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Epidemiological, hereditary, morphological and virological analysis in bovine congenital defects.

Research Project

Project/Area Number 15380216
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionKagoshima University

Principal Investigator

HAMANA Katsumi  Kagoshima University, Faculty of Agriculture, Professor, 農学部, 教授 (30011977)

Co-Investigator(Kenkyū-buntansha) KAMIMURA Shunichi  Miyazaki University, Faculty of Agriculture, Professor, 農学部, 教授 (90233949)
MURAKAMI Takayuki  Miyazaki University, Faculty of Agriculture, Professor, 農学部, 教授 (00040981)
TSUDA Tomoyuki  National Institute of Animal Health, Kyushu Res Stn, Chief, 九州支所, 室長 (70355212)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2003: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsbovine congenital defects / Akabene disease / Chuzan disease / Aino virus infection / heart anomaly / hereditary disease / 疫学調査 / アカバネウイルス / 房室中隔欠損 / 部分肺静脈結合異常 / アルボウイルス感染症 / 卵円孔の早期閉鎖 / クローディン16欠損症 / ネオスポラ症 / フリーマーチン / 二頭体
Research Abstract

In 2000-2005, 535 calves with congenital defects were collected in Kagoshima. Epidemiological, clinical, pathological and virological investigations clarified the outbreaks of Akabane disease characterized by hydranencephaly and arythrogryposis in early 2000, Chuzan disease characterized by hydranencephaly and cerebellar hypoplasia in early 2002 and Aino virus infection characterized by micrencephaly and cerebellar hypoplasia in early 2003. Thereafter, there are no big outbreaks of the defects by these arbovirus infection.
Single-tube multiplex reverse transcription-polymerase chain reaction (mRT-PCR) assay was developed to detect and identify arboviruses in infected cell-culture fluids and field specimens. This technique was sensitive and reliable to detect the Chuzan, Ibaraki, Bluetongue, Akabane and Peaton viruses. Aino virus was inoculated directly to the fetus in utero. Newborn calves had the congenital abnormalities including arthrogryposis, hydranencephaly and cerebellar hypoplasia. This technique first demonstated Aino virus as a causative agent of the defects.
In the morphological investigations of cardiovascular system, conjoind heart, premature closure of the foramen ovale, partial anomalous pulmonary venous connection and atrioventricular septal defects were observed and reported.
In the series of this research projects, the book titled ‘Color Atlas of Bovine Congenital Defects' was published. In this book, the most of the defects found in Japan is explained with the clear 763 color photographs. This is the first book about the bovine congenital defects in Japan and will be very useful for research workers, veterinarians and animal producers.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (29 results)

All 2006 2005 2004 2003 Other

All Journal Article (21 results) Book (2 results) Publications (6 results)

  • [Journal Article] 牛アルボウイルスの脅威と対策2006

    • Author(s)
      津田知幸
    • Journal Title

      酪農ジャーナル 2006,1

      Pages: 40-43

    • NAID

      40007100594

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 子牛に認められた部分肺静脈結合以上の1例2005

    • Author(s)
      村上隆之
    • Journal Title

      日本獣医師会雑誌 58,4

      Pages: 250-253

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Partial anomalous pulmonary venous connection in a calf.2005

    • Author(s)
      Murakami T, Tsuda S
    • Journal Title

      J Jpn Vet Med Assoc 58,4

      Pages: 250-253

    • NAID

      10015464955

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 子牛に認められた部分肺静脈結合異常の1例2005

    • Author(s)
      村上隆之
    • Journal Title

      日本獣医師会雑誌 58,4

      Pages: 250-253

    • NAID

      10015464955

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 子ウシに認められた房室中隔欠損5例の形態学2005

    • Author(s)
      村上隆之
    • Journal Title

      動物の循環器 38,1

      Pages: 21-25

    • NAID

      10016515589

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 日本に侵入する牛のアルボウイルスの脅威について2005

    • Author(s)
      簗瀬 徹
    • Journal Title

      動衛研ニュース 20

      Pages: 4-6

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 3.5年間に収集された先天異常子牛375例の疫学的解析2005

    • Author(s)
      西馬場仁
    • Journal Title

      獣医畜産新報 58,1

      Pages: 21-22

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 子牛に認められた卵円孔早期閉鎖の2例2005

    • Author(s)
      村上隆之
    • Journal Title

      日本獣医師会雑誌 58,1

      Pages: 37-40

    • NAID

      10014270946

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Congenital defects of cattle.2004

