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Studies on the structure and function of tumor necrosis factor (TNF) in fish

Research Project

Project/Area Number 15380136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionNihon University

Principal Investigator

NAKANISHI Teruyuki  Nihon University, Department of Veterinary Medicine, College of Bioresource Sciences, Professor, 生物資源科学部, 教授 (00322496)

Co-Investigator(Kenkyū-buntansha) SOMA Gen-ichiro  Tokushima Bunri University, Institute for Health Sciences, Professor, 健康科学研究所, 教授 (00158990)
YOSHIURA Yasutoshi  National Research Institute of Aquaculture, Division of Aquatic Animal Health, Researcher, 病害防除部, 研究員 (90372052)
井上 裕基  日本大学, 生物資源科学部, 助手 (50333571)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,800,000 (Direct Cost: ¥14,800,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2003: ¥8,200,000 (Direct Cost: ¥8,200,000)
KeywordsRainbow trout / Zebrafish / Ayu fish / Banded dogfish / TNF alpha / Transgenic / mRNA expression / Recombinant TNF / GFP / 組換えTNF / TNFレセプターデコイ / LPS / 定量PCR法 / 組換えニジマスTNF / CCケモカイン
Research Abstract

Tumor necrosis factor (TNF) is a primary mediator of immune regulation and the inflammatory response. TNF is also known to be a mediator involved in the interaction between endocrine nervous and immune systems. There have been also reported that TNF/LT family cytokines play important role in development, maturation and maintenance of secondary lymphoid organs. Thus TNF is one of the most important cytokines investigated so far from various fields and aspects.
To understand the broad range of biological activities of TNF we tried to investigate its pleiotropic nature from phylogenetical and ontogenetical points of view. In the present research we obtained the following results :
1.Structure and function of fish TNF
We isolated one TNF homologue from Ayu fish and two types of TNF from rainbow trout and zebrafish. We also cloned TNF decoy receptor 3 (DcR3) together with several cytokines from cartilaginous fish. Structure and expression of these fish TNF and TNF super family genes resembles to those of mammalian TNF.
2.Production of recombinant TNF and its biological activity
Purified recombinant TNF of Ayu fish induced the production of superoxide from head-kidney leukocytes.
3.Expression of TNF mRNA after stimulation with LPS and/or bacteria
Expression of TNF in tissues after stimulation with LPS was different between two types of TNF in rainbow trout. Studies using transgenic rainbow trout introduced with TNF promoter linked to green fluorescence protein (GFP) as a reporter gene showed that TNF secreting cells are involved in envelopment response against bacteria.
4.Role of TNF in development
Two types of TNF were weakly expressed at the nervous system of zebrafish embryos, and increased TNF expression toward hatching was observed in Ayu embryos suggesting the role of TNF in the morphogenesis of embryonic organs.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (57 results)

All 2006 2005 2004 2003 Other

All Journal Article (44 results) Book (1 results) Publications (12 results)

  • [Journal Article] TNF induces the growth of thymocytes in rainbow trout2006

    • Author(s)
      Hino, K, O.Nakamura, Y.Yoshiura, H.Suetake, Y.Suzuki, T.Watanabe
    • Journal Title

      Dev. Comp. Immunol. 30

      Pages: 639-647

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inherent potential for production of tumor necrosis factor-a by human intestinal macrophages2006

    • Author(s)
      Nakata, K., H.Inagawa, T.Nishizawa, T.Honda, C.Kohchi,.G-I.Soma, et al.
    • Journal Title

      Int J Colorectal Dis. 21

      Pages: 339-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a LPS-regulatory gene having an LPS binding domain in kuruma prawn Marsupenaeus Japonicus.2006

    • Author(s)
      Nagoshi, H., H.Inagawa, K.Morii, H.Harada, C.Kohchi, G-I.Soma, et al.
    • Journal Title

      Molecular Immunology 43

      Pages: 2061-2069

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a TNF-like protein of Plecoglossus altivelis (ayu fish)2006

    • Author(s)
      Uenobe, M., C.Kohchi, N.Yoshioka, A.Yuasa, H.Inagawa, G-I.Soma, et al.
    • Journal Title

