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Pulmonary delivery of microspheres loaded with antituberculosis agents to alveolar macrophages for development of antituberculosis therapy

Research Project

Project/Area Number 15300170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo University of Science

Principal Investigator

TERADA Hiroshi  Tokyo University of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (00035544)

Co-Investigator(Kenkyū-buntansha) MAKINO Kimiko  Tokyo University of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (40147509)
KOJIMA Shuji  Tokyo University of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (90119579)
IKEKITA Masahiko  Tokyo University of Science, Faculty of Pharmaceutical Sciences, Professor, 理工学部, 教授 (70138981)
SOMA Gen-Ichiro  Tokushima Bunri University, Institute for Health Science, Professor, 健康科学研究所, 教授 (00158990)
SHINOHARA Yasuo  The University of Tokushima, Institute for Genome Research, Professor, ゲノム機能研究センター, 教授 (60226157)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2003: ¥6,900,000 (Direct Cost: ¥6,900,000)
KeywordsPLGA / pulmonary delivery / anti-tuberculosis agent / tuberculosis / alveolar macrophage / tuberculosis therapy / phagocytosis / DDS / 微粒子製剤 / PLGA微粒子製剤 / ファゴソーム / 薬物送達システム(DDS) / ポリ乳酸グリコール酸共重合体(PLGA) / 結核菌 / NR8383細胞株 / リファンピシン
Research Abstract

For development of the efficient therapy for overcoming tuberculosis by pulmonary delivery to alveolar macrophages of microspheres containing anti-tuberculosis agent, it is important to examine 1) characterization of microspheres necessary for efficient phagocytosis by microspheres, 2) effect of phagocytosed microspheres on the physiological conditions of macrophages, and 3) phagocytosis of microspheres delivered to alveoli and the bactericidal effect on Mycobacterium tuberculosis. Hence, the microspheres using PLGA (co-polymer consisting of lactic acid and glycolic acid) as a base, and rifampicin as an anti-tuberculosis agents were prepared by spray dry method. Then, the results shown below were obtained. 1) the 3 μm microspheres were most efficient for phagocytosis by each alveolar macrophage cell and they were well taken up by high population of macrophages in the alveoli, 2) the 3 μm microspheres did not affect the variability of macrophages and did not induce NO and TNF-a, showing that PLGA microspheres were not toxic to alveolar macrophages, and 3) PLGA microspheres were well delivered to the rat alveoli, and more than 60% of the microspheres delivered were phagocytosed by alveolar macrophages. These results showed that the pulmonary delivery of PLGA microspheres loaded with anti-tuberculosis agent will be efficient for overcoming tuberculosis.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (67 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (52 results) Book (2 results) Patent(Industrial Property Rights) (8 results) Publications (5 results)

  • [Journal Article] Roles of adjoining Asp and Cys residues of first matrix-facing loop in transport activity of yeast.2006

    • Author(s)
      Y.Kihira, M.Hashimoto, H.Terada et al.
    • Journal Title

      Biochemistry 139

      Pages: 575-582

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inherent potential for production of tumor necrosis factor-α by human intestinaL macrophages.2006

    • Author(s)
      K.Nakata, N.Nagasue, S.Natori, H.Terada et al.
    • Journal Title

      Intemational Journal of Colorectal Diseases 21

      Pages: 339-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Selective delivery of rifampicin incorporated into poly (DL-lactic-co-glycolic)acid microspheres.2006

    • Author(s)
      A.Yoshida, H.Inagawa, K.Makino, H.Terada et al.
    • Journal Title

      Microbes and Infection 8

      Pages: 2484-2491

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The structure of the second cytosolic loop of the yeast mitochondrial ADP/ATP carrier AAC2.2006

    • Author(s)
      A.Iwahashi, Y.Kihira, E.Majima, H.Terada et al.
    • Journal Title

      Mitochondrion 6

      Pages: 245-251

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] VDAC1, having a shorter N-terminus than VDAC2 but showing the same migration in an SDS-polyacrylamide gel.2006

    • Author(s)
      T.Yamamoto, Y.Yoshimura, N.Yamazaki, H.Terada et al.
    • Journal Title

      Journal of Proteome Research 5(12)

      Pages: 3336-3344

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inherent potential for production of tumor necrosis factor- by human intestinal macrophages.2006

