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Translational research in the establishment of treatment strategy for gastrointestinal cancers

Research Project

Project/Area Number 15209040
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

MONDEN Morito  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00127309)

Co-Investigator(Kenkyū-buntansha) SEKIMOTO Mitsugu  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10273658)
FUJIWARA Yoshiyuki  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (40314330)
YAMAMOTO Hirofumi  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (30322184)
IKEDA Masataka  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (80335356)
中森 正二  大阪大学, 医学系研究科, 講師 (70294080)
矢野 正彦  大阪大学, 医学系研究科, 助教授 (70273646)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2005: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2004: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2003: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
KeywordsDigestive organ cancer / DNA chip / gene expression profile / Translational research / 遺伝子発現プロフィル / ヒト全遺伝子型DNAチップ / 遺伝子発現 / オリゴヌクレオチド / 大腸癌 / 肝転移予測 / 予後予測診断
Research Abstract

The aim of this project is to establish the prediction system for the metastasis/prognosis or behavior of gastrointestinal cancers, using molecular biology such as the DNA chip technology, which would have been limited with the conventional clinicopathological diagnosis. This project contains the two major branches, one is multicenter registration system of thousands of cancer samples and their clinicopathological information as the clinical field, and the other is comprehensive molecular analyses system of them using whole human gene 30K DNA chip as the basic research field.
Our results are follows.
1.Approximately 4000 gastrointestinal cancer samples and their detailed pathological information and their prognosis including overall and disease free survival have been collected by the cooperation of 11 hospitals of our series participated in this project.
2.Whole human gene expressions of several hundred samples of each cancer were obtained with 30K DNA chip.
3.The data mining of both huge clinicopathological and molecular information was done with sophisticated statistics.
4.The candidate genes that may be related to or may play an important role for each carcinogenesis such as colorectal, gastric, hepatocellular, esophageal, and pancreatic cancer were identified.
5.After the recognition of the characteristic gene expression patterns correlated with metastasis, recurrence, prognosis, and responsibility for chemotherapy and/or radiotherapy of each cancer, we are succeeded in the establishment of prediction system for the tumor behavior using the results of such gene expression profiles.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report

Research Products

(41 results)

All 2006 2005 2004 2003 Other

All Journal Article Book Publications

  • [Journal Article] Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma : a new approach to identify novel tumor markers.2006

    • Author(s)
      Kurokawa Y, Honma K, Takemasa I, Nakamori S, Kita-Matsuo H, Motoori M, Nagano H, Dono K, Ochiya T, Monden M, Kato K.
    • Journal Title

      Int J Oncol. 28(2)

      Pages: 383-391

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prediction of recurrence in advanced gastric cancer patients after curative resection by gene expression profiling.2005

    • Author(s)
      Motoori M., et al.
    • Journal Title

      Int J Cancer 114(6)

      Pages: 963-968

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DNA chipの癌臨床への応用-大腸癌診断用DNA chip (Mini Chip)の開発・作製-『消火器病学の進歩2005-モノグラフ 消火器病学のニューフロンティア編』2005

    • Author(s)
      山崎誠, 他
    • Journal Title

      財団法人日本消火器病学会

      Pages: 404-407

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prediction of recurrence in advanced gastric cancer patients after curative resection by gene expression profiling.2005

    • Author(s)
      Motoori M., et al.
    • Journal Title

      Int J Cancer. 114(6)

      Pages: 963-968

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prediction of recurrence in advanced gastric cancer patients after curative resection by gene expression profiling.2005

    • Author(s)
      Motoori M, Takemasa I, Yano M, Saito S, Miyata H, Takiguchi S, Fujiwara Y, Yasuda T, Doki Y, Kurokawa Y, Ueno N, Oba S, Ishii S, Monden M, Kato K.
    • Journal Title

      Int J Cancer 114(6)

      Pages: 963-968

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNAマイクロアレイを用いたトランスクリプトーム解析による腫瘍マーカーの探索2005

    • Author(s)
      小森孝通, 竹政伊知朗, 山崎誠, 本告正明, 吉岡慎一, 小山太一, 池田正孝, 山本浩文, 関本貢嗣, (松原謙一), 門田守人
    • Journal Title

