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Elucidation of pathophysiology for various digestive diseases

Research Project

Project/Area Number 15209024
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

CHIBA Tsutomu  Kyoto University, Department of Gastroenterology & Hepatology, Professor, 医学研究科, 教授 (30188487)

Co-Investigator(Kenkyū-buntansha) OKAZAKI Kazuichi  Kansai Medical University, 3^<rd> Department of Internal Medicine, Professor, 医学部, 教授 (70145126)
NISHIO Akiyoshi  Kyoto University, Department of Gastroenterology & Hepatology, Assistant Professor, 医学研究科, 助教授 (50362463)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2005: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2004: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2003: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
KeywordsH.pylori / Gastritis / MALT lymphoma / Th1 / Th2 response / Autoimmune pancreatitis / Inflammatory bowel disease / Mycobacterium patratuberculosis / basic FGF / REG蛋白 / STAT3 / βカテニン / Colitic cancer / 胃癌 / 潰瘍性大腸炎 / colitic cancer / PSTI / INF_γ / IL4 / bFGF
Research Abstract

In this study, we tried to elucidate pathophysiology of H.pylori-induced gastyritis, autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) all of which involve immunological responses, and the following results were obtained. (1)In human, patients with gastric ulcer had Th1-predominant immunological response, whereas patients with duodenal ulcer were more polarized to Th2 response. Moreover, in patients with MALT lymphoma, Th2 reaction was remarkable. (2)In mice, severe gastritis developed by HP infection in C57black mice, a typical Th1-type strain, whereas no gastritis could be observed in Balb/c mice, a typical Th2-type strain. On the other hand, by thymectomy, severe gastritis seen in C57black mice disappeared and MALT lymphoma developed in Balb/c mice. Moreover, for MALT lymphoma B cell growth in vitro, in addition to HP presence of HP specific T cells and peripheral blood DC were essential. (3)By using serum of the patient who was negative for anti CAII antibody or anti-lactoferin but with high serum IgG titer, we identified pancreatic trypsin inhibitor as a candidate target for autoantibody in patients with autoimmune pancreatitis. (4)In patients with IBD, serum titiers for anti-Mycobacterium antibody was significantly higher than normal subjects, and involvement of Mycobacterium paratuberculosis infection in pathophysiology of human IBD was suggested. (5)Moreover, involvement of CMV as well as EBV infection in the pathophysiology of IBD was also suggested, and importance of measurement of and comparison of copy numbers of CMV gene in both affected and non-affected colonic site for diagnosis of CMV infection in patients with IBD was indicated. (6)For development of IBD, abnormality of permeability of epithelial barrier and that of regeneration of the epithelium were found to be involved. Accordingly, administration of growth factors such as bFGF, that enhances repair of epithelial cells appeared to be effective for the treatment of IBD.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (62 results)

All 2006 2005 2004 2003 Other

All Journal Article (46 results) Publications (16 results)

  • [Journal Article] STAT3 activation is involved in nuclear accumulation of b-catenin in colorectal cancer.2006

    • Author(s)
      Kawada M, Seno H, Chiba T, et al.
    • Journal Title

      Cancer Res 66

      Pages: 2913-2917

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gastric mucosal hyperplasia via up-regulation of gastrin induced by persistent activation of gastric innate immunity in MHC class II-deficient mice.2006

    • Author(s)
      Fukui H, Nishio A, Chiba T, et al.
    • Journal Title

      Gut 55

      Pages: 607-615

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific antibodies against recombinant protein of insertion element 900 of Mycobacterium avium subspecies paratuberculosis in Japanese patients with Crohn's disease.2006

    • Author(s)
      Nakase H, Nishio A, Chiba T, et al.
    • Journal Title

      Inflamm Bowel Dis 12

      Pages: 62-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer.2006

    • Author(s)
      Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara Y, Chiba T
    • Journal Title

      Cancer Res. 66

      Pages: 2913-2917

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gastric mucosal hyperplasia via upregulation of gastrin induced by persistent activation of gastric innate immunity in major histocompatibility complex class II deficient mice.2006

    • Author(s)
      Fukui T, Nishio A, Okazaki K, Uza N, Ueno S, Kido M, Inoue S, Kitamura H, Kiriya K, Ohashi S, Asada M, Tamaki H, Matsuura M, Kawasaki K, Suzuki K, Uchida K, Fukui H, Nakase H, Watanabe N, Chiba T
    • Journal Title

      Gut. 55

      Pages: 607-615

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific antibodies against recombinant protein of insertion element 900 of Mycobacterium avium subspecies paratuberculosis in Japanese patients with Crohn's disease.2006

