Molecular mechanisms for hemato-vascular formation

• Project/Area Number: 15390086
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: University of Tsukuba
• Principal Investigator: YAMAMOTO Masayuki University of Tsukuba, Graduate School of Comprehensive Human Sciences, Professor, 大学院・人間総合科学研究科, 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Ritsuko University of Tsukuba, Graduate School of Comprehensive Human Sciences, Lecturer, 大学院・人間総合科学研究科, 講師 (40226262) ; 峯岸 直子 筑波大学, 基礎医学系, 助教授 (40271895)
• Project Period (FY): 2003 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥15,300,000 (Direct Cost: ¥15,300,000); Fiscal Year 2004: ¥7,400,000 (Direct Cost: ¥7,400,000); Fiscal Year 2003: ¥7,900,000 (Direct Cost: ¥7,900,000)
• Keywords: Hematopoietic stem cell / GATA-2 / GFP knock-in mouse in the GATA-2 locus / GATA-2 conditional knock-out mouse / Bone marrow transplantation / GATA-1 / トランスジェニックマウス / 遺伝子破壊マウス / ゼブラフィッシュ / 緑色蛍光蛋白質 / 赤血球 / ヘマンジオブラスト

Research Abstract

We have established green fluorescent protein (GFP) knock-in knockout mice (G2-GFP), in which the GFP gene was inserted into Gata2 gene under the hematopoietic specific promoter/ first exon and analyzed the phenotypes of GFP expressing cells. The percentage of GFP positive cells was 0.5 % in the bone marrow mononuclear cells. These GFP positive cells, expressing c-Kit without any staining lineage markers (Lin), had a potential to develop several lineage committing cells on the OP9 cell layer, suggesting that GFP-positive cells were belonging to either the population of hematopoietic progenitor cells or that of hematopoietic stem cells. The expression of cellular proliferation-related molecules, such as c-Myc, Cyclin A2 and Cyclin B1, in the GFP-positive cells were higher than those in the GFP-negative cells. In addition, more than 30 % of the cells in the population of Lin-/c-Kit^+/GFP^+ accumulated in S/G2/M phase. These findings indicated that GATA-2 had an important role for the tra nscriptional regulation of genes relating to cell cycle progression of the immature hematopoietic progenitor cells.
To further investigate the function of GATA-2 on the hematopoietic cell proliferation in vivo, we established Gata2 gene conditional knockout allele (G2-CKO), in which GATA-2 cDNA sandwiched between two loxP sequences was inserted into the translation initiation site of Gata2 gene. Because the simple Gata2 gene knockout mice were embryonic lethal, this G2-CKO mouse line might be one of the most appropriate means to examine the function of GATA-2 on bone marrow hematopoiesis. We intercrossed the compound GATA-2 targeting mice (G2^<CKO/GFP>) with Mx1-Cre transgenic mice, in which the expression of Cre recombinase was induced by the treatment of interferon, and successfully generated the triple compound mouse colony (Gata2^<CKO/GFP>::Mx1-Cre). We are now ready for bone marrow transplantation analyses using the bone marrow cells of these mice to examine the function of GATA-2 for adult hematopoiesis.

Research Products

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  • Journal Title: Free Rad.Biol.Med. 38 Pages: 325-343
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An activator protein-1-Notch-4 angiogenic vascular remodeling pathway. (2005)
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transgenic overexpression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells. (2005)
  • Author(s): Nakano, M., et al.
  • Journal Title: Genes Cells 10 Pages: 47-62
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. (2005)
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. (2005)
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  • Journal Title: Arch.Biochem.Biophys. 433 Pages: 342-350
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1. (2005)
  • Author(s): Padmanabhan, B., et al.
  • Journal Title: Acta Crystallographica 61 Pages: 153-155
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap 1. (2005)
  • Author(s): Padmanabhan, B., et al.
  • Journal Title: Acta Crystallographica 61 Pages: 153-155
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic overexpression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells. (2005)
  • Author(s): Nakano, M., Ohneda, K., Mukai, H.Y., Shimizu, R., Ohneda, O., Ohmura, S., Suzuki, M., Tsukamoto, S., Yanagawa, T., Yoshida, H., Takakuwa, Y, Yamamoto, M.
  • Journal Title: Genes Cells 10 Pages: 47-62
• [Journal Article] Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. (2005)
  • Author(s): Katsuoka, F., Motohashi, M., Engel, J.D., Yamamoto, M.