      Fish & Shellfish Immunol. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TNF induces the growth of thymocytes in rainbow trout.2006

    • Author(s)
      Hino, K., O.Nakamura, Y.Yoshiura, H.Suetake, Y.Suzuki, T.Watanabe
    • Journal Title

      Dev.Comp.Immunol. 30

      Pages: 639-647

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inherent potential for production of tumor necrosis factor-□ by human intestinal macrophages.2006

    • Author(s)
      Nakata, K., H.Inagawa, T.Nishizawa, T.Honda, C.Kohchi, Y.Tonomoto, H.Yoshimura, N.Nagase, S.Natori, H.Terada, G-I.Soma
    • Journal Title

      Int J Colorectal Dis. 21

      Pages: 339-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a LPS-regulatory gene having an LPS binding domain in kuruma prawn Marsupenaeus japonicus.2006

    • Author(s)
      Nagoshi, H., H.Inagawa, K.Morii, H.Harada, C.Kohchi, T.Nishizawa, Y.Taniguchi, M.Uenobe, T.Honda, M.Kondoh, Y.Takahashi, G-I.Soma
    • Journal Title

      Molecular Immunology 43

      Pages: 2061-2069

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cytotoxic activities of fish leucocytes.2006

    • Author(s)
      Fischer U, Utke K, Somamoto T, Kollner B, Ototake M, Nakanishi T.
    • Journal Title

      Fish Shellfish Immunol. 20(2)

      Pages: 209-226

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inherent potential for production of tumor necrosis factor-α by human intestinal macrophages2006

    • Author(s)
      Nakata, K., H.Inagawa, T.Nishizawa, T.Honda, C.Kohchi,.G-I.Soma, et al.
    • Journal Title

      Int J Colorectal Dis.

      Pages: 1-9

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Specific messenger RNA expression for signal transduction molecules by lipopolysaccharide in intestinal macrophages.2006

    • Author(s)
      Nakata K, Inagawa H, Nishizawa T, Kohchi C, Soma GI.
    • Journal Title

      Clin Exp Immunol. 143(3)

      Pages: 484-493

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular cloning and expression analysis of a macrophage-colonystimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss2005

    • Author(s)
      Honda T, Nishisawa T, Uenobe M, Kochi C, Kuroda A, Ototake M, Nakanishi T, Yokomizo Y, Takahashi Y, Inagawa H, Soma G-I.
    • Journal Title

      Molecular Immunology 42

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) interleukin-10 cDNAs.2005

    • Author(s)
      Inoue Y, Kamota S, Ito K, Yoshiura Y, Ototake M, Moritomo T, Nakanishi T.
    • Journal Title

      Fish Shellfish Immunol. 18(4)

      Pages: 335-344

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and preliminary expression analysis of banded dogfish (Triakis scyllia) CC chemokine cDNAs by use of suppression subtractive hybridization.2005

    • Author(s)
      Inoue, Y., Saito, T., M.Endo, C.Haruta, T.Nakai, Moritomo, T., T.Nakanishi.
    • Journal Title

      Immunogenetics 56

      Pages: 722-734

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Cionaintestinalis.2005

    • Author(s)
      Inoue Y, Ogasawara M, Moroi T, Satake M, Azumi K
    • Journal Title

      Immunogenetics 57

      Pages: 520-534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of respiratory burst activity of ayu (Plecoglossus altivelis) inflammatory neutrophils, comparison with carp (Cyprinus carpio) inflammatory neutrophils.2005

    • Author(s)
      Serada K, T.Moritomo, K.Teshirogi, T.Itou, T.Shibashi, Y.Inoue, T.Nakanishi
    • Journal Title

      Fish & Shellfish Immunol. 19(4)

      Pages: 363-373

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss : The first Th1-type cytokine characterized functionally in fish.2005

    • Author(s)
      Zou J, Carrington A, Collet B, Dijkstra JM, Yoshiura Y, Bols N, Secombes C.
    • Journal Title

      J Immunol. 175(4)

