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Analysis of the antigen epitopes of infectious pathogens in laboratory animals using peptide tips

Research Project

Project/Area Number 15300138
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionHokkaido University

Principal Investigator

AGUI Takashi  Hokkaido University, Graduate School of Veterinary Medicine, Professor, 大学院獣医学研究科, 教授 (00212457)

Co-Investigator(Kenkyū-buntansha) ARIKAWA Jiro  Hokkaido University, Graduate School of Medicine, Professor, 大学院医学研究科, 教授 (10142704)
ASANO Atsushi  Hokkaido University, Graduate School of Veterinary Medicine, Assistant Professor, 大学院獣医学研究科, 助手 (90312404)
TAKAKURA Akira  Central Institute for Experimental Animals, Laboratory Chief, ICLAモニタリングセンター, 室長 (60167484)
KUNIMATU Mitoshi  Nagoya Women's University, Professor, 家政学部, 教授 (70145746)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥16,700,000 (Direct Cost: ¥16,700,000)
Fiscal Year 2005: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2003: ¥8,600,000 (Direct Cost: ¥8,600,000)
Keywordspeptide tip / antigenic epitope / hantavirus / mouse hepatitis virus / Sendai virus / Mycoplasma / マイコフラズマ
Research Abstract

We selected mouse hepatitis virus, Sendai virus, Mycoplasma plumonis, and hantavirus from the aspect of the frequency and danger upon infectious accidents. We determined antigenic epitopes by incubating polyclonal anti-sera with peptide tips produced according to the amino acid sequences reported previously elsewhere. Further, we tried to develop a preliminary ELISA kit using antigenic epitopes that we have determined. With respect to mouse hepatitis virus and Sendai virus, we succeeded to develop an ELISA system, which was more sensitive or equal to the commercially available ELISA system (paper in preparation). With respect to hantavirus, we succeeded to determine an antigenic epitope, EDVNGIRK (amino acid 166-173), to monoclonal antibody E5/G6, which recognizes nuclear protein of hantavirus. With respect to Mycoplasma plumonis, we first searched antigenic protein from the components of the bacteria, since there are a lot of proteins composing of bacteria. We found a protein showing a homology to P46 protein, which had been reported as an antigenic protein in other Mycoplasmas and named it P46L. We produced recombinant P46L protein conjugated with glutathione S-transferase and made an ELISA system with purified P46L. This ELISA system was more sensitive than the commercially available ELISA system.
We further applied this method to the determination of antigenic epitopes of West Nile virus and SARS virus and succeeded it. We furthermore succeeded to apply this method to not only determining antigenic epitopes of infectious pathogens but also determining protein-protein interaction site such as binding sits of FAS-antigen and angiotensin II.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (59 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (57 results) Book (2 results)

  • [Journal Article] Development of serological assays for Thottapalayam virus, an iInsectivore-borne Hantavirus.2007

    • Author(s)
      Okumura M, Yoshimatsu K, S.Kumperasart, Nakamura I, Ogino M, Taruishi M, Sungdee A, Pattamadilok S, Ibrahim I.N., Erlina S, Agui T, Yanagihara R, Arikawa J
    • Journal Title

      Clin. Vaccine Immunol. 14

      Pages: 173-181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.2007

    • Author(s)
      Menon S, Lee J, Abplanalp W.A., Yoo S.-E., Agui T, Furudate S, Kim P.S., Arvan P
    • Journal Title

      J. Biol. Chem. 282

      Pages: 6183-6191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism.2007

    • Author(s)
      Sasaki N, Hosoda Y, Nagata A, Ding M, Cheng J.-M., Miyamoto T, Okano S, Asano A, Miyoshi I, Acui T
    • Journal Title

      Mol. Endocrinol. (in press)

    • NAID

      120000967738

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of serological assays for Thottapalayam virus, an ilnsectivore-borne Hantavirus.2007

    • Author(s)
      Okumura M, Yoshimatsu K, S.Kumperasart, Nakamura I, Ogino M, Taruishi M, Sungdee A, Pattamadilok S, Ibrahim I.N., Erlina S, Agui T, Yanagihara R, Arikawa J.
    • Journal Title