  • Journal Title: J.Biol.Chem. 280 Pages: 4483-4490
• [Journal Article] Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keapl-mediated degradation of the protein by proteasome. (2005)
  • Author(s): Katoh, Y., Iida, K., Kang, M-I, Kobayashi, A., Mizukami, M., Tong, K.I., McMahon, M., Hayes, J.D., Itoh, K., Yamamoto, M.
  • Journal Title: Arch.Biochem.Biophys. 433 Pages: 342-350
• [Journal Article] Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1. (2005)
  • Author(s): Padmanabhan, B., Scharlock, M, Tong, K.I, Nakamura, Y., Kang, M-I., Kobayashi, A., Matsumoto, T., Tanaka, A., Yamamoto, M, Yokoyama, S.
  • Journal Title: Acta Crystallographica 61 Pages: 153-155
• [Journal Article] Essential role of synoviolin in embryogenesis. (2005)
  • Author(s): Yagishita, N., Ohneda, K., Amano, T., Yamasaki, S., Sugiura, A., Tsuchimochi, K., Shin, H., Kawahara, K., Ohneda, O., Ohta, T., Tanaka, S., Yamamoto, M., Maruyama, I., Nishioka, K., Fukamizu, A., Nakajima, T.
  • Journal Title: J.Biol.Chem. (印刷中)
• [Journal Article] Restricted expression of constitutively active-aryl hydrocarbon receptor in T lineage cells causes thymus involution and suppresses immunization-induced splenocyte increase. (2005)
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  • Journal Title: J.Immunol (印刷中)
• [Journal Article] Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish. (2005)
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  • Journal Title: Biochem.J. (印刷中)
• [Journal Article] UVA irradiation induces Nrf2 activation in dermal fibroblasts : Protective role in UVA-induced apoptosis. (2005)
  • Author(s): Hirota, A., Kawachi, Y., Itoh, K., Nakamura, Y., Xu, X., Banno, T., Takahashi, T., Yamamoto, M, Ohtsuka, F.
  • Journal Title: Invest.Dermatol. (印刷中)
• [Journal Article] The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis. (2005)
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  • Journal Title: Mol.Cell.Biol. (印刷中)
• [Journal Article] GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity. (2005)
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  • Journal Title: J.Biol.Chem.
• [Journal Article] Role of 15-deoxyD^<12-14> Prostaglandin J_2 and Nrf2 Pathways in Protection against Acute Lung Injury. (2005)
  • Author(s): Mochizuki, M., Ishii, Y., Itoh, K., Iizuka, T., Morishima, Y., Kimura, T., Kiwamoto, T., Matsuno, Y., Hegab, A.E., Nomura, A., Sakamoto, T., Uchida, K., Yamamoto, M, Sekizawa, K.
  • Journal Title: Am.J.Res.Cri.Care Med (印刷中)
• [Journal Article] Molecular mechanisms activating Nrf2-Keap1 pathway in regulation of antioxidant gene. (2005)
  • Author(s): Kobayashi, M, Yamamoto, M.
  • Journal Title: Antioxidants Redox Signaling 7 Pages: 384-395
• [Journal Article] Gene expression regulation and domain function of hematopoietic GATA factors. (2005)
  • Author(s): Shimizu, R, Yamamoto, M.
  • Journal Title: Seminars in Cell & Developmental Biology 16 Pages: 129-136
• [Journal Article] GATA1 function, a paradigm for transcription factors in hematopoiesis. (2005)
  • Author(s): Ferreira, R., Ohneda, K., Yamamoto, M., Philipsen, S.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 1215-1217
• [Journal Article] Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Δ^<12,14>-prostaglandin J_2. (2004)
  • Author(s): Itoh, K., et al.
  • Journal Title: Mol.Cell.Biol. 24 Pages: 36-45
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for the vertebrate head specification. (2004)
  • Author(s): Kimura-Yoshida, C., et al.
  • Journal Title: Development 131 Pages: 57-71
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging technique. (2004)
  • Author(s): Kyo, M., et al.
  • Journal Title: Genes Cells 9 Pages: 153-164
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia. (2004)
  • Author(s): Shimizu, R., et al.
  • Journal Title: Blood 103 Pages: 2560-2567
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages : activation by oxidatively modified LDL and 4-hydroxynonenal. (2004)
  • Author(s): Ishii, T., et al.
