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Development of asymmetric reactions using multi-reagent complexes

Research Project

Project/Area Number 15390005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionKyoto University

Principal Investigator

TOMIOKA Kiyoshi  Kyoto University, Professor, 薬学研究科, 教授 (50114575)

Co-Investigator(Kenkyū-buntansha) IIDA Akira  Kyoto University, Associate Professor, 薬学研究科, 助教授 (40202816)
YAMADA Ken-ichi  Kyoto University, Assistant Professor, 薬学研究科, 助手 (00335184)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2005: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2003: ¥7,100,000 (Direct Cost: ¥7,100,000)
Keywordslithium enolate / chiral diether ligand / Taxol / asymmetric addition / aryllithium / tandem reactions / (-)-lycorine / chiral amidophosphine / 三成分複合反応剤 / 閉環反応 / キラルアミドモノホスフィン
Research Abstract

1)A precursor of Taxol side chain was stereoselectively synthesized in high yield by the oxidation of the dianion resulting from the asymmetric addition of a chiral lithium enolate, derived from a chiral acetate, to N-PMP imine in the presence of a lithum amide.
2)A formal total synthesis of (-)-1-deoxylycorine was achieved using tandem conjugate addition-cyclization reaction of aryllithium and alkenoate controled by a chiral ligand.
3)5-Arylcyclohexenones and trans-3,6-disubstituted cyclohexanons were synthesized with high stereoselectivity in good yields using an amidophosphane-rhodium catalyzed asymmetric addition of arylborane reagents to substituted cyclohexenones.
4)Chiral amino alcohol controlled asymmetric addition of alkynylzincs to nitroalkenes and aldehydes was developed.
5)Chiral oxazoline ligand controlled catalytic asymmetric intramolecular hydroamination was developed.
6)Chiral amidophosphane ligand controlled asymmetric addition of dialkylzincs to nitroalkene was developed.
7)A formal synthesis of (+)-halichlorine was achieved using tandem Michael addition-alkylation protocol controlled by a chiral diether ligand.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (94 results)

All 2006 2005 2004 2003 Other

All Journal Article (79 results) Book (8 results) Publications (7 results)

  • [Journal Article] Tin-free Intermolecular Addition of Primary Alkyls to Imines via Dimethylzinc-Air Radical Process.2006

    • Author(s)
      K.Yamada
    • Journal Title

      Org. Lett. 8(1)

      Pages: 87-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Ligand-Controlled Asymmetric Conjugate Addition of a Lithium Amide.2006

    • Author(s)
      T.Sakai
    • Journal Title

      J. Org. Chem. 71(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tin-free Intermolecular Addition of Primary Alkyls to Imines via Dimethylzinc-Air Radical Process.2006

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      Org.Lett. 8(1)

      Pages: 87-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Ligand-Controlled Asymmetric Conjugate Addition of a Lithium Amide.2006

    • Author(s)
      Takeo Sakai
    • Journal Title

      J.Org.Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tin-free Intermolecular Addition of Primary Alkyls to Imines via Dimethylzinc-Air Radical Process.2006

    • Author(s)
      富岡 清
    • Journal Title

      Org.Lett. 8・1

      Pages: 87-89

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dimethylzinc-Initiated Radical Reaction of Cyclic Ethers with Arylamines, Alkoxyamines, and Dialkylhydrazines.2005

    • Author(s)
      Y.Yamamoto
    • Journal Title

      Tetrahedron. 61(2)

      Pages: 379-3840

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catalytic Asymmetric Conjugate Addition of Dialkylzinc Reagents to β-Aryl-α,β-unsaturated N-2,4,6-Triisopropylphenylsulfonylaldimines with use of N-Boc-L-Val-Connected Amidophosphane-Copper(I) Catalyst2005

    • Author(s)
      T.Soeta
    • Journal Title

      J. Org. Chem. 70(1)

      Pages: 297-300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Thiol-Catalyzed Acyl Radical Cyclization of Alkenals.2005

