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Clinical Application of Bionic Baroreflex System

Research Project

Project/Area Number 15300165
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKochi University

Principal Investigator

SATO Takayuki  Kochi University, Medicine, Professor, 医学部, 教授 (90205930)

Co-Investigator(Kenkyū-buntansha) KAKINUMA Yoshihiko  Kochi University, Medicine, Associate Professor, 医学部, 助教授 (60265866)
YAMASAKI Fumiyasu  Kochi University, Medicine, Instructor, 医学部附属病院, 助手 (10243841)
ANDO Motonori  Kochi University, Medicine, Instructor, 医学部, 助手 (20222789)
KATARE Rajesh Gopalrao  Kochi University, Medicine, Instructor, 医学部, 助手 (20380313)
谷 俊一  高知大学, 医学部, 教授 (90136250)
牛田 享宏  高知大学, 医学部附属病院, 助手 (60304680)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2003: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywordsarterial baroreflex / Shy-Drager syndrome / dynamics / sympathetic nerve / orthostatic hypotension / bionics / systems physiology
Research Abstract

Background : We developed a bionic technology for the treatment of central baroreflex failure, and tested its efficacy in restoration of arterial pressure(AP) against a clinical model of orthostatic hypotension during surgery.
Methods and Results : The bionic baroreflex system(BBS) was a negative feedback system controlled by a computer, which sensed AP and automatically computed the frequency (STM) of a pulse train to stimulate sympathetic nerves through an epidural catheter placed at the level of lower thoracic spinal cord. According to a classical feedback control theory, i.e., feedback correction with proportional and integral gain factors, we designed an operational rule for the BBS. We first identified the transfer function from STM to AP by a white-noise system-identification method in 12 sevoflurane-anesthetized patients who underwent an orthopedic surgery of cervical vertebrae, and then determined the feedback correction factors with a numerical simulation to enable the BBS to quickly and stably attenuate an external disturbance on AP. The performance of the designed BBS was examined in a clinical model of orthostatic hypotension (n=21). Without the implementation of the BBS, a sudden deflation of the thigh tourniquet dropped AP by 17±3 mmHg in 10 sec and by 25±2 mmHg in 50 sec. During real-time execution of the BBS, on the other hand, the fall in AP was 9±2 mmHg at 10 sec and 1±2 mmHg at 50 sec, and 0±1 mmHg at 100 sec after the deflation.
Conclusions : The bionic technology for the artificial baroreflex system would be applicable to humans.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (78 results)

All 2005 2004 2003 Other

All Journal Article (55 results) Book (3 results) Patent(Industrial Property Rights) (2 results) Publications (18 results)

  • [Journal Article] Effect of serum albumin on QRS wave amplitude in patients free of heart disease.2005

    • Author(s)
      Kudo, Y
    • Journal Title

      Am J Cardiol 95

      Pages: 789-791

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive nonhypoxic induction of HIF-1α.2005

    • Author(s)
      Kakinuma, Y
    • Journal Title

      FEBS Lett 579

      Pages: 2111-2118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel function of neuronal PAS damain protein 1 in erythropoietin expression in neuronal cells.2005

    • Author(s)
      Ohsawa, S
    • Journal Title

      J Neurosci Res 79

      Pages: 451-458

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] HIF-1α is involved in the attenuation of experimentally induced rat glomerulonephritis.2005

    • Author(s)
      Kudo, Y
    • Journal Title

      Nephron Exp Nephrol 100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Continuous intravenous administration of a low dose of epoprostenol greatly decreases serum level of endothelin-1 in primary pulmonary hypertension.2005

    • Author(s)
      Kakinuma, Y
    • Journal Title

      Angiology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association between arterial stiffness and platelet activation.2005

    • Author(s)
      Yamasaki, F
    • Journal Title

      J Hum Hypertens (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein2005

    • Author(s)
      Ando, M
    • Journal Title

      Circulation (in press)

    • NAID

      120001794313

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cisplatinの心嚢内注入が奏功した乳癌心嚢転移の1例2005

    • Author(s)
      杉本健樹
    • Journal Title

      癌と化学療法 (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Acetyicholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive nonhypoxic inductionof HIF-1α.2005

    • Author(s)
      Kakinuma, Y
    • Journal Title

      FEBS Lett 579

      Pages: 2111-2118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] HIF-1α is involved in the attenuation of experimentally induced rat glomerulonephritis2005

    • Author(s)
      Kudo, Y
    • Journal Title

      Nephron Exp Nephrol 100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Continuous intravenous administration of a low dose of epoprostenol greatly decreases serum level of endothelin- 1 in primary pulmonary hypertension.2005

