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Implications of neural stem cells for the pathogenesis of schizophrenia : A new target for schizophrenia research

Research Project

Project/Area Number 15209036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

MORI Norio  Hamamatsu University School of Medicine, Psychiatry and Neurology, Professor, 医学部, 教授 (00174376)

Co-Investigator(Kenkyū-buntansha) TAKEI Noriyoshi  Hamamatsu University School of Medicine, Psychiatry and Neurology, Associate Professor, 医学部, 助教授 (80206937)
MINABE Yoshio  Hamamatsu University School of Medicine, Psychiatry and Neurology, Lecturer, 医学部附属病院, 講師 (60181947)
NAKAMURA Kazuhiko  Hamamatsu University School of Medicine, Psychiatry and Neurology, Lecturer, 医学部附属病院, 講師 (80263911)
SATO Kohji  Hamamatsu University School of Medicine, Anatomy, Professor, 医学部, 教授 (80235340)
岩田 泰秀  浜松医科大学, 医学部, 助手 (10285025)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥49,400,000 (Direct Cost: ¥38,000,000、Indirect Cost: ¥11,400,000)
Fiscal Year 2005: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2004: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2003: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Keywordsschizophrenia / neural stem cell / animal model / LIFR knockout mice / VLDLR / ApoER2 / x-irradiation / peripheral biological markers / 放射線 / LIFR (leukemia inhibitory factor receptor) / VLDLR (very low density lipoprotein receptor) / ApoER2 (apolipoprotein E receptor type 2)
Research Abstract

1.An animal model for schizophrenia based on hypothesis of neural stem cell dysfunction :
(1)Male Sprague-Dawley rats were irradiated to the forebrain using 6 fractions of 5 Gy. After 12 weeks, neural stem cells (BrdU positive cells) were diminished in both subventricular zone and hippocampal dentate gyrus subgranular zone. A significant increase in locomotor activity after administration of methamphetamine (MAP) (2 mg/kg i.p.) or MK-801 (0.2 mg/kg i.p.) was observed. Acoustic prepulse inhibition and social behaviors of the irradiated rats were significantly decreased. Moderate impairments of spatial working memory and reference memory assessed by Morris water maze were found in the model rats. (2)It has been reported that LIFR-deficient mice revealed a reduction in the number of adult neural stem cells. Locomotor activity induced by MAP was significantly increased in the LIFR knockout mice. However, behavioral change after MK-801 or prepulse inhibition of startle responces was not obse … More rved. (3)We transplanted embryonic neural precursor cells (NPCs) into the bilateral ventricles and the dentate gyri of the irradiated rats at 3 months after irradiation. The MAP-induce hyperactivity was not ameliorated at 4 weeks after the NPCs transplantation.
2.Peripheral biological markers for schizophrenia :
Reelin is a secretory protease with major roles in neurodevelopment and plasticity. A reduction of reelin expression is one of the most robust molecular findings in schizophrenia. Apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR) are reelin receptors. In search for peripheral biological markers for schizophrenia we have investigated mRNA levels of ApoER2 and VLDLR in peripheral blood lymphocytes of drug naive patients with schizophrenia, mood disorder and healthy controls. We observed a significant decrease of VLDLR mRNA levels in schizophrenia, but not those in mood disorder, compared with controls. A significant decrease in the ApoER2 mRNA level was found only in mood disorder. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (58 results)

All 2006 2005 2004 2003 Other

All Journal Article (53 results) Book (2 results) Publications (3 results)

  • [Journal Article] Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.2006

    • Author(s)
      Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M.
    • Journal Title

      Biol Psychiatry. 59(7)

      Pages: 652-659

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A transient lesion in splenium of the corpus callosum in a patient with childhood-onset anorexia nervosa.2006

    • Author(s)
      Nishimura K, Takei N, Suzuki K, Kawai M, Sekine Y, Isoda H, Mori N.
    • Journal Title

      Int J Eat Disord. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder.2006

    • Author(s)
      Nakamura K, Yamada K, Iwayama Y, Toyota T, Furukawa A, Takimoto T, Terayama H, Iwahashi K, Takei N, Minabe Y, Sekine Y, Suzuki K, Iwata Y, Pillai A, Nakamoto Y, Ikeda K, Yoshii M, Fukunishi I, Yoshikawa T, Mori N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 141(3)

