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Development of novel therapeutic strategies for AIDS by the molecular regulation strategies for feline immunodeficiency virus infection

Research Project

Project/Area Number 15380209
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

TSUJIMOTO Hajime  The University of Tokyo, Graduate School of Agricultural and life Sciences, Professor (60163804)

Co-Investigator(Kenkyū-buntansha) OHNO Koichi  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate professor (90294660)
IWATA Akira  Nippon Institute of Biological Science, 研究部, Project leader (70193745)
増田 健一  東京大学, 大学院・農学生命科学研究科, 助手 (40313077)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2004: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 2003: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywordscat / feline immunodeficiency virus / antiviral therapy / RNA interference / chemokine receptor / fusion inhibitor / dendritic cell / animal model / 猫免疫不全ウイルス / 遺伝子治療 / 免疫療法 / small interfering RNA / 骨髄内投与 / レトロウイルスベクター / ネコ / 感染症 / 治療
Research Abstract

A series of studies were performed in order to develop novel therapeutic strategies specific to feline immunodeficiency virus (FIV) infection.
1. A therapeutic strategy using RNA interference was employed to inhibit the gene expression of FIV. Transfection of plasmid vectors expressing FIV-specific shRNA into FIV-infected feline cell lines resulted in the consistent suppression of the expression of FIV mRNA/protein and reverse transcriptase.
2. Antiviral effect of several types of CXC-chemokine receptor inhibitors (CXCR4 antagonists) was investigated. C-terminal amidated CXCR4 antagonists synthesized to increase the biostability showed a significant activity to inhibit the replication of FIV.
3. Antiviral effect of the fusion-associated heptad repeat and its derivatives of FIV gp40 was examined. The study revealed several fusion peptides that showed strong antiviral effect for various FIV strains of different subtypes.
4. To develop immunotherapy using dendritic cells (DC), feline peripheral blood monocytes were cultured in the presence of various cytokines. These cells were shown to have dendritic projections and immunological phenotypes characteristic to DC. Function of DC was maintained in asymptomatic carrier cats infected with FIV.
The present study provided innovative findings to develop antiviral therapies in FIV infection. With respect to the RNA interference, viral receptor, membrane fusion, and DC, there is a remarkable similarity between FIV infection in cats and AIDS in humans ; thus, the results obtained in this study can be also useful to utilize the feline system as an animal model of AIDS in humans.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (56 results)

All 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article (46 results) (of which Peer Reviewed: 20 results) Presentation (8 results) Publications (2 results)

  • [Journal Article] An updated nation-wide epidemiological survey of feline immunodeficiency virus (FIV) infection in Japan.2010

    • Author(s)
      Nakamura, Y, et al.
    • Journal Title

      Journal of Veterinary Medical Science (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] An updated nation-wide epidemiological survey of feline immunodeficiency virus(FIV)infection in Japan2010

    • Author(s)
      Nakamura, Y., et al.
    • Journal Title

      Journal of Veterinary Medical Science (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibitory effect of newly developed CXC-chemokine receptor antagonists on the infection with feline immunodeficiency Virus.2009

    • Author(s)
      Mizukoshi, E, et al.
    • Journal Title

      Journal of Veterinary Medical Science 71

      Pages: 121-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein.2009

    • Author(s)
      Mizukoshi, F, et al.
    • Journal Title

      Veterinary Microbiology 136

      Pages: 155-159

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prevalence of hematological abnormalities and detection of infected bone marrow cells in asymptomatic cats with feline immunodeficiency virus infection.2009

    • Author(s)
      Fujino, Y, et al.
    • Journal Title

      Veterinary Microbiology 136

      Pages: 217-225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus.2009

    • Author(s)
      Oishi, S, et al.
    • Journal Title

      Bioorganic and Medicinal Chemistry 17

      Pages: 4916-4920

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus.2009

    • Author(s)
      Mizukoshi, F, et al.
    • Journal Title

      Journal of Veterinary Medical Science 71

      Pages: 865-871

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of newly developed CXC-chemokine receptor antagonists on the infection with feline immunodeficiency virus2009

    • Author(s)
      Mizukoshi, F., et al.
    • Journal Title

      Journal of Veterinary Medical Science 71

      Pages: 121-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein2009

    • Author(s)
      Mizukoshi, F., et al.
    • Journal Title

      Veterinary Microbiology 136

      Pages: 155-159

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of hematological abnormalities and detection of infected bone marrow cells in asymptomatic cats with feline immunodeficiency virus infection2009

    • Author(s)
      Fujino, Y., et al.
    • Journal Title

      Veterinary Microbiology 136

      Pages: 217-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus2009

    • Author(s)
      Oishi, S., et al.
    • Journal Title

      Bioorganic and Medicinal Chemistry 17

      Pages: 4916-4920

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus2009

    • Author(s)
      Mizukoshi, F., et al.
    • Journal Title

      Journal of Veterinary Medical Science 71

      Pages: 865-871

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibition of the replication of feline immunodeficiency virus by lentiviral vector-mediated RNA interference in feline cels.2008