  • Journal Title: Circulation Res. 94 Pages: 609-616
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Protection against electrophile and oxidant stress by induction of the phase 2 response : Fate of cysteines of the Keap 1 sensor modified by inducers. (2004)
  • Author(s): Wakabayashi, N., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 2040-2045
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. (2004)
  • Author(s): Kang, M.I., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 2046-2051
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. (2004)
  • Author(s): Yoshida, S., et al.
  • Journal Title: Dev.Biol. 269 Pages: 447-458
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interleukin-6 and tumor necrosis factor-a in patients with obstructive sleep apnea-hypopnea syndrome. (2004)
  • Author(s): Imagawa, S., et al.
  • Journal Title: Respiration 71 Pages: 24-29
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Small Maf proteins are obligate transcriptional cofactors for normal keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. (2004)
  • Author(s): Motohashi, H., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 6379-6384
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr. (2004)
  • Author(s): Morito, N., et al.
  • Journal Title: Kidney Int. 65 Pages: 1703-1713
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest. (2004)
  • Author(s): Ito, T., et al.
  • Journal Title: J.Biol.Chem. 279 Pages: 25204-25210
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 Mice. (2004)
  • Author(s): Goldring, C.E.P., et al.
  • Journal Title: Hepatology 39 Pages: 1267-1276
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells. (2004)
  • Author(s): Imai, T., et al.
  • Journal Title: Mol.Cell.Endocrinol. 214 Pages: 107-115
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nrf2 deficiency causes tooth decolorization due to iron transport disorder in enamel organ. (2004)
  • Author(s): Yanagawa, T., et al.
  • Journal Title: Genes Cells 9 Pages: 641-651
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox sensitive Neh2 degron and the redox-insensitive Neh6 degron. (2004)
  • Author(s): McMahon, M., et al.
  • Journal Title: J.Biol.Chem. 279 Pages: 31556-31567
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The transcriptional program of antibody class switching involves the repressor Bach2. (2004)
  • Author(s): Muto, A., et al.
  • Journal Title: Nature 429 Pages: 566-571
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The transcription factor Nrf2 protects against pulmonary fibrosis. (2004)
  • Author(s): Cho, H-Y., et al.
  • Journal Title: FASEB J. 18 Pages: 1258-1260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] MafT, a new member of the small Maf protein family in zebrafish. (2004)
  • Author(s): Takagi, Y., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 320 Pages: 62-69
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. (2004)
  • Author(s): Kobayashi, A., et al.
  • Journal Title: Mol.Cell.Biol. 24 Pages: 7310-7319
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of polymorphisms in the promoter region of human NRF2 gene. (2004)
  • Author(s): Yamamoto, T., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 321 Pages: 72-79
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Do β-globin, GATA-1 or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice? (2004)
  • Author(s): Suzuki, N., et al.
  • Journal Title: Blood 104 Pages: 2988-2989
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Multiple, distant Gata2 enhancers specify temporal and tissue-specific patterning in the developing urogenital system. (2004)
  • Author(s): Khandekar, M. J., et al.
  • Journal Title: Mol.Cell.Biol 24 Pages: 10263-10276
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. (2004)
  • Author(s): Iida, K., et al.
  • Journal Title: Cancer Res. 64 Pages: 6124-6431
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. (2004)
  • Author(s): Rangasamy, T., et al.
  • Journal Title: J.Clin.Invest. 114 Pages: 1248-1259
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. (2004)
  • Author(s): Nakano, Y., et al.
  • Journal Title: Blood 104 Pages: 4300-4307
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transcription factor Nrf2 is essential for induction of NAD(P)H : quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. (2004)
  • Author(s): McWalter, G.K., et al.
  • Journal Title: J.Nutr. 134
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Leukemogenesis caused by incapacitated GATA-1 function. (2004)
  • Author(s): Shimizu, R., et al.
  • Journal Title: Mol.Cell.Biol. 24 Pages: 10814-10825
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-D^<12,14>-prostaglandin J_2. (2004)
  • Author(s): Itoh, K., et al.
  • Journal Title: Mol.Cell.Biol. 24 Pages: 36-45
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protection against electrophile and oxidant stress by induction of the phase 2 response : Fate of cysteines of the Keap1 sensor modified by inducers. (2004)
  • Author(s): Wakabayashi, N., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 2040-2045
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Scaffolding of,Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. (2004)
  • Author(s): Kang, M.I., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 2046-2051
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protection against electrophile and oxidant stress by induction of the phase 2 response : Fate of cysteines of the Keap1 sensor modified by inducers. (2004)
  • Author(s): Yoshida, S., et al.
