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Regulation of angiogenesis-related diseases by conjugated trienoic acids, tocotrienol and amadori-glycated phospholipids.

Research Project

Project/Area Number 15380086
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

MIYAZAWA Teruo  Tohoku University, Graduate School of Agricultural Science, professor, 大学院・農学研究科, 教授 (20157639)

Co-Investigator(Kenkyū-buntansha) YAMASITA Mari  Tohoku University, Graduate School of Agricultural Science, professor, 大学院・農学研究科, 教授 (50192430)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2004: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2003: ¥8,100,000 (Direct Cost: ¥8,100,000)
Keywordsangiogenesis inhibition / conjugated trienoic fatty acid / tocotrienol / glycated phosphatidylethanolamine / cancer / atherosclerosis / diabetic retinopathy / vascular endothelial cells
Research Abstract

Angiogenesis is the process of generating new capillary blood vessels, involving proliferation of endothelial cells, cell migration, and capillary tube formation. Abnormal angiogenesis relates to intractable diseases such as cancer, diabetic retinopathy atherosclerosis, and arthritis. Therefore, the present, interestingly, the inhibition of angiogenesis is one of the most attractive approaches for prevention of these diseases. Moreover, regulation of angiogenesis by foods and food components is becoming an important issue.
Our previous researches have shown that conjugated trienoic fatty acid and tocotrienol can inhibit angiogenesis more effectively than some medicinal drugs. Moreover, we have proved the presence of Amadori glycated phosphatidylethanolamine, a lipid-linked glycation compound, as accelerator of angiogenesis.
In this study, 1)conjugated trienoic fatty acids were fed to nude mice with transplant of tumor cells and antitumor mechanism and anti-angiogenesis activity of conjugated trienoic fatty acids were investigated. 2)The anti-angiogenic mechanism of tocotrienol, a natural analog of tocopherol, was investigated both in vitro and in vivo. 3)The stimulation of angiogenesis by glycated phosphatidylethanolamine was investigated by using cultured cells, food components that can inhibit glycation of phospholipids were screened.
Based on these present knowledge, foods and food components that can prevent angiogenic disorders diseases such as cancer, diabetic retinopathy atherosclerosis and arthritis will be effectively developed.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (27 results)

All 2004 2003 2002 Other

All Journal Article (20 results) Patent(Industrial Property Rights) (1 results) Publications (6 results)

  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa H.Inokuchi, H.Hirokane, T.Tsuzuki, K Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Mosc) 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Conjugated eicosapentanoic acid inhibits transplanted tumor growth via membrane lipid peroxidation in nude mice.2004

    • Author(s)
      T.Tsuzuki, M.Igarashi, T.Miyazawa
    • Journal Title

      J.Nutr. 134

      Pages: 1162-1166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tumor growth suppression by a-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation.2004

    • Author(s)
      T.Tsuzuki, Y.Tokuyama, M.Igarashi, T.Miyazawa
    • Journal Title

      Carcinogenesis 25

      Pages: 1417-1425

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antiagiogenic potency of vitamin E.2004

    • Author(s)
      T.Miyazawa, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Ann N Y Acad Sci. 1031

      Pages: 401-404

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA chip analysis of comprehensive food function : Inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol.2004

    • Author(s)
      K.Nakagawa, T.Eitsuka, H.Inokuchi, T.Miyazawa
    • Journal Title

      Biofactors. 21

      Pages: 5-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Moscow) 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi.
    • Journal Title

      Biochemistry (Mosc). 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation.2004

    • Author(s)
      T.Tsuzuki, Y.Tokuyama, M.Igarashi, T.Miyazawa
    • Journal Title

      Carcinogenesis 25

      Pages: 1417-1425

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antiangiogenic potency of vitamin E.2004

    • Author(s)
      T.Miyazawa, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Ann.N.Y. Acad.Sci. 1031

      Pages: 401-404

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA chip analysis of comprehensive food function : Inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol.2004

    • Author(s)
      K.Nakagawa, T.Eitsuka, H.Inokuchi, T.Miyazawa
    • Journal Title

      Biofactors 21

      Pages: 5-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Moscow) 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antiangiogenic potency of vitamin E.2004

    • Author(s)
      T.Miyazawa, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Ann.New York Acad.Sci. 1031

      Pages: 401-404

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DNA chip analysis of comprehensive food function : inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol.2004

    • Author(s)
      K.Nakagawa, T.Eitsuka, H.Inokuchi, T.Miyazawa
    • Journal Title

      Biofactors 21

      Pages: 5-10

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Mosc) 69

      Pages: 67-69

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation.2004

    • Author(s)
      T.Tsuduki, Y.Tokuyama, M.Igarashi, T.Miyazawa
    • Journal Title

      Carcinogenesis 25

      Pages: 1417-1425

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells.2003

    • Author(s)
      J.-H.Oak, K.Nakagawa, S.Oikawa, T.Miyazawa
    • Journal Title

      FEBS Lett. 555

      Pages: 419-423

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anti-angiogenic activity of tocotrienol.2003

    • Author(s)
      H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi, T.Miyazawa
    • Journal Title

      Biosci.Biotechnol.Biochem 67

      Pages: 1623-1627

    • NAID

      110002694279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat.2003

    • Author(s)
      T.Tsuzuki, M.Igarashi, M.Komai, T.Miyazawa
    • Journal Title

      J.Nutr.Sci.Vitaminol. 49

      Pages: 195-200

    • NAID

      130001377372

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells.2003

    • Author(s)
      J.H.Oak, K.Nakagawa, S.Oikawa, T.Miyazawa
    • Journal Title

      FEBS Lett. 555

      Pages: 419-423

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anti-angiogenic activity of tocotrienol.2003

    • Author(s)
      H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi, T.Miyazawa
    • Journal Title

      Biosci.Biotechnol.Biochem. 67

      Pages: 1623-1627

    • NAID

      110002694279

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] Inhibition for neovasculation, cell multiplication, lumen formation and FGF,2002

    • Inventor(s)
      T.Miyazawa et al.
    • Industrial Property Rights Holder
      T.Miyazawa et al.
    • Filing Date
      2002-02-01
    • Acquisition Date
      2003-08-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] J.-H.Oak, K.Nakagawa, S.Oikawa, T.Miyazawa: "Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells"FEBS Lett.. 555. 419-423 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi, T.Miyazawa: "Anti-angiogenic activity of tocotrienol"Biosci.Biotechnol.Biochem.. 67(7). 1623-1627 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Tsuzuki, M.Igarashi, M.Komai, T.Miyazawa: "The metabolic conversion of 9,11,13-eleostearic acid(18:3)to 9,11-conjugated linoleic acid(18:2)in the rat"J.Nutr.Sci.Vitaminol.. 43(3). 195-200 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T Miyazawa, H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi: "Anti-angiogenic potential of tocotrienol in vitro"Biochemistry(Moscow). 69(1). 67-69 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Tsuzuki, M.Igarashi, T.Miyazawa: "Conjugated eicosapentanoic acid inhibits transplanted tumor growth via membrane lipid peroxidation in nude mice"J.Nutr.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Tsuzuki, Y.Tokuyama, M.Igarashi, T.Miyazawa: "Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation"Carcinogenesis. (in press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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