    • Author(s)
      K.Yoshikai
    • Journal Title

      J. Org. Chem. 70(2)

      Pages: 681-683

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanistic Aspects of Thiyl Radical-Promoted Acyl Radical Cyclization of Formylenoate - Cyclization versus Oxidation.2005

    • Author(s)
      K.Yoshikai
    • Journal Title

      Chem. Pharm. Bull. 53(5)

      Pages: 586-588

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Amino Alcohol-Mediated Asymmetric Conjugate Addition of Arylalkynes to Nitroolefins.2005

    • Author(s)
      M.Yamashita
    • Journal Title

      Org. Lett. 7(12)

      Pages: 2369-2371

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Amidophosphane-Copper Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Nitroalkenes.2005

    • Author(s)
      F.Valleix
    • Journal Title

      Tetrahedron 61(31)

      Pages: 7420-7424

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1R,2R)-2-Dimethylamino-1,2-diphenylethanol.2005

    • Author(s)
      M.Yamashita
    • Journal Title

      Adv. Synth. Catal.. 347(11-13)

      Pages: 1649-1652

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Synthesis of 5-Arylcyclohexenones by Rhodium(I)-Catalyzed Conjugate Arylation of Racemic 5-(Trimethylsilyl)cyclohexenone with Arylboronic Acids.2005

    • Author(s)
      Q.Chen
    • Journal Title

      Org. Lett. 7(20)

      Pages: 4439-4441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Mannich-Type Addition of Lithium Glycolates to Imines Producing 3-Hydroxy-4-Phenylazetidin-2-Ones.2005

    • Author(s)
      H.Fujieda
    • Journal Title

      Heterocycles 66

      Pages: 611-619

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dimethylzinc-Initiated Radical Reaction of Cyclic Ethers with Arylamines, Alkoxyamines, and Dialkylhydrazines.2005

    • Author(s)
      Yasutomo Yamamoto
    • Journal Title

      Tetrahedron 61(2)

      Pages: 379-384

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catalytic Asymmetric Conjugate Addition of Dialkylzinc Reagents to (β-Aryl-α,β-unsaturated N-2,4,6-Triisopropylphenylsulfonylaldimines with use of N-Boc-L-Val-Connected Amidophosphane-Copper(I) Catalyst.2005

    • Author(s)
      Takahiro Soeta
    • Journal Title

      J.Org.Chem. 70(1)

      Pages: 297-300

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Thiol-Catalyzed Acyl Radical Cyclization of Alkenals.2005

    • Author(s)
      Kazuya Yoshikai
    • Journal Title

      J Org.Chem. 70(2)

      Pages: 681-683

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanistic Aspects of Thiyl Radical-Promoted Acyl Radical Cyclization of Formylenoate - Cyclization versus Oxidation.2005

    • Author(s)
      Kazuya Yoshikai
    • Journal Title

      Chem.Pharm.Bull. 53(5)

      Pages: 586-588

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Amino Alcohol-Mediated Asymmetric Conjugate Addition of Arylalkynes to Nitroolefins.2005

    • Author(s)
      Mitsuaki Yamashita
    • Journal Title

      Org.Lett. 7(12)

      Pages: 2369-2371

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Amidophosphane-Copper Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Nitroalkenes.2005

    • Author(s)
      Fanny Vakkeux
    • Journal Title

      Tetrahedron 61(31)

      Pages: 7420-7424

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1R,2R)-2-Dimethylamino-1,2-diphenylethanol.2005

    • Author(s)
      Mitsuaki Yamashita
    • Journal Title

      Adv.Synth.Catal. 347(11-13)

      Pages: 1649-1652

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Synthesis of 5-Arylcyclohexenones by Rhodium(I)-Catalyzed Conjugate Arylation of Racemic 5-(Trimethylsilyl)cyclohexenone with Arylboronic Acids.2005