      Pages: 222-226

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increased rate of birth complications and small head size at birth in winter-born male patients with schizophrenia.2006

    • Author(s)
      Takagai S, Kawai M, Toulopoulou T, Tsuchiya KJ, Mori N, Takei N.
    • Journal Title

      Schizophr Res. 83(2-3)

      Pages: 303-305

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Brain serotonin transporter density and aggression in abstinent methamphetamine abusers.2006

    • Author(s)
      Sekine Y, Ouchi Y, Takei N, Yoshikawa E, Nakamura K, Futatsubashi M, Okada H, Minabe Y, Suzuki K, Iwata Y, Tsuchiya KJ, Tsukada H, Iyo M, Mori N.
    • Journal Title

      Arch Gen Psychiatry. 63(1)

      Pages: 90-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 海馬の細胞新生と統合失調症2005

    • Author(s)
      鈴木 勝昭
    • Journal Title

      CLINICAL NEUROSCIENCE 23・1

      Pages: 43-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 統合失調症の神経幹細胞機能異常仮説2005

    • Author(s)
      森 則夫
    • Journal Title

      脳21 8・1

      Pages: 34-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 統合失調症の神経幹細胞機能異常仮説2005

    • Author(s)
      森 則夫
    • Journal Title

      医学のあゆみ 212・8

      Pages: 768-769

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 認知機能と分子生物学(認知障害にかかわる遺伝子背景を含めて)2005

    • Author(s)
      三辺 義雄
    • Journal Title

      分子精神医学 5

      Pages: 21-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Effective adjunctive use of pergolide with quetiapine for cognitive impairment and negative symptoms in schizophrenia.2005

    • Author(s)
      Sekine Y, Takei N, Suzuki K, Nakamura K, Tsuchiya KJ, Takebayashi K, Toulopoulou T, Mori N.
    • Journal Title

      J Clin Psychopharmacol. 25(3)

      Pages: 281-283

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Right orbitofrontal region and obsessive-compulsive behavior : a case report.2005

    • Author(s)
      Ogai M., Iyo M., Mori N., Takei N.
    • Journal Title

      Acta Psychiat Scand 111(1)

      Pages: 74-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Advanced Paternal Age Associated with an Elevated Risk for Schizophrenia in Offspring in a Japanese Population.2005

    • Author(s)
      Tsuchiya K.J., Takagai S., Kawai M., Matsumoto H., Nakamura K., Minabe Y., Mori N., Takei N.
    • Journal Title

      Schizophr Res 76

      Pages: 337-342

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional polymorphism of HSPA5 : Possible association with bipolar disorder.2005

    • Author(s)
      Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T.
    • Journal Title

      Biochemistry Biophysics Research Communications 336

      Pages: 1136-1143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.2005

    • Author(s)
      Kato T, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S, Yoshikawa T.
    • Journal Title

      Mol Psychiatry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders : evidence for association of ASCU with Parkinson's disease.2005

    • Author(s)
      Ide M, Yamada K, Toyota T, Iwayama Y, Ishitsuka Y, Minahe Y, Nakamura K, Hattori N, Asada T, Mizuno Y, Mori N, Yoshikawa T.
    • Journal Title

      Hum Genet.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] No changes in serum epidermal growth factor levels in patients with schizophrenia.2005

    • Author(s)
      Hashimoto K., Shimizu E., Komatsu N., Watanabe H., Shinoda N., Nakazato M., Kumakiri C., Okada S., Takei N., Iye M.
    • Journal Title

      Psychiatr.Res. 135(3)

      Pages: 257-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional polymorphism of HSPA5 : Possible association with bipolar disorder.2005

    • Author(s)
      Kakiuchi C, Ishikawa M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umegaki T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T.
    • Journal Title

      Biochemistry Biophysics Research Communications 336

      Pages: 1136-1143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association between Polymorphisms in the Promoter Region of the Sialyltransferase B (SIAT8B) Gene and Schizophrenia.2005

