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Signal transduction mechanisms in primary afferent neurons following pain transmission

Research Project

Project/Area Number 15300116
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionHyogo College of Medicine

Principal Investigator

NOGUCHI Koichi  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (10212127)

Co-Investigator(Kenkyū-buntansha) DAI Yi  Hyogo College of Medicine, Faculty of Medicine, Assistant professor, 医学部, 講師 (20330441)
NISHIZAKI Tomoyuki  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (00221474)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2006: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥6,500,000 (Direct Cost: ¥6,500,000)
KeywordsDRG / nociception / pain / MAPK / ERK / p38 / primary afferent neurons / 細胞内シグナル / TRPA1 / 一次知覚ニューロン / ニューロパチックペイン / 侵害刺激 / 後根神経節 / P2X受容体 / パッチクランプ法
Research Abstract

There is compelling evidence indicating that not only injured primary afferents, but also their spared neighbors, show an alteration of excitability and gene expression and that these changes have functional roles in nociception, inflammatory pan and neuropathic pain. We examined several forms of mitogen-activated protein kinases (MAPKs) dynamics in primary afferent neurons and also in spinal cord neurons following noxious stimuli to normal tissue or using inflammatory pain model or neuropathic pain model. In mammals, four major MAPK pathways have been discovered. They are the extracellular signal-regulated protein kinases 1/2 (ERK1/2), p38 MAPK, c-Jun N-terminal kinase (JNK), and ERK5. We examined a variety of phases of dynamics of MAPK in pain mechanisms and published 36 papers accepted in scientific journals.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (118 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (112 results) Publications (6 results)

  • [Journal Article] Activation of extracellular signal-regulated protein kinases (ERK) 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation2007

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      J. Neurochem. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sensitization of TRPA1 by PAR-2 through PLC/PIP_2-dependent mechanisms contributes to inflammatory pain2007

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      J. Clin. Invest. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Roles of extracellular signal-regulated protein kinases (ERK) 5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Neurochem. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intensity-dependent activation of extracellular signal-regulated protein kinases (ERK) 5 in sensory neurons contributes to pain hypersensitivity2007

    • Author(s)
      Mizushima, T. et al.
    • Journal Title

      J. Pharmacol. Exp. Ther. 321・1

      Pages: 28-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tissue type plasminogen activator induced in rat dorsalhorn astrocytes contributes to mechanical hypersensitivity following dorsal root injury2007

    • Author(s)
      Kozai, T. et al.
    • Journal Title

      Glia 55・6

      Pages: 595-603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alternation of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain2007

    • Author(s)
      Yamanaka, H. et. at.
    • Journal Title

      Eur. J. Neurosci. 25・4

      Pages: 1097-1111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Axotomy increases plasma membrane Ca^<2+> pumpisoform4 in primary afferent neurons2007

    • Author(s)
      Ogura, H. et al.
    • Journal Title

      Neuroreport 18・1

      Pages: 17-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intensity-dependent activation of extracellular signal-regulated protein kinases (ERK) 5 in sensory neurons contributes to pain hypersensitivity2007

    • Author(s)
      Mizushima, T. et al.
    • Journal Title

      J. Pharmacol. Exp. Ther. 321-1

      Pages: 28-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury2007

    • Author(s)
      Kozai, T. et al.
    • Journal Title

      Glia 55-6

      Pages: 595-603

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Alternation of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain2007

    • Author(s)
      Yamanaka, H. et al.
    • Journal Title

      Eur. J. Neurosci. 25-4

      Pages: 1097-1111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Axotomy increases plasma membrane Ca^<2+> pump isoform4 in primary afferent neurons2007

    • Author(s)
      Ogura, H. et al.
    • Journal Title

      Neuroreport 18-1

      Pages: 17-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Two types of GABAergic miniature inhibitory postsynaptic currents in mouse substantia gelatinosa neurons.2007