      Pages: 2484-2494

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss.2005

    • Author(s)
      Honda T, Nishizawa T, Uenobe M, Kohchi C, Kuroda A, Ototake M, Nakanishi T, Yokomizo Y, Takahashi Y, Inagawa H, G Soma
    • Journal Title

      Mol Immunol. 42(1)

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) interleukin-10 cDNAs.2005

    • Author(s)
      Inoue Y, Kamota S, Ito K, Yoshiura Y, Ototake M, Moritomo T, T Nakanishi
    • Journal Title

      Fish Shellfish Immunol. 18(4)

      Pages: 335-344

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and preliminary expression analysis of banded dogfish (Thiakis scyllia) CC chemokine cDNAs by use of suppression subtractive hybridization.2005

    • Author(s)
      Inoue, Y, Saito, T., M.Endol, C.Haruta, T.Nakai, Moritomo, T., T.Nakanishi
    • Journal Title

      Immunogenetics 56

      Pages: 722-734

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Ciona intestinalis.2005

    • Author(s)
      Inoue Y, Ogasawara M, Moroi T, Satake M, Azumi K, Moritomo T, T.Nakanishi
    • Journal Title

      Immunogenetics. 57

      Pages: 520-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss : The first Th1-type cytokine characterized functionally in fish.2005

    • Author(s)
      Zou J, Carrington A, Collet B, Dijkstra JM, Yoshiura Y, Bols N, C.Secombes
    • Journal Title

      J.Immunol. 175(4)

      Pages: 2484-2494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] p, p'-DDE depresses the immune competence of chinook salmon (Oncorhynchus tshawytscha) leucocytes.2005

    • Author(s)
      Misumi I., A.T.Vella, J.C.Leongi, T.Nakanishi, C.B.Schreck
    • Journal Title

      Fish & Shellfish Immunol. 19(2)

      Pages: 97-114

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of respiratory burst activity of ayu (Plecoglossus altivelis) inflammatory neutrophils, comparison with carp (Cyprinus carpio) inflammatory neutrophils.2005

    • Author(s)
      Serada K, T.Moritomo, K.Teshirogi, T.Itou, T.Shibashi, Y.Inoue, T.Nalcanishi
    • Journal Title

      Fish & Shellfish Immunol. 19(4)

      Pages: 363-373

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular cloning and characterization of two types of CD8α from ginbuna crucian carp, Carassius auratus langsdorfii.2005

    • Author(s)
      Somamoto, T., Y.Yoshiura, T.Nakanishi, M.Ototake
    • Journal Title

      Dev. Comp. Immunol. 29

      Pages: 693-702

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Ciona intestinalis.2005

    • Author(s)
      Inoue Y, Ogasawara M, Moroi T, Satake M, Azumi K, Moritomo T, Nakanishi T.
    • Journal Title

      Immunogenetics 16

      Pages: 1-15

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss2005

    • Author(s)
      Honda T, Nishisawa T, Uenobe M, Kochi C, Kuroda A, Ototake M, Nakanishi T, Yokomizo Y, Takahashi Y, Inagawa H, Soma G-I.
    • Journal Title

      Molecular Immunology 42

      Pages: 1-8

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) interleukin-10 cDNAs.2005

    • Author(s)
      Inoue Y, Kamota S, Ito K, Yoshiura Y, Ototake M, Moritomo T, Nakanishi T
    • Journal Title

      Fish Shellfish Immunol. 18(4)

      Pages: 335-344

    • Related Report
      2004 Annual Research Report
  • [Journal Article] New MHC class Ia domain lineages in rainbow trout (Oncorhynchus mykiss) which are shared with other fish species.2005

    • Author(s)
      Kiryu I, Dijkstra JM, Sarder RI, Fujiwara A, Yoshiura Y, Ototake M.
    • Journal Title

      Fish Shellfish Immunol. 18(3)

      Pages: 243-254

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular cloning and sequencing of Japanese pufferfish (Takifugu rubripes) NADPH oxidase cDNAs2004

    • Author(s)
      Inouee, Y., Y.Suenaga, Y.Yoshiura, T.Moritomo, M.Ototake, T.Nakanishi.
    • Journal Title