      日本分子腫瘍マーカー研究会誌 20

      Pages: 76-77

    • NAID

      130004436355

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 肝細胞癌・化学療法感受性予測-IFN/5FU併用療法の効果予測-2005

    • Author(s)
      黒川幸典, 永野浩昭, 門田守人
    • Journal Title

      肝臓 46・10

      Pages: 35-39

    • NAID

      10016861754

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molresular Prediction of Response to 5-Fluorouracil and Interferon-f Combination Chemotherapy on Advanced Hepatocellular Carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Clinical Cancer Research 10

      Pages: 6029-6038

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular-based prediction of early recurrence in hepatosellular carsinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Journal of Hepatology 41

      Pages: 284-291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] PCR-array Gene Expression Profiling of Hepatocellular Carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      J.Exp.Clin.Cancer Res 23(1)

      Pages: 135-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of Differentially Expressed Genes Involved in Colorectal Carcinogenesis Using a cDNA Microarray.2004

    • Author(s)
      Komori T., et al.
    • Journal Title

      J.Exp.Clin.Cancer Res 23(3)

      Pages: 521-527

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] バイオインフォマティクスに基づく大腸癌の臨床-DNAチップの解析手法と臨床応用-2004

    • Author(s)
      竹政伊知朗, 他
    • Journal Title

      医学のあゆみ 208(8)

      Pages: 694-695

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] PCRアレイを用いた肝細胞癌の網羅的遺伝子発現解析-新しいバイオマーカーの探索-2004

    • Author(s)
      黒川幸典, 他
    • Journal Title

      癌の臨床 50(1)

      Pages: 21-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 分子診断学の進歩と癌検診への応用-DNAチップ技術による大腸癌の遺伝子発現プロファイル解析と臨床応用2004

    • Author(s)
      竹政伊知朗, 他
    • Journal Title

      日本がん検診・診断学会 11(2)

      Pages: 21-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DNAチップによる癌の個別化診断・治療時代の到来2004

    • Author(s)
      竹政伊知朗, 他
    • Journal Title

      外科治療 91(4)

      Pages: 485-491

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular Prediction of Response to 5-Fluorouracil and Interferon-α Combination Chemotherapy on Advanced Hepatocellular Carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Clinical Cancer Research 10

      Pages: 6029-6038

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular-based prediction of early recurrence in hepatocellular carcinoma.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Jounal of Hepatology 41

      Pages: 284-291

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of Differentially Expressed Genes Involved in Colorectal Carcinogenesis Using a cDNA Microarray.2004

    • Author(s)
      Komori T., et al.
    • Journal Title

      J.Exp.Clin.Cancer Res. 23(3)

      Pages: 521-527

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analytical technique and clinical application - of clinical - DNA chip of large bowel cancer based on bioinformatics.2004

    • Author(s)
      Takemasa I., et al.
    • Journal Title

      Medical Ayumi 208(8)

      Pages: 694-695

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Search - of the biomarker that cyclopedic gene expression analysis - is new of the hepatocellular carcinoma which I used PCR array for.2004

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      Rinsyou of cancer 50(1)

      Pages: 21-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene expression profile analysis and clinical application of large bowel cancer by applied - DNA chip technology to progress and a cancer checkup of molecule diagnostics.2004

    • Author(s)
      Takemasa I., et al.
    • Journal Title

      Japanese cancer screening/diagnostics society 11(2)

      Pages: 21-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The arrival of an individualization diagnosis / the treatment times of cancer with DNA chip.2004

    • Author(s)
      Takemasa I., et al.
    • Journal Title

      Surgery treatment 91(4)

      Pages: 485-491

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of differentially expressed genes involved in colorectal carcinogenesis using a cDNA microarray.2004

    • Author(s)
      Komori, T., Monden, M.et al.
    • Journal Title

      J Exp Clin Cancer Res 23(3)

      Pages: 521-527

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatic expression of ANG2 RNA in metastatic colorectal cancer.2004

    • Author(s)
      Ogawa, M., Monden, M.et al.
    • Journal Title

      Hepatology 39(2)

