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MONITORING AND ACTIVE CONTROL OF HEAT AND MASS TRASFER IN MICRO- AND NANOSCALE

Research Project

Project/Area Number 15206024
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thermal engineering
Research InstitutionKEIO UNIVERSITY

Principal Investigator

HISHIDA Koichi  Keio University, Faculty of Science and Technology, Professor, 理工学部, 教授 (40156592)

Co-Investigator(Kenkyū-buntansha) OGAWA Kuniyasu  Keio University, Faculty of Science and Technology, Assistant Professor, 理工学部, 講師 (50272703)
SATO Yohei  Keio University, Faculty of Science and Technology, Associate Professor, 理工学部, 助教授 (00344127)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2005: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2004: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2003: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
KeywordsMicro- and Nanoscale / Micro-TAS / Monitoring of interface molecules / NMR / Self-diffusion coefficient / Nano Particles / Selctive Separation / Acoustic Radiation Pressure / 選択的粒子分離 / 脱プロトン反応 / pH / エバネッセント光 / 界面動電駆動流
Research Abstract

Rapid progress in microtechnology has yielded microfluidic devices that comprise microchannel networks for chip-based biological analyses handling small fluid sample volumes. For further development of micro devices, the in-situ monitoring and feedback control system is strongly required. The present study focused on development of monitoring system of interface molecules consisting of the small-scale planar surface coil and nuclear magnetic resonance detection system, a measurement technique of ion diffusion and transport in a microchannel and selective separation techniques of nanoscale particles. Summary of the results is shown as bellow. An interface monitoring system of water molecules was constructed by small-scale planar surface coils and nuclear magnetic resonance detection technique. Using this system, the dependence of T2(CPMG) relaxation time measured by CPMG method on water content in polymer electrolyte membrane (PEM) as a porous media was observed. In addition, using the … More pulse-field-gradient spin echo method as a pulse sequence in the interface monitoring system, the relationship between self-diffusion coefficient of water molecular and water content and temperature in the PEM was obtained. The accuracies of T2(CPMG) relaxation measurement and self-diffusion coefficient measurement using the small-scale planar surface coils were evaluated. Velocity and pH in microspace that are responsible for chemical reaction and mixing were measured by micron-resolution particle image velocimetry with a high spatial resolution. The zeta-potential of particles and microchannel wall was affected by varing pH, which was confirmed by measurement of electrophoretic velocity of submicron particles and electroosmotic velocity in a microchannel. A selective separation technique of submicron particles was developed by generating the conductivity gradient in a microchannel, inducing a control of electroosmotic velocity and an electrophoretic force acting on particles. Moreover, a continuous separation technique of suspended particles was proposed by utilizing an acoustic radiation force and an electrostatic force, which realized the particle separation taking into account size difference. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (42 results)

All 2006 2005 2004 2003 Other

All Journal Article (33 results) Patent(Industrial Property Rights) (3 results) Publications (6 results)

  • [Journal Article] Local water-content measurement of polymer electrolyte membrane for fuel cell applications using planar surface coil as a NMR signal detector2006

    • Author(s)
      Ogawa, K., Ito, K., Haishi, T., Hishida, K.
    • Journal Title

      Transactions of the Japan Society of Mechanical Engineers Series B Vol.72-716

      Pages: 1013-1020

    • NAID

      110004718562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] サブミクロン蛍光粒子を用いたマイクロチャンネル内電気浸透流速度及びゼータ電位の評価2005

    • Author(s)
      一柳満久, 佐藤洋平, 菱田公一
    • Journal Title

      日本機械学会論文集B編 71巻709号

      Pages: 2316-2323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Particle separation techmipue utilizing acoustic radiation force in electroosmotic flow2005

    • Author(s)
      Ishida, H., Sato, Y., Hishida,K
    • Journal Title

      19th International Symposium on Microscale Bioseparations

      Pages: 68-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 音響放射力および静電気力によるサブミリチャネル内微粒子の連続的分離技術2005