    • Author(s)
      Baba, K, et al.
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 777-783

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hypereosinophihc syndrome in two cats.2008

    • Author(s)
      Takeuchi, Y, et al.
    • Journal Title

      Journal of Veterinary Mediea1 Science 70

      Pages: 1085-1089

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Verification of measurement of the feline serum amyloid A(SAA) concentration by human SAA turbidimetric immunoassay and its application.2008

    • Author(s)
      Tamamoto, T, et al.
    • Journal Title

      Journal of Veterinary Mediea1 Science 70

      Pages: 1247-1252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibition of the replication of feline immunodeficiency virus by lentiviral vector-mediated RNA interference in feline cells2008

    • Author(s)
      Baba K., et al.
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 777-783

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hypereosinophilic syndrome in two cats2008

    • Author(s)
      Takeuchi, Y., et al.
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 1085-1089

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Verification of measurement of the feline serum amyloid A(SAA)concentration by human SAA turbidimetric immunoassay and its application2008

    • Author(s)
      Tamamoto, T., et al.
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 1247-1252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines.2007

    • Author(s)
      Baba, K, et al.
    • Journal Title

      Veterinary Microbiology 120

      Pages: 207-216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines2007

    • Author(s)
      Baba, K., et al.
    • Journal Title

      Veterinary Microbiology 120

      Pages: 207-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomic cloning of feline Fas ligand gene and characterization of the transcription regulatory region.2006

    • Author(s)
      Mizuno, T, et al.
    • Journal Title

      Veterinary Immunology and Immunopathology 114

      Pages: 305-312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genomic cloning of feline Fas ligand gene and characterization of the transcription regulatory region2006

    • Author(s)
      Mizuno, T., et al.
    • Journal Title

      Veterinary Immunology and Immunopathology 114

      Pages: 305-312

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions(Panthera leo) in Japan.2005

    • Author(s)
      Endo, Y, et al.
    • Journal Title

      Journal of Veterinary Mediea1 Science 66

      Pages: 1587-1589

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Urinary transforming growth factor-beta 1 in feline chronic renal failure.2005

    • Author(s)
      Arata, S, et al.
    • Journal Title

      Journal of Veterinary Mediea1 Science 67

      Pages: 1253-1255

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions(Panthers leo)in Japan2005

    • Author(s)
      Endo, Y., et al.
    • Journal Title

      Journal of Veterinary Medical Science 66

      Pages: 1587-1589

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Urinary transforming growth factor-beta 1 in feline chronic renal failure2005

    • Author(s)
      Arata, S., et al.
    • Journal Title

      Journal of Veterinary Medical Science 67

      Pages: 1253-1255

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions (Panthera leo) in Japan.2005

    • Author(s)
      Endo, Y.et al.
    • Journal Title

      J.Vet.Med.Sci. 66

      Pages: 1587-1589

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alternatively spliced transcripts of Fas mRNAs in feline lymphoid cells.2004

    • Author(s)
      Mizuno, T, et al.
    • Journal Title

      European Journal of Immunogenetics 31

      Pages: 159-166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of apoptosis-related gene mRNAs in feline T-cells infected with feline immunodeficiency virus(FIV).2004

    • Author(s)
      Yamazaki, J, et al.
    • Journal Title

      Veterinary Microbiology 101

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of a newly established nonproducer lymphoma cell line for feline leukemia virus.2004

    • Author(s)
      Fujino, Y, et al.
    • Journal Title

      Teterinary Immunology and Immunopathology 102

      Pages: 429-439

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alternatively spliced transcripts of Fas mRNAs in feline lymphoid cells2004

    • Author(s)
      Mizuno, T., et al.
    • Journal Title

      European Journal of Immunogenetics 31

      Pages: 159-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of apoptosis-related gene mRNAs in feline T-cells infected with feline immunodeficiency virus(FIV)2004

    • Author(s)
      Yamazaki, J., et al.
    • Journal Title

      Veterinary Microbiology 101

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characterization of a newly established nonproducer lymphoma cell line for feline leukemia virus2004

    • Author(s)
      Fujino, Y., et al.
    • Journal Title

      Veterinary Immunology and Immunopathology 102

      Pages: 429-439

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alternatively spliced transcripts of Fas mRNAs in feline lymphoid cells.2004

    • Author(s)
      Mizuno, T.et al.
    • Journal Title

      Eur.J.Immunogenetics 31

      Pages: 159-166

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of apoptosis-related gene mRNAs in feline T-cells infected with feline immunodeficiency virus (FIV).2004

    • Author(s)
      Yamazaki, J.et al.
    • Journal Title

      Vet.Microbiol. 101

      Pages: 1-8

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular cloning of feline tumor necrosis factor receptor type I(TNFR I) and expression of TNFR I and TNFR II in lymphoid cells in cats.2003

    • Author(s)
      Mizuno, T, et al.
    • Journal Title

      European Journal of Immunogenetics 30

      Pages: 107-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of Fas and Fas ligand mRNAs in a feline Tlymphoid cell line after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus.2003