    • Author(s)
      K.Nakat a, N.Nagasue, S.Natori, H.Terada, et al.
    • Journal Title

      International Journal of Colorectal Diseases 21

      Pages: 339-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Selective delivery of rifampicin incorporated into pol (DL-lactic-co-glycolic) acid microspheres after phagocytosis.2006

    • Author(s)
      A.Yoshida, H.Inagawa, K.Makino, H.Terada, et al.
    • Journal Title

      Microbes and Infection 8

      Pages: 2484-2491

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The structure of the second cytosolic loop of the yeast mitochondrial ADP/ATP carrier AAC2.2006

    • Author(s)
      A.Iwahashi, Y.Kihira, E Majima, H.Terada et al.
    • Journal Title

      Mitochondrion 6

      Pages: 245-251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] VDAC1, having a shorter N-terminus than VDAC2 but showing the same migration in an SDS-polyacrylamide gel.2006

    • Author(s)
      T.Yamamoto, Y.Yoshimura, N.Yamazaki, H.Terada et al.
    • Journal Title

      Journal of Proteome Research 5 (12)

      Pages: 3336-3344

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Roles of adjoining Asp and Cys residues of first ma-trix-facing loop in transport activity of yeast.2006

    • Author(s)
      Y.Kihira, M.Hashimoto, H.Terada, et al.
    • Journal Title

      Biochemistry 139

      Pages: 575-582

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inherent potential for production of tumor necrosis factor-α by human intestinal macrophages.2006

    • Author(s)
      K.Nakata, N.Nagasue, S.Natori, H.Terada, et al.
    • Journal Title

      Int. j. Colorectal Diseases 21

      Pages: 339-347

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selective delivery of rifampicin incorporated into poly (DL-lactic-co-glycolic) acid microspheres after phago.2006

    • Author(s)
      A.Yoshida, H.Inagawa, K.Makino, H.Terada, et al.
    • Journal Title

      Microbes and Infection 8

      Pages: 2484-2491

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The structure of the second cytosolic loop of the yeast mitochondrial ADP/ATP carrier AAC2 is dependent.2006

    • Author(s)
      A.Iwahashi, Y.Kihira, E.Majima, H.Terada, et al.
    • Journal Title

      Mitochondrion 6

      Pages: 245-251

    • Related Report
      2006 Annual Research Report
  • [Journal Article] VDAC1,having a shorter N-terminus than VDAC2 but showing the same migration in an SDS-polyacrylamide gel.2006

    • Author(s)
      T.Yamamoto, Y.Yoshimura, N.Yamazaki, H.terada, et al.
    • Journal Title

      J. Proteome Res. 5(12)

      Pages: 3336-3344

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Essential stage of 3T3-L1 cells for their effective differentiation into fat cells.2005

    • Author(s)
      K.Kajimoto, H.Terada, Y.Baba, Y.Shinohara
    • Journal Title

      Molecular Genetics and Metabolism 85

      Pages: 46-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyanine labeling studies detect conformational changes in region 106-132 of the mitochondrial ADP/ATP carrier.2005

    • Author(s)
      Y.Kihara, E.Majima, Y.Shinohara, H.Terada
    • Journal Title

      Biochemistry 44

      Pages: 184-192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Establishment of in vitro model using NR8383 cells and mycobacterium Bovis calmette-guerin.2005

    • Author(s)
      M.Hino, Kohchi, T.Nishizawa, K.Makino, H.Terada et al.
    • Journal Title

      In Vivo 19

      Pages: 821-830

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Innate-immune therapy for lung carcinoma based on tissue-macrophage activation with lipopolysaccharide.2005

    • Author(s)
      M.Hino, C.Kouchi, T.Nishizawa, K.Makino, H.Terada, et al.
    • Journal Title

      Anticancer Researh 25

      Pages: 3747-3754

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Two critical factors affecting the release of mitochondrial cytochrome c as revealed by studies using.2005

    • Author(s)
      T.Yamamoto, S.Terauchi, A.Tachikawa, H.Terada et al.
    • Journal Title

      Journal of Bioenergetics and Biomembranes 37

      Pages: 299-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 処方改良インドメタシンゲル(K-103-CG)の製剤的特性および抗炎症効果に関する検討2005

    • Author(s)
      寺田 弘
    • Journal Title

      医学と薬学 54

      Pages: 307-310

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Essential stage of 3T3-L1 cells for their effective differentiation into fat cells, as revealed by stud2005

