| Project/Area Number |
15300177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
KANAI Hiroshi Tohoku University, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (10185895)
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| Co-Investigator(Kenkyū-buntansha) |
SAIJO Yoshifumi Tohoku University, Institute of Development, Aging and Cancer, Associate Professor, 加齢医学研究所, 助教授 (00292277)
小岩 喜郎 東北大学, 大学院・医学系研究科, 助教授 (80091685)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2004: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2003: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | Ultrasonic Doppler method / Local change in thickness / Myocardial contraction / relaxation / Myocardial motility / Spectrum analysis / Color-coded display / Tissue Characterization / phased tracking method / 医用超音波工学 / 心臓壁弾性特性 / 非侵襲計測 / 組織性状診断 / 心臓壁粘性特性 / ラム波伝搬 / 粘弾性特牲 / 心筋 / バイオレオロジー |
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| Research Abstract |
For the serious heart diseases, the different transmural layers of the myocardium have transmural heterogeneity with respect to the strength of contraction. A method for measuring such transmural heterogeneity with sufficient spatial resolution has never been developed. In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed. Moreover, a novel method for measuring the myocardial viscoelasticity was developed and its principle was confirmed by the basic experiments and in vivo experiments as follows :
1.In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed.
2.Based on the basic experiments using a spherical shell made of silicone rubber, which physical parame
… More
ters are known, as a heart-mimicking phantom, the accuracy of the measurement of the developed method was confirmed.
3.Moreover, this study developed the following novel method for noninvasively measuring the myocardial viscoelasticity at the beginning of diastole and for imaging the transmural heterogeneity in the propagation of the elastic waves. The method was applied to healthy subjects and patients with heart diseases. By this method, a velocity signal of the heart wall can be successfully detected with sufficient reproducibility. In this study, the pulsive waves were measured almost simultaneously at about 160 points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions, obtained by the Fourier transform of the measured waves, clearly revealed wave propagation along the heart wall for the first time. Based on this phenomenon, we developed a means to measure the myocardial viscoelasticity in vivo using the model of the Lamb wave propagation in a viscoelastic plate. This method has a potential to noninvasively evaluate the myocardial viscoelasticity. Less
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