    • Author(s)
      石田洋哉, 佐藤洋平, 菱田公一
    • Journal Title

      日本機械学会熱工学コンファレンス2005講演論文集 No.05-17

      Pages: 235-236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Development Of a local NMR sensor for wetness monitoring of polymer electrolyte membrane using a planar suface ciol2005

    • Author(s)
      Kuniyasu Ogawa, Tomoyuki Haishi, Kohei Ito
    • Journal Title

      Proceeding of 6th World Conference on Experrimental Heat Transfer,Fluid Mechanics, and Thermodynamics

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 小型表面コイルによる燃料電池用固体高分子膜の局所水分計測法の開発2005

    • Author(s)
      小川邦康, 榊原浩志郎, 菱田公一, 拝師智之, 宇津澤慎, 伊藤衡平
    • Journal Title

      第42回日本電熱シンポジウム講演論文集 Vol.I

      Pages: 99-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 小型表面コイルによる燃料電池用固体高分子電解質幕内の水分子の局所自己拡散計測2005

    • Author(s)
      小川邦康, 榊原浩志郎, 伊藤衡平, 菱田公一, 拝師智之, 宇津澤慎
    • Journal Title

      日本機械学会工学コンファレンス2005講演論文集 No.05-17

      Pages: 237-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of electroosmotic velocity and zeta-potential in microchannel using submicron fluorescent particles2005

    • Author(s)
      Ichiyanagi, M., Sato, Y., Hishida, K.
    • Journal Title

      Transactions of the Japan Society of Mechanical Engineers Series B Vol.71-709

      Pages: 2316-2323

    • NAID

      110005051671

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Particle separation technique utilizing acoustic radiation force in electroosmotic flow2005

    • Author(s)
      Ishida, H., Sato, Y., Hishida, K.
    • Journal Title

      19th International Symposium on Microscale Bioseparations

      Pages: 68-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Development of a local NMR sensor for wetness monitoring of polymer electrolyte membrane using a planar surface coil2005

    • Author(s)
      Kuniyasu Ogawa, Tomoyuki Haishi, Kohei Ito
    • Journal Title

      Proceedings of 6th World Conference on Experimental Heat Transfer, Fluid Mechanics, and Thermodynamics, April 17-21,2005, Matsushima, Miyagi, Japan 2-a-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Measurements of pH and zeta-potential distribution in electrokinetically driven flow2005

    • Author(s)
      Ichiyanagi, M., Sato, Y., Hishida, K.
    • Journal Title

      Proceedings of 2005 Annual Meeting, Japan Society of Fluid Mechanics (CD-ROM)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Spatial-distribution measurement of multi-variables for mixing in microchannel2005

    • Author(s)
      Ichiyanagi, M., Sato, Y., Hishida, K.
    • Journal Title

      Proceedings of Thermal Engineering Conference '05

      Pages: 219-220

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Continuous separation technique of particle in a sub-mili channel by utilizing acoustic radiation and electrostatic force2005

    • Author(s)
      Ishida, H., Sato, Y., Hishida, K.
    • Journal Title

      Proceedings of Thermal Engineering Conference '05

      Pages: 235-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a local NMR sensor for wetness monitoring of polymer electrolyte membrane using a planar surface coil2005

    • Author(s)
      Ogawa, K., Sakakibara, K., Hishida K., Haishi, T., Utsuzawa, S., Ito, K.
    • Journal Title

      Proceedings of 42th National Heat Transfer Symposium Vol.I

      Pages: 99-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Local self-diffusion measurement of water molecular in polymer electrolyte membrane using a planar surface coil2005

    • Author(s)
      Ogawa, K., Sakakibara, K., Ito, K., Hishida K., Haishi, T., Utsuzawa, S.
    • Journal Title

      Proceedings of Thermal Engineering Conference '05

      Pages: 237-238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] サブミクロン蛍光粒子を用いたマイクロチャネル内電気浸透流速度及びゼータ電位の評価2005

