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Molecular mechanism whereby Type I interferon is induced in host immune cells by measles virus infection : possible involvement of Toll-like receptors (TLRs)

Research Project

Project/Area Number 15390154
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionHOKKAIDO UNIVERSITY (2004-2005)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2003)

Principal Investigator

SEYA Tsukasa  Hokkaido Univ., Grad.School of Med., Professor, 大学院・医学研究科, 教授 (10301805)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Misako  Hokkaido Univ., Grad.School of Med., Asso.Professor, 大学院・医学研究科, 助教授 (30332456)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2005: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2004: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2003: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsMeasles virus / TLR3 / dendritic cell / dsRNA / CD46 / SLAM / IRE-3 / IFN-β / 麻疹ウィルス / TLR2 / irf-3
Research Abstract

TLR3 fosters the induction of type I interferon (IFN) in myeloid dendritic cells (mDCs) in response to exogenously-added dsRNA. Recently, CARD-helicase family proteins, RIG-I and MDA5, are found to be involved in recognition of cytoplasmic dsRNA, presumably of viral origin. Thus, through these sensor molecules virus infection culminates in IFN response. In this study, we have identified the adapter molecule of TLR3 that induces IFN-β and named TICAM-1 (also called Trif). We established CD46/CD150 double TG mice and performed measles infection studies using the TG mice. The TG mice were not measles-sensitive until the IFNAR gene was simultaneously disrupted in addition to the TG. CD11c-positive mDCs were engaged in establishing the initial infection with measles virus. What are the role of TLR3 in mDCs during measles infection and their relation to immune suppression are currently under investigation.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (138 results)

All 2006 2005 2004 2003 Other

All Journal Article (113 results) Book (2 results) Publications (23 results)

  • [Journal Article] A novel cyclohexene derivative, TAK-242, selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.2006

    • Author(s)
      Ii, M., Seya T., et al.
    • Journal Title

      Mol Pharmacol. 69

      Pages: 1288-1295

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.2006

    • Author(s)
      Muromoto, R., Seya T., et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 93-98

    • NAID

      120000957225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IRAK-4-dependent phosphorylation and ubiquitination of 1RAK-1 is a negative feedback signal for TLR-mediated NF-κ B activation.2006

    • Author(s)
      Murai, M., Seya T., et al.
    • Journal Title

      FEBS J. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protein kinase Cd associates TIRAP/Mal and regulates NF-kB and mitogen-activated protein kinases in Toll-like receptor signaling.2006

    • Author(s)
      Sukenobu, N., Seya T., et al.
    • Journal Title

      J. Immunol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of the TLR pathway for interferon-beta induction by soluble G protein of respiratory syncytial virus.2006

    • Author(s)
      Shingai, M., Seya T., et al.
    • Journal Title

      J. Immunol. (submitted)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] NAP1 (NAK-associated protein 1) participates in both the TLR3 and he cytoplasmic pathways in type I interferon induction.2006

    • Author(s)
      Sasai, M., Seya T., et al.
    • Journal Title

      J. Immunol. (submitted)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor 3-mediated eotaxin-1 release from human bronchial smooth muscle cells.2006

    • Author(s)
      IViimi, K., Seya, T., et al.
    • Journal Title

      J. Immunol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential gene-inducing programs induced by polyl : C and measles virus infection.2006

    • Author(s)
      Shingai, M., Seya T., et al.
    • Journal Title

      Int. Immunol. (submitted)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC).2006

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J. Biochem (Tokyo) (review) 139

      Pages: 171-175

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of Toll-like receptors in adjuvant-augmented immune therapies.2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      eCAM. (review) 3

      Pages: 31-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptors in lower vertebrates.2006

    • Author(s)
      Seya T., et al.
    • Journal Title

      Comprehensive Glycoscience. (review) (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel cyclohexene derivative, TAK-242, selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.2006

    • Author(s)
      Ii, M., Seya, T., et al.
    • Journal Title

      Mol Pharmacol. 69

      Pages: 1288-1295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.2006

    • Author(s)
      Muromoto, R., Seya, T., et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 93-98