    • Author(s)
      Takahashi, A. et al.
    • Journal Title

      Eur.J.Pharmacol. 553・1-3

      Pages: 120-128

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Roles of extracellular signal-regulated protein kinases (ERK) 5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J.Neurochem. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Neurosci. 26・46

      Pages: 11974-11986

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neuroscience 137・3

      Pages: 961-970

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Exp.Neurol. 200・1

      Pages: 112-123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed kneejoint.2006

    • Author(s)
      Seino.D.et al.
    • Journal Title

      Pain 123・1-2

      Pages: 193-203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] BDNF in sensory neurons and chronic pain.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neurosci. Res. 55・1

      Pages: 1-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Noxious cold stimulation induces MAPK activation in TRPA1- and TRPM8-containing small sensory neurons.2006

    • Author(s)
      Mizushima, T. et al.
    • Journal Title

      Neuroscience 140・4

      Pages: 1337-1348

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.2006

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J. Comp. Neurol. 498・4

      Pages: 443-454

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Agonist of PAR2 increases painful behavior produced by a,b-methylene ATP.2006

    • Author(s)
      Zhu, W.et al.
    • Journal Title

      Neuroreport 17・12

      Pages: 1257-1261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Chem. Senses 31・7

      Pages: 681-688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      J. Neurosci. 26・34

      Pages: 8680-8690

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Two types of GABAergic miniature inhibitory postsynaptic currents in mouse substantia gelatinosa neurons.2006

    • Author(s)
      Takahashi, A. et al.
    • Journal Title

      Eur. J. Pharmacol 553・1-3

      Pages: 120-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Neurosci. 26-46

      Pages: 11974-11986

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neuroscience 137-3

      Pages: 961-970

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antisense knock down of TRPA1, but not TR PM8, alleviates cold hyperalgesia after spinal nerve ligation in rats2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Exp.Neurol. 200-1

      Pages: 112-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint2006

    • Author(s)
      Seino, D. et al.
    • Journal Title

      Pain 123-1-2

      Pages: 193-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] BDNF in sensory neurons and chronic pain2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neurosci. Res. 55-1

      Pages: 1-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Noxious cold stimulation induces MAPK activation in TRPA1-and TRPM8-containing small sensory neurons.2006

    • Author(s)
      Mizushima, T. et al.
    • Journal Title

      Neuroscience 140-4

      Pages: 1337-1348

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.2006

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J. Comp. Neurol. 498-4

      Pages: 443-454

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Agonist of PAR2 increases painful behavior produced by a, b-methylene AT P.2006

    • Author(s)
      Zhu, W.et al.
    • Journal Title

      Neuroreport 17-12

      Pages: 1257-1261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Chem. Senses 31-7

      Pages: 681-688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      J. Neurosci. 26-34

      Pages: 8680-8690

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Two types of GABAergic miniature inhibitory postsynaptic currents in mouse substantia gelatinosa neurons.2006

    • Author(s)
      Takahashi, A. et al.
    • Journal Title

      Eur. J. Pharmacol 553-1-3

      Pages: 120-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J.Neurosci. 26・46

      Pages: 11974-11986

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A ntisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Exp.Neurol. 200・1

      Pages: 112-123

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint.2006

    • Author(s)
      Seino, D. et al.
    • Journal Title

      Pain 123・1-2

      Pages: 193-203

    • Related Report
      2006 Annual Research Report
  • [Journal Article] BDNF in sensory neurons and chronic pain.2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neurosci.Res. 55・1

      Pages: 1-10

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.2006

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J.Comp.Neurol. 498・4

      Pages: 443-454

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Chem.Senses 31・7

      Pages: 681-688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      J.Neurosci. 26・34

      Pages: 8680-8690

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The effect of site and type of nerve injury on the expression of brain-derived eurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior2006

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neuroscience 137・3

      Pages: 961-970

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats2006

    • Author(s)
      Katsura, H. et al.
    • Journal Title

      Exp.Neurol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] TRPA1 induced in sensory neurons contributes to colhyperalgesia after inflammation and nerve injury2005

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Clin. Invest. 115・9

      Pages: 2393-2401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Distinct expression of TRPM8, TRPA1 and TRPV1 mRNAs in rat primary afferent neurons with A/C- fibers and colocalization with Trk receptors2005

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J. Comp. Neurol. 493・4

      Pages: 596-606

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ca^<2+>/calmodulin-protein kinase II a in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection2005

    • Author(s)
      Ogawa, A. et al.
    • Journal Title

      Exp. Neurol. 192・2

      Pages: 310-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury2005

    • Author(s)
      Yamanaka, H. et al.
    • Journal Title

      Neuroscience 132・1

      Pages: 183-191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia2005

    • Author(s)
      Zhu, W-J. et al.
    • Journal Title

      Brain Res. 1041・2

      Pages: 205-211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ca^<2+>/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy2005

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      Eur. J. Neurosci. 21・9

      Pages: 2467-2474

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia2005

    • Author(s)
      Mizushima, T. et al.
    • Journal Title

      Pain 113・1-2

      Pages: 51-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat2005

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J. Comp. Neurol. 481・4

      Pages: 377-390

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] TRPA1 induced in sensory neurons contributes to col hyperalgesia after inflammation and nerve injury2005

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Clin. Invest. 115-9

      Pages: 2393-2401

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Distinct expression of TRPM8, TRPA1 and TRPV1 mRNAs in rat primary afferent neurons with A/C-fibers and colocalization with Trk receptors2005

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J. Comp. Neurol. 493-4

      Pages: 596-606

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ca^<2+>/calmodulin-protein kinase II a in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection2005

    • Author(s)
      Ogawa, A. et al.
    • Journal Title

      Exp. Neurol. 192-2

      Pages: 310-319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of plasminogen activator inhibitor-1 and-2 in dorsal root ganglion neurons after peripheral nerve injury2005

    • Author(s)
      Yamanaka, H. et al.
    • Journal Title

      Neuroscience 132-1

      Pages: 183-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia2005

    • Author(s)
      Zhu, W-J. et al.
    • Journal Title

      Brain Res. 1041-2

      Pages: 205-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ca^<2+>/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy2005

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      Eur. J. Neurosci. 21-9

      Pages: 2467-2474

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia2005

    • Author(s)
      Mizushima, T. et al.
    • Journal Title

      Pain 113-1-2

      Pages: 51-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat2005

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J. Comp. Neurol. 481-4

      Pages: 377-390

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] TRPA1 induced in sensory neurons contributes to col hyperalgesia after inflammation and nerve injury2005

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J.Clin.Invest. 115・9

      Pages: 2393-2401

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Distinct expression of TRPM8, TRPA1 and TRPV1 mRNAs in rat primary afferent neurons with A/C- fibers and colocalization with Trk receptors2005

    • Author(s)
      Kobayashi, K. et al.
    • Journal Title

      J.Comp.Neurol. 493・4

      Pages: 596-606

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ca^<2+>/calmodulin-protein kinase II a in the trigeminal subnucleus caudalis contributes to neuropathic pain following inferior alveolar nerve transection2005

    • Author(s)
      Ogawa, A. et al.
    • Journal Title

      Exp.Neurol. 192・2

      Pages: 310-319

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia2005

    • Author(s)
      Zhu, W-J. et al.
    • Journal Title

      Brain Res 1041・2

      Pages: 205-211

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      Dai, Y.et al.
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      Eur.J.Neurosci. 21・9

      Pages: 2467-2474

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      Kobayashi, K. et al.
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      J.Comp.Neurol. 481・4

      Pages: 377-390

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      Obata, K. et al.
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      J. Neurosci. 24・45

      Pages: 10211-10222

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] PAR2- mediated potentiation of TRPV1 activity reveals a mechanism for proteinase-induced inflammatory pain2004

    • Author(s)
      Dai, Y.et al.
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      J. Neurosci. 24・18

      Pages: 4293-4299

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons2004

    • Author(s)
      Dai, Y.et al.
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      Pain 108・3

      Pages: 258-266

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model2004

    • Author(s)
      Liu, Y.et al.
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      Pain 109・1-2

      Pages: 64-72

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats2004

    • Author(s)
      Obata, K. et al.
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      Eur. J. Neurosci. 20・11

      Pages: 2881-2895

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury2004

    • Author(s)
      Yamanaka, H. et al.
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      Eur. J. Neurosci. 19・1

      Pages: 93-102

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury2004

    • Author(s)
      Wang, H. et al.
    • Journal Title

      Eur. J. Neurosci. 19・4

      Pages: 884-890

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following Inflammation near the nerve cell body2004

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neuroscience 126・4

      Pages: 1011-1021

    • Description
      「研究成果報告書概要(和文)」より
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      2006 Final Research Report Summary
  • [Journal Article] Role of the MAPK activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation2004

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Neurosci. 24-45

      Pages: 10211-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] PAR2-mediated potentiation of TRPV1 activity reveals a mechanism for proteinase-induced inflammatory pain2004

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      J. Neurosci. 24-18

      Pages: 4293-4299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons2004

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      Pain 108-3

      Pages: 258-266

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model2004

    • Author(s)
      Liu, Y.et al.
    • Journal Title

      Pain 109-1-2

      Pages: 64-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats2004

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Eur. J. Neurosci. 20-11

      Pages: 2881-2895

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury2004

    • Author(s)
      Yamanaka, H. et al.
    • Journal Title

      Eur. J. Neurosci. 19-1

      Pages: 93-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury2004

    • Author(s)
      Wang, H. et al.
    • Journal Title

      Eur. J. Neurosci. 19-4

      Pages: 884-890

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following Inflammation near the nerve cell body2004

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Neuroscience 126-4

      Pages: 1011-1021

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of the MAPK activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation2004

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J.Neurosci 24

      Pages: 10211-10222

    • Related Report
      2004 Annual Research Report
  • [Journal Article] PAR2 mediated potentiation of TRPV1 activity reveals a mechanism for proteinase-induced inflammatory pain2004

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      J.Neurosci 24

      Pages: 4293-4299

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons2004

    • Author(s)
      Dai, Y.et al.
    • Journal Title

      Pain 108

      Pages: 258-266

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model2004

    • Author(s)
      Liu, Y.et al.
    • Journal Title

      Pain 109

      Pages: 67-72

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats2004

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Eur.J.Neurosci. 20

      Pages: 2881-2895

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury2004

    • Author(s)
      Yamanaka, H. et al.
    • Journal Title

      Eur.J.Neurosci. 19

      Pages: 93-102

    • Related Report
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  • [Journal Article] Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion2003

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Exp. Neurol. 188・1

      Pages: 149-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
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  • [Journal Article] Plasma Membrane Calcium ATPase Expression in the Rat Spinal Cord2003

    • Author(s)
      Tachibana, T. et al.
    • Journal Title

      Brain Res. Mol. Brain Res. 131・1-2

      Pages: 26-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of injured and uninjured DRG neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats2003

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Pain 101・1-2

      Pages: 65-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury2003

    • Author(s)
      Takahashi, N. et al.
    • Journal Title

      Neuroscience 121・2

      Pages: 441-450

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hard-food mastication suppresses complete FREUND's adjuvant - induced nociception2003

    • Author(s)
      Ogawa, A. et al.
    • Journal Title

      Neuroscience 120・4

      Pages: 1081-1092

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity2003

    • Author(s)
      Moriyama, T. et al.
    • Journal Title

      J. Neurosci. 23・14

      Pages: 6058-6062

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increase of preprotachykinin mRNA in the uninjured mandibular neurons after rat infraorbital nerve transection2003

