| Project/Area Number |
15300204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Department of Rehabilitation and Physical Medicine, Kagoshima University Hospital |
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Principal Investigator |
TANAKA Nobuyuki Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Professor, 医学部・歯学部附属病院, 教授 (40041454)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Satoshi Kagoshima University, Graduate school of Medical and Dental Sciences, Research associate, 大学院・医歯学総合研究科, 助手 (00343369)
YOSHIDA Akira Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Research associate, 医学部・歯学部附属病院, 助手 (40347109)
NAKAGAWA Shiro Kagoshima University, Graduate school of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (70073666)
HORINOUCHI Keisuke Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Resident, 医学部・歯学部附属病院, 医員
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | muscle strengthening / molecular biology / transcription factor / rehabilitation medicine / rat / 成長因子 |
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| Research Abstract |
Aim of this study is to clarify the correlation between plasticity of central nervous system and various stimulation concerned as the main mechanism of functional recovery from dysfunction of central nervous system. The plasticity of central nervous system play a important role on the recovery of central nervous disease like stroke as well as heeling of lesion. Kaas reported that cortical reorganization made functional recovery after cortical injury on primate. Nudo et al. indicated the recovery of paralytic finger is obtained from repetitive exercise of the finger with enlargement of cortical finger motor area. Ikeda indicated cortical activity of transcription factor was enhanced immediate after spinal cord injury. However, there is no study about which stimulation is better on functional recovery. This study is to investigate the nature of stimulation which enhances the recovery on central nervous disease like stroke or spinal cord injury and to obtain mere recovery on clinical rehabilitation.
We made cerebral infarction model using photosensitive die Rose-bengal and irradiate the 560nm green light on rat sensori-motor cortex and evaluated the functional recovery by Beam Walking test. Then we examined the expression of neurotrophic factor GDNF on the infarcted cortex. The expression of GDNF is significantly increased on the surrounding infarction at the period of functional recovery. Then we investigated the rehabilitative exercise effects on the hemiplegic infarcted rat. There is significant change between the exercise group and the non-exercise group. Additionally, complex exercise group recovered significantly earlier than simple exercise group. These findings suggested that appropriate exercise has more effects to functional recovery.
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