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Basic Research for Individualized Medicine

Research Project

Project/Area Number 15209005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionHokkaido University

Principal Investigator

KAMATAKI Tetsuya  Hokkaido Univ., Grad.Sch.Pharm.Sci., Professor, 大学院・薬学研究科, 教授 (00009177)

Co-Investigator(Kenkyū-buntansha) 山崎 浩史  北海道大学, 大学院・薬学研究科, 助教授 (30191274)
藤枝 正輝  北海道大学, 大学院・薬学研究科, 助手 (00344474)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2005: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2004: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2003: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Keywordsindividualized medicine / genetic polymorphism / individual variation / cytochrome P450 / CYP2A6 / anti cancer drug / whole gene deletion / drug oxidation / P450 / CYP1A2 / カフェイン / NAT2 / 個別化医療 / オーダーメイド
Research Abstract

Cytochrome P450 2A6 (CYP2A6) is involved in the metabolism of several kinds of anti cancer drugs, including tegafur, fadrozole and letrozole. Notably, the expression levels of CYP2A6 and its catalytic activities in humans show wide inter-individual variation. One of the causes of this variation has been thought to be the genetic polymorphisms of the CYP2A6. However, this variation could not be fully explained by reported polymorphisms. Therefore, we investigated the CYP2A6 gene of 49 Japanese and 28 Caucasian samples. We identified 45 novel genetic polymorphisms from these samples. We clarified that CYP2A6^*9, which contains SNP in the 5'-flanking region of the CYP2A6 gene, reduced the expression of mRNA and protein, leading to reduction of the enzymatic activities of CYP2A6. We investigate the function of mutant CYP2A6 caused by newly identified SNP using E. coli expression system and human liver microsomes. Coumarin 7-hydroxylase activities of CYP2A6.15 (Lys194Glu) and CYP2A6.16 (Arg203Ser) were lower than that of wild-type CYP2A6. Coumarin 7-hydroxylase activities of liver microsomes with CYP2A6^*15 or CYP2A6^*16 alleles were lower than that with CYP2A6^*1 alleles. These variant alleles were thought to be one of the causes of inter-individual variation of CYP2A6 activity.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (91 results)

All 2006 2005 2004 2003 Other

All Journal Article (81 results) Book (3 results) Publications (7 results)

  • [Journal Article] Dose dependent on inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.2006

    • Author(s)
      Takeuchi, H, et al.
    • Journal Title

      Cancer Lett. 234(2)

      Pages: 232-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Optimal antidiarrhea treatment for antitumor agent irinotecan hydrochlorid (CPT-11)-induced delayed diarrhea.2006

    • Author(s)
      Takasuna, K, et al.
    • Journal Title

      Cancer Chemother.Pharmacol. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dose dependent on inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.2006

    • Author(s)
      Takeuchi, H, et al.
    • Journal Title

      Cancer Lett. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons.2006

    • Author(s)
      Iwano, S, et al.
    • Journal Title

      FEBS Lett. 580(3)

      Pages: 890-893

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.2005

    • Author(s)
      Iwano, S, et al.
    • Journal Title

      Biochem. Biophys. Res. Conimun. 337(2)

      Pages: 708-712

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.2005

    • Author(s)
      Iwano, S, et al.
    • Journal Title

      Biochem. Biophys. Res. Conimun. 335(1)

      Pages: 220-226

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] CYP2A6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.2005

    • Author(s)
      Kimura, M, et al.
    • Journal Title

      Drug Metab. Dispos. 33(9)

      Pages: 1361-1366

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.2005

    • Author(s)
      Miyazaki, M, et al.
    • Journal Title

      Carcinogenesis 26(11)

      Pages: 1947-1955

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Novel genger-related regulation of CYP2C12 gene expression in rats.2005

    • Author(s)
      Endo, M, et al.
    • Journal Title

      Mol. Endocrinol. 19(5)

      Pages: 1181-1190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibitory. effects of nicardipine to CYP in human liver microsomes.2005

    • Author(s)
      Nakamura, K, et al.
    • Journal Title

      Biol. Pharm. Bull. 28(5)

      Pages: 882-885

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4,CYP3A5 and CYP3A7 : lack of co-regulation of the expression of CYP3A in Japanese livers.2005

    • Author(s)
      Yamaori, M, et al.
    • Journal Title

      Xenobiotica 35(1)

      Pages: 69-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High prevalence of cytochrome P450 2A6^*1A alleles in a black African population of Ghana.2005

    • Author(s)
      Gyamfi, MA, et al.
    • Journal Title

      Eur. J. Cli. Pharmacol. 60(12)

      Pages: 855-857

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mild trimethylaminuria observed in a Japanese cohort with liver damage.2005