    • Author(s)
      Nakase H, Nishio A, Tamaki H, Matsuura M, Asada M, Chiba T. Okazaki K
    • Journal Title

      Inflamm Bowel Dis. 12

      Pages: 62-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.2006

    • Author(s)
      Tanaka Y, Marusawa H, Chiba T, et al.
    • Journal Title

      Biochem Biophys Res Commun 341

      Pages: 314-319

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of APOBEC2 is transcriptionally regulatedd by NF-kappaB in human hepatocytes.2006

    • Author(s)
      Matsumoto, Marusawa H, Chiba T, et al.
    • Journal Title

      FEBS Lett 580

      Pages: 731-735

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Host factors are important in determining clinical outcomes of Helicobacter pylori infection.2006

    • Author(s)
      Chiba T, Seno H, et al.
    • Journal Title

      J Gastroenterol 41

      Pages: 1-9

    • NAID

      10017328156

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gastric mucosal hyperplasia via up-regulation of gastrin induced by persistent activation of gastric innate immunity in MHC class II-deficient mice.2006

    • Author(s)
      Fukui T, Nishio A, Chiba T, et al.
    • Journal Title

      Gut (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Risk of subsequent development of gastric cancer in patients with previous gastric epithelial neoplasia.2006

    • Author(s)
      Aoi T, Marusawa H, Chiba T, et al.
    • Journal Title

      Gut (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Possible role of REG Iα protein in ulcerative colitis and colitic cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Chiba T, et al.
    • Journal Title

      Gut 54

      Pages: 1437-1444

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Distinct gastric mucosal T cell responses to H.pylori infection : Th1 and Th2, may result in different clinical outcomes : gastric ulcer and duodenal ulcer.2005

    • Author(s)
      Itoh T, Seno H, Chiba T, et al.
    • Journal Title

      Scand J Gastroenterol 40

      Pages: 641-647

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis.2005

    • Author(s)
      Matsuura M, Nakase H, Chiba T, et al.
    • Journal Title

      Gastroenterology 128

      Pages: 975-986

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Th response to Helicobacter pylori differs between patients with gastric ulcer and duodenal ulcer.2005

    • Author(s)
      Itoh T, Seno H, Kita T, Chiba T. Wakatsuki Y
    • Journal Title

      Scand J Gastroenterol 40

      Pages: 641-647

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Possible role of REG Ia protein in ulcerative colitis and colitic cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Fujii S, Nanakin A, Kanda N, Uenoyama Y, Sawabu T, Hisatsune H, Kusaka T, Ueno S, Nakase H, Seno H, Fujimori T, Chiba T
    • Journal Title

      Gut 54

      Pages: 1437-1444

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis.2005

    • Author(s)
      Matsuura M, Okazaki K, Nishio A, Nakase H, Tamaki H, Uchida K, Nishi T, Asada M, Kawasaki K, Fukui T, Yoshizawa H, Ohashi S, Inoue S, Kawanami C, Hiai H, Tabata Y, Chiba T
    • Journal Title

      Gastroenterology 128

      Pages: 975-986

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] REG Ia protein may function as a trophic and/or anti-apoptitic factor in the development of gastric cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, Seno H, Takasawa S, Okamoto H, Fujimori T, Chiba T
    • Journal Title

      Gastroenterology 128

      Pages: 642-653

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Adenomyoma of the minor duodenal papilla.2005

    • Author(s)
      Fukuda A, Yazumi S, Chiba T, et al.
    • Journal Title

      Gastrointest Endsc 61

      Pages: 475-479

    • Related Report
      2005 Annual Research Report
  • [Journal Article] REG Ia protein may function as a trophic and/or anti-apoptitic factor in the development of gastric cancer.2005

    • Author(s)
      Sekikawa A, Fukui H, Chiba T, et al.
    • Journal Title

      Gastroenterology 128

      Pages: 642-653

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis.2005

    • Author(s)
      Fujii S, Tominaga K, Chiba T, et al.
    • Journal Title

      Gut 54

      Pages: 1287-1292

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Usefulness of famotidine in functional dyspepsia patient treatment : comparison among prokinetic, acid suppression and antianxiety therapies.2005

    • Author(s)
      Seno H, Nakase H, Chiba T
    • Journal Title

      Aliment Pharmacol Ther 21(supple2)

      Pages: 32-36

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1.2005

    • Author(s)
      Kawasaki K, Nishio A, Chiba T, et al.
    • Journal Title

      Lab Invest 85

      Pages: 1104-1117

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CD4+CD25+T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen.2005

