• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of protein kinase(s) involved in abnormal phosphorylation of alpha-synuclein

Research Project

Project/Area Number 15300119
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

HASEGAWA Masato  Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Head of department, 東京都精神医学総合研究所, 副参事研究員 (10251232)

Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2005: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2004: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2003: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywordsalpha-synuclein / phosphorylation / ubiquitination / filaments / casein kinase 2 / Parkinson's disease / Lewy body / レヴィー小体 / レヴィー小体型痴呆 / 多系統萎縮症
Research Abstract

Filamentous inclusions made of alpha-synuclein in nerve cells or glial cells are the defining neuropathological feature of a group of neurodegenerative diseases which include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy. In these so-called "alpha-synucleinopathies", a-synuclein is deposited in a hyperphosphorylated form at Ser129 in the carboxyl-terminal region. In this study, we have attempted to identify a protein kinase that phosphorylates Ser129 of alpha-synuclein in brain, using a monoclonal antibody P-Ser129 which specifically recognizes phosphorylated Ser129 of alpha-synuclein. Recombinant human alpha-synuclein was incubated with brain extracts from 6-week rat in the presence of ATP, and the protein kinase activity was detected by immunoblotting of phosphorylated alpha-synuclein with the P-Ser129 antibody. The protein kinase activity was partially purified by ammonium sulfate fractionation and anion exchange column chromatography, and cha … More racterized by immunoblotting and some inhibitors. The protein kinase activity was precipitated with 33% ammonium sulfate and eluted with 0.4-0.5M NaCl on a Q-Sepharose column chromatography. Immunoblot analysis of these fractions with anti-casein kinase 2 (CK2) antibody revealed that CK2 catalytic subunit was enriched through these steps. The protein kinase activities in the partially purified fraction and crude brain extracts were dramatically inhibited by heparin, a well-known specific inhibitor of CK2. These findings strongly suggest that CK2 may be the major protein kinase in brain that phosphorylates Serl29 of alpha-synuclein. In DLB brains, aberrant CK2 immunoreactivities were also observed in the Sarkosyl-insoluble fraction where the hyperphosphorylated alpha-synuclein was enriched, whereas no such immunoreactivity was detected in the fraction from control brains. These results suggest that CK2 may be involved in the abnormal phosphorylation of alpha-synuclein in alpha-synucleinopathies. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (68 results)

All 2006 2005 2004 2003 Other

All Journal Article (59 results) Publications (9 results)

  • [Journal Article] Small Molecule Inhibitors of alpha-Synuclein Filament Assembly.2006

    • Author(s)
      Masuda, M., Szuki, N., Goedrt, M., Hasegawa, M.
    • Journal Title

      Biochemistry (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biochemistry and molecular biology of tauopathies.2006

    • Author(s)
      Hasegawa, M.
    • Journal Title

      Neuropathology (in press)

    • NAID

      10019264205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006

    • Author(s)
      Wakabayashi K, Mori F, Hasegawa M et sl.
    • Journal Title

      Neuropathology 26

      Pages: 66-71

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006

    • Author(s)
      Masuda, M., Dohmae, N., Goedert,, Hasegawa, M.
    • Journal Title

      FEBS Lett. 580

      Pages: 1775-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006

    • Author(s)
      Masuda M, Dohmae N, Nonaka T, Oikawa T, Hisanaga S, Goedert M, Haseaewa M
    • Journal Title

      FEBS Left 580

      Pages: 1775-1779

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cysteine misincorporation in bacterially expressed human alpha-synuclein.2006

    • Author(s)
      Masuda, M., Dohmae, N., Goedert, M., Hasegawa, M.
    • Journal Title

      FEBS Lett. 580

      Pages: 1775-1779

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006

    • Author(s)
      Wakabayashi K, Mori F, Hasegawa M, et al.
    • Journal Title

      Neuropathology 26

      Pages: 66-71

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Small Molecule Inhibitors of alpha-Synuclein Filament Assembly.2006

    • Author(s)
      Masuda, M., Suzuki, N., Goedert, M., Hasegawa, M.
    • Journal Title