    • Author(s)
      Yamazaki, H. et al.
    • Journal Title

      Am. J. Med. 118(7)

      Pages: 803-805

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.2005

    • Author(s)
      Iwano.S, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 337(2)

      Pages: 708-712

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.2005

    • Author(s)
      Iwano, S, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 335(1)

      Pages: 220-226

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] CYP2A6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.2005

    • Author(s)
      Kimura, M, et al.
    • Journal Title

      Drug Metab.Dispos. 33(9)

      Pages: 1361-1366

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Novel genger-related regulation of CYP2C12 gene expression in rats.2005

    • Author(s)
      Endo, M, et al.
    • Journal Title

      Mol.Endocrinol. 19(5)

      Pages: 1181-1190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Inhibitory effects of nicardipine to CYP in human liver microsomes.2005

    • Author(s)
      Nakamura, K, et al.
    • Journal Title

      Biol.Pharm.Bull. 28(5)

      Pages: 882-885

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7 : lack of co-regulation of the expression of CYP3A in Japanese livers2005

    • Author(s)
      Yamaori, M, et al.
    • Journal Title

      Xenobiotica 35(1)

      Pages: 69-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High prevalence of cytochrome P450 2A6^*1A alleles in a black African population of Ghana.2005

    • Author(s)
      Gyamfi, MA, et al.
    • Journal Title

      Eur.J.Clin.Pharmacol. 60(12)

      Pages: 855-857

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mild trimethylaminuria observed in a Japanese cohort with liver damage.2005

    • Author(s)
      Yamazaki, H, et al.
    • Journal Title

      Am.J.Med. 118(7)

      Pages: 803-805

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.2005

    • Author(s)
      Iwano, S, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 337(2)

      Pages: 708-712

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk.2005

    • Author(s)
      Kamataki, T, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338(1)

      Pages: 306-310

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108.2004

    • Author(s)
      Miyazaki, M, et al.
    • Journal Title

      Mutat. Res. 581(1-2)

      Pages: 165-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of NO-1886 (1brolipim), a lipoprotein lipase-promoting agent, on gene induction of c'ytochrome P450s. carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes.2004

    • Author(s)
      Nishimura, M, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 19(6)

      Pages: 422-429

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.2004

    • Author(s)
      Fujieda, M. et al.
    • Journal Title

      Carcinogenesis 25(12)

      Pages: 2451-2458

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004

    • Author(s)
      Yamazaki, Y. et al.
    • Journal Title

      Mutat. Res. 562(1-2)

      Pages: 151-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of deletion-junction site of CYP2A6^*4B allele lacking entire coding region of CYP2A6 in Japanese.2004

    • Author(s)
      Ariyoshi, N. et al.
    • Journal Title

      Pharmacogenetics 14(10)

      Pages: 701-705

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.2004

    • Author(s)
      Furukawa, M. et al.
    • Journal Title

      Cancer Sci. 95(6)

      Pages: 520-529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes.2004

    • Author(s)
      Toide, K. et al.
    • Journal Title

      Biochem. Pharmacol. 67(7)

      Pages: 1269-1278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs2004

    • Author(s)
      Sakuma, T. et al.
    • Journal Title

      Drug. Metab. Dispos. 32(4)

      Pages: 376-378

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects.2004

    • Author(s)
      Yamaori.S.et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 19(2)

      Pages: 120-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.2004

    • Author(s)
      Nukaya, M, et al.
    • Journal Title

      FEBS Lett. 558(1-2)

      Pages: 96-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.2004

    • Author(s)
      Yamazaki, H, et al.
    • Journal Title

      Life Sci. 74(22)

      Pages: 2739-2747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of a novel polymorphic enhancer of the human CYP3A4 gene.2004

    • Author(s)
      Matsumura, K, et al.
    • Journal Title

      Mol. Pharmacol. 65(2)

      Pages: 326-334

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108.2004

    • Author(s)
      Miyazaki, M. et al.
    • Journal Title

      Mutat.Res. 581(1-2)

      Pages: 165-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes.2004

    • Author(s)
      Nishimura, M, et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 19(6)

      Pages: 422-429

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers.2004

    • Author(s)
      Fujieda, M, et al.
    • Journal Title

      Carcinogenesis 25(12)

      Pages: 2451-2458

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004

    • Author(s)
      Yamazaki, Y, et al.
    • Journal Title

      Mutat.Res. 562(1-2)

      Pages: 151-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of deletion-junction site of CYP2A6^*4B allele lacking entire coding region of CYP2A6 in Japanese.2004

    • Author(s)
      Ariyoshi, N, et al.
    • Journal Title

      Pharmacogenetics 14(10)