    • Author(s)
      Watanabe T, Yamori M, Chiba T, et al.
    • Journal Title

      Inflamm Bowel Dis 11

      Pages: 541-550

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hepatitis B virus infecction in lymphatic tissues in inactive hepatitis B carriers.2005

    • Author(s)
      Umeda M, Marusawa H, Chiba T, et al.
    • Journal Title

      J Hepatol 42

      Pages: 806-812

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Intragraft expression of recipient-type ABO blood group antigens : Long-term follow-up and histological features after liver transplantation.2005

    • Author(s)
      Tanaka Y, Haga H, Chiba T, et al.
    • Journal Title

      Liver Transpl 11

      Pages: 547-554

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.2005

    • Author(s)
      Ko K, Yamazaki S, Chiba T, et al.
    • Journal Title

      J Exp Med 202

      Pages: 885-891

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner.2004

    • Author(s)
      Iwai A, Marusawa H, Matsuzawa S, Fukushima T, Hijikata M, Reed JC, Shimotohno K, Chiba T
    • Journal Title

      Oncogene 23

      Pages: 7593-7600

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004

    • Author(s)
      Kanda N, Seno H, Konda Y, Marusawa H, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, Sekikawa A, Kawada M, Suzuki K, Kayahara T, Fukui H, Sawada M, Chiba T
    • Journal Title

      Oncogene 23

      Pages: 4921-4929

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulfate sodium.2004

    • Author(s)
      Fujii S, Fujimori T, Kawamata H, Takada J, Kitajima K, Omotehara F, Kaihara T, Kusaka T, Ichikawa K, Ohkura Y, Ono Y, Imura J, Yamaoka S, Sakamoto C, Ueda Y, Chiba T
    • Journal Title

      Gut 53

      Pages: 710-716

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immuno-genetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice.2004

    • Author(s)
      Fukui T, Okazaki K, Tamaki H, Kawasaki K, Matsuura M, Asada M, Nishi T, Uchida K, Iwano M, Ohana M, Hiai H, Chiba T
    • Journal Title

      Lab Invest 84

      Pages: 485-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immuno-genetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice.2004

    • Author(s)
      Fukui T., Chiba T., et al.
    • Journal Title

      Lab Invest 84(4)

      Pages: 485-492

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulfate sodium.2004

    • Author(s)
      Fujii S., Chiba T., et al.
    • Journal Title

      Gut 53(5)

      Pages: 710-716

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of RegIα protein in human gastric cancer.2004

    • Author(s)
      Fukui H., Chiba T., et al.
    • Journal Title

      Digestion 69(3)

      Pages: 177-184

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut.2004

    • Author(s)
      Suzuki K., Chiba T., et al.
    • Journal Title

      Proc Nat Acad Sci USA 101(7)

      Pages: 1981-1986

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characteristics of gastric B cell lymphoma of mucosa-associated lymphoid tissue type involving multiple organs.2004

    • Author(s)
      Iwano M., Chiba T., et al.
    • Journal Title

      J. Gastroenterol 39(8)

      Pages: 739-746

    • NAID

      80016835116

    • Related Report
      2004 Annual Research Report
  • [Journal Article] STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.2004

    • Author(s)
      Kanda N., Chiba T., et al.
    • Journal Title

      Oncogene 23(28)

      Pages: 4921-4929

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A coordinated cytotoxic effect of IFN-γ and cross-reactive antibodies in the pathogenesis of Helicobacter pylori gastritis.2003

    • Author(s)
      Itoh T, Yoshida M, Chiba T, et al.
    • Journal Title

      Helicobacter 8

      Pages: 268-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prevention of the development of autoimmune gastritis by Helicobacter pylori infectgion in neonatal thymectomised mice.2003

    • Author(s)
      Ohana M, Okazaki K, Chiba T, et al.
    • Journal Title

      Gut 52

      Pages: 1102-1110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid follicles in Helicobacter pylori-infected BALB/c mice with neonatal thymectomy.2003

    • Author(s)
      Nishi T, Okazaki K, Chiba T, et al.
    • Journal Title

      Infect Immun 71

      Pages: 2153-2162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Elimination of local macrophages in the intestine prevents chronic colitis in interleukin-10 deficient mice.2003

    • Author(s)
      Watanabe N, Ikuta K, Chiba T, et al.
    • Journal Title

      Dig Dis Sci 48

      Pages: 408-414

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of Helicobacter pylori infection on the link between regenerating gene expression and serum gastrin levels in mongolian gerbils.2003