      Biochemistry (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies2005

    • Author(s)
      Yamazaki, M., Hasegawa, M., Mori, O.et al.
    • Journal Title

      J. Neuropathol. Exp. Neurol 64

      Pages: 839-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy2005

    • Author(s)
      Saito, Y., N, Hasegawa, M, Murayama, S.
    • Journal Title

      J. Neuropathol. Exp. Neurol 64

      Pages: 839-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005

    • Author(s)
      Ikeda, M., Shoji, M., Kawatai, T, Hasegawa.M.et al.
    • Journal Title

      Am. J. Pathol 166

      Pages: 521-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins2005

    • Author(s)
      Taniguchi, S., Suzuki, N...., Goedert, M., Hasegawa, M.
    • Journal Title

      J. Biol. Chem 280

      Pages: 7614-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35, p25, or p39.2005

    • Author(s)
      Sakaue, F., Saito, T., Hasegawa, M., Hisanaga, S
    • Journal Title

      J. Biol. Chem 280

      Pages: 31522-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005

    • Author(s)
      Motoi, Y., Hasegawa, M., Mizumo, Y., Mori, H
    • Journal Title

      Acta Neuropathol.(Berl) 110

      Pages: 431-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ubiquitination of alpha-synuclein.2005

    • Author(s)
      Nonaka T, Iwatsubo T, Hasegawa M:
    • Journal Title

      Biochemistry 44

      Pages: 361-368

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polvphenols and porphyrins.2005

    • Author(s)
      Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M
    • Journal Title

      J Biol Chem 280

      Pages: 7614-7623

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies.2005

    • Author(s)
      Yamazaki M, Hasegawa M, Mori O, Murayama S, Tsuchiya K, Ikeda K, Chen K-M, Katayama Y, Oyanagi K
    • Journal Title

      J Neuropathol Exp Neurol 64

      Pages: 839-846

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35, p25, or p39.2005

    • Author(s)
      Sakaue, F., Saito, T., Sato, Y., Asada, A., Ishiguro, K., Hasegawa, M., Hisanaga, S.
    • Journal Title

      J Biol Chem 280

      Pages: 31522-31529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005

    • Author(s)
      Motoi Y, Iwamoto H, Itaya M, Kobayashi T, Hasegawa M, Yasuda M, Mizuno Y, Mori H.
    • Journal Title

      Acta Neuropathol (Berl) 110

      Pages: 431-433

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005

    • Author(s)
      Saito Y, Motoyoshi Y, Kashima T, Izumiyama-Shimoharma M, Toda T, Nakano I, Hasegawa M, Murayama S.
    • Journal Title

      J Neuropathol Exp Neurol 64

      Pages: 1118-1126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005

    • Author(s)
      Ikeda, M., Shoji, M., Kawarai, T., Kawarabayashi, T., Matsubara, E., Murakami, T., Sasaki, A., Tomidokoro, Y., Ikarashi, Y., Kuribara, H., Ishiguro, K., Hasegawa, M., Yen, S.H., Chishti, M.A., Harigaya, Y., Abe, K., Okamoto, K., St George-Hyslop.P., Westaway, D.
    • Journal Title

      Am J Pathol 166

      Pages: 521-531

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ubiquitination of alpha-synuclein.2005

    • Author(s)
      Nonaka, T., Iwatsubo, T., Hasegawa, M.
    • Journal Title

      Biochemistry 44

      Pages: 361-368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005

    • Author(s)
      Ikeda, M., Shoji, M., Kawarai, T, Hasegawa, M., et al.
    • Journal Title

      Am.J.Pathol 166

      Pages: 521-531

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins2005

    • Author(s)
      Taniguchi, S., Suzuki, N., Goedert, M., Hasegawa, M.
    • Journal Title

      J.Biol.Chem 280

      Pages: 7614-7623

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phosphorylation of FTDP-17 mutant TAU by cyclin-dependent kinase 5 complexed with p35,p25,or p39.2005

    • Author(s)
      Sakaue, F., Saito, T., Hasegawa, M., Hisanaga, S
    • Journal Title