      Clin. Vaccine Immunol 14

      Pages: 173-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.2007

    • Author(s)
      Menon S, Lee J, Abplanalp W.A., Yoo S.-E., Agui T Furudate S, Kim P.S., Aryan P.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 6183-6191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Deficiency of the tensin2 gene in the ICGN mouse, an animal model for congenital nephrotic syndrome.2006

    • Author(s)
      Cho A-R., Uchio-Yamada k, Torigai T, Miyamoto T, Miyoshi I, Matsuda J, Kurosawa T, Kon Y, Asano A, Sasaki N, Agui T
    • Journal Title

      Mamm. Genome. 17

      Pages: 407-416

    • NAID

      120000958625

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of the cell cycle of fibroblasts derived from the LEC rat after X-irradiation.2006

    • Author(s)
      Masuda K, Miyamoto T, Cho A-R., Agui T
    • Journal Title

      Jpn. J. Vet. Res. 53

      Pages: 141-148

    • NAID

      120000954053

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phylogenetic analysis of isolates of Pasteurella pneumotropica from aboratory animals based on the gyrB gene sequence.2006

    • Author(s)
      Hayashimoto N, Ueno M, Takakura A, Itoh T
    • Journal Title

      Exp. Anim. 55

      Pages: 487-490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Peptide array-based interaction assay of solid-bound peptides and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design.2006

    • Author(s)
      Kato R, Kaga C, Kunimatsu M, Kobayashi T, Honda H
    • Journal Title

      J. Biosci. Bioeng. 101(6)

      Pages: 485-495

    • NAID

      110004758121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.2006

    • Author(s)
      Fujimoto S, Mori M, Tsushima H, Kunimatsu M
    • Journal Title

      Eur. J. Pharmacol. 530

      Pages: 144-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Deficiency of the tensin2 gene in the ICGN mouse, an animal model for congenital nephrotic syndrome.2006

    • Author(s)
      Cho A-R., Uchio-Yamada k, Torigai T, Miyamoto T, Miyoshi I, Matsuda J, Kurosawa T, Kon Y, Asano A, Sasaki N, Agui T.
    • Journal Title

      Mamm. Genome 17

      Pages: 407-416

    • NAID

      120000958625

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of the cell cycle of fibroblasts derived from the LEC rat after X-irradiation.2006

    • Author(s)
      Masuda K, Miyamoto T, Cho A-R., Agui T.
    • Journal Title

      Jpn. J. Vet. Res. 53

      Pages: 141-148

    • NAID

      120000954053

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phylogenetic analysis of isolates of Pasteurella pneumotropica from laboratory animals based on the gyrB gene sequence.2006

    • Author(s)
      Hayashimoto N, Ueno M, Takakura A, Itoh T.
    • Journal Title

      Exp. Anim. 55

      Pages: 487-490

    • NAID

      10018307969

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Peptide array-based interaction assay of solid-bound peptides and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design.2006

    • Author(s)
      Kato R, Kaga C, Kunimatsu M, Kobayashi T, Honda H.
    • Journal Title

      J. Biosci. Bioeng. 101(6)

      Pages: 485-495

    • NAID

      110004758121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.2006

    • Author(s)
      Fujimoto S, Mori M, Tsushima H, Kunimatsu M.
    • Journal Title

      Eur. J. Pharmacol 530

      Pages: 144-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] VII-A3(1). Infectious diseases in livestock and vaccine. Handbook of Experimental Immunology. Ed..2006

    • Author(s)
      Agui T.
    • Journal Title

      IV-El. Use of Laboratory Animals. Nakashima IThe University of Nagoya Press 325

      Pages: 170-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative trait loci analysis of heat stress resistance of spermatocytes in the MRL/MpJ mouse.2005

    • Author(s)
      Namiki Y, Kon Y, Kazusa K, Asano A, Sasaki N, Agui T
    • Journal Title

      Mamm. Genome. 16

      Pages: 96-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse.2005

    • Author(s)
      Okano S, Asano A, Sasaki N, Kon Y, Watanabe T, Agui T
    • Journal Title