      Dev. Comp. Immunol. 28

      Pages: 911-925

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and sequencing of Japanese pufferfish (Takifugu rubripes) NADPH oxidase cDNAs.2004

    • Author(s)
      Inoue Y, Suenaga Y, Yoshiura Y, Moritomo T, Ototake M, T Nakanishi
    • Journal Title

      Dev Comp Immunol. 28(9)

      Pages: 911-925

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Profile of cytokines produced in tumor tissue after administration of cyclophosphamide in a combination therapy with tumor necrosis factor2004

    • Author(s)
      Takiguchi K, Nakamoto T, Inagawa H, Kochi C, Nishizawa, T, Nagasue N, Soma G-I.
    • Journal Title

      Anticancer Research 24(3)

      Pages: 1823-1828

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer2004

    • Author(s)
      Ohno S, Ohno Y, Suzuki N, Kamei T, Koike K, Inagawa H, Kohchi C, Soma G-I, Inoue M.
    • Journal Title

      Anticancer Reseach 24(5C)

      Pages: 3335-3342

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres : Effects of molecular weight and composition of PLGA on release of rifampicin.2004

    • Author(s)
      Makino K, Nakajima T, Shikamura M, Ito F, Ando S, Kochi C, Inagawa H, Soma G-I, Terada H.
    • Journal Title

      Colloids and Surfaces B : Biointerfaces 36

      Pages: 35-42

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular cloning and sequencing of Japanese pufferfish (Takifugu rubripes) NADPH oxidase cDNAs2004

    • Author(s)
      Inoue, Y., Y.Suenaga, Y.Yoshiura, T.Moritomo, M.Ototake, T.Nakanishi
    • Journal Title

      Dev.Comp.Immunol. 28

      Pages: 911-925

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular cloning and expression of shark interleukin-8 cDNA.2003

    • Author(s)
      Inoue, Y., Haruta, Usui, K., Moritomo, T., T.Nakanishi
    • Journal Title

      Fish & Shellfish Immunol. 14

      Pages: 275-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and sequencing of the silver chimaera (Chimaera phantasma) interleukin-8 cDNA.2003

    • Author(s)
      Inoue Y., M.Endo, C.Haruta, T.Taniuchi, T.Moritomo, T.Nakanishi
    • Journal Title

      Fish & Shellfish Immunol. 15

      Pages: 269-274

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and characterization of Fugu orthologues of mammalian interleudin-12 subunits.2003

    • Author(s)
      Yoshiura, Y., I.Kiryu, A.Fuji-wara, H.Suetake, Y.Suzuki, T.Nakanishi, M.Ototoke
    • Journal Title

      Immunogenetics 55

      Pages: 296-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and sequencing of the banded dogfish (Triakis scyllia) interleukin-8 cDNA.2003

    • Author(s)
      Inoue Y, Haruta, Usui, K., Moritomo, T., T.Nakanishi
    • Journal Title

      Fish & Shellfish Immunol. 14

      Pages: 275-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular cloning and sequencing of the silver chimaera (Chimaera phantasma) interleukin-8 cDNA.2003

    • Author(s)
      Inoue Y, M.Endo, C.Haruta, T.Taniuchi, T.Moritomo, T.Nakanishi
    • Journal Title

      Fish & Shellfish Immunol. 15

      Pages: 269-274

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification and characterization of Fugu orthologues of mammalian interleukin-12 subunits.2003

    • Author(s)
      Yoshiura Y, Kiryu I, Fujiwara A, Suetake H, Suzuki Y, Nakanishi T, M Ototake
    • Journal Title

      Immunogenetics. 55(5)

      Pages: 296-306

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression profiles of TCRβ and CD8α mRNA correlate with virus-specific cell-mediated cytotoxic activity in ginbuna crucian carp

    • Author(s)
      Somamoto, T., Y.Yoshiura, A.Sato, T.Nakanishi, N.Okamoto, M.Ototake
    • Journal Title

      Virology (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] TNF induces the growth of thymocytes in rainbow trout

    • Author(s)
      Hino, K., O.Nakamura, Y.Yoshiura, H.Suetake, Y.Suzuki, T.Watanabe
    • Journal Title

      Dev. Comp. Immunol. (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cloning and characterization of a LPS-regulatory gene having an LPS binding domain in kuruma prawn Marsupenaeus japonicus.