      Pages: 701-705

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.2004

    • Author(s)
      Furukawa, M, et al.
    • Journal Title

      Cancer Sci. 95(6)

      Pages: 520-529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes.2004

    • Author(s)
      Toide, K, et al.
    • Journal Title

      Biochem.Pharmacol. 67(7)

      Pages: 1269-1278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs2004

    • Author(s)
      Sakuma, T, et al.
    • Journal Title

      Drug Metab.Dispos. 32(4)

      Pages: 376-378

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects.2004

    • Author(s)
      Yamaori, S, et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 19(2)

      Pages: 120-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.2004

    • Author(s)
      Nukaya.M.et al.
    • Journal Title

      FEBS Lett. 558(1-3)

      Pages: 96-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of a novel polymorphic enhancer of the human CYP3A4 gene.2004

    • Author(s)
      Matsumura, K, et al.
    • Journal Title

      Mol.Pharmacol. 65(2)

      Pages: 326-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes2004

    • Author(s)
      Toide, K., et al.
    • Journal Title

      Biochem.Pharmacol. 67

      Pages: 1269-1278

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients2004

    • Author(s)
      Yamazaki, H., et al.
    • Journal Title

      Life Sci 74

      Pages: 2739-2747

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Establishment of ten strains of genetically engineered salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens2004

    • Author(s)
      Yamazaki, Y., et al.
    • Journal Title

      Mutat.Res. 562

      Pages: 151-162

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of a novel polymorphic enhancer of the human CYP3A4 gene2004

    • Author(s)
      Matsumura, K., et al.
    • Journal Title

      Mol.Pharmacol. 65

      Pages: 326-334

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers2004

    • Author(s)
      Fujieda, M., et al.
    • Journal Title

      Carcinogenesis 25

      Pages: 2451-2458

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CYP3A5 contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects2004

    • Author(s)
      Yamaori, S., et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 19

      Pages: 120-129

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.2003

    • Author(s)
      Takeuchi, H, et al.
    • Journal Title

      Cancer Res. 63(22)

      Pages: 7581-7583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Production of inhibitory polyclonal antibodies against cytochrome P450s.2003

    • Author(s)
      Ng, PS, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 18(3)

      Pages: 163-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6^*9).2003

    • Author(s)
      Kiyotani, K, et al.
    • Journal Title

      Pharmacogenetics 13(11)

      Pages: 689-695

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of cytochrome b5 on drug oxidation activities of human cytochrome P450 (CYP) 3As : similarity of CYP3A5 with CYP3A4 but not CYP3A7.2003

    • Author(s)
      Yamaori, S, et al.
    • Journal Title

      Biochem. Pharmacol. 66(12)

      Pages: 2333-2340

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese.2003

    • Author(s)
      Fujieda, M, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 18(5)

      Pages: 333-335

    • NAID

      10012554262

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two novel haplotypes of CYP2D6 gene in a Japanese population.2003

    • Author(s)
      Yamazaki, H, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 18(4)

      Pages: 269-271

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.2003

    • Author(s)
      Mizuno, D, et al.
    • Journal Title

      Biochim. Biophys. Acta. 1627(2-3)

      Pages: 121-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Reply : Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells : trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.2003

    • Author(s)
      Toide, K, et al.
    • Journal Title

      Cancer Epidemiol. Biomarkers Prev. 12(10)

      Pages: 1118-1118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults.2003

    • Author(s)
      Ando, M, et al.
    • Journal Title

      J. Epidemiol. 13(3)

      Pages: 176-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel nonsynonymous polymorphisms of the CYP1A1 gene in Japanese.2003

    • Author(s)
      Saito, T, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 18(3)

      Pages: 218-221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Studies on the interactions between drug and estrogen. 11. On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17.2003

    • Author(s)
      Satoh, T, et al.
    • Journal Title

      Biol. Pharm. Bull. 26(5)

      Pages: 695-700

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.2003

    • Author(s)
      Fujiedai, M, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 18(1)

      Pages: 86-90

    • NAID

      130004462884

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells : trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.2003

    • Author(s)
      Toide, K, et al.
    • Journal Title

      Cancer Epidemiol. Biomarkers Prev. 12(3)

      Pages: 219-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Large-scale production of genetically engineered CYP3A4 in E.coli : application of a jarfermenter.2003

    • Author(s)
      Kanamori, Y, et al.
    • Journal Title

      Drug Metab. Pharmacokinet. 18(1)

      Pages: 42-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxicity of bisphenol A glycidyl methacrylate on cytochrome P450-producing cells.2003