    • Author(s)
      Kakinuma, Y
    • Journal Title

      Angiology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efferent Vagal Nerve Stimulation Protects Heart against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein.2005

    • Author(s)
      Ando, M
    • Journal Title

      Circulation (in press)

    • NAID

      120001794313

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive nonhypoxic induction of HIF-1α.2005

    • Author(s)
      Kakinuma, Y
    • Journal Title

      FEBS Lett (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] HIF-1α is involved in the attenuation of experimentally induced rat glomerulonephritis.2005

    • Author(s)
      Kudo, Y
    • Journal Title

      Nephron Exp Nephrol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel function of neuronal PAS damain protein 1 in erythropoietin expression in neuronal cells.2005

    • Author(s)
      Ohsawa, S
    • Journal Title

      J Neurosci Res 79・(4)

      Pages: 451-458

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neural reflex hypotension induced by very small dose of hypertonic NaCl solution in anesthetized rats.2005

    • Author(s)
      Zhang, D
    • Journal Title

      Jpn J Physiol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats.2004

    • Author(s)
      Li, M
    • Journal Title

      Circulation 109

      Pages: 120-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bionic epidural stimulation restores arterial pressure regulation during orthostasis.2004

    • Author(s)
      Yanagiya, Y
    • Journal Title

      J Appl Physiol 97

      Pages: 984-990

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of electrical modification of cardiomyocytes on transcriptional activity through 5'AMP-activated protein kinase.2004

    • Author(s)
      Kakinuma, Y
    • Journal Title

      J Cardiovasc Pharmacol 44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] A Self-calibrating telemetry system for measurement of ventricular pressure-volume relations in conscious, freely moving rats.2004

    • Author(s)
      Uemura, K
    • Journal Title

      Am J Physiol 287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice.2004

    • Author(s)
      Maki, S
    • Journal Title

      Life Sci 74

      Pages: 1105-1118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of β-catenin.2004

    • Author(s)
      Kakinuma, Y
    • Journal Title

      J Neurosci Res 77

      Pages: 653-661

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A mechanism of impaired mobility of oligodendrocyte progenitor cells by tenascin C through modification of wnt signaling.2004

    • Author(s)
      Kakinuma, Y
    • Journal Title

      FEBS Lett 568

      Pages: 60-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels.2004

    • Author(s)
      Katare, RG
    • Journal Title

      Int J Cardiol 96

      Pages: 41-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epidermal growth factor and insulin inhibit cell death in pancreatic beta cells by activation of PI3-kinase/AKT signaling pathway under oxidative stress.2004

    • Author(s)
      Maeda, H
    • Journal Title

      Transplant Proc 36

      Pages: 1163-1165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 神経インターフェイス技法を用いた心不全治療と術中血圧制御2004

    • Author(s)
      佐藤隆幸
    • Journal Title

      循環制御 25

      Pages: 348-351

    • NAID

      10014245777

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] バイオニックラットからの提言:迷走神経の電気刺激療法2004

    • Author(s)
      佐藤隆幸
    • Journal Title

      循環制御 25

      Pages: 23-27

    • NAID

      10012695187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 高血圧治療における塩酸ベニジピンとAII受容体拮抗薬併用療法の検討2004

    • Author(s)
      佐藤恭子
    • Journal Title

      新薬と臨床 53

      Pages: 13-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 腹臥位での手術中に冠動脈攣縮から心室頻拍へ移行した1症例2004

    • Author(s)
      真鍋 渉
    • Journal Title

      麻酔 53

      Pages: 1065-1068

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 病的肥満を伴うレノックス症候群患者の麻酔経験2004

    • Author(s)
      横山武志
    • Journal Title

      臨床麻酔 28

      Pages: 1811-1814

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A self-calibrating telemetry system for measurement of ventricular pressure-volume relations in conscious, freely moving rats.2004

    • Author(s)
      Uemura, K
    • Journal Title

      Am J Physiol 287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of β-catenin.2004

    • Author(s)
      Kakinuma, Y
    • Journal Title

      J Neurosci Res 7

      Pages: 653-661

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epidermal growth factor and insulin inhibit cell death in pancreatic beta cells by activatio n of P13-kinase/AKT signaling pathway under oxidative stress.2004

    • Author(s)
      Maeda, H
    • Journal Title

      Transplant Proc 36

      Pages: 1163-1165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A self- calibrating telemetry system for measurement of ventricular pressure-volume relations in conscious, freely moving rats.2004

    • Author(s)
      Uemura, K
    • Journal Title

      Am J Physiol 287・(6)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Establishment of hypoxia inducible factor-la overexpressing cells that produce endothelin-1.2004