    • Author(s)
      Qian Chen
    • Journal Title

      Org.Lett. 7(20)

      Pages: 4439-4441

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Mannich-Type Addition of Lithium Glycolates to Imines Producing 3-Hydroxy-4-Phenylazetidin-2-Ones.2005

    • Author(s)
      Hiroki Fujieda
    • Journal Title

      Heterocycles (Prof Kenji Koga's Memorial issue) 66

      Pages: 611-619

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Mannich-Type Addition of Lithium Glycolates to Imines Producing 3-Hydroxy-4-Phenylazetidin-2-Ones2005

    • Author(s)
      富岡 清
    • Journal Title

      Heterocycles 66

      Pages: 611-619

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Asymmetric Synthesis of 5-Arylcyclohexenones by Rhodium(I)-Catalyzed Conjugate Arylation of Racemic 5-(Trimethylsilyl) cyclohexenone with Arylboronic Acids2005

    • Author(s)
      富岡 清
    • Journal Title

      Org.Lett. 7・20

      Pages: 4439-4441

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by(1R,2R)-2-Dimethylamino-1,2-diphenylethanol2005

    • Author(s)
      富岡 清
    • Journal Title

      Adv.Synth.Catal. 347・11-13

      Pages: 1649-1652

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chiral Amidophosphane-Copper Catalyzed Asymmetric Conjugate Addition of Dialkylzinc Reagents to Nitroalkenes2005

    • Author(s)
      富岡 清
    • Journal Title

      Tetrahedron 61・31

      Pages: 7420-7424

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chiral Amino Alcohol-Mediated Asymmetric Conjugate Addition of Arylalkynes to Nitroolefins2005

    • Author(s)
      富岡 清
    • Journal Title

      Org.Lett. 7・12

      Pages: 2369-2371

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dimethylzinc-Initiated Radical Reaction of Cyclic Ethers with Arylamines, Alkoxyamines, and Dialkylhydrazines.2005

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrahedron 61・2

      Pages: 379-384

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Catalytic Asymmetric Conjugate Addition of Dialkylzinc Reagents to β-Aryl-α,β-unsaturated N-2,4,6-Triisopropylphenylsulfonylaldimines with use of N-Boc-L-Val-Connected Amidophosphane-Copper(I) Catalyst.2005

    • Author(s)
      K.Tomioka
    • Journal Title

      J.Org.Chem. 70・1

      Pages: 297-300

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Thiol-Catalyzed Acyl Radical Cyclization of Alkenals.2005

    • Author(s)
      K.Tomioka
    • Journal Title

      J.Org.Chem. 70・2

      Pages: 681-683

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unexpected reaction of a dimethylzinc-generated THF radical with aldehydes2004

    • Author(s)
      Y.Yamamoto
    • Journal Title

      Tetrahedron Lett. 45(4)

      Pages: 795-797

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Ligand-Controlled Asymmetric Conjugate Addition of α-Trimethylsilanylacetate to Acyclic and Cyclic Enones.2004

    • Author(s)
      M.Iguchi
    • Journal Title

      Chem. Pharm. Bull. 52(1)

      Pages: 125-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Introduction of Functionalized C1, C2, and C3 Units to Imines through the Dimethylzinc-Air-Initiated Radical Addition.2004

    • Author(s)
      K.Yamada
    • Journal Title

      J. Org. Chem. 69(5)

      Pages: 1531-1534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Construction of Arene-Fused-Piperidine Motifs by Asymmetric Addition of 2-Trityl-oxymethylaryllithiums to Nitroalkenes : the Asymmetric Synthesis of a Dopamine D1 Full Agonist. A-86929.2004

    • Author(s)
      M.Yamashita
    • Journal Title

      J. Am. Chem. Soc. 126(7)

      Pages: 1954-1955

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient Synthesis of (±)-γ-Lycorane Employing Stereoselective Conjugate Addition to Nitroolefin.2004