      Jpn. J. Vet. Res. 52

      Pages: 145-149

    • NAID

      110004665685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intracellular localization and their antiviral property of canine Mx proteins.2005

    • Author(s)
      Nakamura T, Asano A, Okano S, Ko J.-H., Kon Y, Watanabe T, Agui T
    • Journal Title

      J. Interferon Cyokine Res. 25

      Pages: 169-173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification procedure for Pasteurella pneumotropica in nicrobiologic monitoring of laboratory animals.2005

    • Author(s)
      Hayashimoto N, Takakura A, 他
    • Journal Title

      Exp. Anim. 54

      Pages: 123-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic diversity on 16S DNA sequence and phylogenic tree analysis in Pasteurella pneumotropica strains isolated from laboratory animals.2005

    • Author(s)
      Hayashimoto N, Takakura A, Itoh T
    • Journal Title

      Curr. Microbiol. 51

      Pages: 239-243

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pentamer peptide from Fas antigen ligand inhibits tumor-growth with solid-bound form found by peptide array.2005

    • Author(s)
      Kato R, Okuno Y, Kaga C, Kunimatsu M, Kobayashi T, Honda H
    • Journal Title

      J. Pept. Res. 66 Suppl 1

      Pages: 146-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Both HDL3 and HDL2 exert a powerful anti-oxidative and protective effect against acceleration of oxidative modification of LDL by ascorbic acid.2005

    • Author(s)
      Sakuma N, Saeki T, Yajima K, Hibino T, Yoshida T, Mizuno H, Mukai S, Sakata S, Kunimatsu M, Kimura G
    • Journal Title

      J. Nutr. Sci. Vitaminol. 51

      Pages: 75-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative trait loci analysis of heat stress resistance of spermatocytes in the MRL/MpJ mouse.2005

    • Author(s)
      Namiki Y, Kon Y, Kazusa K, Asano A, Sasaki N, Agui T.
    • Journal Title

      Mamm. Genome 16

      Pages: 96-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse.2005

    • Author(s)
      Okano S, Asano A, Sasaki N, Kon Y, Watanabe T, Agui T.
    • Journal Title

      Jpn. J. Vet. Res. 52

      Pages: 145-149

    • NAID

      110004665685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intracellular localization and their antiviral property of canine Mx proteins.2005

    • Author(s)
      Nakamura T, Asano A, Okano S, Ko J.-H., Kon Y, Watanabe T, Agui T.
    • Journal Title

      J. Interferon Cyokine Res. 25

      Pages: 169-173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ldentification procedure for Pasteurella pneumotropica in microbiologic monitoring of laboratory animals.2005

    • Author(s)
      Hayashimoto N, Takakura A, 他
    • Journal Title

      Exp. Anim. 54

      Pages: 123-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pentamer peptide from Fas antigen ligand inhibits tumor-growth with solid-bound form found by peptide array.2005

    • Author(s)
      Kato R, Okuno Y, Kaga C, Kunimatsu M, Kobayashi T, Honda H.
    • Journal Title

      J. Pept. Res. 66 Suppl 1

      Pages: 146-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Both HDL3 and HDL2 exert a powerful anti-oxidative and protective effect against acceleration of oxidative modification of LDL by ascorbic acid.2005

    • Author(s)
      Sakuma N, Saeki T, Yajima K, Hibino T, Yoshida T, Mizuno H, Mukai S, Sakata S, Kunimatsu M, Kimura G.
    • Journal Title

      J. Nutr. Sci. Vitaminol. 51

      Pages: 75-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Peptide array (in Japanese)2005

    • Author(s)
      Kunimtu M, Kato R, Honda Y.
    • Journal Title

      Medical Review Corp.

      Pages: 87-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of the chicken PKR : Polymorphism of the gene and antiviral activity against vesicular stomatitis virus.2004

    • Author(s)
      Ko J.-H., Asano A, Kon Y, Watanabe T, Agui T
    • Journal Title

      Jpn. J. Vet. Res. 51

      Pages: 123-133

    • NAID

      110004101377

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differences in spermatogenesis in cryptorchid testes among various strains of mice.2004

    • Author(s)
      Kazusa K, Namiki Y, Asano A, Kon Y, Endo D, Agui T
    • Journal Title

      Comp. Med. 54

      Pages: 179-184

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Native antiviral specificity of chicken Mx protein depends on amino acid variation at position 631.2004

    • Author(s)
      Ko J.-H., Takada A, Mitsuhashi T, Agui T, Watanabe T
    • Journal Title

      Anim. Genet. 35

      Pages: 119-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epitope analysis of monoclonal antibody E5/G6, which binds to a linear epitope in the nucleocapsid protein of hantaviruses.2004

    • Author(s)
      Okumura M, Yoshimatsu K, Araki K, Lee B.-H., Asano A, Aeui T, Arikawa J
    • Journal Title

      Arch. Virol. 149

      Pages: 2427-2434

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The mRNA regulation of protein double-stranded RNA-activated protein kinase gene.2004

    • Author(s)
      Asano A, Kon Y, Agui T
    • Journal Title

      J. Vet. Med. Sci. 66

      Pages: 1523-1528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Exon skipping of exonuclease 1 in MRL/MpJ mice is caused by a nucleotide substitution of the branchpoint sequence in intron eight.2004

    • Author(s)
      Namiki Y, Kon Y, Sasaki N, Agui T, Endoh D
    • Journal Title

      Jpn. J. Vet. Res. 52

      Pages: 125-134

    • NAID

      110004101385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain.2004

    • Author(s)
      Ogawa Y, Sugiura K, Watanabe A, Kunimatsu M, Mishima M, Tomita Y, Muro Y
    • Journal Title

      J. Autoimmun. 23

      Pages: 221-231

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Angiotensin II inhibitory peptide found in the receptor sequence using peptide array.2004

    • Author(s)
      Kato R, Kunimatsu M, Kobayashi T, Honda H
    • Journal Title

      Biochem. Biophys. Res. Commun. 315

      Pages: 22-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of the chicken PKR : Polymorphism of the gene and antiviral activity against vesicular stomatitis virus.2004

    • Author(s)
      Ko J.-H., Asano A, Kon Y, Watanabe T, Agui T.
    • Journal Title

      Jpn. J. Vet. Res. 51

      Pages: 123-133

    • NAID

      110004101377

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differences in spermatogenesis in cryptorchid testes among various strains of mice.2004

    • Author(s)
      Kazusa K, Namiki Y, Asano A, Kon Y, Endo D, Agui T.
    • Journal Title

      Comp. Med. 54

      Pages: 179-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Native antiviral specificity of chicken Mx protein depends on amino acid variation at position 631.2004

    • Author(s)
      Ko J.-H., Takada A, Mitsuhashi T, Agui T, Watanabe T.
    • Journal Title

      Anim. Genet. 35

      Pages: 119-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epitope analysis of monoclonal antibody E5/G6, which binds to a linear epitope in the nucleocapsid protein of hantaviruses.2004

    • Author(s)
      Okumura M, Yoshimatsu K, Araki K, Lee B.-H., Asano A, Agui T, Arikawa J.
    • Journal Title

      Arch. Virol. 149

      Pages: 2427-2434

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The mRNA regulation of protein double-stranded RNA-activated protein kinase gene.2004

    • Author(s)
      Asano A, Kon Y, Agui T.
    • Journal Title

      J. Vet. Med. ScL 66

      Pages: 1523-1528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Exon skipping of exonuclease 1 in MRL/MpJ mice is caused by a nucleotide substitution of the branchpoint sequence in intron eight.2004

    • Author(s)
      Namiki Y, Kon Y, Sasaki N, AguiT, Endoh D.
    • Journal Title

      J. Vet. Res. 52

      Pages: 125-134

    • NAID

      110004101385

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain.2004

    • Author(s)
      Ogawa Y, Sugiura K, Watanabe A, Kunimatsu M, Mishima M, Tomita Y, Muro Y.
    • Journal Title

      J. Autoimmun. 23

      Pages: 221-231

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Angiotensin II inhibitory peptide found in the receptor sequence using peptide array.2004