    • Author(s)
      Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M.
    • Journal Title

      Biological Psychiatry (on-line published)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders : evidence for association of ASCL1 with Parkinson's disease.2005

    • Author(s)
      Ide M, Yamada K, Toyota T, Iwayama Y, Ishitsuka Y, Minabe Y, Nakamura K, Hattori N, Asada T, Mizuno Y, Mori N, Yoshikawa T.
    • Journal Title

      Hum Genet.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] No changes in serum epidermal growth factor levels inpatients with schizophrenia.2005

    • Author(s)
      Hashimoto K., Shimizu E., Komatsu N., Watanabe H., Shinoda N., Nakazato M., Kumakiri C., Okada S., Takei N., Iyo M.
    • Journal Title

      Psychiatr.Res. 135(3)

      Pages: 257-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stigmatisation of people with schizophrenia in Japan.2005

    • Author(s)
      Takei N, Takagai S, Mori N.
    • Journal Title

      Br J Psychiatry. 187

      Pages: 589-590

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B2004

    • Author(s)
      Toyota Tomoko
    • Journal Title

      Human Molecular Genetics 13・5

      Pages: 551-561

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Genetic Expression Analysis of FZD3 in Schizophrenia2004

    • Author(s)
      Masayuki Ide
    • Journal Title

      Biol Psychiatry 56・6

      Pages: 462-465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism2004

    • Author(s)
      Sekizawa T., Iwata Y., Nakamura K., Matsumoto H., Suzuki A., Minabe Y., Mori N.
    • Journal Title

      Am J Med Genet 128B

      Pages: 24-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Focus on psychiatry in Japan.2004

    • Author(s)
      Tsuchiya K.J., Takei N.
    • Journal Title

      Br J Psychiatr 184

      Pages: 88-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Do Jiko-shu-kyofu (a subtype of Taijin-kyofu) and olfactory reference syndrome share a common entity?2004

    • Author(s)
      Suzuki K., Takei N., Sekine Y., Tani K., Toyoda T., Ohashi Y., Kawai M., Hoshino R., Iyo M., Mori N.
    • Journal Title

      Acta Psychiar Scand 109(2)

      Pages: 150-155

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolite Alterations in Basal Ganglia Associated with Psychiatric Symptoms of Abstinent Toluene Users : A Proton MRS Study.2004

    • Author(s)
      Takebayashi K., Sekine Y., Takei N., Minabe Y., Isoda H., Takeda H., Nishimura K., Nakamura K., Suzuki K., Iwata Y., Sakahara H., Mori N.
    • Journal Title

      Neuropsychopharmacol 29(5)

      Pages: 1019-1026

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Is inseki-jisatsu, responsibility-driven suicide, a culture-bound form of suicide?2004

    • Author(s)
      Takei N., Nakamura K.
    • Journal Title

      Lancet 363(9418)

      Pages: 1400-1400

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Childhood-onset schizophrenia and tryotophan hydroxylase gene polymorphism.2004

    • Author(s)
      Sekizawa T., Osada N., Iwata Y., Matsumoto H., Suzuki K., Minabe Y., Takei N., Mori N.
    • Journal Title

      Am J Med Genet 128B(1)

      Pages: 24-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Poor maternal care and high maternal body mass index in pregnancy as a risk factor for schizophrenia in offspring.2004

    • Author(s)
      Kawai M., Minabe Y., Takagai S., Ogai M., Matsumoto H., Mori N., Takei N.
    • Journal Title

      Acta Psychiat Scand 110(4)

      Pages: 257-263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic and expression analyses of FDZ3 in schizophrenia.2004

    • Author(s)
      Ide M., Muratake T., Yamada K., Iwayama-Shigeno Y., Iwamoto K., Takao H., Toyota T., Kaneko N., Minabe Y., Nakamura K., Kato T., Mori N., Asada T., Someya T., Yoshikawa T.
    • Journal Title

      Biol Psychiatry 56

      Pages: 462-465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 1H NMR spectroscopy show an increase in the NAAG and glutamate contents in the hippocampus of amygdaloid kindled rat.2004

