| Project/Area Number |
15256003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University (2005)
Kyushu University (2003-2004) |
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Principal Investigator |
SHIMOKAWA Hiroaki Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (00235681)
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Jouji Kyushu University Hospital, Assistant, 病院・助手 (90325522)
ITO Akira Kyushu University Hospital, Assistant Prof., 病院・講師 (00360868)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2005: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2004: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2003: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Keywords | coronary vasospasm / vasospastic angina / Rho-kinase / genetic analysis / international collaboration |
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| Research Abstract |
1. We have demonstrated that Rho-kinase is substantially involved in the molecular mechanism for coronary vasospasm.
2. We have demonstrated that Rho-kinase is substantially involved in the molecular mechanism fornot only epicardial vasospasm but also microvascular vasospasm.
3. We have demonstrated that long-term inhibition of Rho-kinase causes a regression of both coronary arteriosclerosis and coronary vasospasm.
4. We have identified the novel SNP of Rho-kinase, G930T in its catalytic domain and have demonstrated that this SNP is associated with an enhancement of Rho-kinase activity.
5. We have demonstrated that the frequency of the T930allele is significantly higher in patients with coronary vasospasm than in those without the spasm or controls. We have further demonstrated that this SNP is not noted in Caucasian patients with angina pectoris.
6. Taken together, those results suggest that the relatively higher frequency of G930T could explain, at least in part, the racial difference in the prevalence of coronary vasospasm between Japanese and Caucasian populations.
7. We have published the English review regarding the therapeutic importance of Rho-kinase.
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