    • Author(s)
      一柳満久, 佐藤洋平, 菱田公一
    • Journal Title

      日本機械学会論文集B編 71巻709号

      Pages: 2316-2323

    • NAID

      110005051671

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of a local NMR sensor for wetness monitoring of polymer electrolyte membrane using a planar surface coil2005

    • Author(s)
      Kuniyasu Ogawa, Tomoyuki Haishi, Kohei Ito
    • Journal Title

      Proceedings of 6th World Conference on Experimental Heat Transfer, Fluid Mechanics, and Thermodynamics

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 小型表面コイルによる燃料電池用固体高分子膜の局所水分計測法の開発2005

    • Author(s)
      小川邦康, 榊原浩志郎, 菱田公一, 拝師智之, 宇津澤慎, 伊藤衡平
    • Journal Title

      第42回日本伝熱シンポジウム講演論文集 Vol.I

      Pages: 99-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 小型表面コイルによる燃料電池用固体高分子電解質膜内の水分子の局所自己拡散計測2005

    • Author(s)
      小川邦康, 榊原浩志郎, 伊藤衡平, 菱田公一, 拝師智之, 宇津澤慎
    • Journal Title

      日本機械学会熱工学コンファレンス2005講演論文集 NO.05-17

      Pages: 237-238

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of a Local NMR Sensor for Wetness Monitoring of Polymer Electrolyte Membrane Using a Planar Surface Coil2005

    • Author(s)
      K.Ogawa, T.Hayashi, K.Ito
    • Journal Title

      Proceedings of 6th World Conference on Experimental Heat Transfer, Fluid Mechanics, and Thermodynamics (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 小型表面コイルによる燃料電池用固体高分子膜の局所水分計測法の開発2005

    • Author(s)
      小川邦康, 榊原浩志郎, 菱田公一, 拝師智之, 宇津澤慎, 伊藤衡平
    • Journal Title

      第42回日本伝熱シンポジウム講演論文集 (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Separation technique of sub-micron particles using electrokinetically driven flow2004

    • Author(s)
      Yamamoto, T., Devasenathipathy, S., Sato, Y., Hishida, K.
    • Journal Title

      Transactions of the Japan Society of Mechanical Engineers Series B Vol.70-697

      Pages: 2378-2385

    • NAID

      110004999613

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of spatially-distributed electric double layer on electrokinetic separation of submicron particles2004

    • Author(s)
      Kazoe, Y., Yamamoto, T., Sato, Y.
    • Journal Title

      5th International Conference on Mulitphase Flow (CD-ROM)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Measurements of electric double layer formation affected by submicron particles and varying pH2004

    • Author(s)
      Ichiyanagi, M., Sato, Y., Hishida, K.
    • Journal Title

      5th International Conference on Mulitphase Flow (CD-ROM)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Spatial distribution of electrokinetically driven flow measured by micro-PIV (An evaluation of electric double layer in microchannel)2004

    • Author(s)
      Ichiyanagi, M., Saiki, K., Sato, Y., Hishida, K.
    • Journal Title

      12th International Symposium on Applications of Laser Techniques to Fluid Mechanics (CD-ROM)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 界面動電現象によるサブミクロン粒子分離技術2004

    • Author(s)
      山本尊博, Shankar Devasenathipathy, 佐藤洋平, 菱田公一
    • Journal Title

      日本機械学会論文集B編 第70巻・697号

      Pages: 2378-2385

    • NAID

      110004999613

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Measurements of Electric Double Layer Formation Affected by Submicron Particles and Varying pH2004

    • Author(s)
      M.Ichiyanagi, Y.Sato, K.Hishida
    • Journal Title

      5th International Conference on Multiphase Flow (CD-ROM)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Spatial Distribution of Electrokinetically Driven Flow Measured by Micro-PIV (An Evaluation of Electric Double Layer in Microchannel)2004