  • Journal Title: Dev.Biol. 269 Pages: 447-458
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of polymorphisms in the promoter region of human NRF2 gene. (2004)
  • Author(s): Yamamoto, T., et al.
  • Journal Title: Biochem.Biophys.Res.Common. 321 Pages: 72-79
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Do b-globin, GATA-1 or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice? (2004)
  • Author(s): Suzuki, N., et al.
  • Journal Title: Blood 104 Pages: 2988-2989
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Multiple, distant Gata2 enhancers specify temporal and tissue-specific patterning in the developing urogenital system. (2004)
  • Author(s): Khandekar, M. J., et al.
  • Journal Title: Mol.Cell.Biol. 24 Pages: 10263-10276
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transcription factor Nrf2 is essential for induction of NAD(P)H : quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. (2004)
  • Author(s): Mc Walter, G.K., et al.
  • Journal Title: J.Nutr. 134
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia. (2004)
  • Author(s): Shimizu, R., Ohneda, K., Engel, J.D., Trainor, C.D., Yamamoto, M.
  • Journal Title: Blood 103 Pages: 2560-2567
• [Journal Article] Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages : activation by oxidatively modified LDL and 4-hydroxynonenal (2004)
  • Author(s): Ishii, T., Itoh, K., Ruiz, E., Leake, D.S., Unoki, H., Yamamoto, M., Mann, G.E.
  • Journal Title: Circulation 94 Pages: 609-616
• [Journal Article] Protection against electrophile and oxidant stress by induction of the phase 2 response : Fate of cysteines of the Keap1 sensor modified by inducers. (2004)
  • Author(s): Wakabayashi, N., Dinkova-Kostova, A.T.Holizclaw, W.D., Kang, M-L, Kobayashi, A., Yamamoto, M., Kensler, T.W., Talalay, P.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 2040-2045
• [Journal Article] Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. (2004)
  • Author(s): Kang, MI, Kobayashi, A., Wakabayashi, N., Kim, S.G., Yamamoto, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 2046-2051
• [Journal Article] Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. (2004)
  • Author(s): Yoshida, S., Takakura, A., Ohbo, K., Abe, K., Wakabayashi, J., Yamamoto, M., Suda, T., Nabeshima, Y-i.
  • Journal Title: Dev.Biol 269 Pages: 447-458
• [Journal Article] Interleukin-6 and tumor necrosis factor-a in patients with obstructive sleep apnea-hypop nea syndrome (2004)
  • Author(s): Imagawa, S., Yamaguchi, Y., Ogawa, K., Obara, N., Suzuki, N., Yamamoto, M., Nagasawa, T.
  • Journal Title: Respiration 71 Pages: 24-29
• [Journal Article] Small Maf proteins are obligate transcriptional cofactors for normal keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. (2004)
  • Author(s): Motohashi, H., Katsuoka, F., Engel, J.D., Yamamot, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 6379-6384
• [Journal Article] Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr (2004)
  • Author(s): Morito, N., Yoh, K., Hirayama, A., Itoh, K., Nose, M., Koyama, A., Yamamoto, M.
  • Journal Title: Kidney Int. 65 Pages: 1703-1713
• [Journal Article] A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest. (2004)
  • Author(s): Ito, T., Tsukumo, S., Suzuki, N., Motohashi, H., Yamamoto, M., Fujii-Kuriyama, Y.
  • Journal Title: J.Biol.Chem. 279 Pages: 25204-25210
• [Journal Article] Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 Mice. (2004)
  • Author(s): Goldring, C.E.P., Kitteringham, N.R., Elsby, R., Randle, L.E., Clement, Y.N., Williams, D.P., McMahon, M., Hayes, J.D., Itoh, K., Yamamoto, M., Park, B.K.
  • Journal Title: Hepatology 39 Pages: 1267-1276
• [Journal Article] In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells. (2004)
  • Author(s): Imai, T., Kawai, Y., Tadokoro, Y., Yamamoto, M., Nishimune, Y., Yomogida K.
  • Journal Title: Mol.Cell.Endocrinol. 214 Pages: 107-115
• [Journal Article] Nrf2 deficiency causes tooth decolorization due to iron transport disorder in enamel organ. (2004)
  • Author(s): Yanagawa, T., Itoh, K., Uwayama, J., Shibata, Y., Yamaguchi, A., Sato, T., Ishii, T., Yoshida, H., Yamamoto, M.