    • Author(s)
      K.Kajimoto, H.Terada, Y.Baba Y.Shinohara
    • Journal Title

      Molecular Genetics & Metabolism 85

      Pages: 46-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyanine labeling studies detect conformational changes i region 106-132 of the mitochondrial ADP/ATP carrier.2005

    • Author(s)
      Y.Kihara, E.Majima, Y.Shinohara, H.Terada
    • Journal Title

      Biochemistry 44

      Pages: 184-192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Establishment of in vitro model using NR8383 cells and mycobacterium Bovis calmette-guerin.2005

    • Author(s)
      M.Hino, T.Nishizawa, K.Makino, H.Terada et al.
    • Journal Title

      In Vivo 19

      Pages: 821-830

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Innate-immune therapy for lung carcinoma based on tissue- macrophage activation with lipopolysaccharide.2005

    • Author(s)
      M.Hino, T.Nishizawa, K.Makino, H.Terada et al.
    • Journal Title

      Anticancer Research 25

      Pages: 3747-3754

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Two critical factors affecting the release of mitochondria' cytochrome c as revealed by studies using.2005

    • Author(s)
      T.Yamamoto, S.Terauchi, H.Terada et al.
    • Journal Title

      Journal of Bioenergetics and Biomembranes 37

      Pages: 299-306

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Essential stage of 3T3-L1 Cells for Their Effective Differentiation into Fat Cells, as Revealed by Studies Using Specific Inhibitors of Mitochondria.2005

    • Author(s)
      K.Kajimoto, H.Terada, Y.Baba, Y.Shinohara
    • Journal Title

      Mol.Genet.Metab. 85

      Pages: 46-53

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cyanine Labeling Studies Detect Conformational Changes in Region 106-132 of the Mitochondrial ADP/ATP Carrier of Sacchaomysces cerevisiae.2005

    • Author(s)
      Y.Kihara, E.Majima, Y.Shinohara, H.Terada
    • Journal Title

      Biochemistry 44

      Pages: 184-192

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Establishment of In Vitro Model using NR8383 Cells and Mycobacterium Bovis Calmette-Guerin that Mimes a Chronic Infection of Mycobaceterium Tuberculosis.2005

    • Author(s)
      M.Hino, Kohchi, T.Nishizawa, H.Inagawa, H.Hori, K.Makino, H.Terada, G.Soma
    • Journal Title

      In Vivo. 19

      Pages: 821-830

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Innate-immune Therapy for Lung Carcinoma Based on Tissue-macrophage Activation with Lipopolysaccharide.2005

    • Author(s)
      M.Hino, C.Kouchi, T.Nishizawa, H.Inagawa, H.Hori, K.Makino, H.Terada, G.Soma
    • Journal Title

      Anticancer Res. 25

      Pages: 3747-3754

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Two Critical Factors Affecting the Release of Mitochondrial Cytochrome c as Revealed by Studies Using N,N'-Dicyclo-hexylcarbodiimide as an Atypical Inducer of Permeability Transition2005

    • Author(s)
      T.Yamamoto, S.Terauchi, A.Tachikawa, K.Yamashita, M.Kataoka, H.Terada, Y.Shinohara
    • Journal Title

      J.Bioenerg.Biomembr. 37

      Pages: 299-306

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 処方改良インドメタシンゲル(K-103-CG)の製剤的特性および抗炎症効果に関する討2005

    • Author(s)
      寺田 弘
    • Journal Title

      医学と薬学 54

      Pages: 307-310

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres.2004

    • Author(s)
      K.Makino, T.Nakajima, M.Shikamura, H.Terada et al.
    • Journal Title

      Colloids Surfaces B : Biointerfaces 36

      Pages: 35-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Utilization of macrophages in anticancer therapy : the macrophage network theory.2004

    • Author(s)
      C.Kochi, H.Inagawa, A.Yoshida, H.Terada et al.
    • Journal Title

      Anticancer Research 24

      Pages: 3311-3320

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Twisting of the second transmembrane alpha-helix of the mitochondrial ADP/ATP carrier.2004

    • Author(s)
      Y.Kihira, A.Iwahashi, E.Majima, H.Terada et al.
    • Journal Title