    • Author(s)
      T.Yasuhara
    • Journal Title

      Tetrahedron Lett. 45(15)

      Pages: 3043-3045

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Improved Asymmetric Synthesis of Dopamine D1 Full Agonist, Dihydrexidine. Employing Chiral Ligand-Controlled Asymmetric Conjugate Addition of Aryllithium to a Nitroalkene.2004

    • Author(s)
      M.Yamashita
    • Journal Title

      Tetrahedron 60(19)

      Pages: 4237-4242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lithium Amide-Assisted Asymmetric Mannich-Type Reactions of Menthyl Acetate with PMP-Aldimines.2004

    • Author(s)
      S.Hata
    • Journal Title

      Org.Lett. 6(11)

      Pages: 1721-1723

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catalytic Enhancement Effect of a Chiral Ligand on the Asymmetric Mannich-Type Reactions of Menthyl Alkanoates with Aldimines.2004

    • Author(s)
      S.Hata
    • Journal Title

      Synthesis (9)

      Pages: 1471-1475

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] N-Allyl-N-tert-butyldimethylsilylamine for Chiral Ligand-Controlled Asymmetric Conjugate Addition to tert-Butyl Alkenoates.2004

    • Author(s)
      H.Doi
    • Journal Title

      Chem. Commun. (16)

      Pages: 1850-1851

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] N-Boc-L-Valine-Connected Amidomonophosphane-Rhodium(I) Catalyst for Asymmetric Arylation of N-Tosylarylimines with Arylboroxines.2004

    • Author(s)
      M.Kuriyama
    • Journal Title

      J. Am. Chem. Soc. 126(26)

      Pages: 8128-8129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Synthesis of Nitrogen-Functionalized Cyclohexanes using Chemoselective Conjugate Addition of Phenyllithium to Linear ω-Nitro-α,β,ψ,ω-Unsaturated Ester and Subsequent Stereoselective Intramolecular Nitro-Michael Cyclization.2004

    • Author(s)
      T.Yasuhara
    • Journal Title

      Chem. Pharm. Bull. 52(9)

      Pages: 1109-1113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct Aminoalkylation of Cycloalkanes through Dimethylzinc-Initiated Radical Process.2004

    • Author(s)
      K.Yamada
    • Journal Title

      Tetrahedron Lett. 45(35)

      Pages: 6595-6597

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structure Tuning of Lithium Amide for Asymmetric 1,4-Addition to Cinnamate and Subsequent Demasking.2004

    • Author(s)
      T.Sakai
    • Journal Title

      Tetrahedron Lett. 45(50)

      Pages: 9261-9263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unexpected reaction of a dimethylzinc-generated THF radical with aldehydes.2004

    • Author(s)
      Yasutomo Yamamoto
    • Journal Title

      Tetrahedron Lett. 45(4)

      Pages: 795-797

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Ligand-Controlled Asymmetric Conjugate Addition of a-Trimethylsilanylacetate to Acyclic and Cyclic Enones.2004

    • Author(s)
      Mayu Iguchi
    • Journal Title

      Chem.Pharm.Bull. 52(1)

      Pages: 125-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Introduction of Functionalized C1, C2, and C3 Units to Imines through the Dimethylzinc-Air-Initiated Radical Addition.2004

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      J.Org.Chem. 69(5)

      Pages: 1531-1534

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Construction of Arene-Fused-Piperidine Motifs by Asymmetric Addition of 2-Trityl-oxymethylaryllithiums to Nitroalkenes : the Asymmetric Synthesis of a Dopamine D1 Full Agonist, A-86929.2004

    • Author(s)
      Mitsuaki Yamashita
    • Journal Title

      J.Am.Chem.Soc. 126(7)

      Pages: 1954-1955

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient Synthesis of (±)-γ-Lycorane Employing Stereoselective Conjugate Addition to Nitroolefin.2004