    • Author(s)
      Hamana K
    • Journal Title

      Proc. 13th FAVA Congress

      Pages: 108-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Arthrogryposis, hydranencephaly and cerebellar hypoplasia syndrome in neonatal calves resulting from intrauterine infection with Aino virus.2004

    • Author(s)
      Tsuda T
    • Journal Title

      Vet Res 35

      Pages: 531-538

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Competitive enzyme-linked immunosorbent assay for the detection of the antibodies specific to Akabane virus.2004

    • Author(s)
      Tsuda T
    • Journal Title

      J Vet Diagn Invest 16

      Pages: 571-576

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Simultaneous detection of bovine arboviruses using single-tube multiplex reverse lranscription-polymerase chain reaction.2004

    • Author(s)
      Ohashi S
    • Journal Title

      J Viological Methods 120

      Pages: 79-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Congenital defects of cattle.2004

    • Author(s)
      Hamana K
    • Journal Title

      Proc 13th FAVA Congress

      Pages: 108-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Arthrogryposis, hydranencephaly and cerebellar hypoplasia syndrome in neonatal calves resulting from intrauterine infection with Aino virus.2004

    • Author(s)
      Tsuda T, Yoshida K, Ohashi S, Yanase T, Sueyoshi M, Kamimura S, Misumi K, Hamana K, Sakamoto H, Yamakawa M
    • Journal Title

      Vet Res 35

      Pages: 531-538

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Competitive enzyme-linked immunosorbent assay for the detection of the antiodies specific to Akabane virus.2004

    • Author(s)
      Tsuda T, Yoshida K, Yanase T, Ohashi S, Yamakawa M
    • Journal Title

      J Vet Diagn Invest 16

      Pages: 571-576

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Simultaneous detection of bovine arboviruses using single-tube multiplex reverse transcription-polymerase chain reaction.2004

    • Author(s)
      Ohashi S, Yoshida K, Yanase T, Kato T, Tsuda T
    • Journal Title

      J Virologicazl Methods 120

      Pages: 79-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Congenital defects of cattle.2004

    • Author(s)
      Hamana K
    • Journal Title

      Proc.13th FAVA Congress

      Pages: 108-111

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Simultaneous detection of bovine arboviruses using single-tube multiplex reverse transcription-polymerase chain reaction.2004

    • Author(s)
      Ohashi S
    • Journal Title

      J Virological Methods 120

      Pages: 79-85

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 鹿児島県内で発生した6例のクローディン16欠損症2004

    • Author(s)
      楢崎知長
    • Journal Title

      鹿児島県獣医師会会報 18,2

      Pages: 14-16

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sequence analysis of the medium RNA segment of three Simbu serogroup viruses, Akabane, Aino and Peaton viruses.2003

    • Author(s)
      Yanase T
    • Journal Title

      Virus Research 93

      Pages: 63-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sequence analysis of the medium RNA segment of three Simbu serogroup viruses, Akabane, Aino, and Peaton viruses.2003

    • Author(s)
      Yanase T, Yoshida, K, Ohashi S, Kato T, Tsuda T
    • Journal Title

      Virus Research 93

      Pages: 63-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] カラーアトラス 牛の先天異常2006

    • Author(s)
      浜名克己
    • Total Pages
      314
    • Publisher
      学窓社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Book] Color Atlas of Bovine Congenital Defects.2006

    • Author(s)
      Hamana K ed
    • Total Pages
      314
    • Publisher
      Gakusosha, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Yanase T: "Sequence analysis of the medium RNA segment of three Simbu serogroup viruses, Akabane, Aino, and Peaton viruses"virus Research. 93. 63-69 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 水野 恵: "ホルスタイン種乳牛の三つ子にみられたフリーマーチンの一例"鹿児島県獣医師会会報. 16,1. 6-7 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 村上隆之: "結合体ウシの心大血管系"動物の循環器. 36,1. 18-26 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 芝原 彩: "黒毛和種牛の左卵巣に未分化胚細胞腫、右卵巣に顆粒膜細胞腫がみられた1例"日本獣医師会雑誌. 56,9. 592-594 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山村 拓: "鹿児島県内における牛ネオスポラ症の疫学的調査"日本獣医師会雑誌. 56,10. 645-648 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 村上隆之: "二頭体子牛に認められた結合心の1例"日本獣医師会雑誌. 56,10. 653-656 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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