      J.Biol.Chem 280

      Pages: 31522-31529

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies.2005

    • Author(s)
      Motoi, Y., Hasegawa, M., Yasuda, M., Mizuno, Y., Mori, H
    • Journal Title

      Acta Neuropathol.(Berl) 110

      Pages: 431-433

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tau-positive fine granules in the cerebral white matter : a novel finding exclusive to parkinsonism-dementia complex of Guam among the tauopathies2005

    • Author(s)
      Yamazaki, M., Hasegawa, M., Mori, O., et al.
    • Journal Title

      J.Neuropathol.Exp.Neurol 64

      Pages: 839-846

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Unique tauopathy in Fukuyama-type congenital muscular dystrophy.2005

    • Author(s)
      Saito, Y., N, Hasegawa, M., Murayama, S.
    • Journal Title

      J.Neuropathol.Exp.Neurol 64

      Pages: 839-846

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.2005

    • Author(s)
      Ikeda M, Hasegawa M, Westaway D, et al.
    • Journal Title

      Am J Pathol 166

      Pages: 521-531

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ubiquitination of alpha-synuclein.2005

    • Author(s)
      Nonaka T, Iwatsubo T, Hasegawa M
    • Journal Title

      Biochemistry 44

      Pages: 361-368

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins.2005

    • Author(s)
      Taniguchi S, Suzuki N, Masuda M, Hisanaga SI, Iwatsubo T, Goedert M, Hasegawa M
    • Journal Title

      J Biol Chem 280

      Pages: 7614-7623

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia patients with multiple system atrophy.2004

    • Author(s)
      Nishie M, Mori F, Hasegawa M, Takehashi H, Wakabayashi K et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 292-298

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylated alpha-synuclein in normal mouse brain.2004

    • Author(s)
      Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M
    • Journal Title

      FEBS Lett 572

      Pages: 227-232

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene.2004

    • Author(s)
      Pickering-Brown SM, Hasegawa M, Mann DMA et al.
    • Journal Title

      Brain 127

      Pages: 1415-1426

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stress-and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD95 by activation of SAPK3/p38g and ERKI1/ERK2.2004

    • Author(s)
      Sabio G, Hasegawa M, Goedert M, Garner C, Cuenda A et al.
    • Journal Title

      Biochem J 380

      Pages: 19-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004

    • Author(s)
      Umeda Y, Taniguchi S, Arima K, Piao Y-S, Mann D, Hasegawa M et al.
    • Journal Title

      Neurosci. Lett 359

      Pages: 151-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of amino-terminal cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration.2004

    • Author(s)
      Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M et al.
    • Journal Title

      Ann Neurol 55

      Pages: 72-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein.2004

    • Author(s)
      Tniguchi S, McDonagh AM, Hasegawa M et al.
    • Journal Title

      Neuropathol Appl Neurobiol 30

      Pages: 1-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylated alpha-synuclein in normal mouse brain.2004

    • Author(s)
      Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M
    • Journal Title

      FEBS Left 572

      Pages: 227-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.2004

    • Author(s)
      Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K
    • Journal Title

      Acta Neuropathol 107

      Pages: 292-298

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.2004

    • Author(s)
      Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhlendahl S Leal-Ortiz S, Goedert M, Garner C, Cuenda A
    • Journal Title

      Biochem J 380

      Pages: 19-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mann DMA : Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tam gene.2004

    • Author(s)
      Pickering-Brown SM, Baker M, Nonaka T, Ikeda K, Sharma S, Mackenzie J, Simpson SA, Moore JW, Snowden JS, de Silva R, Revesz T, Hasegawa M, Hutton M
    • Journal Title

      Brain 127

      Pages: 1415-1426

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of amino-terminal cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration.2004

    • Author(s)
      Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, Tsuchiya K, Iseki E, Yagishita S, Oda T, Mochizuki A
    • Journal Title

      Ann Neurol 55

      Pages: 72-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004

    • Author(s)
      Umeda Y, Taniguchi S, Arima K, Piao Y-S, Takahashi H, Iwatsubo T, Mann D, Hasegawa M
    • Journal Title