      Biochemistry 43

      Pages: 15204-15209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multiple effects of DiS-C3(5) on mitochondrial structure and function.2004

    • Author(s)
      T.Yamamoto, A.Tachikawa, S.Terauchi, H.Terada et al.
    • Journal Title

      European Journal of Biochemistry 271

      Pages: 3573-3579

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue.2004

    • Author(s)
      K.Kajimoto, N.Yamazaki, H.Terada, Y.Shinohara, et al.
    • Journal Title

      Journal of Medical Investigation 51

      Pages: 20-28

    • NAID

      110002239093

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres.2004

    • Author(s)
      K.Makino, T.Nakaj ima, M.Shikamura, H.Terada et al.
    • Journal Title

      Colloids Surfaces B : Biointerfaces 36

      Pages: 35-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Utilization of macrophages in anticancer therapy : the macrophage network theory.2004

    • Author(s)
      C.Kochi, H.Inagawa, A.Yos hida, H.Terada et al.
    • Journal Title

      Anticancer Research 24

      Pages: 3311-3320

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue.2004

    • Author(s)
      K.Kajimoto, N.Yamazaki,.H.Terada, Y.Shinohara, et al.
    • Journal Title

      Journal of Medical Investigation 51

      Pages: 20-28

    • NAID

      110002239093

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres.2004

    • Author(s)
      K.Makino, T.Nakajima, M.Shikamura, F.Itoh, S.Ando, H.Terada
    • Journal Title

      Colloids Surfaces B : Biointerfaces 36

      Pages: 35-42

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Utilization of macrophages in anticancer therapy : the macrophage network theory.2004

    • Author(s)
      C.Kochi, H.Inagawa, A.Yoshida, H.Terada, M.Makino, G.Soma
    • Journal Title

      Anticancer Res. 24

      Pages: 3311-3320

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Twisting of the second transmembrane alpha-helix of the mitochondrial ADP/ATP carrier.2004

    • Author(s)
      K.Kihira, A.Iwahashi, E.Majima, H.Terada, Y.Shinohara
    • Journal Title

      Biochemistry 43

      Pages: 15204-15209

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Multiple effects of DiS-C3(5) on mitochondrial structure and function.2004

    • Author(s)
      T.Yamamoto, A.Tachikawa, S.Terauchi, H.Terada, Y.Shinohara
    • Journal Title

      Eur.J.Biochem. 271

      Pages: 3573-3579

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue2004

    • Author(s)
      K.Kajimoto, N.Yamazaki, H.Terada, Y.Shinohara
    • Journal Title

      J.Med.Invest. 51

      Pages: 20-28

    • NAID

      110002239093

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of liposomal phosphatidylserine on phagocytic uptake of liposomes by macrophage-like HL-60RG cells.2003

    • Author(s)
      K.Makino, T.Yoshioka, H.Ohshima, H.Terada et al.
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 29

      Pages: 277-284

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] PCR- select subtraction for characterization of messages differentially expressed in brown compared with white adipose tissue.2003

    • Author(s)
      K.Kajimoto, T.Daikoku, H.Terada, Y.Shinohara, et al.
    • Journal Title

      Molecular Genetics and Metabolism 80

      Pages: 255-261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression profiles of three isoforms of inositol 1,4,5-triphosphate receptor in brown adipose tissue of the rat.2003

    • Author(s)
      K.Kajimoto, T.Daikoku, N.Yamazaki, H.Terada et al.
    • Journal Title

      Biochemical Pharmacology 65

      Pages: 995-998

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The gene encoding muscle-type carnitine palmitoyltransferase2003

    • Author(s)
      N.Yamazaki, Y.Hashimoto, Y.Shinohara, H.Terada et al.
    • Journal Title

      Journal of Biochemistry 133

      Pages: 523-532

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine.2003

    • Author(s)
      K.Kogure, K.Tsuchiya, K.Fukuzawa, H.Terada et al.
    • Journal Title

      Biochimica et Biophysica Acta 1622

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of liposomal phosphatidyl serine on phagocytic uptake of liposomes by macrophage-like HL-6ORG cells.2003

    • Author(s)
      K.Makino, T.Yoshioka, H.Ohshima, H.Terada et al.
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 29

      Pages: 277-284

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] PCR-select subtraction for characterization of messages differentially expressed in brown compared with white adipose tissue.2003