    • Author(s)
      Shirayama Y., Takahashi S., Minabe Y., Ogino T.
    • Journal Title

      J Neurochem 92

      Pages: 1317-1326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Augmentation of milnacipran by risperidone in treatment for major depression.2004

    • Author(s)
      Tani K., Takei N., Kawai M., Suzuki K., Sekine Y., Minabe Y., Mori N.
    • Journal Title

      Int J Neuropsychopharmacol 7(1)

      Pages: 55-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers.2004

    • Author(s)
      Koizumi H., Hashimoto K., Kumakiri C., Shimizu E., Sekine Y., Ozaki N., Inada T., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Takei N., Iyo M.
    • Journal Title

      Am J Med Genet 126B(1)

      Pages: 43-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Obstetric adversity and age at the first presentation in schizophrenia : evidence of a casual relationship.2004

    • Author(s)
      Kelly B.D., Feeney L., Browne R.., Byrne M.., Mulryyan N., Scully A., Morris M., Kinesella A., Takei N., McNeil T., Walsh D., Larkin C., O'Callaghan E.
    • Journal Title

      Am J Psychatr 161. 161(5)

      Pages: 920-922

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia sepctrum disorders.2004

    • Author(s)
      Matsuura M., Adachi N., Oana Y., Okubo Y., Kato M., Nakano T., Takei N.
    • Journal Title

      Schizophr Res 69(2-3)

      Pages: 189-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts.2004

    • Author(s)
      Yamada K., Nakamura K., Minabe Y., Iwayama-Shigeno Y., Takao H., Toyota T., Hattori E., Takei N., Sekine Y., Suzuki K., Iwata Y., Miyoshi K., Honda A., Baba K., Katayama T., Tohyama M., Mori N., Yoshikawa T.
    • Journal Title

      Biol Psychiatr 56(9)

      Pages: 683-690

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of FEZ1 gene-variants including Asp 123Glu with schizophrenia subset in Japan.2004

    • Author(s)
      Yamada K.#, Nakamura K.#, Minabe Y.# (#equally contributed to this work), Shigeno Y., Takao H., Toyota T., Hattori E., Takei N., Sekine Y., Suzuki K., Iwata Y., Miyoshi K., Honda A., Baba K., Katayama T., Tohyama M., Mori N., Yoshikawa T.
    • Journal Title

      Biol Psychiatry 56

      Pages: 583-590

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B.2004

    • Author(s)
      Toyota T., Yoshitsugu K., Ebihara M., Yamada K., Ohba H., Fukasawa M., Minabe Y., Nakamura K., Sekine Y., Takei N., Suzuki K., Itokawa M., Meerabux J.M., Iwayama-Shigeno Y., Tomaru Y., Shimizu H., Hattori E., Mori N., Yoshikawa T.
    • Journal Title

      Hum Mol Genet 13(5)

      Pages: 551-561

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers.2004

    • Author(s)
      Koizumi H., Hashimoto K., Kumakiri C., Shimizu E., Sekine Y., Ozaki N., Inada T., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Takei N., Iyo M.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 126(1)

      Pages: 43-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Neuromechanism of developing methamphetamine psychosis : a neuroimaging study.2004

    • Author(s)
      Iyo M., Sekine Y., Mori N
    • Journal Title

      Ann.N.Y.Acad Sci 1025

      Pages: 288-295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Related Articles, Links Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats : an in vivo electrophysiological study.2004

    • Author(s)
      Minabe Y, Shirayama Y, Hashimoto K, Routledge C, Hagan JJ, Ashby CR Jr.
    • Journal Title

      Synapse. 52(1)

      Pages: 20-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of the acute and chronic administration of the putative atypical antipsychotic drug Y-931 (8-fluoro-12- (4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3b][1,5] benzodiazepine maleate) on spontaneously active rat midbrain dopamine neurons : an in vivo electrophysiological study.2004

    • Author(s)
      Minabe Y, Hashimoto K, Shirayama Y, Ashby CR Jr.
    • Journal Title

      Synapse. 51(1)

      Pages: 19-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Untility of neuropsychological tests to genetic studies of schizophrenia.2004

