| Project/Area Number |
15300191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
IZUMI Shinichi Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (80176239)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Takeo Tohoku University, Hospital, Lecturer, 病院・講師 (30282130)
中里 信和 広南病院, 臨床研究部長(研究職) (80207753)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥12,900,000 (Direct Cost: ¥12,900,000)
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| Keywords | stroke / hemiplegia / transcranial magnetic stimulation / therapy / 脳神経疾患 / 脳卒中 / MRI |
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| Research Abstract |
Purpose : We evaluated therapeutic effectiveness of transcranial magnetic stimulation (TMS) during maximal effort at a target movement in patients with chronic hemiplegia involving the hand.
Subjects : 9 stroke patients with hemiplegia for at least 6 months
Design : Double-blinded trial
Methods : For the intervention group (n=5), TMS (100 stimuli ; intensity, 80% of stimulator output ; interstimulus interval, 10 sec) was administered at the optimal site for the extensor digitorum muscle of the affected side weekly during maximal effort at finger extension for 4 weeks. For control group (n=4), sham stimulation was delivered otherwise in the same way as the intervention group. The outcome measures were Brunnstrom's recovery stage, Stroke Impairment Assessment Set (SIAS), Modified Ashworth Scale (MAS) for the wrist, Manual Function Test (MFT), tested just before the 1st and immediately after 4th session.
Results : All the participants completed the trial, without any adverse. 4 participants of the intervention group showed improvement for either MAS or MFT, while participants of the control group showed neither of these scales (chi square test, P<0.05). One participant of each group showed improvement of the hand motor function for either Brunnstrom's recovery stage or SIAS. Either MAS or MFT improved in all the participants who showed enhancement of amplitudes for motor evoked potentials to TMS more than 30%.
Conclusions : Repetitive TMS over the affected hemisphere of the hemiplegic stroke patients synchronized with maximal effort at a target movement improves the voluntary movement or reduces spasticity.
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