    • Author(s)
      Hikage, S, et al.
    • Journal Title

      J. Oral. Rehabil. 30(5)

      Pages: 544-549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.2003

    • Author(s)
      Takeuchi, H. et al.
    • Journal Title

      Cancer Res. 63(22)

      Pages: 7581-7583

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Production of inhibitory polyclonal antibodies against cytochrome P450s.2003

    • Author(s)
      Ng, PS, et al.
    • Journal Title

      Drug Metab.Pharmacokinet. 18(3)

      Pages: 163-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of cytochrome b5 on drug oxidation activities of human cytochrome P450 (CYP) 3As : similarity of CYP3A5 with CYP3A4 but not CYP3A7.2003

    • Author(s)
      Yamaori, S, et al.
    • Journal Title

      Biochem.Pharmacol. 66(12)

      Pages: 2333-2340

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese.2003

    • Author(s)
      Fujieda, M, et al.
    • Journal Title

      Drug Metabol.Pharmacokinet. 18(5)

      Pages: 333-335

    • NAID

      10012554262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two novel haplotypes of CYP2D6 gene in a Japanese population.2003

    • Author(s)
      Yamazaki, H. et al.
    • Journal Title

      Drug Metabol.Pharmacokinet. 18(4)

      Pages: 269-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.2003

    • Author(s)
      Mizuno, D, et al.
    • Journal Title

      Biochim.Biophvs.Acta 1627(2-3)

      Pages: 121-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Reply : Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells : trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.2003

    • Author(s)
      Toide, K, et al.
    • Journal Title

      Cancer Epidemiol.Biomarkers Prev. 12(10)

      Pages: 1118-1118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults.2003

    • Author(s)
      Ando, M, et al.
    • Journal Title

      J Epidemiol. 13(3)

      Pages: 176-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel nonsynonymous polymorphisms of the CYP1A1 gene in Japanese.2003

    • Author(s)
      Saito, T, et al.
    • Journal Title

      Drug Metabol.Pharmacokinet. 18(3)

      Pages: 218-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Studies on the interactions between drug and estrogen. II. On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17.2003

    • Author(s)
      Satoh, T, et al.
    • Journal Title

      Biol.Pharm.Bull. 26(5)

      Pages: 695-700

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.2003

    • Author(s)
      Fujiedai, M, et al.
    • Journal Title

      Drug Metabol.Pharmacokinet. 18(1)

      Pages: 86-90

    • NAID

      130004462884

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells : trimodal distribution of Japanese population according to induction of CYP1B1I mRNA by environmental dioxins.2003

    • Author(s)
      Toide, K, et al.
    • Journal Title

      Cancer Epidemiol.Biomarkers Prev. 12(3)

      Pages: 219-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Large-scale production of genetically engineered CYP3A4 in E.coil : application of a jarfermenter.2003

    • Author(s)
      Kanamori, Y, et al.
    • Journal Title

      Drug Metabol.Pharmacokinet. 18(1)

      Pages: 42-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxicity of bisphenol A glycidyl methacrylate on cytochrome P450-producing cells.2003

    • Author(s)
      Hikage, S, et al.
    • Journal Title

      J.Oral Rehabil. 30(5)

      Pages: 544-549

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 「分子予防環境医学」薬物・外来異物に対する生体の代謝機構(分子予防環境医学研究会編)2003

    • Author(s)
      山崎浩史ら
    • Total Pages
      20
    • Publisher
      本の泉社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 「P450の分子生物学」2003

    • Author(s)
      大村恒雄ら
    • Total Pages
      13
    • Publisher
      株式会社講談社サイエンティフィク
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 「くすりの効き方は人によって違うの?」2003

    • Author(s)
      千葉寛ら
    • Total Pages
      112
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Toide K, Yamazaki H, et al.: "Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells"Cancer Epidem Biomarker Prev. 12. 219-222 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toide K, Yamazaki H, Kamataki T: "Reply : Correspondence re : K. Toide et al."Cancer Epidem Biomarker Prev. 12. 1118 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saito T et al.: "Novel nonsynonymous polymorphisms of the CYP1A1 gene in Japanese"Drug Metab Pharmacokin. 18. 218-221 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamaori S, Yamazaki H, et al.: "Effects of cytochrome b5 on drug oxidation activities of human cytochrome P450 (CYP) 3As"Biochem Pharmacol. 66. 2333-2340 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeuchi H et al.: "Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice"Cancer Res. 63. 7571-7583 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kiyotani K, Yamazaki H, et al.: "Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)"Pharmacogenetics. 13. 689-695 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山崎浩史, 藤枝正輝, 鎌滝哲也: "「分子予防環境医学」薬物・外来異物に対する生体の代謝機構"本の泉社,分子予防環境医学研究会編. 20 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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