    • Author(s)
      Toulopoulou T., Takei N.
    • Journal Title

      Jap J Mol Psychiatr 4

      Pages: 48-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two cases of perospirone-induced mania in schizophrenia.2004

    • Author(s)
      Yokoshima T., Takei N., Tani K., Kawai M., Minabe Y., Mori N.
    • Journal Title

      J Clin Psychiatr 65

      Pages: 135-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic Expression Analysis of FZD3 in Schiaophrenia2004

    • Author(s)
      Masayuki Ide
    • Journal Title

      Biol Psychiatry 56・6

      Pages: 462-465

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Is taijin kyofusho a culture-bound syndrome?2003

    • Author(s)
      Suzuki K, Takei N, Kawai M, Minabe Y, Mori N.
    • Journal Title

      Am J Psychiatry. 160(7)

      Pages: 1358-1358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms.2003

    • Author(s)
      Sekine Y, Minabe Y, Ouchi Y, Takei N, Iyo M, Nakamura K, Suzuki K, Tsukada H, Okada H, Yoshikawa E, Futatsubashi M, Mori N.
    • Journal Title

      Am J Psychiatry. 160(9)

      Pages: 1699-1701

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Auditory hallucinations and cognitive impairment in a patient with a lesion restricted to the hippocampus.2003

    • Author(s)
      Suzuki K, Takei N, Toyoda T, Iwata Y, Hoshino R, Minabe Y, Mori N.
    • Journal Title

      Schizophr Res. 164(1)

      Pages: 87-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acetaldehyde adducts in the brain of alcoholics.2003

    • Author(s)
      Nakamura K, Iwahashi K, Furukawa A, Ameno K, Kinoshita H, Ijiri I, Sekine Y, Suzuki K, Iwata Y, Minabe Y, Mori N.
    • Journal Title

      Arch Toxicol. 77(10)

      Pages: 591-593

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute and chronic administration of the selective 5-HT1A receptor antagonist WAY-405 significantly alters the activity of midbrain dopamine neurons in rats : an in vivo electrophysiological study.2003

    • Author(s)
      Minabe Y, Schechter L, Hashimoto K, Shirayama Y, Ashby CR Jr.
    • Journal Title

      Synapse. 50(3)

      Pages: 181-190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inseki-jisatsu, shinju (double suicide), and muri-shinju (forced suicide).

    • Author(s)
      Takei N., Nakamura K., Kawai M.
    • Journal Title

      Brit.J.Psychatr. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An association study between COMT gene polymorphism and methamphetamine psychotic disorder

    • Author(s)
      Suzuki A., Nakamura K., Sekine Y., Minabe Y., Takei N., Suzuki K., Iwata Y., Kawai M., Takebayashi K., Iyo M., Ozaki N., Inada T., Iwata N., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Mori N.
    • Journal Title

      Psychiat Genet (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Infection and Psychiatric Disoders2005

    • Author(s)
      S.H.Fatemi
    • Total Pages
      282
    • Publisher
      Taylor & Francis
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Have recent studies of the seasonality of birth in schizophrenia added to our knowledge of the disease? (Infection and Psychiatric Disoders(eds.S.H.Fatemi, R.A.Machon.))2005

    • Author(s)
      Kawai M., Takei N., Murray R.M.
    • Publisher
      Taylor & Francis
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Ueki T, Tanaka M, Yamashita K, Mikawa S, Qiu Z, Maragakis NJ, Hevner RF, Miura N, Sugimura H, Sato K.: "A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus."J Neurosci. 23・37. 11732-11740 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 笹征史, 西昭徳, 小林和人, 佐野裕美, 籾山俊彦, 浦村一秀, 矢田俊彦, 森則夫, 鈴木勝昭, 三辺義雄: "ドパミンによる運動精神機能調節:新たな研究への展開"日本薬理学雑誌. 122・3. 215-225 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuzaki H, Namikawa K, Kiyama H, Mori N, Sato K.: "Brain-derived neurotrophic factor rescues neuronal death induced by methamphetamine."Biol Psychiatry. 55・1. 52-60 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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