      Neurosci.Lett 359

      Pages: 151-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein.2004

    • Author(s)
      Taniguchi S, McDonagh AM, Pickering-Brown SA, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA
    • Journal Title

      Neuropathol Appl Neurobiol 30

      Pages: 1-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.2004

    • Author(s)
      Nishie M, Mori F, Hasegawa M, Takahashi H, Wakabayashi K, et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 292-298

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies.2004

    • Author(s)
      Umeda Y, Taniguchi S, Arima K, Piao Y-S, Mann D, Hasegawa M, et al.
    • Journal Title

      Neurosci.Lett 359

      Pages: 151-154

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD95 by activation of SAPK3/p38g and ERK1/ERK2.2004

    • Author(s)
      Sabio G, Hasegawa M, Goedert M, Garner C, Cuenda A, et al.
    • Journal Title

      Biochem J 380

      Pages: 19-30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene.2004

    • Author(s)
      Pickering-Brown SM, Hasegawa M, Hutton M, Mann DMA, et al.
    • Journal Title

      Brain 127

      Pages: 1415-1426

    • Related Report
      2004 Annual Research Report
  • [Journal Article] alpha-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy.2003

    • Author(s)
      Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M et al.
    • Journal Title

      J Neuropathol Exp Neurol 62

      Pages: 812-819

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.2003

    • Author(s)
      Arai T, Nonaka T, Hasegawa M et al.
    • Journal Title

      Neurosci Lett 342

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of phosphorylated alpha-synuclein in aging human brain.2003

    • Author(s)
      Saito Y, Kawashima A, Ruberu NN, Hasegawa M et al.
    • Journal Title

      J Neuropathol Exp Neurol 62

      Pages: 644-645

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 1. Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila2003

    • Author(s)
      Takahashi M, Kanuka H, Fujiwara H, Hasegawa M et al.
    • Journal Title

      Neurosci Lett 336

      Pages: 155-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique pathology2003

    • Author(s)
      Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M et al.
    • Journal Title

      Ann Neurol 53

      Pages: 133-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] alpha-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy.2003

    • Author(s)
      Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K
    • Journal Title

      J Neuropathol Exp Neurol 62

      Pages: 812-819

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.2003

    • Author(s)
      Arai T, Nonaka T, Hasegawa M, Akiyama H, Yoshida M, Hashizume Y, Tsuchiya K, Oda T, Ikeda K
    • Journal Title

      Neurosci Lett 342

      Pages: 41-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Accumulation of phosphorylated alpha-synuclein in aging human brain.2003

    • Author(s)
      Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S
    • Journal Title

      J Neuropathol Exp Neurol 62

      Pages: 644-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila2003

    • Author(s)
      Takahashi M, Kanuka H, Fujiwara H, Hasegawa M, Miura M, Iwatsubo T
    • Journal Title

      Neurosci Lett 336

      Pages: 155-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau apthology.2003

    • Author(s)
      Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H
    • Journal Title

      Ann Neurol 53

      Pages: 133-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Saito Y, et al.: "Accumulation of phosphorylated alpha-synuclein in aging human brain."J Neuropathol Exp Neurol. 62. 644-654 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arai T, et al.: "Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62."Neurosci Lett. 342. 41-44 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mori F, et al.: "alpha-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy."J Neuropathol Exp Neurol. 62. 812-819 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Taniguchi S, et al.: "The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein."Neuropathol Appl Neurobiol. 30. 1-18 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arai T, et al.: "Identification of amino-terminal cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration."Ann Neurol. 55. 72-79 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishie M, et al.: "Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy."Acta Neuropathol. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Pickering-Brown SM, et al.: "Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene."Brain. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Sabio G, et al.: "Stress- & mitogen-induced phosphorylation of the synapse-associated protein SAP9O/PSD95 by activation of SAPK3/p38γ & ERK1/ERK2"Biochem J. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Umeda Y, et al.: "Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies."Neurosci Lett. (in press).

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi