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Clinical research for relationship between periodontal disease and systemic disease

Research Project

Project/Area Number 15209071
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

KURIHRA Hidemi  Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (40161765)

Co-Investigator(Kenkyū-buntansha) KAWANAMI Masamitsu  Hokkaido University, Graduate School of Dental Medicine, Professor, 大学院・歯学総合研究科, 教授 (10133761)
YAMASAKI Kazuhisa  Niigata University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (00182478)
NISHIMURA Fusanori  Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (80208222)
NAGATA Toshihiko  Tokushima University, School of Dentistry, Professor, 歯学部, 教授 (10127847)
KAWAGUCHI Hiroyuki  Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (10224750)
国松 和司  岩手医科大学, 歯学部, 教授 (20170011)
玉澤 かほる  東北大学, 歯学部附属病院, 講師 (00124602)
新田 浩  東京医科歯科大学, 大学院・医歯学総合研究科, 助手 (70237767)
高橋 潤一  東京歯科大学, 歯学部, 講師 (30287180)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥52,910,000 (Direct Cost: ¥40,700,000、Indirect Cost: ¥12,210,000)
Fiscal Year 2005: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2004: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2003: ¥28,600,000 (Direct Cost: ¥22,000,000、Indirect Cost: ¥6,600,000)
Keywordsperiodontitis / daibetes / systemic disease / atherosclerosis / epidemiology / 歯周炎 / インスリン抵抗性 / 循環器疾患 / 口腔ケア / 全身疾患
Research Abstract

The purpose of this research is to identify the relationship between periodontitis and systemic disease such as diabetes, atherosclerosis, et al. in Japanese. We collaborated with 13 university in Japan and progressed this research. As results, we got some new views as follows.
1. Periodontitis is associated with diabetes in Japanese subjects.
2. Periodontitis is also associated with atherosclerosis and other systemic disease in Japanese.
3. Periodontal treatment improve the diabetic condition to healthy one.
4. Examination of the effects of surgery or non-surgery periodontal therapy in diabetic patients.
5. Examination of relationship between paeriodontits and high blood pressure.
6. Periodontal bacteria affect cardiovascular disease.
We got many new views on periodontal medicine in Japanese. Periodontitis is tightly associated with systemic disease such as diabetes, atherosclerosis, low weight birth, and others. It was clear that periodontal treatment improve systemic condition. After treatment of periodontitis, diabetic index was improved.
In the future, we have to continue this research to identify the relationship between periodontitis and sysytemic disease. And we have to develop new therapy of periodontitis on the basis of EBM(evidence based medicine).

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (12 results)

All 2006 2005 2004 2003

All Journal Article (12 results)

  • [Journal Article] Periodontal infection and dyslipidemia in type2 diabetics.Association with increased HMG-CoA reductase expression2006

    • Author(s)
      Fusanori Nishimura
    • Journal Title

      Hormone and Metabolic Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Periodontal infection and dyslipidemia in type2 diabetics Association with increased HMG-CoA reductase expression2006

    • Author(s)
      Fusanori Nishimura
    • Journal Title

      Hormone and Metabolic Research (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A tumor necrosis factor-α antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice2006

    • Author(s)
      Suzuki Y
    • Journal Title

      J Periodont Res 41

      Pages: 81-91

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Periodontal disease as part of the insulin resistance syndrome in diabetic patients2005

    • Author(s)
      Fusanori Nishimura
    • Journal Title

      Journal of International Academy of Periodontology 7/1

      Pages: 16-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Periodontal disease as part of the insulin resistance syndrome in diabetic patients2005

    • Author(s)
      Fusanori Nishimura
    • Journal Title

      Journal of the international academy of periodontology 7・1

      Pages: 16-20

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 糖尿病と歯周病2005

    • Author(s)
      西村 英紀
    • Journal Title

      臨床と研究 81・4

      Pages: 143-146

    • NAID

      10013202368

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Thiazolidinedione (pioglitazone) blocks P. igngivalis and F. nucleatum, but not E. coli, lipopolysaccharide (LPS)-induced Interleukin-6) IL-6) production in adipocytes2005

    • Author(s)
      M.Yamaguchi
    • Journal Title

      Journal of dental research 84・3

      Pages: 240-244

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Oral bacteria in the occluded arteries of patients with Buerger disease.2005

    • Author(s)
      Iwai T
    • Journal Title

      J Vasc Surg 42

      Pages: 107-115

    • Related Report
      2005 Annual Research Report
  • [Journal Article] T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis2004

    • Author(s)
      Kazuhisa Yamasaki
    • Journal Title

      Oral microbiology and immunology 19

      Pages: 160-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis2004

    • Author(s)
      Kazuhisa Yamasaki
    • Journal Title

      Oramicrobiology and immunology 19

      Pages: 160-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antimicrobial periodontal treatment decreases serum c-reactive protein, TNF-alpha, but not adiponectin levels in patients with chronic periodontitis2003

    • Author(s)
      Fusanori Nishimura
    • Journal Title

      J Periodontol 74・8

      Pages: 1231-1236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antimicrobial periodontal treatment decreases serum c-reactive protein, TNF-alpha, but not adiponectin levels in patients with chronic periodontitis2003

    • Author(s)
      Fusanori Nishimura
    • Journal Title

      J Periodontol 74/8

      Pages: 1231-1236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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