scaffold"Cell Transplantation. 12. 481-490 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakayama Y, Nishi S, Ueda-Ishibashi H, Matsuda T: "Fabrication of micropored elastomeric film-covered stents and acute-phase performances"J.Biomed Mater Res.. 64A. 52-61 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shirota T, He H, Yasui H, Matsuda T.: "Human endothelial progenitor cell(EPC)-seeded hybrid graftproliferative and antithrombogenic potentials of EPC"Tissue Eng. 9(1). 127-136 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ibusuki S, Fujii Y, Iwamoto Y, Matauda T.: "Tissue-engineered cartilage using an injectable and in situ gelable thermoresponsive gelatin : fabrication and in vitro performances"Tissue Eng. 9(2). 371-384 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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