    • NAID

      120000957225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IRAK-4-dependent phosphorylation and ubiquitination of IRAK-1 is a negative feedback signal for TLR-mediated NF-κB activation.2006

    • Author(s)
      Murai, M., Seya, T., et al.
    • Journal Title

      FEBS J. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Inhibition of the TLR pathway for interferon-beta induction by soluble G protein of respiratory syncytial virus.2006

    • Author(s)
      Shingai, M., Seya T., et al.
    • Journal Title

      J.Immunol. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] NAP1 (NAK-associated protein 1) participates in both the TLR3 and the cytoplasmic pathways in type 1 interferon induction.2006

    • Author(s)
      Sasai, M., Seya T., et al.
    • Journal Title

      J.Immunol. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor 3-mediated eotaxin-1 release from human bronchial smooth muscle cells.2006

    • Author(s)
      Niimi, K., Seya, T., et al.
    • Journal Title

      J.Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential gene-inducing programs induced by polyl : C and measles virus infection.2006

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      Int.Immunol. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC).2006

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J.Biochem (Tokyo) 139(review)

      Pages: 171-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of Toll-like receptors in adjuvant-augmented immune therapies2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      eCAM. 3(review)

      Pages: 31-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptors in lower vertebrates.2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Comprehensive Glycoscience (in press)(review)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin.2006

    • Author(s)
      Tsujita, T., Seya, T., et al.
    • Journal Title

      Vaccine 24

      Pages: 2193-2199

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Protein kinase Cd associates TIRAP/Mal and regulates NF-kB and mitogen-activated protein kinases in Toll-like receptor signaling.2006

    • Author(s)
      Sukenobu, N., Seya, T., et al.
    • Journal Title

      J.Immunol. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel cyclohexene derivative, TAK-242, selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.2006

    • Author(s)
      Ii M., Seya, T., et al.
    • Journal Title

      Mol Pharmacol.[Epub ahead of print]

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.2006

    • Author(s)
      Muromoto R., Seya, T., et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 93-98

    • NAID

      120000957225

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The TICAM-1 pathway in Toll-like receptor signaling.2006

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J.Biochem(Tokyo)(review) 139

      Pages: 171-175

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Application of Toll-like receptor agonists to vaccine adjuvant therapy.2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      eCAM.(review) (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cutting Edge : NF- κ B-activating kinase-associate protein 1participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN Regulatory Factor 3 activation.2005

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J. Immunol. 174

      Pages: 27-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Surface-expressed TLR 6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells.2005

    • Author(s)
      Nakao, Y., Seya, et al.
    • Journal Title

      J. Immunol. 174

      Pages: 1566-1573

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene-inducing program of human dendritic cells in response to BCG ce11-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy.2005

    • Author(s)
      Ishii, K., Seya, T., et al.
    • Journal Title

      J Immunol. Lett. 98

      Pages: 280-290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005

    • Author(s)
      Xie, X., Seya, T., et al.
    • Journal Title

      Biol. Reprod. 73

      Pages: 510-518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Wild-type measles virus infection in human CD46/CD150-trangenic mice : CD11c-positive dendritic establish systemic viral infection.2005

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J. Immunol. 175

      Pages: 3252-3261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interferon-β induction through Toll-like receptor 3 depends on double-stranded RNA structure.2005

    • Author(s)
      Okahira, S., Seya T., et al.
    • Journal Title

      DNA Cell Biol. 24

      Pages: 614-623

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines.2005

    • Author(s)
      Tsuji, Y., Seya, T., et al.
    • Journal Title

      Int J Mol Med. 16

      Pages: 889-893

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor natural killer cell activation induced by spirulina extract.2005

    • Author(s)
      Masuda, H., Seya T., et al.
    • Journal Title

      Int. Immunopharmacology (submitted)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antibodies against human Toll-like receptors (TLRs) : TLR distribution and localization in human dendritic cells.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      J. Endotoxin Res. (review)

