• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biological Responses to Extremely Low Dose Radiation

Research Project

Project/Area Number 15310042
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionOsaka Prefecture University

Principal Investigator

SHIOMI Nobuyuki (2004-2005)  Osaka Prefecture University, Organization for University-Industry-Government Cooperation, Professor, 産学官連携機構, 教授 (90100198)

米澤 司郎 (2003)  大阪府立大学, 先端科学研究所, 教授 (80090463)

Co-Investigator(Kenkyū-buntansha) YAGI Takashi  Osaka Prefecture University, Organization for University-Industry-Government Cooperation, Professor, 産学官連携機構, 教授 (80182301)
MATSUDA Yatsuka  Osaka Prefecture University, Organization for University-Industry-Government Cooperation, Associate Professor, 産学官連携機構, 助教授 (70090438)
TANIGUCHI Ryoichi  Osaka Prefecture University, Organization for University-Industry-Government Cooperation, Associate Professor, 産学官連携機構, 助教授 (60155215)
SHIRAISHI Kazunori  Osaka Prefecture University, Organization for University-Industry-Government Cooperation, Assistant Professor, 産学官連携機構, 助手 (40347513)
KAWANISHI Masanobu  Osaka Prefecture University, Organization for University-Industry-Government Cooperation, Assistant Professor, 産学官連携機構, 助手 (70332963)
汐見 信行  大阪府立大学, 先端科学研究所, 教授 (90100198)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥15,600,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2003: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsBackground Radiation / Adaptive Response / Radiation Hormesis / Paramecium tetraurelia / Gamma Ray / Neutron / 放射線ホルミシス / 低線量放射線 / 生物影響
Research Abstract

We constructed a radiation-shield box containing an apparatus for cell growth experiments. The box was made of 15 cm-thick iron surrounded by 10 cm-thick paraffin. Background natural radiation dose of gamma ray and neutron in the shield was decreased to 1/40 and 1/6, respectively, compared with that of outside the shield.
Paramecium tetraurelia mating type 4 was cultured for 10 days in and out of the shield box. The growth rate was not affected by the radiation shield in any experimental condition we adopted. This does not support the findings of Planell et al. The Paramecium tetraurelia was then cultured from autogamy to the end of proliferation (about 3 months) in and out of the shield box. The growth rate was decreased significantly by the shield, and recovered by a ^<60>Co gamma ray (0.018 μGy/h) source put in the box.
Mouse lymphoma L5178Y cells were cultured for 10 days in and out of the shield box. The growth rate of the cells was significantly reduced by the shield of the background radiation. This result is consistent to the findings of Takizawa et al. The reduction of the growth rate by radiation shielding was not found in the radiosensitive mutant M10 cells that lack XRCC4 protein, which means that XRCC4 has an important role for this phenomenon.
Our results can be explained as follows. Organisms live under low background radiation that may become stimuli for gene expression to proliferate cells of the organisms.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (19 results)

All 2006 2005 2004 2003 Other

All Journal Article (15 results) Book (1 results) Publications (3 results)

  • [Journal Article] 生物は放射線に「適応応答」する2006

    • Author(s)
      米澤司郎
    • Journal Title

      月間エネルギー 39(3)

      Pages: 46-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 生物は放射綜に「適応応答」する2006

    • Author(s)
      米澤司郎
    • Journal Title

      月刊エネルギー 39(3)

      Pages: 46-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Translesion DNA synthesis across mono ADP-ribosylated deoxyguanosine by Y-family DNA polymerases.2006

    • Author(s)
      M.Kawanishi, K.Matsukawa, E.Ohashi, T.Takamura, Y.Totsuka, W.Watanabe, T.Sugimura, K.Wakabayashi, F.Hanaoka, H.Ohmori, T.Yagi
    • Journal Title

      New Developments in Mutation Research (Charles L.Valon (eds.))(Nova Science Publishers, NY, USA) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine.2006

    • Author(s)
      Arlt, M.Volker
    • Journal Title

      International Journal of Cancer 118・9

      Pages: 2139-2146

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Translesion DNA synthesis across mono ADP-ribosylated dG by Y-family DNA polymerases.2006

    • Author(s)
      Kawanishi, Masanobu
    • Journal Title

      Developments in Mutation Research in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.2005

    • Author(s)
      M.Toyoshima
    • Journal Title

      Oncogene 24(20)

      Pages: 3229-3235

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.2005

    • Author(s)
      M.Toyoshima, T.Shimura, S.K.Adiga, M.Taga, K.Shiraishi, M.Inoue, Z.M.Yuan, O.Niwa
    • Journal Title

      Oncogene 24(20)

      Pages: 3229-3235

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radioresistance of mammals induced by low level chronic irradiation : modeling and and experimental investigations.2004

    • Author(s)
      O.A.Smirnova
    • Journal Title

      Health Physics 87(4)

      Pages: 366-374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increase in endogenous spleen colonies without recovery of blood cell counts in radioadaptive survival response in C57BL/6 mice.2004

    • Author(s)
      M.Yonezawa
    • Journal Title

      Radiation Research 161

      Pages: 161-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radioresistance of mammals induced by low level chronic irradiation : modeling and and experimental investigations.2004

    • Author(s)
      O.A.Smirnova, M.Yonezawa
    • Journal Title

      Health Physics. 87(4)

      Pages: 366-374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increase in endogenous spleen colonies without recovery of blood cell counts in radioadaptive survival response in C57BL/6 mice.2004

    • Author(s)
      M.Yonezawa, K.Horie, H.Kondo, K.Kubo
    • Journal Title

      Radiat.Research. 161

      Pages: 161-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radioprotection effect of low level preirradiation on mammals : Modeling and experimental investigation.2003

    • Author(s)
      O.A.Smirnova
    • Journal Title

      Health Physics 85(2)

      Pages: 151-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Point Defects in Silicon Crystals via Complexes with Hydrogen.2003

    • Author(s)
      M.Suezawa
    • Journal Title

      Microelectronic Engineering 66(1-4)

      Pages: 258-267

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radioprotection effect of low level preirradiation on mammals : Modeling and experimental investigation.2003

    • Author(s)
      O.A.Smirnova, M.Yonezawa
    • Journal Title

      Health Physics 85(2)

      Pages: 151-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Point Defects in Silicon Crystals via Complexes with Hydrogen.2003

    • Author(s)
      M.Suezawa, N.Fukata, Y.Takada, R.Taniguchi, F.Hori, R.Oshima
    • Journal Title

      Microelectronic Engineering 66(1-4)

      Pages: 258-267

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] New Developments in Mutation Research2006

    • Author(s)
      M.Kawanishi
    • Publisher
      Nova Science Publishers (In press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Smirnova, O.A., Yonezawa, M.: "Radioprotection effect of low level preirradiation on mammals : modeling and experimental investigation."Health Physics. 85(2). 150-158 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsubara, J., Yonezawa, M.: "Activation of host-defense mechanism induced by exposure to a low dose of radiation : an approach to accumulate evidence on the interaction between the whole body and radiation."International Journal of Low Radiation. 1(2). 180-188 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yonezawa, M., Hone, K., Kondo, H., Kubo, K.: "Increase in endogenous spleen colonies without recovery of blood cell counts in Radioadaptive survival response in C57BL/6 mice."Radiation Research. 161. 161-167 (2004)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi