| Project/Area Number |
15209047
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
KATAYAMA Yoichi Nihon Univ. School of Medicine, Professor, Dept., 医学部, 教授 (00125048)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Takamitsu Nihon Univ. School of Medicine, Professor, Dept., 医学部, 教授 (50158284)
SAKATANI Kaoru Nihon Univ. School of Medicine, Professor, Dept., 医学部, 教授 (90244350)
SEKINE Yoshifumi Nihon Univ. College of Science and Technology, Prof., 理工学部, 教授 (90059965)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2005: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2004: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2003: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
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| Keywords | deep brain stimulation / spinal cord stimulation / motor cortex stimulation / feed back control / feed forward control / brain computer interface / brain machine interface / pain / 神経科学 / 脳・神経 / 臨床 / 不随意運動 / 脳深部刺激療法 / tremor cell / deep brain stimulation / involuntary movement disorder / Parkinson disease |
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| Research Abstract |
Deep brain stimulation (DBS) of the thalamus (Vo/Vim) has become popular as a means of controlling involuntary movements, including post-stroke movement disorders. We have also found that post-stroke movement disorders and motor weakness can sometimes be controlled by motor cortex stimulation (MCS). In some forms of movement disorders, motor dysfunction becomes evident only when patients intend to move their body. We have developed an on-demand type stimulation system which triggers stimulation by detecting intrinsic signals of intention to move. Such a system represents feed-forward control (FFC) of involuntary movements. We report here our experience of DBS and MCS for controlling post-stroke movement disorders, and discuss the value of FFC. Excellent control of post-stroke movement disorders was achieved by conventional DBS and/or MCS in 20 of 28 patients with hemichoreoathetosis, hemiballism tremor and motor weakness. FFC was tested in 6 patients who demonstrated excellent control of post-stroke postural tremor or motor weakness by conventional DBS or MCS. The on-demand stimulation provided satisfactory FFC in 4 of 4 patients with postural tremor and 2 of 2 patients with motor weakness, when the activity of muscles involved in posturing or intention to move was fed into the system. These findings justify further clinical studies on DBS and MCS in patients with post-stroke movement disorders. The on-demand type stimulation system may also be useful for overcoming various post-stroke movement disorders.
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