      Pages: 369-374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecules in Focus : TICAM-1 and TICAM-2 : Toll-like receptor adapters that participate in induction of type 1 interferons.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Int. J. Biochem. Cell Biol. (review) 37

      Pages: 524-529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cutting Edge : NF-κ B-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN Regulatory Factor 3 activation.2005

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J.Immunol. 174

      Pages: 27-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Surface-expressed TLR 6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells.2005

    • Author(s)
      Nakao, Y., Seya, T., et al.
    • Journal Title

      J.Immunol. 174

      Pages: 1566-1573

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy.2005

    • Author(s)
      Ishii, K., Seya, T., et al.
    • Journal Title

      Immunol.Lett. 98

      Pages: 280-290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005

    • Author(s)
      Xie, X., Seya, T., et al.
    • Journal Title

      Biol.Reprod 73

      Pages: 510-518

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Wild-type measles virus infection in human CD46/CD150-trangenic mice : CD11c-positive dendritic establish systemic viral infection.2005

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J.Inimunol. 175

      Pages: 3252-3261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interferon-β induction through Toll-like receptor 3 depends on double-stranded RNA structure.2005

    • Author(s)
      Okahira, S., Seya, T., et al.
    • Journal Title

      DNA Cell Biol. 24

      Pages: 614-623

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines.2005

    • Author(s)
      Tsuji, Y., Seya T., et al.
    • Journal Title

      Int J Mol Med. 16

      Pages: 889-893

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor natural killer cell activation induced by spirulina extract.2005

    • Author(s)
      Masuda, H., Sea T., et al.
    • Journal Title

      Int.Immunopharmacology (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antibodies against human Toll-like receptors (TLRs) : TLR distribution and localization in human dendritic cells.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      J.Endotoxin Res. 11(review)

      Pages: 369-374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecules in Focus : TICAM-1 and TICAM-2 : Toll-like receptor adapters that participate in induction of type 1 interferons.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Int.J.Biochem.Cell Biol. 37(review)

      Pages: 524-529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] NF-κB-activating kinase (NAK)-associated protein 1 participates in Toll-like receptor (TLR) 3/Toll-IL-1 homology domain-containing adapter molecule (TICAM)-1-medaited IRF3 activation2005

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J.Immunol. 174

      Pages: 27-30

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Surface-expressed Toll-like receptor 6 participates in the recognition of diacylated-lipopeptide and peptidoglycan in human cells.2005

    • Author(s)
      Nakao, T., Seya, T., et al.
    • Journal Title

      J.Immunol 174

      Pages: 1566-1573

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dendritic cell maturation Induced by Muramyl Dipeptide (MDP) Derivatives : Monoacylated MDP confers TLR2/TLR4 activation.2005

    • Author(s)
      Uehori, J., Seya, T., et al.
    • Journal Title

      J.Immunol. 174

      Pages: 7096-7103

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The regulator of complement activation (RCA) locus in the chicken : Identification of the chicken RCA gene cluster and functional characterization of the RCA proteins.2005

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      J.Immunol. 175

      Pages: 1724-1734

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)2005

    • Author(s)
      Wali, A., Seya, T., et al.
    • Journal Title

      Lung Cancer. 48

      Pages: 19-29

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A mouse model for wild-type measles virus infection : CD11c-positive dendritic cells are nidus for systemic viral spreading.2005

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J.Immunol. 175

      Pages: 3252-3261

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antibodies against human Toll-like receptors (TLRs) : TLR distribution and localization in human dendritic cells.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      J.Endotoxin Res.(review) 11

      Pages: 369-374

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecules in Focus : TICAM-1 and TICAM-2 : Toll-like receptor adapters that participate in induction of type 1 interferons.2005

    • Author(s)
      Seya, T. et al.
    • Journal Title

      Int.J.Biochem.Cell Biol. 37

      Pages: 524-529

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The TICAM-1 pathway in Toll-like receptor signaling.2005

