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Molecular biological analysis of tooth germ and odontogenic tumor

Research Project

Project/Area Number 15209060
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOkayama University

Principal Investigator

NAGAI Noriyuki  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oral Pathology and Medicine, Professor, 大学院医歯薬学総合研究科, 教授 (90085770)

Co-Investigator(Kenkyū-buntansha) NAGATSUKA Hitoshi  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oral Pathology and Medicine, Associate Professor, 大学院医歯薬学総合研究科, 助教授 (70237535)
MEHMET Gunduz  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oral Pathology and Medicine, Assistant, 大学院医歯薬学総合研究科, 助手 (70333507)
YAMAMOTO Toshio  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oral Pathology and Medicine, Professor, 大学院医歯薬学総合研究科, 教授 (30107776)
TAKAGI Shin  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oral Pathology and Medicine, Associate Professor, 大学院医歯薬学総合研究科, 助教授 (40116471)
TAMAMURA Ryo  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oral Pathology and Medicine, Assistant, 大学院医歯薬学総合研究科, 助手 (00403494)
長岡 紀幸  岡山大学, 歯学部, 教授 (70304326)
井上 正久  徳島文理大学, 薬学部, 助手 (20223274)
辻極 秀次  岡山大学, 大学院・医歯学総合研究科, 助手 (70335628)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2006: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2005: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2004: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2003: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
KeywordsOdontogenic tumor / Tooth germ / Ameloblastoma / Immunohistochemistry / In situ hybridization / Cell differentiaton / Protein expression / Gene expression / ヘパラナーゼ / ヘパラン硫酸 / 口腔癌 / ING / Notch / Jagged / Hes / Math / 遺伝子 / 基底膜 / IV型コラーゲン / α鎖 / 成長因子 / Amelogenin / MDPC-23
Research Abstract

To clarify the characteristics of odontogenic tumors and the mechanism of tooth germ development, we investigated several gene and protein expressions through molecular biological analysis.
1.The expression pattern of Amelogenin gene in ameloblastoma was different from that of the tooth germ. It was suggested that epigenetic change in sex chromosomes might have some correlations in the tumorigenesis of ameloblastoma.
2.The immunolocalization of type IV collagen alpha chains in benign odontogenic tumor was similar to that of the tooth germ but a different pattern was observed in malignant odontogenic tumor. The alpha chain-staining pattern in malignant odontogenic tumors was irregular.
3.We examined the expressions of Notch1, HES5, Jagged2 and Math1 in molar tooth germ by using in situ hybridization. Our results suggest that Notch1 signaling pathway through Jagged2 has an important effect on Math1, regulating odontogenesis through lateral specification and inductive signaling.
4.We investigated the localization of heparanase and heparan sulphate proteoglycan (HSPG) in tooth germ and odontogenic tumors. We suggest that : 1) the increase in immunolocalization of heparanase molecules may be a responsible factor for the neoplastic growth of odontogenic tissues. 2) the main function of heparanase in normal odontogenic tissue may be local modulation of HSPG and heparan sulphate-bound bioactive molecules. 3) the function of heparanase is locally and tightly regulated in normal tooth germ and to some extent in benign odontogenic tumors. 4) the change in localization of HSPG and increased immunoexpression of heparanase in neoplastic cells may represent the malignant progression of ameloblastoma to ameloblastic carcinoma.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (69 results)

All 2007 2006 2005 2004 Other

All Journal Article (64 results) Publications (5 results)

  • [Journal Article] Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer.2007

    • Author(s)
      Cengiz B
    • Journal Title

      Oral Oncol. 43(3)

      Pages: 241-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer2007

    • Author(s)
      Cengiz B
    • Journal Title

      Oral Oncol 43(3)

      Pages: 241-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fine deletion mapping of chromosome 2Q21-37 shows three preferentially deleted regions in oral cancer.2007

    • Author(s)
      Cengiz B
    • Journal Title

      Oral Oncol. 43(3)

      Pages: 241-7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Microcystic adnexal carcinoma with mandibular bone marrow involvement : a case report with immunohistochemistry.2006

    • Author(s)
      Nagatsuka H
    • Journal Title

      Am J Dermatopathol. 28(6)

      Pages: 518-522

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential expression of basement membrane collagen-IV alpha1 to alpha6 chains during oral carcinogenesis.2006

    • Author(s)
      Tamamura R
    • Journal Title

      Virchows Arch. 449(3)

      Pages: 358-366

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intraaortic stent graft in esophageal carcinoma invading the aorta. Prophylaxis for fatal hemorrhage.2006

    • Author(s)
      Yamatsuji T
    • Journal Title

      Int J Clin Prac. 60(12)

      Pages: 1600-1603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Epigenetic alterations of BRG1 leads to cancer development through its nuclear-cytoplasmic shuttling abnormalities.2006

    • Author(s)
      Gunduz E
    • Journal Title

      Mied Hypotheses. 67(6)

      Pages: 1313-1316

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma.2006

    • Author(s)
      Okabe M
    • Journal Title

      Clin Cancer Res. 12(13)

      Pages: 3902-3907

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of Notch1 and Hes5 in the developing olfactory epithelium.2006

    • Author(s)
      Orita Y
    • Journal Title

      Acta Otolaryngol. 126(5)

      Pages: 498-502

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Efficacy of atelocollagen honeycomb scaffold in bone formation using KUSA/A1 cells.2006

    • Author(s)
      Rodriguez AP
    • Journal Title

      J Biomed Mater Res A. 77(4)

      Pages: 707-717

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclooxygenase 2 expression in otitis media with effusion.2006

    • Author(s)
      Kakiuchi M
    • Journal Title

      Am J Otolaryngol. 27(2)

      Pages: 81-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.2006

    • Author(s)
      Tsujigiwa H
    • Journal Title

      J Biomed Mater Res A. 77(3)

      Pages: 507-511

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.2006

    • Author(s)
      Ohtawa Y
    • Journal Title

      Hum Pathol. 37(9)

      Pages: 1145-1152

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Three cases of adenocarcinoma arising in extremely long-segment Barrett's esophagus.2006

    • Author(s)
      Fujiwara T
    • Journal Title

      Dig Dis Sci 51(3)

      Pages: 533-538

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lymphoepithelial cyst of the cervical esophagus.2006

    • Author(s)
      Asami S
    • Journal Title

      J Gastroenterol. 41(1)

      Pages: 88-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration.2006

    • Author(s)
      Ueyama Y
    • Journal Title

      J Mater Sci Mater Med. 17(3)

      Pages: 281-288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] COX-2 induction by heparanase in the progression of breast cancer.2006

    • Author(s)
      Imada T
    • Journal Title

      Int J Mol Med. 17(2)

      Pages: 221-228

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy.2006

    • Author(s)
      Hata T
    • Journal Title

      Oral Maxillofac Surg. 35(4)

      Pages: 378-382

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.2006

    • Author(s)
      Beder LB
    • Journal Title

      Cancer Res Clin Oncol. 132(1)

      Pages: 19-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transforming Growth Factor Beta (TGFb) Gene Family Members in Developing and Neoplastic Odontogenic Tissues2006

    • Author(s)
      Kristiina Heikinheimo
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Histopathological Study of Matrix Mineralization by Osteoblastic-like and Odontoblastic-like Cells in Diffusion Chamber.2006

    • Author(s)
      Andrea Paola Rodriguez
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 6-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of Rhubarb on Heat Shock Protein 70 Expression in Lung Tissues from Rats with Acute Lung Injury Induced by Lipopolysaccharide.2006

    • Author(s)
      Kang Jin
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 11-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hepatotoxicity Induced by Excessive Intake of Rhubarb.2006

    • Author(s)
      Kang Jin
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 16-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Frequent Deletion of BRG1 Locus at 19p13 Predicts Recurrence and Previous Cancer History in Oral Squamous Cell Carcinomas.2006

    • Author(s)
      Esra Gunduz
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 20-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro.2006

    • Author(s)
      Hidetsugu Tsujigiwa
    • Journal Title

      J Hard Tissue Biology. 15(1)

      Pages: 27-33

    • NAID

      110004737681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A Case Report of Ameloblastoma of the Mandible with Examination of Notch Signaling.2006

    • Author(s)
      Siar Chong Huat
    • Journal Title

      Oral Med. Pathol. 11

      Pages: 35-39

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Immunodetection of Heparan Sulphate and Heparanase Molecules in Benign and Malignant Odontogenic Tumors2006

    • Author(s)
      Phuu Pwint Han
    • Journal Title

      Oral Med. Pathol. 11

      Pages: 49-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Microcystic adnexal carcinoma with mandibular bone marrow involvement : a case report with immunohistochemistry2006

    • Author(s)
      Nagatsuka H
    • Journal Title

      Am J Dermatopatho1 28(6)

      Pages: 518-522

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential expression of basement membrane collagen-IV alphal to al pha6 chains during oral carcinogenesis2006

    • Author(s)
      Tamamura R
    • Journal Title

      Virchows Arch 449(3)

      Pages: 358-366

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intraaortic stent graft in esophageal carcinoma invading the aorta. Prophylaxis for fatal hemorrhage2006

    • Author(s)
      Yamatsuji T
    • Journal Title

      Int J Clin Prac. 60(12)

      Pages: 1600-1603

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Epigenetic alterations of BRG1 leads to cancer development through its nuclear-cytoplasmic shuttling abnormalities2006

    • Author(s)
      Gunduz E
    • Journal Title

      Med Hypotheses 67(6)

      Pages: 1313-1316

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma2006

    • Author(s)
      Okabe M
    • Journal Title

      Clin Cancer Res 12(13)

      Pages: 3902-3907

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of Notch 1 and Hes5 in the developing olfactory epithelium2006

    • Author(s)
      OritaY
    • Journal Title

      Acta Otolaryngol 126(5)

      Pages: 498-502

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Efficacy of atelocollagen honeycomb scaffold in bone formation using KUSA/Al cells2006

    • Author(s)
      Rodriguez AP
    • Journal Title

      J Biomed Mater Res A 77(4)

      Pages: 707-717

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclooxygenase 2 expression in otitis media with effusion2006

    • Author(s)
      Kakiuchi M
    • Journal Title

      Am J Otolaryngo1 27(2)

      Pages: 81-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells2006

    • Author(s)
      Tsujigiwa H
    • Journal Title

      J Biomed Mater Res A 77(3)

      Pages: 507-511

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach2006

    • Author(s)
      Ohtawa Y
    • Journal Title

      Hum Pathol. 37(9)

      Pages: 1145-1152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Three cases of adenocarcinoma arising in extremely long-segment Barrett's esophagus2006

    • Author(s)
      Fujiwara T
    • Journal Title

      Dig Dis Sci 51(3)

      Pages: 533-538

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lymphoepithelial cyst of the cervical esophagus.2006

    • Author(s)
      Asami S.
    • Journal Title

      J Gastroenterol. 41(1)

      Pages: 88-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration2006

    • Author(s)
      Ueyama Y
    • Journal Title

      J Mater Sci Mater Med 17(3)

      Pages: 281-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] COX-2 induction by heparanase in the progression of breast cancer.2006

    • Author(s)
      Imada T
    • Journal Title

      Int J Mol Med 17(2)

      Pages: 221-228

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy2006

    • Author(s)
      Hata T
    • Journal Title

      Int J Oral Maxillofac Surg 35(4)

      Pages: 378-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of a candidate tumor suppressor gene RHOBTB 1 located at a novel allelic loss region 10q21 in head and neck cancer2006

    • Author(s)
      Beder LB
    • Journal Title

      J Cancer Res Clin Oncol 32(1)

      Pages: 19-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transforming Growth Factor Beta (TGFb) Gene Family Members in Developing and Neoplastic Odontogenic Tissues.2006

    • Author(s)
      Kristiina Heikinheimo
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Frequent Deletion of BRG 1 Locus at 19p13 Predicts Recurrence and Previous Cancer History in Oral Squamous Cell Carcinomas.2006

    • Author(s)
      Esra Gunduz
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 20-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of Immobilized rhBMP-2/atelocollagen in vivo and in vitro.2006

    • Author(s)
      Hidetsugu Tsujigiwa
    • Journal Title

      J Hard Tissue Biology 15(1)

      Pages: 27-33

    • NAID

      110004737681

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A Case Report of Ameloblastoma of the Mandible with Examination of Notch Signaling2006

    • Author(s)
      Siar Chong Huat
    • Journal Title

      Oral Med. Pathol 11

      Pages: 35-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Immunodetection of Heparan Sulphate and Heparanase Molecules in Benign and Malignant Odontogenic Tumor2006

