| Budget Amount *help |
¥11,600,000 (Direct Cost: ¥11,600,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2003: ¥4,100,000 (Direct Cost: ¥4,100,000)
|
|---|
| Research Abstract |
We have synthesized epoxyquinol A, B, C and epoxytwinol A, by the biomimetic dimerization of 2H-pyran derivatives. The former three natural products were derived by the Diels-Alder reaction, while the latter was synthesized by the formal 4+4 cycloaddition reaction, which is a very rare reaction. We have investigated the reaction mechanism of this 4+4 cycloaddition via ab initio calculation and found that the reaction would proceed via a biradical mechanism. We have also synthesized several natural products with strong biological activities, such as lucilactaene, synerazol, pseurotin A, RK-805, fumagillol, FR65814, ovalicin, 5-demethylovalicin, EI-1941-1, EI-1941-2, EI-1941-3, panepophenanthrin, nikkomycin B, and fostriecin. During these syntheses, we developed several practical asymmetric reactions using oragnocatalysts such as direct aldol reaction in the presence of water, Mannich reaction, α-aminoxylation of carbonyl compounds, and Michael reaction.
|