    • Author(s)
      Sasai, M., Seya et al.
    • Journal Title

      J.Biochem(Tokyo). (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Application of Toll-like receptor agonists to vaccine adjuvant therapy.2005

    • Author(s)
      Seya T.et al.
    • Journal Title

      eCAM. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanism of tumor regression by adjuvant immunotherapy : poly(I:C) and BCG cell wall confer the unique properties on dendritic cells that lead to NK and CTL induction.2005

    • Author(s)
      Seya, T. et al.
    • Journal Title

      Cancer Immunol.Immunother. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Antibodies against human Toll-like receptors(TLRs) : TLR distribution and localization in human dendritic cells.2005

    • Author(s)
      Seya T.et al.
    • Journal Title

      J.Endotoxin Res. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Toll signaling and viral infection that link interferon-beta induction.2005

    • Author(s)
      Seya T.et al.
    • Journal Title

      Rev.Med.Virol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Toll-like receptors engaging viral nucleic acid recognition.2005

    • Author(s)
      Matsumoto, M., Seya et al.
    • Journal Title

      DNA Cell Biol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cutting Edge : NF-κB-activating kinase(NAK)-associated protein 1 participates in Toll-like receptor(TLR). 3/Toll-IL-1 homology domain-containing adapter molecule(TICAM)-1-medaited IRF3 activation.2005

    • Author(s)
      Sasai, M., Seya et al.
    • Journal Title

      J.Immunol. 174

      Pages: 27-30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A soluble form of TLR5(TLR5s) in fish : an acute phase protein with flagellin-recognition activity.2005

    • Author(s)
      Tsukada, H., Seya et al.
    • Journal Title

      Int.J.Molec.Med. 15

      Pages: 519-525

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Surface-expressed Toll-like receptor 6 participates in the recognition of diacylated-lipopeptide and peptidoglycan in human cells.2005

    • Author(s)
      Nakao, Y., Seya et al.
    • Journal Title

      J.Immunol. 174

      Pages: 1566-1573

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The regulator of complement activation(RCA) locus in the chicken : Identification of the chicken RCA gene cluster and functional characterization of the RCA proteins.2005

    • Author(s)
      Oshiumi, H., Seya et al.
    • Journal Title

      J.Immunol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton(CWS), which reflects adjuvancy required for tumor immunotherapy.2005

    • Author(s)
      Ishii, K., Seya et al.
    • Journal Title

      Immunol.Lett. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dendritic cell(DC) maturation induced by muramyl dipeptide(MDP) derivatives : Monoacylated MDP confers TLR2/TLR4 activation.2005

    • Author(s)
      Uehori, J., Seya et al.
    • Journal Title

      J.Immunol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] TLRとがん免疫2005

    • Author(s)
      北川翔, 奥田直樹, 松本美佐子, 瀬谷 司
    • Journal Title

      先端医学 13

      Pages: 66-71

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CR1/CR2 補体receptors2005

    • Author(s)
      瀬谷司
    • Journal Title

      血液・尿化学検査・免疫学的検査(日本臨床) 48

      Pages: 641-646

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CR3/CR4 補体receptors2005

    • Author(s)
      舟見健児, 瀬谷司
    • Journal Title

      血液・尿化学検査・免疫学的検査(日本臨床) 48

      Pages: 641-646

    • Related Report
      2004 Annual Research Report
  • [Journal Article] メンブランコファクタープロテイン2005

    • Author(s)
      新開大史, 瀬谷司
    • Journal Title

      血液・尿化学検査・免疫学的検査(日本臨床) 48

      Pages: 673-676

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus.2004

    • Author(s)
      T Ishida, H., Seya, T., et al.
    • Journal Title

      Microbiol. Immunol. 48

      Pages: 277-287

    • NAID

      10012840263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.2004

    • Author(s)
      Funami, K., Seya, T., et al.
    • Journal Title

      Int. Immunol. 16

      Pages: 1143-54

    • NAID

      10013425376

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like Receptor, 3; A Link between Toll-like Receptor, Interferon and Viruses.2004

