| Project/Area Number |
15300183
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | Osaka University, Graduate School of Medicine |
|---|
Principal Investigator |
BEPPU Shintaro Osaka University, Graduate School of Medicine, Prof., 医学系研究科, 教授 (40113500)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIKURA Fuminobu Osaka University, Graduate School of Medicine, Associate Prof., 医学系研究科, 助教授 (50303970)
MINE Yoshitaka Toshiba Medical Systems, 主務(技術研究者)
嶺 善隆 (株)東芝医用機器, 主務(技術研究社)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2003: ¥4,600,000 (Direct Cost: ¥4,600,000)
|
|---|
| Keywords | Ultrasound / Contrast / Microbubble / Contrast Echo / Perfusion Imaging / Selective |
|---|
| Research Abstract |
Background : Intravenous myocardial contrast echocardiography (MCE) cannot identify each perfusion area of coronary vessels separately. However, by destroying microbubbles passing through a specific vessel using high-power ultrasound during intravenous MCE, vessel-selective perfusion imaging (VSPI) may he feasible.
Methods : In 10 open-chest dogs, intermittent short-axis images were obtained during Definity infusion using a Sequoia 512 system. For VSPI, an S3 probe coupled to a Sonos 5500 was placed on the proximal left circumflex(LCx) artery. High-power ultrasound pulses were transmitted to destroy bubbles passing through the LCx artery. A negative contrast area on VSPI was considered to represent the perfusion area of the LCx artery (LCx-VSPI). A negative contrast area on conventional MCE during LCx occlusion (LCx-Occ) and a region without staining by Evans blue dye (LCx-EB) were used as gold standards for defining the LCx perfusion area. LCx-VSPI was compared with LCx-Occ and LCx-EB.
Results : Despite lack of LCx artery occlusion, high-power destructive pulses produced a definite area of negative contrast on the LCx region. Decreased power of ultrasound pulses resulted in disappearance of the negative contrast area. An excellent relationship was demonstrated between both LCx-VSPI and LCx-Occ (r=0.93,P<.0001), and LCx-VSPI and LCx-EB (r=0.92,P=.0002).
Conclusion : VSPI during intravenous MCE may be feasible for noninvasive assessment of perfusion areas associated with specific vessels.
|