  • Journal Title: Genes Cells 9 Pages: 641-651
• [Journal Article] Redox-regulated tumover of Nrf2 is determined by at least two separate protein domains the redox sensitive Neh2 degron and the redox-insensitive Neh6 degron. (2004)
  • Author(s): McMahon, M., Thomas, N., Itoh, K., Yamamoto, M., Haves, J.D.
  • Journal Title: J.Biol.Chem. 279 Pages: 31556-31567
• [Journal Article] The transcriptional program of antibody class switching involves the repressor Bach2. (2004)
  • Author(s): Muto, A., Tashiro, S., Nakajima, O., Hoshino, H., Takahashi, S., Sakoda, E., Ikebe, D., Yamamoto, M., Igarashi, K.
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• [Journal Article] The transcription factor Nrf2 protects against pulmonary fibrosis. (2004)
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  • Journal Title: FASEB J. 18 Pages: 1258-1260
• [Journal Article] MafT, a new member of the small Maf protein family in zebrafish. (2004)
  • Author(s): Takagi, Y., Kobayashi, M., Li, L., Suzuki, T., Nishikawa.K., Yamamoto, M.
  • Journal Title: Biochem.Biophys.Res.Connnun. 320 Pages: 62-69
• [Journal Article] Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. (2004)
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  • Journal Title: Mol.Cell.Biol. 24 Pages: 7310-7319
• [Journal Article] Identification of polymorphisms in the promoter region of human NRF2 gene. (2004)
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  • Journal Title: Biochem.Biophys.Res.Connnun. 321 Pages: 72-79
• [Journal Article] Do b-globin, GATA-1 or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice? (2004)
  • Author(s): Suzuki, N., Imagawa, S., Noguchi C.T., Yamamoto, M.
  • Journal Title: Blood 104 Pages: 2968-2969
• [Journal Article] Multiple, distant Gata2 enhancers specify temporal and tissue-specific patterning in the developing urogenital system. (2004)
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  • Journal Title: Mol.Cell.Biol. 24 Pages: 10263-10276
• [Journal Article] Nrf2 Is Essential for the Chemopreventive Efficacy of Oltipraz against Urinary Bladder Carcinogenesis. (2004)
  • Author(s): Iida, K., Itoh, K., Kumagai, Y., Oyasu, R., Hattori, K., Kawai, K., Shimazui, T., Akaza, H., Yamamoto, M.
  • Journal Title: Cancer Res. 64 Pages: 6124-6431
• [Journal Article] Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice (2004)
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• [Journal Article] A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1b, TNF-a or L-NMMA. (2004)
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  • Journal Title: Blood 104 Pages: 4300-4307
• [Journal Article] Transcription factor Nrf2 is essential for induction of NAD(P)H : quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. (2004)
  • Author(s): McWalter, G.K., Higgins, L.G., McLellan, L.I., Henderson, C.J., Song, L., Thomalley, P.J., Itoh, K., Yamamoto, M., Hayes, J.D.
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• [Journal Article] Leukemogenesis caused by incapacitated GATA-1 function. (2004)
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  • Journal Title: Mol.Cell.Biol. 24 Pages: 10814-10825
• [Journal Article] Gene expression profiling of NRF2-mediated protection against oxidative injury. (2004)
  • Author(s): Cho, H-Y., Reddy, S.P., DeBiase, A., Yamamoto, M, Kleeberger, S.R.
  • Journal Title: Free Rad.Biol.Med. 38 Pages: 325-343
• [Journal Article] An activator protein-1-Notch-4 angiogenic vascular remodeling pathway. (2004)
  • Author(s): Wu, J., Iwata, F., Grass, J.A., Elnitski, L., Ohneda, O., Yamamoto, M., Bresnick, E.H.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 1458-1474
• [Journal Article] Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. (2004)
  • Author(s): Kobayashi, A., Ohta, T, Yamamoto, M.
  • Journal Title: Methods Enzymol. 378 Pages: 1208-1213
• [Journal Article] Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. (2004)
  • Author(s): Itoh, K., Tong, K.I., Yamamoto, M.
  • Journal Title: Free Radical Biol.Med. 36 Pages: 1208-1121
• [Journal Article] Nrf2-Keap1 defines a physiologically important stress response mechanism. (2004)
  • Author(s): Motohashi, H, Yamamoto, M.