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      Microbiol. Immunol. (review) 48

      Pages: 147-154

    • NAID

      10012684286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential maturation of dendtitic cells by TLR adapters : application to immunotherapy. Cancer Immunotherapy Ed. By K. Toyoshima, J. C. Banett, E. Klein, Y. Hashimoto, and H. Wakasugi. Princess Takamatsu Cancer Research Fund.2004

    • Author(s)
      Seya T., et al.
    • Journal Title

      Princess Takamatsu Symposia 34

      Pages: 12-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor 2 agonists with unique properties synthesized with reference to a product of Streptosporsngium.2004

    • Author(s)
      Matsuo-Tanabe, M., Seya T., et al.
    • Journal Title

      Immunology 2004

      Pages: 235-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus.2004

    • Author(s)
      Ishida, H., Seya, T., et al.
    • Journal Title

      Microbiol.Immunol 48

      Pages: 277-287

    • NAID

      10012840263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.2004

    • Author(s)
      Funami, K., Seya, T., et al.
    • Journal Title

      Int.Immunol. 16

      Pages: 1143-1154

    • NAID

      10013425376

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like Receptor 3 : A Link between Toll-like Receptor, Interferon and Viruses.2004

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      Microbiol.Immunol. 48(review)

      Pages: 147-154

    • NAID

      10012684286

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential maturation of dendritic cells by TLR adapters : application to immunotherapy. Cancer Immunotherapy2004

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Princess Takamatsu Symposia (Ed. By K.Toyoshima, J.C.Barrett, E.Klein, Y.Hashimoto, and H.Wakasugi.) (Princess Takamatsu Cancer Research Fund.) 34

      Pages: 12-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor 2 agonists with unique properties synthesized with reference to a product of Streptosporangium.2004

    • Author(s)
      Matsuo-Tanabe, M., Seya, T., et al.
    • Journal Title

      Immunology 2004

      Pages: 235-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular mechanism of TLR3-mediated interferon-beta induction.2004

    • Author(s)
      Matsumoto M., Seya T.
    • Journal Title

      Microbiol.Immunol. 48

      Pages: 147-154

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential maturation of dendritic cells by TLR adapters : application to immunotherapy.2004

    • Author(s)
      Seya, T. et al.
    • Journal Title

      Princess Takamatsu Symposia 34

      Pages: 12-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Toll-like receptor 2 agonists with unique properties synthesized with reference to a product of Streptosporangium.2004

    • Author(s)
      Matsuo-Tanabe, M., Seya et al.
    • Journal Title

      Immunology 2004

      Pages: 235-241

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Adjuvant-mediated tumor regression and tumor-specific CTL induction are impaired in MyD88-deficient mice.2004

    • Author(s)
      Akazawa T., Seya et al.
    • Journal Title

      Cancer Res. 64

      Pages: 757-764

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of differentially expressed novel genes from BCG-stimulated human macrophages by cDNA subtraction and mRNA-differential display.2004

    • Author(s)
      Begum, N.A., Seya et al.
    • Journal Title

      Infect.Immun. 72

      Pages: 937-948

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Infection of different cell lines of neural origin with subacute sclerosing panencephalitis(SSPE) virus.2004

    • Author(s)
      Ishida, H., Seya et al.
    • Journal Title

      Microbiol.Immunol. 48

      Pages: 277-287

    • NAID

      10012840263

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Multifunctional feature of Toll-like receptor 3 cytoplasmic tail that regulates receptor localization and signaling.2004

    • Author(s)
      Funami, K., Seya et al.
    • Journal Title

      Int.Immunol. 16

      Pages: 1143-1154

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A short consensus repeat-containing complement regulatory protein of Lamrpey, which participates in cleayage of lamprey C3.2004

    • Author(s)
      Kimura, Y., Seya et al.
    • Journal Title

      J.Immunol. 173

      Pages: 1118-1128

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout(Onchorhynchus mikiss).2004

    • Author(s)
      Tsujita, T., Seya et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 48588-48597