    • Author(s)
      M.Ichiyanagi, K.Saiki, Y.Sato, K.Hishida
    • Journal Title

      12th International Symposium on Application to Laser Techniques to Fluid Mechanics (CD-ROM)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Micro-NMR Sensor for Micro-scale Transport Phenomena in Reactors2004

    • Author(s)
      K.Ogawa
    • Journal Title

      Proceedings of 1st International symposium on Micro & Nanoscale Sensing Techniques for Energy and Bio System 1

      Pages: 57-64

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Electrokinetic particle separation2003

    • Author(s)
      Devasenathipathy, S., Santiago, J.G., Yamamoto, T., Sato, Y., Hishida, K.
    • Journal Title

      Micro Total Analysis Systems 2003 Vol.1

      Pages: 845-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Electrokinetic particle migration in heterogeneous electrolyte systems2003

    • Author(s)
      Devasenathipathy, S., Santiago, J.G., Yamamoto, T., Sato, Y., Hishida, K.
    • Journal Title

      2003 ASME, International Mechanical Engineering Congress and Exposition (CD-ROM)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Separation technique of sub-micron particles using electrokinetically driven flow2003

    • Author(s)
      Yamamoto, T., Devasenathipathy, S., Sato, Y., Hishida, K.
    • Journal Title

      Proceedings of Thermal Engineering Conference '03

      Pages: 427-428

    • NAID

      110004999613

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transient characteristic of electric double layer formation in buffer solutions by varying pH2003

    • Author(s)
      Ichiyanagi, M., Devasenathipathy, S., Sato, Y., Hishida, K.
    • Journal Title

      Proceedings of Thermal Engineering Conference '03

      Pages: 429-430

    • NAID

      110002489801

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 浮遊微粒子の連続的分離方法及び装置2006

    • Inventor(s)
      菱田公一, 佐藤洋平, 石田洋哉
    • Industrial Property Rights Holder
      学校法人慶応義塾
    • Industrial Property Number
      2006-051494
    • Filing Date
      2006-02-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 浮遊微粒子の連続的分離方法及び装置2006

    • Inventor(s)
      菱田 公一, 佐藤 洋平, 石田 洋哉
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Number
      2006-051494
    • Filing Date
      2006-02-28
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 粒子の分離方法及び装置2003

    • Inventor(s)
      菱田 公一, 佐藤 洋平・他2名
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2003-09-17
    • Acquisition Date
      2004-12-17
    • Related Report
      2004 Annual Research Report
  • [Publications] Y.Sato, G.Irisawa, M.Ishizuka, K.Hishida, M.Maeda: "Visualization of Convective Mixing in Microchannel by Fluorescence Imaging"Measurement Science and Technology. 14. 114-121 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中島慶卓, 山本尊博, 佐藤洋平, 菱田公一, 前田昌信: "交番電界によるマイクロチャネル内の液液混合の促進"第39回日本伝熱シンポジウム講演論文集. II. 353-354 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Sato, S.Inaba, K.Hishida, M.Maeda: "Spatially Averaged Time-Resolved Particle Tracking Velocimetry in Microspace Considering Brownian Motion of Submicron Particles"Experiments in Fluids. 35. 167-177 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Devasenathipathy, J.G.Santiago, T.Yamamoto, Y.Sato, K.Hishida: "Electrokinetic Particle Separation"Micro Total Analysis Systems 2003. 1. 845-848 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Devasenathipathy, J.G.Santiago, T.Yamamoto, Y.Sato, K.Hishida: "Electrokinetic Particle Migration in Heterogeneous Electrolyte Systems"2003 ASME, Int.Mech.Engng.Congress and Exposition. (CD-ROM). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山本尊博, S.Devasenathipathy, 佐藤洋平, 菱田公一: "界面動電駆動流によるサブミクロン粒子選択的分離技術の開発"熱工学コンファレンス2003. 1. 427-428 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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