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Development of Selective Localized Hyperthermia for Deep Seated Cancer with Magnetic Seramic Microspheres.

Research Project

Project/Area Number 15200041
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

HIRAOKA Masahiro  KYOTO UNIVERSITY, Graduate School of Medicine, Professor, 医学研究科, 教授 (70173218)

Co-Investigator(Kenkyū-buntansha) MITSUMORI Michihide  KYOTO UNIVERSITY, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (10263089)
ARAKI Norio  KYOTO UNIVERSITY, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (20362486)
KAWASHITA Masakazu  KYOTO UNIVERSITY, Graduate School of Engineering, Lecturer, 工学研究科, 講師 (70314234)
KOKUBO Tadashi  CHUBU UNIVERSITY, Dept. of Biomedical Sciences, College of Life and Health Sciences, Professer, 生命健康科学部, 教授 (30027049)
MIYAZAKI Toshiki  Kyushu Institute of Technology, Graduate School of Life Science and Systems Engineering, Assistant Professor, 大学院生命体工学研究科, 助手 (20324973)
川嵜 一博  高周波熱錬株式会社, 技術本部技術部, 取締役部長(研究職)
斎藤 靖弘  日本板硝子(株), 技術研究所関西センター, 主席研究員
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2005: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2004: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2003: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Keywordshyperthermia / hyperthermia micro sphere / liver tumor / magnetic particle / deep hyperthemia / magnetite / hollow microspheres / emulsion / Fe304 / Fe_3O_4
Research Abstract

Hollow ferrimagnetic microspheres are more suitable for hyperthermia of cancer than dense ones, since the former is hard to sediment in blood vessels. In Kyushu Institute of Technology, preparation of hollow magnetite microspheres was examined. Emulsion was prepared where iron hydroxide sol was dispersed in 2-ethyl-l-hexanol that are immiscible with water. The iron hydroxide sol was gelled in butanol by dehydration of the sol. The obtained powders were filtered and then subjected to heat treatments at different temperatures in vacuo. Microspheres ranging 10 to 100 μm in diameter were obtained. Most of the microspheres over 100 μm in diameter was broken, but not those under 50 μm in diameter. It was confirmed by powder X-ray diffraction that hematite, mixture of hematite and magnetite, and magnetite was formed by the heat treatment at 800, 1000 and 1150℃, respectively. The formed microspheres were confirmed to be hollow by SEM observation of their cross-sections. The results in this year show that hollow magnetite microspheres 20-30 μm in diameter suitable for the hyperthermia of cancer can be successfully obtained by the present method.
We injected the ferrimagnetic microspheres into the rabbit kidney, and confirmed the local heating. In histological evaluation, the microspheres were uniformly distributed in renal tissue. Although temporary elevation of hepatic enzymes was detected, but no major adverse effect was detected in the rabbit's liver injections. We confirmed the feasibility of the injection into the beagle liver in the experimental procedures. Our ferrimagnetic microspheres appear safe and promising, and clinical application is highly encouraged. And we developed an automatic injection system in Department of Therapeutic Radiology & Oncology, Kyoto University. Using the injector, the microsphere can be slowly injected, at same speed without overflow.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (28 results)

All 2006 2005 2004 2003 Other

All Journal Article (28 results)

  • [Journal Article] Enzymatic preparation of hollow yttrium oxide microspheres for in situ radiotherapy of deep-seated cancer.2006

    • Author(s)
      M.Kawashita.st al.
    • Journal Title

      J Am Ceram Soc 89

      Pages: 1347-1351

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enzymatic preparation of hollow yttrium oxide microspheres for in situ radiotherapy of deep-seated cancer.2006

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      J Am Ceram Soc. 89

      Pages: 1347-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enzymatic preparation of hollow yttrium oxide microspheres for in situ radiotherapy of deep-seated cancer.2006

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      J Am Ceram Soc 89

      Pages: 1347-1351

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ceramic microspheres for biomedical applications2005

    • Author(s)
      M.Kawashita
    • Journal Title

      Int.J.Appl.Ceram.Technol. 2

      Pages: 173-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 医用ベクトルセラミック微小球2005

    • Author(s)
      川下将一
    • Journal Title

      Matereials Integration 18

      Pages: 18-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] がん放射線治療用セラミック微小球2005

    • Author(s)
      川下将一
    • Journal Title

      ナノマテリアル技術大系 1(ニューセラミックス・ガラス編)

      Pages: 471-478

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Ceramic microspheres for biomedical applications2005

