| Project/Area Number |
15300179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAGANO Isamu Kanazawa University, Graduate School of Natural Science & Technology, Professor, 自然科学研究科, 教授 (50019775)
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| Co-Investigator(Kenkyū-buntansha) |
YAGITANI Satoshi Kanazawa University, Graduate School of Natural Science and Technology, Associate Professor, 自然科学研究科, 助教授 (30251937)
TAZAWA Kenji Toyama Medical and Pharmaceutical University, Faculty of Medicine, Professor, 医学部, 教授 (80018887)
ODA Makoto Kanazawa University, Graduate School of Medical Science, Lecturer, 医学系研究科, 講師 (50224241)
KASAHARA Toshio Kanazawa University, Graduate School of Medical Science, Lecturer, 医学部附属病院, 講師 (30272967)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2004: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2003: ¥8,600,000 (Direct Cost: ¥8,600,000)
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| Keywords | Induction heating / Cancer treatment / Ritz wire / Applicator / Ferrite / One-dimensional heat conduction simulation / EMC / 小電力化 / 小型化 / 癌 / 動物実験 / シミュレーション / 共振鋭度 |
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| Research Abstract |
-Device development
In order to extend the maximum range for cancer treatment, we have improved the first prototype device (which could generate the magnetic field of 3 mT at 40 mm from the induction coil). By increasing the output power to 10kW, the resonance current to 300 A, and the coil diameter to 30 cm, we have been able to realize 3 mT at about 90 mm, which was confirmed by the actual measurement of induced magnetic field strength from the improved device.
-Highly effective applicator
(a)Use of a high magnetic permeability material (ferrite)
The range of the treatment has been further extended to 120 mm, by placing a ferrite board under the coil. From an electromagnetic simulation, we have also confirmed that this ferrite board reduces the electromagnetic waves leaking from the applicator.
(b)Use of "litz wire" with low "high-frequency resistance"
The copper loss of the applicator on a previous device was as high as 5 kW, because of the high "high-frequency resistance" of the coil wir
… More
es. Making use of the low "high-frequency resistance" of "litz wire," we have reduced the power consumption of the device by approximately 30%.
-DM heating mechanisms
In order to clarify the heating mechanism of Dextran Magnetite (DM), we have measured its "hysteresis loss" by filling the DM solution into a toroidal tube. As a result, we have found that the hysteresis loss occupies about 40 percent of the total amount of DM heating.
-Simulation of cooling blood flow
The cooling mechanism of the heated regions due to the blood flow has been examined by a one-dimensional heat conduction simulation.
-Eddy current reduction
In the tests using large animals such as pigs, it is necessary to reduce the "eddy current heating" on normal cells. By assuming a simple model, we have found theoretically that the eddy current heating can be reduced even when the DM is sufficiently heated, by adjusting the output frequency of the device as approximately 150 kHz.
-Other EMC measurement techniques have been developed associated with the induction heating. Less
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