    • Author(s)
      Tomohisa Yasuhara
    • Journal Title

      Tetrahedron Lett. 45(15)

      Pages: 3043-3045

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Improved Asymmetric Synthesis of Dopamine D1 Full Agonist, Dihydrexidine, Employing Chiral Ligand-Controlled Asymmetric Conjugate Addition of Aryllithium to a Nitroalkene.2004

    • Author(s)
      Mitsuaki Yamashita
    • Journal Title

      Tetrahedron 60(19)

      Pages: 4237-4242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lithium Amide-Assisted Asymmetric Mannich-Type Reactions of Menthyl Acetate with PMP-Aldimines.2004

    • Author(s)
      Seiji Hata
    • Journal Title

      Org.Lett. 6(11)

      Pages: 1721-1723

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Catalytic Enhancement Effect of a Chiral Ligand on the Asymmetric Mannich-Type Reactions of Menthyl Alkanoates with Aldimines2004

    • Author(s)
      Seiji Hata
    • Journal Title

      Synthesis (9) Prof. Teruaki Mukaiyama issue

      Pages: 1471-1475

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] N-Allyl-N-tert-butyldimethylsilylamine for Chiral Ligand-Controlled Asymmetric Conjugate Addition to tert-Butyl Alkenoates.2004

    • Author(s)
      Hirohisa Doi
    • Journal Title

      Chem.Commun. (16)

      Pages: 1850-1851

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] N-Boc-L-Valine-Connected Amidomonophosphane-Rhodium(I) Catalyst for Asymmetric Arylation of N-Tosylarylimines with Arylboroxines.2004

    • Author(s)
      Masami Kuriyama
    • Journal Title

      J.Am.Chem.Soc. 126(26)

      Pages: 8128-8129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Synthesis of Nitrogen-Functionalized Cyclohexanes using Chemoselective Conjugate Addition of Phenyllithium to Linear ω-Nitro-α,β,ψ,ω-Unsaturated Ester and Subsequent Stereoselective Intramolecular Nitro-Michael Cyclization.2004

    • Author(s)
      Tomohisa Yasuhara
    • Journal Title

      Chem.Pharm.Bull. 52(9)

      Pages: 1109-1113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct Aminoalkylation of Cycloalkanes through Dimethylzinc-Initiated Radical Process.2004

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      Tetrahedron Lett. 45(35)

      Pages: 6595-6597

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structure Tuning of Lithium Amide for Asymmetric 1,4-Addition to Cinnamate and Subsequent Demasking.2004

    • Author(s)
      Takeo Sakai
    • Journal Title

      Tetrahedron Lett. 45(50)

      Pages: 9261-9263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Improved Asymmetric Synthesis of Dopamine D 1 Full Agonist, Dihydrexidine, Employing Chiral Ligand-Controlled Asymmetric Conjugate Addition of Aryllithium to a Nitroalkene2004

    • Author(s)
      Mitsuaki Yamashita
    • Journal Title

      Tetrahedron 60(19)

      Pages: 4237-4242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] N-Boc-L-Valine-Connected Amidomonophosphanc-Rhodium(I) Catalyst for Asymmetric Arylalion of N-Tosylarylimines with Arylboroxines.2004

    • Author(s)
      K.Tomioka
    • Journal Title

      J.Am.Chem.Soc. 126・26

      Pages: 8128-8129

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Direct Aminoalkylation of Cycloalkanes through Dimethylzinc-Initiated Radical Process.2004

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrahedron Lett. 45・35

      Pages: 6595-6597

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Structure Tuning of Lithium Amide for Asymmetric 1,4-Addition to Cinnamate and Subsequent Demasking.2004

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrahedron Lett. 45・50

      Pages: 9261-9263

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Chiral Ligand-Controlled Asymmetric Conjugate Addition of Lithium Amides to Enoates.2003

    • Author(s)
      H.Doi
    • Journal Title

      J. Am. Chem. Soc. 125(10)

      Pages: 2886-2887

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Total Synthesis of (±)-α- and β-Lycoranes by Sequential Chemoselective Conjugate Addition-Stereoselective Nitro-Michael Cyclization of an ω-Nitro-α,β,ψ,ω-unsaturated Ester2003

    • Author(s)
      T.Yasuhara
    • Journal Title

      Org. Lett. 5(7)

      Pages: 1123-1126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Michael-aldol tandem cyclization of ω-oxo-α,β-unsaturated esters with 10-mercaptoisobomeol methyl ether.2003

    • Author(s)
      K.Nishimura
    • Journal Title

      Tetrahedron Lett. 44(11)

      Pages: 2323-2326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stereoselective Synthesis of the Optically Pure AB-Ring Moiety of Trichothecene Sesquiterpene (+)-Calonectrin.2003

    • Author(s)
      A.Iida
    • Journal Title

      Heterocycles 59(2)

      Pages: 595-604

    • NAID

      80015822568

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Initiator-Dependent Chemoselective Addition of THF Radical to Aldehyde and Aldimine and Its Application to a Three-Component Reaction.2003

    • Author(s)
      K.Yamada
    • Journal Title

      Org. Lett. 5(10)

      Pages: 1797-1799

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cancer preventive potential of trichothecenes from Trichothecium roseum.2003

    • Author(s)
      K.Konishi
    • Journal Title

      Bioorganic & Medicinal Chemistry 11(12)

      Pages: 2511-2518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral ligand-controlled catalytic asymmetric epoxidation of unsaturated carbonyl compounds with peroxide.2003

    • Author(s)
      Y.Tanaka
    • Journal Title

      Tetrahedron 59(25)

      Pages: 4549-4556

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular Assembly of C_2-Symmetric Bis-(2S)-2-methyldodecanoyl-amides of α,ω-Alkylidenediamines into Coiled Coil and Twisted Ribbon Aggregates.2003

    • Author(s)
      T.Sumiyoshi
    • Journal Title

      J. Am. Chem. Soc. 125(40)

      Pages: 12137-12142

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Alkylation of N-Toluenesulfonylimines with Dialkylzinc Reagents Catalyzed by Copper-Chiral Amidophosphine.2003

    • Author(s)
      T.Soeta
    • Journal Title

      J. Org. Chem. 68(25)

      Pages: 9723-9727

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral Ligand-Controlled Asymmetric Conjugate Addition of Lithium Amides to Enoates.2003

    • Author(s)
      Hirohisa Doi
    • Journal Title

      J.Am.Chem.Soc 125(10)

      Pages: 2886-2887

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Total Synthesis of (±)-α- and β-Lycoranes by Sequential Chemoselective Conjugate Addition-Stereoselective Nitro-Michael Cyclization of an w-Nitro-α,β,ψ,ω-unsaturated Ester.2003

    • Author(s)
      Tomohisa Yasuhara
    • Journal Title

      Org.Lett. 5(7)

      Pages: 1123-1126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Michael-aldol tandem cyclization of ω-oxo-α,β-unsaturated esters with 10-mercaptoisoborneol methyl ether.2003

    • Author(s)
      Katsumi Nishimura
    • Journal Title

      Tetrahedron Lett. 44(11)

      Pages: 2323-2326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stereoselective Synthesis of the Optically Pure AB-Ring Moiety of Trichothecene Sesquiterpene (+)-Calonectrin.2003

    • Author(s)
      Akira Iida
    • Journal Title

      Heterocycles 59(2)

      Pages: 595-604

    • NAID

      80015822568

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Initiator-Dependent Chemoselective Addition of THF Radical to Aldehyde and Aldimine and Its Application to a Three-Component Reaction.2003

    • Author(s)
      Ken-ichi Yamada
    • Journal Title

      Org.Lett. 5(10)

      Pages: 1797-1799

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cancer preventive potential of trichothecenes from Trichothecium roseum.2003

    • Author(s)
      Kazuhide Konishi
    • Journal Title

      Bioorganic & Medicinal Chemistry 11(12)

      Pages: 2511-2518

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chiral ligand-controlled catalytic asymmetric epoxidation of unsaturated carbonyl compounds with peroxide.2003

    • Author(s)
      Yoshihito Tanaka
    • Journal Title

      Tetrahedron 59(25)

      Pages: 4549-4556

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular Assembly of C_2-Symmetric Bis-(2S)-2-methyldodecanoyl-amides of α,ω-Alkylidenediamines into Coiled Coil and Twisted Ribbon Aggregates.2003

    • Author(s)
      Takaaki Sumiyoshi
    • Journal Title

      J.Am.Chem.Soc. 125(40)

      Pages: 12137-12142

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Asymmetric Alkylation of N-Toluenesulfonylimines with Dialkylzinc Reagents Catalyzed by Copper-Chiral Amidophosphine.2003

    • Author(s)
      Takahiro Soeta
    • Journal Title

      J.Org.Chem. 68(25)

      Pages: 9723-9727

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Conjugate Addition of Organometallics to Activated Olefins2004

    • Author(s)
      K.Tomioka
    • Total Pages
      10
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] The Chemistry of Organolithium Compounds2004

    • Author(s)
      H.Yamataka
    • Total Pages
      41
    • Publisher
      Wiley
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] ブルース有機化学2004

    • Author(s)
      P.Y.Bruice
    • Total Pages
      1529
    • Publisher
      化学同人
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Modern Allene Chemistry2004

    • Author(s)
      H.Ohno
    • Total Pages
      10
    • Publisher
      Wiley
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] The Chemistry of Organolithium Compounds2004

    • Author(s)
      K.Tomioka
    • Total Pages
      41
    • Publisher
      Wiley
    • Related Report
      2004 Annual Research Report
  • [Book] メディシナルケミストリー2003

    • Author(s)
      G.L.Patrick
    • Total Pages
      597
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Asymmetric addition reaction of organolithium reactants under control of chiral ligands2003

    • Author(s)
      K.Tomioka
    • Total Pages
      10
    • Publisher
      プロセス化学会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents2003

    • Author(s)
      M.Iguchi
    • Total Pages
      18
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] K.Tomioka: "Initiator-Dependent Chemoselective Addition of THF Radical to Aldehyde and Alidimine and Its Application to Three-Component Reaction"Org.Lett.. 5・10. 1797-1799 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tomioka: "Molecular Assembly of C2-Symnietric Bis-(2S)-2-methyldodecanoyl-amides of a, w-Allylidenediamines into Coiled Coil and Twisted Ribbon Aggregates"J.Am.Chem.Soc.. 125・40. 12137-12142 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tomioka: "Asymmetric Alkylation of N-Toluenesulfonylimines with Dialkylzinc Reagents Catalyzed by Copper-Chiral Amidophosphine"J.Org.Chem.. 68・25. 9723-9727 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tomioka: "Unexpected Reaction of a dimethylzinc-generated THF radical with aldehyde"Tetrahedron Lett.. 45・4. 795-797 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tomioka: "Introduction of Functionalized C1, C2, and C3 Units to Imines through the Dimethylzinc-Air-Initiated Radical Addition"J.Org.Chem.. 69・5. 1531-1534 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tomioka: "Construction of Arene-Fused-Piperidine Motifs by Asymmetric Addition of 2-Trityloxymethylaryllithiums to Nitroalkenes : The Asymmetric Synthesis of a Dopamine D1 Full Agonist, A-86929"J.Am.Chem.Soc.. 126・7. 1954-1955 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tomioka: "Organolithiums in Enantioselective Synthesis (Topics in Organometallic Chemistry 5)"Springer. 23 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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