    • Author(s)
      Mizuno, T, et al.
    • Journal Title

      Veterinary Immunology and Immunopathopathology 93

      Pages: 117-123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Molecular cloning of the feline thymus and activation-regulated chemokine cDNA and its expression in lesional skin of cats with eosinophilic plaque.2003

    • Author(s)
      Maeda, S, et al.
    • Journal Title

      Journal of Veterinary Medieal Strienee 65

      Pages: 275-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of RANTES mRNA in skin lesions of feline eosinophilic plaque.2003

    • Author(s)
      Kimura, T, et al.
    • Journal Title

      Veterinary Dermatology 14

      Pages: 269-273

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Molecular cloning of feline tumor necrosis factor receptor type I(TNFR I)and expression of TNFR I and TNFR II in lymphoid cells in cats2003

    • Author(s)
      Mizuno, T., et al.
    • Journal Title

      European Journal of Immunogenetics 30

      Pages: 107-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative analysis of Fas and Fas ligand mRNAs in a feline Tlymphoid cell line after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus2003

    • Author(s)
      Mizuno, T., et al.
    • Journal Title

      Veterinary Immunology and Immunopathology 93

      Pages: 117-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular cloning of the feline thymus and activation-regulated chemokine cDNA and its expression in lesional skin of cats with eosinophilic plaque2003

    • Author(s)
      Maeda, S., et al.
    • Journal Title

      Journal of Veterinary Medical Science 65

      Pages: 275-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of RANTES mRNA in skin lesions of feline eosinophilic plaque2003

    • Author(s)
      Kimura, T., et al.
    • Journal Title

      Veterinary Dermatology 14

      Pages: 269-273

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Detection of the integrated feline leukemia viruses in a cat lymphoid tumor cell line by fluorescence in situ hybridization.2003

    • Author(s)
      Fujino, Y.et al.
    • Journal Title

      J.Hered. 94

      Pages: 251-255

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular cloning of the feline telomerase reverse transcriptase (TERT) gene and its expression in cell lines and normal tissues.2003

    • Author(s)
      Yazawa, M.et al.
    • Journal Title

      J.Vet.Med.Sci. 65

      Pages: 573-577

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Quantitative analysis of Fas and Fas ligand mRNAs in a feline T lymphoid cell line after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus.2003

    • Author(s)
      Mizuno, T.et al.
    • Journal Title

      Vet.Immunol.Imunopathol. 93

      Pages: 117-123

    • Related Report
      2004 Annual Research Report
  • [Presentation] FIV感染症に対する抗ウイルス療法の開発に向けて.2006

    • Author(s)
      水越文徳, ら
    • Organizer
      第141回日本獣医学会学術集会
    • Place of Presentation
      つくば、日本
    • Year and Date
      2006-03-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] Recent development of antiviral therapies for FIV infection2006

    • Author(s)
      Mizukoshi, F., et al.
    • Organizer
      141st Congress of Japanese Society of Veterinary Science
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2006-03-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] Inhibition of the replication of feline immunodeficiency virus (FIV) by retroviral vector-mediated expression of short hairpin RNA (shRNA) in chronically FIV-infected cells.2004

    • Author(s)
      Baba, K, et al.
    • Organizer
      7th Int. Feline Retrovirus Research Symposium
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2004-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus2004

    • Author(s)
      Mizukoshi, F, et al.
    • Organizer
      7th Int. Feline Retrovirus Research Symposium
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2004-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] Inhibition of the replication of feline immunodeficiency virus(FIV)by retroviral vector-mediated expression of short hairpin RNA(shRNA)in chronically FIV-infected cells2004

    • Author(s)
      Baba, K., et al.
    • Organizer
      7th Int.Feline Retrovirus Research Symposium
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2004-09-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus2004

    • Author(s)
      Mizukoshi, F., et al.
    • Organizer
      7th Int.Feline Retrovirus Research Symposium
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2004-09-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] short interfering RNAs(siRNAs)によるFIV特異的遺伝子発現抑制.2003

    • Author(s)
      馬場健司, ら
    • Organizer
      第135回日本獣医学会学術集会
    • Place of Presentation
      東京、日本
    • Year and Date
      2003-04-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Presentation] FIV-specific gene expression inhibition with short interfering RNAs(siRNAs)2003

    • Author(s)
      Baba, K., et al.
    • Organizer
      135^<th> Congress of Japanese Society of Veterinary Science
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2003-04-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Mizuno, T., Goto, Y., Baba, K., Masuda, K., Ohno, K., Tsujimoto, H.: "Molecular cloning of feline tumor necrosis factor receptor type I (TNFR I) and expression of TNFR I and TNFR II in lymphoid cells in cats."Eur.J.Immunogenetics. 30. 107-113 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizuno, T., Goto, Y., Baba, K., Momoi, Y., Endo, Y., Nishimura, K., Masuda, K., Ohno, K., Tsujimoto, H.: "Quantification analysis of Fas and Fas ligand mRNAs in feline T lymphoid cell lines after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus."Vet.Immunol.Imunopathol.. 93. 117-123 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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