    • Author(s)
      Phuu PP
    • Journal Title

      Oral Med.Pathol 11

      Pages: 49-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential expression of basement membrane collagen-IV alphal to alpha6 chains during oral carcinogenesis.2006

    • Author(s)
      Tamamura R
    • Journal Title

      Virchows Arch. 449(3)

      Pages: 358-66

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Immunodetection of Heparan Sulphate and Heparanase Molecules in Benign and Malignant Odontogenic Tumors.2006

    • Author(s)
      Phuu PH
    • Journal Title

      Oral Med. Pathol. 11

      Pages: 49-54

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Efficacy of atelocollagen honeycomb scattold in bone formation using KUSA/A1 cells.2006

    • Author(s)
      Rodriguez AP
    • Journal Title

      J Biomed Mater Res A. 77(4)

      Pages: 707-17

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A Case Report of Ameloblastoma of the Mandible with Examination of Notch Signaling.2006

    • Author(s)
      Siar CH
    • Journal Title

      Oral Med. Pathol. 11

      Pages: 35-39

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epigenetic alterations of BRG1 leads to cancer development through its nuclear-cytoplasmic shuttling abnormalities.2006

    • Author(s)
      Gunduz E
    • Journal Title

      Med Hypotheses. 67(6)

      Pages: 1313-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of Notch1 and Math1 in mandibular condyle cartilage in neonatal mice.2005

    • Author(s)
      Shimizu T
    • Journal Title

      Angle Orthod. 75(6)

      Pages: 993-995

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Immunohistochemical examination of cytological differentiation in osteosarcomas.2005

    • Author(s)
      Kawakami T
    • Journal Title

      Eur J Med Res. 10(11)

      Pages: 475-479

    • Related Report
      2005 Annual Research Report
  • [Journal Article] In vivo effect of fluoride-substituted apatite on rat bone.2005

    • Author(s)
      Inoue M
    • Journal Title

      Dent Mater J. 24(3)

      Pages: 398-402

    • NAID

      110002983732

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells.2005

    • Author(s)
      Tsujigiwa H
    • Journal Title

      J Biomed Mater Res A. 75(1)

      Pages: 210-215

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma.2005

    • Author(s)
      Nagatsuka H
    • Journal Title

      Virchows Arch. 447(4)

      Pages: 710-716

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma.2005

    • Author(s)
      Tsujigiwa H
    • Journal Title

      Ohral Oncol. 41(8)

      Pages: 843-850

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of Notch in a case of osteosarcoma of the maxilla2004

    • Author(s)
      Kawakami T
    • Journal Title

      European Journal of Medical Research 9(11)

      Pages: 533-535

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of demethylating agent 5-aza-2(')-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines2004

    • Author(s)
      Murakami J
    • Journal Title

      Oral Oncology 40(6)

      Pages: 597-603

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in rat osteoporosis induced by immunosuppressant FK5062004

    • Author(s)
      Fukunaga J
    • Journal Title

      Bone 34(3)

      Pages: 425-431

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cyclin A correlates with the sensitivity of human cancer cells to cytotoxic effests of 5-FU2004

    • Author(s)
      Kawashima R
    • Journal Title

      International Journal of Oncology 24(2)

      Pages: 273-278

    • Related Report
      2004 Annual Research Report
  • [Journal Article] In vitro response of osteoblast-like and odontoblast-like cells to unsubstituted and substituted apatites2004

    • Author(s)
      Inoue M
    • Journal Title

      Journal of Biomedical Materials Research 70A(4)

      Pages: 585-593

    • Related Report
      2004 Annual Research Report
  • [Publications] Kimura A: "Gene expression of type I collagen in neoplastic chondrocytes"European Journal Medical Research. 8(4). 165-167 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishizaki K: "Mastoid obliteration by BMP-2/collagen composites : an experimental study using tissue engineering"American Journal of Otolaryngology. 24(1). 14-18 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Beder LB: "Abstract Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas"Laboratory Investigation. 83(1). 99-105 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takaoka M: "Heparanase expression correlates with invasion and poor prognosis in gastric cancers"Laboratory Investigation. 83(5). 613-622 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakamura H: "Role of osteoclast extracellular signal-regulated kinase(ERK)in cell survival and maintenance of cell polarity"Journal of Bone and Mineral Reserch. 18(7). 1198-1205 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2021-04-07  

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