    • Author(s)
      Tsuzuki.K.et al.
    • Journal Title

      Neurosci. Lett. 345・1

      Pages: 57-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential activation of extracellular signal - regulated protein kinase in primary afferent neurons regulates brain - derived neurotrophic factor expression after peripheral inflammation and nerve injury2003

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Neurosci. 23・10

      Pages: 4117-4126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model2003

    • Author(s)
      Shimode, N. et al.
    • Journal Title

      Neurosci. Lett. 343・1

      Pages: 45-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased expression of 3β - hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons following peripheral nerve injury2003

    • Author(s)
      Hashimoto, N. et al.
    • Journal Title

      Neurosci. Lett. 340・1

      Pages: 45-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root2003

    • Author(s)
      Kominato, Y. et al.
    • Journal Title

      Brain Res. 967・1-2

      Pages: 89-97

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via a2 adrenoceptors in the jejunal myenteric plexus2003

    • Author(s)
      Nishizaki, K. et al.
    • Journal Title

      Brain Res. 965・1-2

      Pages: 121-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion2003

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Exp. Neurol. 188-1

      Pages: 149-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Plasma Membrane Calcium ATPase Expression in the Rat Spinal Cord2003

    • Author(s)
      Tachibana, T. et al.
    • Journal Title

      Brain Res. Mol. Brain Res. 131-1-2

      Pages: 26-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of injured and uninjured DRG neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats2003

    • Author(s)
      Obata, K. et al.
    • Journal Title

      Pain 101-1-2

      Pages: 65-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury2003

    • Author(s)
      Takahashi, N. et al.
    • Journal Title

      Neuroscience 121-2

      Pages: 441-450

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hard-food mastication suppresses complete FREUND's adjuvant- induced nociception2003

    • Author(s)
      Ogawa, A. et al.
    • Journal Title

      Neuroscience 120-4

      Pages: 1081-1092

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity2003

    • Author(s)
      Moriyama, T. et al.
    • Journal Title

      J. Neurosci. 23-14

      Pages: 6058-6062

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increase of preprotachykinin mRNA in the uninjured mandibular neurons after rat infraorbital nerve transection2003

    • Author(s)
      Tsuzuki.K.et al.
    • Journal Title

      Neurosci. Lett. 345-1

      Pages: 57-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury2003

    • Author(s)
      Obata, K. et al.
    • Journal Title

      J. Neurosci. 23-10

      Pages: 4117-4126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative pain model2003

    • Author(s)
      Shimode, N. et al.
    • Journal Title

      Neurosci. Lett. 343-1

      Pages: 45-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased expression of 3β- hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons following peripheral nerve injury2003

    • Author(s)
      Hashimoto, N. et al.
    • Journal Title

      Neurosci. Lett. 340-1

      Pages: 45-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root2003

    • Author(s)
      Kominato, Y. et al.
    • Journal Title

      Brain Res. 967-1-2

      Pages: 89-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via a2-adrenoceptors in the jejunal myenteric plexus2003

    • Author(s)
      Nishizaki, K. et al.
    • Journal Title

      Brain Res. 965-1-2

      Pages: 121-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] Obata.K.et al.: "Contribution of injured and uninjured DRG neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats"Pain. 101. 65-77 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Obata.K.et al.: "Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury."J.Neurosci.. 23. 4117-4126 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nisnizaki.K. et al.: "Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via 2-adrenoceptors in the jejunal myenteric plexus."Brain Res.. 965. 121-129 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Moriyama.T.et al.: "Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity."J.Neurosci.. 23. 6058-6062 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi.N. et al.: "Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury."Neuroscience. 121. 441-450 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hashimoto.N. et al.: "Increased expression of 3-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons following peripheral nerve injury."Neurosci.Lett.. 340. 45-48 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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