      Pages: 529-539

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Application of TR-PCR to clinical diagnosis of micrometastasis of colorectal cancer : A translational research study.2004

    • Author(s)
      Takayama O., Monden, M.et al.
    • Journal Title

      International Journal of Oncology 25

      Pages: 597-604

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 分子診断学の進歩と癌検診への応用-DNAチップ技術による大腸癌の遺伝子発現プロファイル解析と臨床応用2004

    • Author(s)
      竹政伊知朗, 門田守人 他
    • Journal Title

      日本がん検診・診断学会 11(2)

      Pages: 21-25

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular features of non-B, non-C hepatocellular carcinoma: a PCR-array gene expression profiling study.2003

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      J Hepatol 39(6)

      Pages: 1004-1012

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data.2003

    • Author(s)
      Muro S., et al.
    • Journal Title

      Genome Biol 4(3)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A bayesian missing value estimation method for gene expression profile data.2003

    • Author(s)
      Oba S., et al.
    • Journal Title

      Bioinformatics 19(16)

      Pages: 2088-2096

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular features of non-B,non-C hepatocellular carcinoma : a PCR-array gene expression profiling study.2003

    • Author(s)
      Kurokawa Y., et al.
    • Journal Title

      J Hepatol 39(6)

      Pages: 1004-1012

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A bayesian missing value estimation method for gene expression profile data.2003

    • Author(s)
      Oba S., Sato M., Takemasa I., Monden M., Matsubara K., Ishii S.
    • Journal Title

      Bioinformatics 19(16)

      Pages: 2088-2096

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prediction of recurrence in advanced gastric cancer patients after curative resection by gene expression profiling.

    • Author(s)
      Motoori, M., Monden, M.et al.
    • Journal Title

      Int J Cancer (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DNAマイクロアレイを用いたトランスクリプトーム解析による腫瘍マーカーの探索

    • Author(s)
      小森孝通, 門田守人 他
    • Journal Title

      日本分子腫瘍マーカー研究会電子ジャーナル (In press)

    • NAID

      130004436355

    • Related Report
      2004 Annual Research Report
  • [Book] DNA chip for cancer clinical への application-large bowel cancer diagnoses of DNA chip(Mini Chip) development/manufacture-.2005

    • Author(s)
      Yamasaki M., et al.
    • Publisher
      Japan digestive organ disease society Foundation
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 『消火器病学の進歩2005-モノグラフ 消火器病学のニューフロンティア編』DNA chipの癌臨床への応用-大腸癌診断用DNA chip (Mini Chip)の開発・作製-(荒川泰行 編集)2005

    • Author(s)
      山崎誠, 竹政伊知朗, 門田守人
    • Total Pages
      407
    • Publisher
      財団法人日本消火器病学会
    • Related Report
      2005 Annual Research Report
  • [Book] 『癌転移のメカニズムがよくわかる 肺転移のすべて』2.網羅的遺伝子・タンパク解析 1)DNAマイクロアレイ2005

    • Author(s)
      竹政伊知朗, 池田正孝, 山本浩文, 関本貢嗣, 門田守人
    • Total Pages
      146
    • Publisher
      永井書店
    • Related Report
      2005 Annual Research Report
  • [Publications] I.Takemasa, M.Monden et al.: "Identification of the differentially expressed genes involved in colorectal carcinogenesis using cDNA microarray"J Exp Clin Canc Res. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] 竹政伊知朗, 門田守人 他: "分子診断学の進歩と癌検診への応用-DNAチップ技術による大腸癌の遺伝子発現プロファイル解析と臨床応用"日本がん検診・診断学会誌. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] 竹政伊知朗, 門田守人: "バイオインフォマティクスの基づく大腸癌の臨床-DNAチップの解析手法と臨床応用"医学のあゆみ. 208. 694-695 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] I.Takemasa, M.Monden et al.: "Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression dat"GenomeBiology. 4(3). R21 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] I.Takemasa, M.Monden et al.: "A Bayesian missing value estimation method for gene expression profile data"Bioformatics. 19. 2088-2096 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-03-31   Modified: 2016-04-21  

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