| Project/Area Number |
15200043
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MURAYAMA Hideo National Institute of Radiological Sciences, Department of Medical Physics, Head of Imaging Physics, 医学物理部, 研究員 (50166310)
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| Co-Investigator(Kenkyū-buntansha) |
TANADA Shuji National Institute of Radiological Sciences, Department of Medical Imaging, Head of Medical Imaging, 画像医学部, 研究員 (40116950)
KAWAI Hideyuki Chiba University, Department of Physics, Associate Professor, 理学部, 助教授 (60214590)
HANEISHI Hideaki Chiba University, Department of Information and Image Sciences, Associate Professor, 工学部, 助教授 (20228521)
HASEGAWA Tomoyuki Kitasato University, Department of Allied Health Sciences, Assistant, 医療衛生学部, 講師 (10276181)
OBI Takashi Tokyo Institute of Technology, Imaging Science and Engineering Laboratory, Assistant, 工学部, 助教授 (40280995)
山本 誠一 神戸市立工業高等専門学校, 電気工学科, 教授 (00290768)
高橋 浩之 東京大学, 大学院・工学系研究科原子力国際専攻, 教授 (70216753)
山谷 泰賀 独立行政法人放射線医学総合研究所, 医学物理部, 研究員 (40392245)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2005: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2004: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2003: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Keywords | PET / nuclear medicine / Instrumentation for diagnosis / scintillation detector / coincident count / radioisotope / image reconstruction / medical imaging |
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| Research Abstract |
Key technologies to realize the next-generation PET system with high sensitivity, high spatial resolution and high speed has been studied. We have developed growing technology of large gadolinium silicate (GSO) single crystals with a diameter of 100 mm. In our depth-of-interaction (DOI) detector, we can control the behavior of scintillation photons by inserting the reflector between crystal elements. The determination of the crystal of the interaction is performed on a two-dimensional histogram mapped by Anger-type positioning arithmetic calculation with output signals from PS-PMT optically coupled to the crystal array. A high-performance brain DOI-PET scanner, jPET-D4, has been developed at NIRS. This scanner was designed to achieve not only high spatial resolution but also high sensitivity using four-layered DOI detectors. The scanner has five detector rings with the ring diameter of 390mm and each detector ring consists of 24 DOI detectors. Each DOI detector consists of 1,024 GSO crystals, which are arranged in four layers of 16 x 16 arrays, coupled to a 52 mm square 256ch position sensitive PMT (FP-PMT). The crystal elements are 2.9 x 2.9 x 7.5 mm^3. The crystals of layer-1, 2 and layer-3, 4 are GSO doped with 0.5 mol% and 1.5 mol% Ce, respectively. The sensitivity at the center of FOV is 112 kcps/MBq and spatial resolution is less than 3 mm all over the FOV.
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