    • Author(s)
      M.Kawashita
    • Journal Title

      Int. J. Appl. Ceram. Technol. 2

      Pages: 173-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Vector ceramic microspheres2005

    • Author(s)
      Masakazu Kawashita
    • Journal Title

      Materials Integration 18

      Pages: 18-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ceramic microspheres for cancer treatment2005

    • Author(s)
      Masakazu Kawashita
    • Journal Title

      Outline of nanomaterial technology 1(Newceramics and glasses)

      Pages: 471-478

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 医用ベクトルセラミック微小球2005

    • Author(s)
      川下将一
    • Journal Title

      Materials Integration 18

      Pages: 18-25

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 低侵襲局所がん治療用セラミック微小球2004

    • Author(s)
      川下将一
    • Journal Title

      バイオマテリアル-生体材料 22

      Pages: 36-42

    • NAID

      10012041645

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 放射性微小球を用いた肝腫瘍の血管内放射治療の基礎的研究2004

    • Author(s)
      光森通英他
    • Journal Title

      INNERVISION 19(8)

      Pages: 85-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 低侵襲局所がん治療用セラミック微小球2004

    • Author(s)
      川下将一
    • Journal Title

      バイオマテリアルー生体材料 22

      Pages: 36-42

    • NAID

      10012041645

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 放射性微小球を用いた肝腫瘍の血管内放射線治療の 基礎的研究2004

    • Author(s)
      光森通英他
    • Journal Title

      INNERVISION 19(8)

      Pages: 85-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transthoracic percutaneous radiofrequency ablation for liver tumors in the hepatic dome.2004

    • Author(s)
      Shibata T, Maetani Y, Kubo T, Itoh K, Togashi K, Hiraoka M.
    • Journal Title

      J Vasc Interv Radiol. 15

      Pages: 1323-1327

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 放射性微小球を用いた肝腫瘍の血管内放射線治療の基礎的研究2004

    • Author(s)
      光森通英, 荒木則雄, 平岡眞寛
    • Journal Title

      INNERVISION 19・8

      Pages: 85-85

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ceramics for biomedical applications,"in Handbook of Advanced Ceramics2003

    • Author(s)
      T.Kokubo.et al.
    • Journal Title

      Elsevier Academic Press

      Pages: 385-416

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ceramic microspheres for in situ treatment of cancer2003

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      Techna Srl

      Pages: 111-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Preparation of ceramic microspheres for in situ radiotherapy of deep-seated cancer.2003

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      Biomaterials 24(17)

      Pages: 2955-2963

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 深部がん局所温熱治療のための強磁性微小球2003

    • Author(s)
      川下将一他
    • Journal Title

      New Glass 18

      Pages: 27-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 放射性ベクトルセラミックス-がんを治療する放射性あるいは強磁性セラミック微小球2003

    • Author(s)
      川下将一他
    • Journal Title

      バイオマテリアル-生体材料 21

      Pages: 368-376

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ceramics for biomedical applications," in Handbook of Advanced Ceramics2003

    • Author(s)
      T.Kokubo.et al.
    • Journal Title

      Elsevier Academic Press

      Pages: 385-416

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 放射性ベクトルセラミックスーがんを治療する放射性ある いは強磁性セラミック微小球2003

    • Author(s)
      川下将一他
    • Journal Title

      バイオマテリアルー生体材料 21

      Pages: 368-376

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enzymatic preparation of hollow magnetite microspheres for hyperthermic treatment of cancer

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      J.Mater.Sci. : Mater.Med. 印刷中

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enzymatic preparation of hollow magnetite microspheres for hyperthermic treatment of cancer

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      J. Mater. Sci. : Mater. Med. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enzymatic preparation of hollow magnetite microspheres for hyperthermic treatment of cancer

    • Author(s)
      M.Kawashita.et al.
    • Journal Title

      J.Mater.Sci. : Mater.Med. 印刷中

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Radiofrequency ablation for small hepatocellular carcinoma : comparis on of internally cooled electrode and expandable electrode.

    • Author(s)
      Shibata T, Maetani Y, Isoda H, Hiraoka M.
    • Journal Title

      Radiology (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transcatheter arterial embolization for tumor seeding in the thoracic wall after radiofrequency ablation for hepatocellular carcinoma.

    • Author(s)
      Shibata T, Nishida N, Maetani Y, Kubo T, Itoh K, Hiraoka M.
    • Journal Title

      Cardiovasc Intervent Radiol (印刷中)

    • Related Report
      2004 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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