| Project/Area Number |
15209041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
SASAKI Iwao Tohoku University, Graduate School of Medicine, Professor, 大学院医学研究科, 教授 (60125557)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Kouhei Tohoku University, Hospital, Lecturer, 病院・講師 (20271900)
FUNAYAMA Yuji Tohoku University, Graduate School of Medicine, Associate Professor, 大学院医学研究科, 助教授 (50192315)
SHIBATA Chikashi Tohoku University, Hospital, Research Associate, 病院・助手 (30270804)
TAKAHASHI Kenichi Tohoku University, Graduate School of Medicine, Research Associate, 大学院医学系研究科, 助手 (80359520)
BENNO Yoshimi Riken, Bioscience Technology center, Chief Investigator, 理化学研究所・微生物系統保存施設, 主任研究員 (40087599)
小川 仁 東北大学, 病院・助手 (00312570)
田畑 泰彦 京都大学, 再生医科学研究所, 教授 (50211371)
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| Project Period (FY) |
2003 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2006: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2005: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2004: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2003: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | ulcerative colitis / total proctocolectomy / intestinal adaptation / pouchitis / drug delivery system / 潰瘍性大腸炎 / 治療指針 / drug delivery system / 大腸全摘術 / 家族性大腸腺腫癌 / 家族性大腸腺腫症 / 回腸襄炎 |
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| Research Abstract |
1.Analysis of mechanisms of intestinal adaptation after total proctocolectomy for ulcerative colitis
Comparative studies of oral and anal mucosae demonstrated that in addition to hormonal changes, fecal stream is required for full induction of the sodium transport system (which includes SGLT1-mediated transport) in the remnant ileum following total proctocolectomy. Colonic transformation is thought to be a phenotypic alteration in the ileum following total colectomy (TC) but has not been well addressed at molecular level. We demonstrated using cDNA roicroarray that altered gene expression following TC is, in part, characterized by "colon-like" transformation. Furthermore, circulating aldosterone appears to play a part of roles in altoring and/or adapting gene expression in intestinal epithelium.
2.A novel approach to promote intestinal adaptation
Oral administration of aldosterone-PLGA microsheres successfully induced the expression of several molecules and activated sodium transport in the ileal mucosa, both of which are essential for intestinal adaptation. Pre-and/or post-operative treatment with this drug may compensate for the excessive loss of sodium and water following proctocolectomy.
3.Diagnosis and treatment of pouchitis, a novel mucosal inflammation
Because endoscopic finding is a key component of this criteria, we edited pouchitis atlas. Atlas includes description of special consideration for pouch endoscopy and many photos showing a wide variety of findings and various degree of inflammation. Atlas enabled us to evaluate endoscopic findings more objectively and classify findings into normal, mild, moderate, and severe.
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