    • Author(s)
      Kato R, Kunimatsu M, Kobayashi T, Honda H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 315

      Pages: 22-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Establishment of an Enzyme-Linked Immunosorbent Assay for Detection of Hantavirus Antibody of Rats Using a Recombinant of Nucleocapsid Protein Expressed in Escherichia coli.2003

    • Author(s)
      Takakura A, Goto K, Itoh T, Yoshimatsu K, Takashima I, Arikawa J
    • Journal Title

      Exp. Anim. 52

      Pages: 25-30

    • NAID

      130000068480

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interaction of protein-bound polysaccharide (PSK) with smooth muscle myosin regulatory light chain.2003

    • Author(s)
      Fujii T, Kunimatsu M
    • Journal Title

      Biol. Pharm. Bull. 26

      Pages: 771-774

    • NAID

      110003608516

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increased serum triglyceride clearance and elevated high-density lipoprotein 2 and 3 cholesterol during treatment of primary hypertriglyceridemia with Bezafibrate.2003

    • Author(s)
      Sakuma N, Ikeuchi R, Kunimatsu M, 他10名, 12番目.
    • Journal Title

      Curr. Therap. Res. 64

      Pages: 697-706

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Taurochenodeoxycholic acid induced biphasic hepatotoxicity in isolated perfused rat liver : roles of Ca2+ and calpain.2003

    • Author(s)
      Hasegawa C, Kunimatsu M, 他10名, 7番目.
    • Journal Title

      Hepatogastroenterology 50

      Pages: 972-978

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Calpain is involved in the HIV replication from the latently infected OM10.1 cells.2003

    • Author(s)
      Teranishi F, Liu ZQ, Kunimatsu M, 他5名, 3番目.
    • Journal Title

      Biochem. Biophys. Res. Commun. 303

      Pages: 940-946

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Establishment of an Enzyme-Linked Immunosorbent Assay for Detection of Hantavirus Antibody of Rats Using a Recombinant of Nucleocapsid Protein Expressed in Escherichia coli.2003

    • Author(s)
      Takakura A, Goto K, Itoh T, Yoshimatsu K, Takashima I, Arikawa J.
    • Journal Title

      Exp. Anim. 52

      Pages: 25-30

    • NAID

      130000068480

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interaction of protein-bound polysaccharide (PSK) with smooth muscle myosin regulatory light chain.2003

    • Author(s)
      Fujii T, Kunimatsu M.
    • Journal Title

      Biol. Pharm. Bull. 26

      Pages: 771-774

    • NAID

      110003608516

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increased serum triglyceride clearance and elevated high-density lipoprotein 2 and 3 cholesterol during treatment of primary hypertriglyceridemia with Bezafibrate.2003

    • Author(s)
      Sakuma N, Ikeuchi R, Kunimatsu M, with other 10 people.
    • Journal Title

      Curr. Therap. Res. 64

      Pages: 697-706

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Taurochenodeoxycholic acid induced biphasic hepatotoxicity in isolated perfused rat liver : roles of Ca2+ and calpain.2003

    • Author(s)
      Hasegawa C, Kunimatsu M, with other 10 people.
    • Journal Title

      Hepatogastroenterology 50

      Pages: 972-978

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Calpain is involved in the HIV replication from the latently infected OM10.1 cells.2003

    • Author(s)
      Teranishi F, Liu ZQ, Kunimatsu M, with other 5 people.
    • Journal Title

      Biochem. Biophys. Res. Commun. 303

      Pages: 940-946

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism.

    • Author(s)
      Sasaki N, Hosoda Y, Nagata A, Ding M, Cheng J.-M., Miyamoto T, Okano S, Asano A, Miyoshi I, Agui T.
    • Journal Title

      Mol. Endocrinol. (in press)

    • NAID

      120000967738

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 免疫実験法ハンドブックIV E 1.実験動物の取り扱い。VII 3.(1) 家畜の感染症とワクチン。(中島泉 編)2006

    • Author(s)
      安居院高志
    • Publisher
      名古屋大学出版会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] ゲノム医学 ペプチドアレイ2005

    • Author(s)
      国松己歳, 加藤竜司, 本多裕之
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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