  • Journal Title: Trends Mal.Med. 10 Pages: 549-557
• [Journal Article] GATA転写因子からみる赤血球の発生・分化 (2004)
  • Author(s): 長野真澄, 山本雅之
  • Journal Title: 実験医学 22 Pages: 361-366
• [Journal Article] 親電子性物質応答の分子機構 (2004)
  • Author(s): 伊東 健, 山本雅之
  • Journal Title: 生化学 76 Pages: 339-348
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• [Journal Article] Keap1-Nrf2システムによる抗酸化酵素群の統一的発現制御機構 (2004)
  • Author(s): 細谷朋方, 山本雅之
  • Journal Title: 分子呼吸器病 8 Pages: 147-150
• [Journal Article] 血色素の分子進化 (2004)
  • Author(s): 鈴木教郎, 山本雅之
  • Journal Title: 日本医事新報 4177 Pages: 99-100
• [Journal Article] 転写因子と血液疾患 (2004)
  • Author(s): 峯岸直子, 山本雅之
  • Journal Title: 臨床検査 48 Pages: 473-781
• [Journal Article] GATA-1ノックダウンマウス (2004)
  • Author(s): 清水律子, 山本雅之
  • Journal Title: Mebio 21 Pages: 58-62
• [Journal Article] GATA-1変異と白血病-転写因子の質的異常と量的異常 (2004)
  • Author(s): 長野真澄, 清水律子, 長野真澄, 清水律子,
  • Journal Title: 医学の歩み 211 Pages: 159-162
• [Journal Article] Small Maf compound mutants display CNS neuronal degeneration, aberrant transcription and Bach protein mislocalization coincident with myoclonus and abnormal startle response. (2003)
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hemogenic and non-hemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis. (2003)
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  • Journal Title: Blood 101 Pages: 886-893
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Aberrant iron accumulation and oxidized status of erythroid-specific δ-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts. (2003)
  • Author(s): Harigae, H., et al.
  • Journal Title: Blood 101 Pages: 1188-1193
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• [Journal Article] Functional analysis of basic transcription element binding protein (BTEB) by gene targeting technology. (2003)
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• [Journal Article] Influence of nrf2 genotype on modulation by oltipraz of benzo[a]pyrene-DNA adducts and tumor yield in mice. (2003)
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  • Journal Title: Carcinogenesis 24 Pages: 461-467
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Modulation of keapl and nrf2 - dependent gene expression by cancer chemopreventive dithiolethiones : IDENTIFICATION OF NOVEL GENE CLUSTERS. (2003)
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• [Journal Article] Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. (2003)
  • Author(s): Itoh, K., et al.
  • Journal Title: Genes Cells 8 Pages: 379-391
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• [Journal Article] HLF (HIF-2α) is a key factor for pathological angiogenesis in proliferative retinopathy. (2003)
  • Author(s): Morita, M., et al.
  • Journal Title: EMBO J. 22 Pages: 1134-1146
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• [Journal Article] EPR imaging and analysis of reducing activity in oxidative stress-related Nrf2 transcription factor deficient mice. (2003)
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  • Journal Title: Free Rad.Biol.Med. 34 Pages: 1236-1242
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• [Journal Article] Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2. (2003)
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  • Journal Title: Arch.Toxicol. 77 Pages: 267-273
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• [Journal Article] Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse. (2003)
  • Author(s): Noda, S., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 303 Pages: 105-111
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• [Journal Article] Distinct specificity of xenobiotic response in AhR-humanized model mouse. (2003)
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  • Journal Title: Proc.Natl.Acad.Sci.USA 100 Pages: 5652-5657
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• [Journal Article] Keap 1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of ARE-driven gene expression. (2003)
  • Author(s): McMahon, M., et al.
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• [Journal Article] Regulation of YB-1 gene expression by GATA transcription factors. (2003)
  • Author(s): Yokoyama, H., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 303 Pages: 140-145
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• [Journal Article] Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. (2003)
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  • Journal Title: Blood 102 Pages: 896-905
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• [Journal Article] GATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene in transgenic mouse. (2003)
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  • Journal Title: Genes Cells 8 Pages: 619-630
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. (2003)
  • Author(s): Aono, J., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 305 Pages: 271-277
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• [Journal Article] Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H : quinone oxidoreductase 1 gene : reassessment of the ARE consensus sequence. (2003)
  • Author(s): Nioi, P., et al.
  • Journal Title: Biochem.J. 374 Pages: 337-348
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• [Journal Article] A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits. (2003)
  • Author(s): Pi, J., et al.
  • Journal Title: Free Rad.Biol.Med. 35 Pages: 102-113
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down's syndrome. (2003)
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  • Journal Title: Blood 102 Pages: 2960-2968
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transgenic overexpression of GATA-3 in T-lymphocytes improves autoimmune glomerulonephritis in mice with BXSB/MpJ-Yaa genetic background. (2003)
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  • Journal Title: J.Am.Soc.Nephrol. 14 Pages: 2494-2502
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• [Journal Article] Identification and characterization of two types of erythroid progenitors that express GATA-1 at distinct levels. (2003)
  • Author(s): Suzuki, N., et al.
  • Journal Title: Blood 102 Pages: 3575-3583
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• [Journal Article] Self-association of Gata1 enhances transcriptional activity in vivo in zebrafish embryos. (2003)
  • Author(s): Nishikawa, K., et al.
  • Journal Title: Mol.Cell.Biol. 23 Pages: 8295-8305
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1β, TNF-α or L-NMMA. (2003)
  • Author(s): Imagawa, S., et al.
  • Journal Title: FASEB J. 17 Pages: 1742-1744
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nrf2 regulates the sensitivity of death receptor signals through intracellular glutathione levels. (2003)
  • Author(s): Morito, N., et al.
  • Journal Title: Oncogene 18 Pages: 9275-9281
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. (2003)
  • Author(s): Wakabayashi, N., et al.
  • Journal Title: Nature Genetics 35 Pages: 238-245
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 (Mrp1/Abcc1) in mouse embryo fibroblasts. (2003)
  • Author(s): Hayashi, A., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 310 Pages: 824-829
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. (2003)
  • Author(s): Jowsey, I.R., et al.
  • Journal Title: Mol.Pharmacol. 64 Pages: 1018-1028
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hematological aspects of a novel 9-aminoanthracycline, amrubicin. (2003)
  • Author(s): Obara, N., et al.
  • Journal Title: Cancer Sci. 94 Pages: 1104-1106
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antioxidants enhance mammalian proteasome expression through the Keap 1-Nrf2 signaling pathway. (2003)
  • Author(s): Kwak, M.K., et al.
  • Journal Title: Mol.Cell.Biol. 23 Pages: 8786-8794
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Aberrant iron accumulation and oxidized status of erythroid-specific d-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts. (2003)
  • Author(s): Harigae, H., et al.
  • Journal Title: Blood 101 Pages: 1188-1193
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modulation of keap1 and nrf2 -dependent gene expression by cancer chemopreventive dithiolethiones : IDENTIFICATION OF NOVEL GENE CLUSTERS. (2003)
  • Author(s): Kwak, M.K., et al.
  • Journal Title: J.Biol.Chem. 278 Pages: 8135-8145
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] HLF (HIF-2a) is a key factor for pathological angiogenesis in proliferative retinopathy. (2003)
  • Author(s): Morita, M., et al.
  • Journal Title: EMBO J. 22 Pages: 1134-1146
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse. (2003)
  • Author(s): Noda, S., et al.
  • Journal Title: Biochem.Biophys.Res.Common. 303 Pages: 105-111
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of ARE-driven gene expression. (2003)
  • Author(s): McMahon, M., et al.
  • Journal Title: J.Biol.Chem. 278 Pages: 21592-21600
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Self-association of Gatal enhances transcriptional activity in vivo in zebrafish embryos. (2003)
  • Author(s): Nishikawa, K., et al.
  • Journal Title: Mol.Cell.Biol. 23 Pages: 8295-8305
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1b, TNF-a or L-NMMA. (2003)
  • Author(s): Imagawa, S., et al.
  • Journal Title: FASEB J. 17 Pages: 1742-1744
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nrf2 regulates the sensitivity of death receptor signals through intra-cellular glutathione levels. (2003)
  • Author(s): Morito, N., et al.
  • Journal Title: Oncogene 18 Pages: 9275-9281
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 (Mrp1/Abcc1) in mouse embryo fibroblasts. (2003)
  • Author(s): Hayashi, A., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 310 Pages: 824-829
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. (2003)
  • Author(s): Kwak, M.K., et al.
  • Journal Title: Mol.Cell.Biol. 23 Pages: 8786-8794
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment.
  • Author(s): Toki, T., et al.
  • Journal Title: Blood (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Essential role of synoviolin in embryogenesis.
  • Author(s): Yagishita, N., et al.
  • Journal Title: J.Biol.Chem. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Restricted expression of constitutively active-aryl hydrocarbon receptor in T lineage cells causes thymus involution and suppresses immunization-induced splenocyte increase.
  • Author(s): Nohara, K., et al.
  • Journal Title: J.Immunol. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish.
  • Author(s): Suzuki, T., et al.
  • Journal Title: Biochem.J. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] UVA irradiation induces Nrf2 activation in dermal fibroblasts : Protective role in UVA-induced apoptosis.
  • Author(s): Hirota, A., et al.
  • Journal Title: Invest.Dermatol. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis.
  • Author(s): Kelly, V.P., et al.
  • Journal Title: Mol.Cell.Biol. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.
  • Author(s): Ezoe, S., et al.
  • Journal Title: J.Biol.Chem. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of 15-deoxyΔ^<12-14> Prostaglandin J_2 and Nrf2 Pathways in Protection against Acute Lung Injury.
  • Author(s): Mochizuki, M., et al.
  • Journal Title: Am.J.Res.Cri.Care Med. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Increased dose of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.
  • Author(s): Yanagida, M., et al.
  • Journal Title: Oncogene (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
  • Author(s): Minegishi, N., et al.
  • Journal Title: Genes Cells (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] MafA is a key regulator of glucose-stimulated insulin secretion.
  • Author(s): Zhang, C., et al.
  • Journal Title: Mol.Cell.Biol. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment.
  • Author(s): Toki, T., et al.
  • Journal Title: Blood (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Essential role of synoviolin in embryogenesis.
  • Author(s): Yagishita, N., et al.
  • Journal Title: J.Biol.Chem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Restricted expression of constitutively active-aryl hydrocarbon receptor in T lineage cells causes thymus involution and suppresses immunization-induced splenocyte increase.
  • Author(s): Nohara, K., et al.
  • Journal Title: J.Immunol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish.
  • Author(s): Suzuki, T., et al.
  • Journal Title: Biochem J. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] UVA irradiation induces Nrf2 activation in dermal fibroblasts : Protective role in UVA-induced apoptosis.
  • Author(s): Hirota, A., et al.
  • Journal Title: Invest.Dermatol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis.
  • Author(s): Kelly, V.P., et al.
  • Journal Title: Mol.Cell.Biol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity.
  • Author(s): Ezoe, S., et al.
  • Journal Title: J.Biol.Chem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of 15-deoxyD^<12-14> Prostaglandin J_2 and Nrf2 Pathways in Protection against Acute Lung Injury.
  • Author(s): Mochizuki, M., et al.
  • Journal Title: Am.J.Res.Cri.Care Med. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Increased dose of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.
  • Author(s): Yanagida, M., et al.
  • Journal Title: Oncogene (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
  • Author(s): Minegishi, N., et al.
  • Journal Title: Genes Cells (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MafA is a key regulator of glucose-stimulated insulin secretion.
  • Author(s): Zhang, C., et al.
  • Journal Title: Mol.Cell.Biol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment.
  • Author(s): Toki, T., Katsuoka, F., Kanezaki, R., Xu, G., Kurotaki, H., Sun, J., Kamio, T., Watanabe, S., Tandai, S., Terui, K., Yagihashi, S., Komatsu, N., Igarashi, K, Yamamoto, M, Ito, E.
  • Journal Title: Blood (印刷中)
• [Publications] Suzuki N, Suwabe N, Yamamoto M, et al.: "Identification and characterization of two types of erythroid progenitors that express GATA-1 at distinct levels"Blood. 102. 3575-3583 (2003)
• [Publications] Shimizu R, Ohneda K, yamamoto M: "Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia"Blood, 2003 Dec [Epub ahead of print]. (2004)
• [Publications] Nishikawa K, Kobayashi M, Yamamoto, M, et al.: "Self-association of Gata1 enhances transcriptional activity in vivo in zebrafish embryos"Mol.Cell.Biol.. 22. 8295-8305 (2003)
• [Publications] Minegishi N, Suzuki N, Yamamoto M, et al.: "Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos"Blood. 102. 896-905 (2003)
• [Publications] Moriguchi T, Motohashi H, Yamamoto M, et al.: "Distinct response to dioxin in an arylhydrocarbon receptor (AHR) humanized mouse"Proc.Natl.Acad.Sci.USA. 100. 5652-5657 (2003)
• [Publications] Itoh K., Mochizuki M., Yamamoto M, et al.: "Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-D12,14-prostaglandin J2"Mol.Cell.Biol.. 24. 26-45 (2004)