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Establishment of Testing System for Simian Herpes B Virus Antibody and an Eco-evolutional Study on the Viral Pathogenesis

Research Project

Project/Area Number 15300143
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionNagasaki University

Principal Investigator

SATO Hiroshi  Nagasaki University, Center for Frontier Life Sciences Div. Of Comparative Medicine, Professor (50072947)

Co-Investigator(Kenkyū-buntansha) OHSAWA Kazutaka  Nagasaki University, Center for Frontier Life Sciences, Div. Of Comparative Medicine, Assoc. Professor (90244756)
YAMAMOTO Hiroshi  Toyama Medical and Pharmaceutical University, 生命科学先端研究センター, Assoc. Professor (00108797)
ITOH Toshio  ICLAS Monitoring Center, Central Inst. for Experimental Animals, Vice Dir (20106644)
TORII Ryuzou  Shiga University of Medical Science, 動物生命科学研究センター, Professor (50106647)
HAYAMI Masanori  Kyoto Univ., Virus Res. Inst., Professor (40072946)
松林 清明  京都大学, 霊長類研究所・人類進化モデル研究センター, 教授 (50027497)
万年 和明  大分大学, 総合科学研究支援センター, 助教授 (20145361)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2005: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2004: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2003: ¥3,900,000 (Direct Cost: ¥3,900,000)
KeywordsCercopithecine Herpes B virus B virus Macaques ELI / Bウイルス / マカク / ELISA / ヒヒヘルペス2型ウイルス / 国際情報交換 / 米国:中国:台湾
Research Abstract

Following results were obtained during 2005〜2008.
1. The safety and high-specific antibody assay kit for simian B herpesvirus antibody was established with some modifications of using Herpesvirus Papio 2 (alpha herpesvirus) as native antigen instead of B virus.
2. The kits showed reproducible and reliable results.
3. We have distributed above testing kits to 13 institutions and facilities with 94 kits in Japan and Hanoi, Vietnam during 4 years.
4. For eco-evolutional study, we attempted to the wild monkeys which were inhabited around Mt. Shirakami, Akita Prefecture to survey B virus antibody status.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report

Research Products

(31 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article Publications

  • [Journal Article] Lymphocytic choriomeningitis infection undetected by dirty-bedding sentinel monitoring and revealed after embryo transfer of an inbred strain derived from wild mice2007

    • Author(s)
      F.Ike
    • Journal Title

      Comp.Medicine 57・3

      Pages: 272-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 床面清掃用モップの性能評価-細菌汚染と保水性の因果関係および清拭効果について2007

    • Author(s)
      大沢 一貴
    • Journal Title

      環境感染 22・4

      Pages: 272-277

    • NAID

      10024358483

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] マカクのBウイルス抗体保有率調査-1999〜2006年2007

    • Author(s)
      大沢 牧子
    • Journal Title

      九州実験動物雑誌 23

      Pages: 63-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lymphocytic choriomeningitis infection undetected by dirty-bedding sentinel monitoring and revealed after embryo transfer of an inbred strain derived from wild mice.2007

    • Author(s)
      F. Ike, et. al.
    • Journal Title

      Comp. Med. 57, 3

      Pages: 272-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Isolation and characterization of a chimpanzee alphaherpesvirus2006

    • Author(s)
      E.Luebecke
    • Journal Title

      J.Gen.Virol. 87・1

      Pages: 11-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 大学等の動物実験施設における労働安全衛生について2006

    • Author(s)
      塩見 雅志
    • Journal Title

      アニテックス 18・4

      Pages: 3-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] RT-nested PCR法を用いたパラインフルエンザウイルス1型と3型の鑑別2006

    • Author(s)
      大沢 牧子
    • Journal Title

      九州実験動物雑誌 22

      Pages: 29-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-Macrophage Migration Inhibitory Factor Antibody SuppressesChronic Rejection of Heterotopically Transplanted Trachea in Rats2006

    • Author(s)
      Y.Sumida
    • Journal Title

      Acta Medica Nagasakiensia 51・2

      Pages: 51-56

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Isolation and characterization of a chimpanzee alphaherpesvirus.2006

    • Author(s)
      E. Luebcke, et. al.
    • Journal Title

      J. gen. Virology 87, 1

      Pages: 11-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Occupational safety for animal facility in Univ.2006

    • Author(s)
      M. Shiomi, et. al.
    • Journal Title

      Anitex 18, 4

      Pages: 3-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genetic identification of Parainfluenza virus 1 and 3 by RT-nested PCR.2006

    • Author(s)
      M. Ohsawa, et. al.
    • Journal Title

      Kyushu J. Experimental Animals 22

      Pages: 29-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-macrophage migration inhibitory factor antibody suppressor chronic rejection of heterotopically transplanted trachea in rats.2006

    • Author(s)
      Y. Sumida, et. al.
    • Journal Title

      Acta Medica Nagasakiensia 51, 2

      Pages: 51-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Isolation and characterization of a chimpanzee alphaherpesvirus2006