    • Author(s)
      Nagoshi, H., H.Inagawa, K.Morii, H.Harada, C.Kohchi, G-I.Soma, et al.
    • Journal Title

      Molecular Immunology (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cloning and characterization of a TNF-like protein of Plecoglossus altivelis (ayu fish)

    • Author(s)
      Uenobe, M., C.Kohchi, N.Yoshioka, A.Yuasa, H.Inagawa, G-I.Soma, et al.
    • Journal Title

      Fish & Shellfish Immunol. (発表予定)

    • Related Report
      2005 Annual Research Report
  • [Book] 魚類の生体防御の分子機構(生体防御医学事典)2006

    • Author(s)
      中西照幸
    • Publisher
      朝倉書店(印刷中)
    • Related Report
      2005 Annual Research Report
  • [Publications] Inoue Y., M.Endo, C.Haruta, T.Taniuchi, T.Moritomo, T.Nakanishi: "Molecular cloning and sequencing of the silver chimaera (Chimaera phantasma) interleukin-8 cDNA"Fish & Shellfish Immunol.. 15. 269-274 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue, Y., Haruta, Usui, K., Moritomo, T., T.Nakanishi: "Molecular cloning and expression of shark interleukin-8 cDNA"Fish & Shellfish Immunol.. 14. 275-281 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshiura, Y., I.Kiryu, A.Fujiwara, H.Suetake, Y.Suzuki, T.Nakanishi, M.Ototake: "Identification and characterization of Fugu orthologues of mammalian interleukin-12 subunits"Immunogenetics. 55. 296-306 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue, Y., Y.Yoshiura, T.Moritomo, M.Ototake, T.Nakanishi: "Molecular Cloning and Sequencing of Japanese pufferfish (Fugu rubripes) NADPH oxidase cDNAs"Dev.Comp.Immunol.. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohno, S., Inagawa, H., Dhar, DK., Fujii, T., Ueda, S., Tachibana, M., Suzuki, N., Inoue, M., Soma, G-I., Nagasue, N.: "The Degree of Macrophage Infiltration into the Cancer Cell Nest is a Significant Predictor of Survival in Gastric Cancer Patients"Anticancer Research. 23. 5015-5022 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukushima, T., Yamamoto, M., Oshiro, S., Tsugu, H., Hirakawa, K., Soma, G-I: "Recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2) immunotherapy with ranimustine chemotherapy and concurrent radiation therapy for malignant astrocytomas"Anticancer Research. 23. 4473-4481 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohno S., Suzuki N., Ohno Y., Inagawa H., Soma G-I., Inoue M.: "Tumor-associated Macrophages : Foe or Accomplece of Tumors?"Anticancer Research. 23. 4395-4410 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshimura, H., Dhar, DK., Nakamoto, T., Kotoh, T., Takano, M., Soma, G-I, Nagasue, N: "Prognostic significance of tumor necrosis factor receptor in colorectal adenocarcinoma"Anticancer Research. 23. 85-89 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kamei, H., T.Ohira, Y.Yoshiura, N.Uchida, H.Nagasawa, K.Aida: "Expression of a biologically active recombinant follicle stimulating hormone of Japanese Eel Anguilla japonica using methylotropic yeast, Pichia pastoris"Gen Comp Endocrinol. 134. 244-254 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 杣源一郎, 稲川裕之, 河内千恵: "マクロファージと健康維持"健康創造研究会誌. 2. 105-112 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 杣源一郎, 稲川裕之, 河内千恵: "自然免疫とマクロファージ"News Letter. 2. 17-20 (2003)

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      2003 Annual Research Report
  • [Publications] Soma, G-I., Kuroki, M., Fukushima, T.: "Proceedings of the Sixth Meeting of the society of Biotherapeutic Approaches. Special Issue"International Institute for Anticancer Research. 137 (2003)

    • Related Report
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Published: 2003-04-01   Modified: 2016-04-21  

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