    • Author(s)
      Takanashi, M
    • Journal Title

      J Cardiovasc Pharmacol 44

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bionic epidural stimulation restores arterial pressure regulation during orthostasis.2004

    • Author(s)
      Yanagiya, Y
    • Journal Title

      J Appl Physiol 97・(3)

      Pages: 984-990

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of β-catenin.2004

    • Author(s)
      Kakinuma, Y
    • Journal Title

      J Neurosci Res 77・(5)

      Pages: 653-661

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A mechanism of impaired mobility of oligodendrocyte progenitor cells by tenascin C through modification of wnt signaling.2004

    • Author(s)
      Kakinuma, Y
    • Journal Title

      FEBS lett 568・(1-3)

      Pages: 60-64

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels.2004

    • Author(s)
      Katare, Rajesh G
    • Journal Title

      Int J Cardiol 96・(1)

      Pages: 41-49

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epidermal growth factor and insulin inhibit cell death in pancreatic beta cells by activation of P13-kinase/AKT signaling pathway under oxidative stress.2004

    • Author(s)
      Maeda H
    • Journal Title

      Transplant Proc 36・(4)

      Pages: 1163-1165

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 神経インターフェイス技法を用いた心不全治療と術中血圧制御2004

    • Author(s)
      佐藤隆幸
    • Journal Title

      循環制御 25・(4)

      Pages: 348-351

    • NAID

      10014245777

    • Related Report
      2004 Annual Research Report
  • [Journal Article] バイオニックラットからの提言:迷走神経の電気刺激療法2004

    • Author(s)
      佐藤隆幸
    • Journal Title

      循環制御 25・(1)

      Pages: 23-27

    • NAID

      10012695187

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dynamics of sympathetic baroreflex control of arterial pressure in rats.2003

    • Author(s)
      Sato, T
    • Journal Title

      Am J Physiol 285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Carotid-sinus baroreflex modulation of core and skin temperatures in rats : an open-loop approach.2003

    • Author(s)
      Zhang, D
    • Journal Title

      Jpn J Physiol 53

      Pages: 461-466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biphasic response of action potential duration to sudden sympathetic stimulation in anesthetized cats.2003

    • Author(s)
      Tatewaki, T
    • Journal Title

      Circ J 67

      Pages: 876-880

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aquaporin-1(AQP1) is expressed in the stria vascularis of rat cochlea.2003

    • Author(s)
      Sawada, S
    • Journal Title

      Hear Res 181

      Pages: 15-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional importance of degenerative spondylolisthesis in cervical spondylotic myelopathy in the elderly.2003

    • Author(s)
      Tani, T
    • Journal Title

      Spine 28

      Pages: 1128-1134

    • NAID

      10017366173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Paradoxical enhancement of spinal-cord-evoked potentials rostral and caudal to the site of progressive cord compression in the cat.2003

    • Author(s)
      Kishimoto, H
    • Journal Title

      Spinal Cord 41

      Pages: 231-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Recovery of spinal cord conduction after surgical decompression for cervical spondylotic myelopathy : serial somatosensory evoked potential2003

    • Author(s)
      Ishida, K
    • Journal Title

      Am J Phys Med Rehabil 82

      Pages: 130-136

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Rhythm-independent feature of heart rate dynamics common to atrial fibrillation and sinus rhythm in patients with paroxysmal atrial fibrillation2003

    • Author(s)
      Sato, K
    • Journal Title

      J Cardiol 42

      Pages: 269-276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical significance of low voltage in asymptomatic patients with pericardial effusion free of heart disease.2003

    • Author(s)
      Kudo, Y
    • Journal Title

      Chest 124

      Pages: 2064-2067

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Left ventricular free wall rupture after reperfusion therapy for acute myocardial infarction.2003

    • Author(s)
      Sugiura, T
    • Journal Title

      Am J Cardiol 92

      Pages: 282-284

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aspirin reversal--an incremental administration of aspirin shortens the bleeding time prolonged by low-dose aspirin.2003

    • Author(s)
      Yokoyama, T
    • Journal Title

      Masui 52

      Pages: 399-401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Aquaporin-1 (AQP1) is expressed in the stria vascularis of rat cochlea.2003

    • Author(s)
      Sawada, S
    • Journal Title

      Hear Res 181

      Pages: 15-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Rhythm-independent feature of heart rate dynamics common to atrial fibrillation and sinus rhythm in patients with paroxysmal atrial fibrillation.2003

    • Author(s)
      Sato, K
    • Journal Title

      J Cardiol 42

      Pages: 269-276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Bionic Baroreflex in PRIMER ON THE AUTONOMIC NERVOUS SYSTEM Second Edition.(edited by Robertson D et al.)2005

    • Author(s)
      Sato, T
    • Publisher
      Elsevier Science(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 起立性低血圧の機序と治療「Annual Review神経 2004」XV.自律神経疾患(柳澤信夫, 篠原幸人, 岩田 誠, 清水輝夫, 寺本 明編)2004

    • Author(s)
      佐藤隆幸
    • Total Pages
      6
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 橈骨動脈と大動脈の脳波の比較-伝達関数の意義「脈をどう診るか-新しい脈波の臨床応用」(臨床動脈波研究会 小澤利男, 増田善昭, 山科 章 編)2003

    • Author(s)
      佐藤隆幸
    • Total Pages
      8
    • Publisher
      Elsevier Science(USA)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 自動血圧制御装置2004

    • Inventor(s)
      小椋 敏彦, 佐藤 隆幸, 山崎 文靖
    • Industrial Property Rights Holder
      コーリンメディカルテクノロジー株式会社
    • Industrial Property Number
      2004-171875
    • Filing Date
      2004-06-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 生体圧迫装置および血圧測定装置2004

    • Inventor(s)
      小椋 敏彦, 佐藤 隆幸, 山崎 文靖
    • Industrial Property Rights Holder
      コーリンメディカルテクノロジー株式会社
    • Industrial Property Number
      2004-171876
    • Filing Date
      2004-06-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Publications] Zhang D: "Neural reflex hypotension induced by very small dose of hypertonic NaCl solution in anesthetized rats."Jpn J Physiol. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kakinuma Y: "Continuous intravenous administration of a low dose of epoprostenol greatly decreases serum level of endothelin-1 in primary pulmonary hypertension."Angiology. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Li M: "Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats."Circulation. 109. 120-124 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Maki S: "The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice."Life Sciences. 74. 1105-1118 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Zhang D: "Carotid-sinus baroreflex modulation of core and skin temperatures in rats : an open-loop approach."Jpn J Physiol. 53. 461-466 (2003)

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  • [Publications] Tatewaki T: "Biphasic response of action potential duration to sudden sympathetic stimulation in anesthetized cats."Circ J. 67. 876-880 (2003)

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  • [Publications] Sato T: "Dynamics of sympathetic baroreflex control of arterial pressure in rats."Am J Physiol. 285. R262-R270 (2003)

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  • [Publications] Sawada S: "Aquaporin-1 (AQP1) is expressed in the stria vascularis of rat cochlea."Hear Res. 181. 15-19 (2003)

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  • [Publications] Tani T: "Functional importance of degenerative spondylolisthesis in cervical spondylotic myelopathy in the elderly."Spine. 28. 1128-1134 (2003)

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  • [Publications] Kishimoto H: "Paradoxical enhancement of spinal-cord-evoked potentials rostral and caudal to the site of progressive cord compression in the cat."Spinal Cord. 41. 231-238 (2003)

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  • [Publications] Ishida K: "Recovery of spinal cord conduction after surgical decompression for cervical spondylotic myelopathy : serial somatosensory evoked potential studies."Am J Phys Med Rehabil. 82. 130-136 (2003)

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  • [Publications] Sato K: "Rhythm-independent feature of heart rate dynamics common to atrial fibrillation and sinus rhythm in patients with paroxysmal atrial fibrillation"J Cardiol. 42. 269-276 (2003)

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  • [Publications] Kudo Y: "Clinical significance of low voltage in asymptomatic patients with pericardial effusion free of heart disease."Chest. 124. 2064-2067 (2003)

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  • [Publications] Sugiura T: "Left ventricular free wall rupture after reperfusion therapy for acute myocardial infarction."Am J Cardiol. 92. 282-284 (2003)

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  • [Publications] Yokoyama T: "Aspirin reversal--an incremental administration of aspirin shortens the bleeding time prolonged by low-dose aspirin."Masui. 52. 399-401 (2003)

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  • [Publications] 佐藤隆幸: "起立性低血圧の機序と治療.「Annual Review 神経 2004」(柳澤信夫,篠原幸人,岩田 誠,清水輝夫,寺本 明 編)XV.自立神経疾患"中外医学社. 6 (2004)

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  • [Publications] Sato T: "Bionic Baroreflex in PRIMER ON THE AUTONOMIC NERVOUS SYSTEM Second Edition. edited by Robertson D et al."Elsevier Science(in press). (2004)

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  • [Publications] 佐藤隆幸: "橈骨動脈と大動脈の脳波の比較-伝達関数の意義.「脈をどう診るか-新しい脈波の臨床応用」(臨床動脈波研究会 小澤利男,増田善昭,山科 章 編)"Elsevier Science (USA). 8 (2003)

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Published: 2003-04-01   Modified: 2021-04-07  

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