    • Author(s)
      Fukui H, Franceschi F, Penland RL, Sakai T, Sepulveda AR, Fujimori T, Terano A, Chiba T, Genta RM
    • Journal Title

      Lab Invest 83

      Pages: 1777-1786

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A coordinated cytotoxic effect of IFN-γ and cross-reactive antibodies in the pathogenesis of Helicobacter pylori gastritis.2003

    • Author(s)
      Itoh T, Yoshida M, Chiba T, Kita T, Wakatsuki Y
    • Journal Title

      Helicobacter 8

      Pages: 268-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibitory effects of Helicobacter pylori infection on murine autoimmune gastritis.2003

    • Author(s)
      Ohana M, Okazaki K, Oshima C, Kawasaki K, Fukui T, Tamaki H, Matsuura M, Asada M, Nishi T, Uchida K, Uose S, Nakase H, Iwano M, Matsushima Y, Hiai H, Chiba T
    • Journal Title

      Gut 52

      Pages: 1102-1110

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid follicles in Helicobacter pylori-infected neonatal thymectomized BALB/c mice.2003

    • Author(s)
      Nishi T, Okazaki K, Kawasaki K, Fukui T, Tamaki H, Matsuura M, Asada M, Watanabe T, Uchia K, Watanabe N, Nakase H, Ohana M, Hiai H, Chiba T
    • Journal Title

      Infect Immun 71

      Pages: 2153-2162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.2003

    • Author(s)
      Watanabe N, Ikuta K, Okazaki K, Nakase H, Tabata Y, Matsuura M, Tamaki H, Kawanami C, Honjo T, Chiba T
    • Journal Title

      Dig Dis Sci. 48

      Pages: 408-414

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Watanabe N, Chiba T, et al.: "Spontaneous regression of Epstein-Barr virus-associated T-cell lymphoma of the stomach"Gastrointest Endosc. 57. 414-417 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe N, Chiba T, et al.: "Elimination of local macrophages in the intestine prevents chronic colitis in interleukin-10 deficient mice"Dig Dis Sci. 48. 408-414 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida K, Chiba T, et al.: "A case of chronic pancreatitis involving an autoimmune mechanism that extended to retroperitoneal fibrosis"Pancreas. 26. 92-94 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishi T, Chiba T, et al.: "Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid foliicles in Helicobacter pylori-infected BALB/c mice with neonatal thymectomy"Infect Immun. 71. 2153-2162 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohana M, Chiba T, et al.: "Prevention of the development of autoimmune gastritis by Helicobacter pylori infectgion in neonatal thymectomised mice"Gut. 52. 1102-1110 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe T, Chiba T, et al.: "A liver tolerates to a portal antigen by generating CD11c+cells which select regulatory CD4+T cells via apoptosis"Hepatology. 38. 403-412 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujii S, Chiba T, et al.: "Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia"J Exp Clin Cancer Res. 22. 421-429 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Itoh T, Chiba T, et al.: "A coordinated cytotoxic effect of IFN-γ and cross-reactive antibodies in the pathogenesis of Helicobacter pylori gastritis"Helicobacter. 8. 268-278 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe T, Chiba T, et al.: "CD4 T cells for IgE response to a dietary antigen develop in the liver"J Allergy Clin Immunol 111:1375-1385:2003. 111. 1375-1385 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Taniguchi T, Chiba T, et al.: "High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes : Concept of autoimmune exocrinopathy and endocrinopathy of the pancreas"Pancreas. 27. 26-30 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukui T, Chiba T, et al.: "Immuno-genetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice"Lab Invest. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujii S, Chiba T, et al.: "Development of colonic neoplasia in p53 deficient mice with experimental coiitis induced by dextran sulfate sodium"Gut. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujii S, Chiba T, et al.: "Efficacy of surveillance and molecular markers for detection of ulcerative colitis-associated colorectal neoplasia"J Gastroenterol. 38. 1117-1125 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okazaki K, Chiba T, et al.: "Interaction of Helicobacter pylori-induced follicular gastritis and autoimmune gastritis in BALB/c mice with post-thymectomy autoimmune gastritis"J Gastroenterol. 38. 1131-1137 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suzuki K, Chiba T, et al.: "Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut"Proc Nat Acad Sci USA. 101. 1981-1986 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwano M, Chiba T, et al.: "Characteristics of gastric B cell lymphoma of mucosa-associated lymphoid tissue type involving multiple organs"J Gastroenterol. (in press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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