    • Author(s)
      E.Luebcke
    • Journal Title

      J.gen.Virology 87・1

      Pages: 11-19

    • Related Report
      2006 Annual Research Report 2005 Annual Research Report
  • [Journal Article] 大学等の動物実験施設における労働安全衛生について2006

    • Author(s)
      塩見雅志
    • Journal Title

      アニテックス 18・4

      Pages: 3-41

    • Related Report
      2006 Annual Research Report
  • [Journal Article] RT-nested PCR法を用いたパラインフルエンザウィルス1型と3型の識別2006

    • Author(s)
      大沢牧子
    • Journal Title

      九州実験動物雑誌 22

      Pages: 29-33

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Anti-Macrophage Migration Inhibitory Factor Antibody Suppresses Chronic Rejection of Heterotopically Transplanted Trachea in Rats.2006

    • Author(s)
      Y.Sumida
    • Journal Title

      Acta Medica Nagasakiensia 51・2

      Pages: 51-56

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Validation of an Enzyme-linked Immunosorbent Assay Kit using Herpesvirus papio2(HVP2)antigen for Detection of Herpesvirus simiae(B virus)Infection in Rhesus Monkeys2005

    • Author(s)
      H.Yamamoto
    • Journal Title

      Comp.Med. 55・3

      Pages: 244-287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Validation of an Enzyme-linked Immunosorbent Assay Kit using Herpesvirus papio2(HVP2) antigen for Detection of Herpesvirus simiae(B virus) Infection in Rhesus Monkeys2005

    • Author(s)
      H. Yamamoto, et. al.
    • Journal Title

      Comp. Med. 55(3)

      Pages: 244-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Validation of an Enzyme-linked Immunosorbent Assay Kit of Herpesvirus papio2 (HVP2) antigen for Detection of Herpesvirus simiae (B virus) Infection in Rhesus Monkeys.2005

    • Author(s)
      H.Yamamoto
    • Journal Title

      Comp.Medicine 55・3

      Pages: 244-248

    • Related Report
      2005 Annual Research Report
  • [Journal Article] マカカ属サルのBウイルス感染2005

    • Author(s)
      大沢 一貴
    • Journal Title

      アニテックス 17・6

      Pages: 201-207

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 実験動物の感染症診断について2005

    • Author(s)
      大沢 一貴
    • Journal Title

      実験動物技術 40・2

      Pages: 103-106

    • NAID

      10026883080

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Validation of an Enzyme-linked Immunosorbent Assay Kit of Herpesvirus papio2 (HVP2) antigen for Detection of Herpesvirus simiae (B virus) Infection in Rhesus Monkeys.2005

    • Author(s)
      H.Yamamoto
    • Journal Title

      Comp.Medicine in press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 実験動物におけるセキュリティー(総括)2004

    • Author(s)
      佐藤 浩
    • Journal Title

      実験動物と環境 11・2

      Pages: 103-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Epizootiological and Epidemiological Study of Hantavirus Infection in Japan2004

    • Author(s)
      N.Lokugamage
    • Journal Title

      Microbiol.lmmunol. 48・11

      Pages: 843-851

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Use of Herpesvirus papio 2 as an Alternative Antigen in immunoblotting assay for B virus Diagnosis2004

    • Author(s)
      S.Tanaka
    • Journal Title

      J.Vet.Med.Sci. 66・5

      Pages: 529-532

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epizootiological and Epidemiological Study of Hantavirus Infection in Japan2004

    • Author(s)
      N.Lokugamage
    • Journal Title

      Microbiol.Immunol. 48・11

      Pages: 843-851

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Allogeneic cell stimulation enhances Cytomegalovirus replication in the early eriod of primary infection in an experimental rat model2003

    • Author(s)
      K.Tamura
    • Journal Title

      J.of Heart and Lung Transplantation 22・4

      Pages: 452-459

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sequence and Genetic Arrangement of the UL Region of the Monkey B Virus(Cercopithecine herpesvirus 1)Genome and Comparison with the UL Region of Other Primate Herpesviruses2003

    • Author(s)
      K.Ohsawa
    • Journal Title

      Arch.Virology 148・5

      Pages: 989-997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Allogeneic cell stimulation enhances Cytomegalovirus replication in the early period of primary infection in an experimental rat model.2003

    • Author(s)
      K. Tamura, et. al.
    • Journal Title

      J. of Heart Lung Transplant. 22

      Pages: 452-459

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sequence and Genetic Arrangement of the U_2 Region of the Monkey B Virus(Cercopithecine herpesvirus 1) Genome and Comparison with the U_2Region of Other Primate Herpesviruses.2003

    • Author(s)
      K. Ohsawa, et. al.
    • Journal Title

      Arch. Virology 148

      Pages: 989-997

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] S.Tanaka, K.Mannen, H.Sato: "Use of Herpesvirus papio 2 as an Alternative Antigen in immunoblotting assay for B virus Diagnosis"J.Vet.Med.Sci.. (in press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-03-31   Modified: 2016-04-21  

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