| Project/Area Number |
15370103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
生理人類学
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| Research Institution | Kobe University (2005)
Hamamatsu University School of Medicine (2003-2004) |
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Principal Investigator |
NAKAMURA Harunobu Kobe University, Faculty of Human Development, Associate Professor, 発達科学部, 助教授 (10322140)
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| Co-Investigator(Kenkyū-buntansha) |
KOUDA Katsuyasu Kansai Medical University, Department of Hygiene, Assistant Professor, 医学部, 講師 (60273182)
TERADA Mamoru Hamamatsu University School of Medicine, Department of Parasitology, Professor, 医学部, 教授 (30046297)
OKUDA Toyoko Osaka Kyoiku University, Department of Arts and Sciences, Professor, 教育学部, 教授 (90047308)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | dietary restriction / acclimatization / brain hormone / appetite / 順化 |
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| Research Abstract |
Dietary restriction is well known to be a unique interventional method to prolong lifespan in laboratory animals. Dietary restriction is a sort of nutritional stress to a living body, and, thus acclimatization is needed to receive the full benefit of dietary restriction. In this study, we investigated the acclimatization process on nutrition modification and also investigated the role of brain hormone during nutritional modification.
The study was approved by both the Ethical Committee of Kansai Medical University and the Ethical Committee of Hamamatsu University School of Medicine. The study was conducted at the health farm in a company in Osaka Subjects of this study were selected from among the participants of the health education programs carried out from 2003 to 2005. Subjects were divided into 2 groups : slight diet-restricted group, and moderate diet-restricted group.
Mean body weight was decreased in both groups by this health program, since energy intake was decreased through this program. Whereas the decrease of body weight by the decrease of energy intake, active ghrelin and non-active ghrelin did not show increase. In addition, appetite and profile of mood status has not significantly increased.
These results indicate the possibility that acclimatization has worked from the early phase of the dietary restriction.
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