    • Author(s)
      K.Kajimoto, T.Daikoku, H.Terada, Y.Shinohara et al.
    • Journal Title

      Molecular Genetics and Metabolism 80

      Pages: 255-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The gene encoding muscle-type carnitine palmito- yltransferase2003

    • Author(s)
      N.Yamazaki, Y.Hashimoto, H.Terada et al.
    • Journal Title

      Journal of Biochemistry 133

      Pages: 523-532

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 抗菌・抗カビの最新技術とDDSの実際2005

    • Author(s)
      牧野公子, 杣 源一郎, 寺田 弘
    • Total Pages
      283
    • Publisher
      エヌ・ティー・エス
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] Recent advances in antibacterial and antifungal treatment an DDS2005

    • Author(s)
      K.Makino, G.Soma, H.Terad
    • Total Pages
      283
    • Publisher
      N.T.S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 薬物送達システムのシュミレーション方法、シュミトション装置、シュミレーションプログラム2007

    • Inventor(s)
      大矢雅則, 牧野公子, 寺田弘
    • Industrial Property Rights Holder
      大矢雅則, 牧野公子, 寺田弘
    • Industrial Property Number
      2007-037037
    • Filing Date
      2007-02-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 薬物送達システムのシュミレーション方法、シュミレーション装置、シュミレーションプログラム2007

    • Inventor(s)
      大矢雅則, 牧野公子, 寺田弘
    • Industrial Property Rights Holder
      大矢雅則, 牧野公子, 寺田弘
    • Industrial Property Number
      2007-037037
    • Filing Date
      2007-02-16
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 外用剤2006

    • Inventor(s)
      稲木敏男, 寺田弘, 牧野公子
    • Industrial Property Rights Holder
      稲木敏男, 寺田弘, 牧野公子
    • Filing Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 藥物送達粒子及びその製造方法2006

    • Inventor(s)
      牧野公子, 中嶋武尚, 寺田弘
    • Industrial Property Rights Holder
      牧野公子, 中嶋武尚, 寺田弘
    • Industrial Property Number
      2006-111294
    • Filing Date
      2006-04-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 外用剤2006

    • Inventor(s)
      稲木敏男, 寺田弘, 牧野公子
    • Industrial Property Rights Holder
      稲木敏男, 寺田弘, 牧野公子
    • Filing Date
      2006-10-11
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 薬物送達粒子及びその製造方法2006

    • Inventor(s)
      牧野公子, 中嶋武尚, 寺田弘
    • Industrial Property Rights Holder
      牧野公子, 中嶋武尚, 寺田弘
    • Industrial Property Number
      2006-111294
    • Filing Date
      2006-04-13
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 治療薬2003

    • Inventor(s)
      寺田 弘, 牧野公子, 柚 源一郎
    • Industrial Property Rights Holder
      寺田 弘, 牧野公子, 柚 源一郎
    • Filing Date
      2003-08-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 治療薬2003

    • Inventor(s)
      寺田 弘, 牧野 公子, 杣 源一郎
    • Industrial Property Rights Holder
      寺田 弘, 牧野 公子, 杣 源一郎
    • Filing Date
      2003-08-27
    • Related Report
      2004 Annual Research Report
  • [Publications] K.Makino, T.Yashioka, H.Ohshima, H.Terada: "Effects of liposomal phosphatidylserine on phagocytic uptake of liposomes by macrophage-like HL-60RG cells"Colloids and Surfaces B : Biointerfaces. 29. 277-284 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Kajimoto, T.Daikoku, H.Terada, Y.Shinohara: "PCR-select subtraction for characterization of messages differentially expressed in brown compared with white adipose tissue."Molecular Genetics and Metabolism. 80. 255-261 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Kajimoto, T.Daikoku, N.Yamazaki, H.Terada, Y.Shin: "Expression profiles of three isoforms of inositol 1,4,5-trip hosphate receptor in brown adipose tissue of the rat."Biochemical Pharmacology. 65. 995-998 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Yamazaki, Y.Hashimoto, Y.Shinohara, H.Terada: "The gene encoding muscle-type carnitine palmitoyltransferase I"Journal of Biochemistry. 133. 523-532 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Kogure, K.Tsuchiya, K.Fukuzawa, H.Terada: "Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine"Biochimica et Biophysica Acta. 1622. 1-5 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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