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pathogen-associated molecular pattern(PAMP)とがん免疫2004

    • Author(s)
      瀬谷司, 赤澤隆, 松本美佐子
    • Journal Title

      臨床免疫 41

      Pages: 606-610

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 抗腫瘍免疫における自然免疫系の役割2004

    • Author(s)
      瀬谷司, 松本美佐子, 赤澤隆
    • Journal Title

      血液・免疫・腫瘍 9

      Pages: 17-23

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 樹状細胞上に発現されるTLR2004

    • Author(s)
      舟見 健児, 松本 美佐子, 瀬谷 司
    • Journal Title

      臨床免疫 41

      Pages: 656-661

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Toll-like receptor(TLR)と抗ウィルス応答2004

    • Author(s)
      瀬谷司, 新開大史, 松本美佐子
    • Journal Title

      ウイルス学会誌 542

      Pages: 1-8

    • NAID

      10013152932

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.2003

    • Author(s)
      Hazeki, K., Seya, T., et al.
    • Journal Title

      Eur. J. Immunol. 33

      Pages: 740-747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Disruption of the mouse CD46 causes an accelerated spontaneousacrosome reaction in sperm.2003

    • Author(s)
      Inoue, N., Seya, T., et al.
    • Journal Title

      Molec. Cell. Biol. 23

      Pages: 2614-2622

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TICAM-1, an adapter molecule that participates in Toll-like receptor3-mediated interferon-beta induction.2003

    • Author(s)
      Oshiumi, H., Se a T., et al.
    • Journal Title

      Nature Imrnunol. 4

      Pages: 161-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Down-regulation of TolHike receptor expression in monocyte- eriveLangerhans cell-like cells : implications of low-responsiveness tobacterial_components in the epidermal Langerhans cells.2003

    • Author(s)
      Takeuchi, J., Seya, T., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 306

      Pages: 674-679

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Receptor use by vesicular stomatitis virus ~seu ofypes withlycoproteins of defective variants of measles virus isolated frombrains of patients with subacute sclerosing panencephalitis.2003

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J. Gen. Virol. 84

      Pages: 2133-2143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subcellular localization of Toll-like receptor 3 in human dendriticcells.2003

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      J. Immunol. 171

      Pages: 3154-3162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] T1R-containing adapter molecule(T1CAM)-2 a bridigng adapter recruiting to Toll-like receptor 4 T1CAM-1 that inducesinterferon-beta.2003

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      J Biol. Chem. 278

      Pages: 49751-49762

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.2003

    • Author(s)
      Tanabe, M., Seya, T., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 311

      Pages: 39-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective contribution of IFN- a/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectin.2003

    • Author(s)
      Honda, K., Seya, T., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 100

      Pages: 10872-10877

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.2003

    • Author(s)
      Hazeki, K., Seya, T., et al.
    • Journal Title

      Eur.J.Immunol 33

      Pages: 740-747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Disruption of the mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.2003

    • Author(s)
      Inoue, N., Seya, T., et al.
    • Journal Title

      Molec.Cell.Biol. 23

      Pages: 2614-2622

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.2003

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      Nature Immunol. 4

      Pages: 161-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells : implications of low-responsiveness to bacterial components in the epiderml Langerhans cells.2003

    • Author(s)
      Takeuchi, J., Sea T., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 306

      Pages: 674-679

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis.2003

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J.Gen.Virol. 84

      Pages: 2133-2143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subcellular localization of Toll-like receptor 3 in human dendritic cells.2003

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      J.Immunol. 171

      Pages: 3154-3162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TIR-containing adapter molecule(TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta.2003

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 49751-49762

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.2003

    • Author(s)
      Tanabe, M., Seya T., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 311

      Pages: 39-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectin.2003

    • Author(s)
      Honda, K., Seya, T., et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 100

      Pages: 10872-10877

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protein kinase Cd associates TIRAP/Mal and regulates NF-κB and mitogen-activated protein kinases in Toll-like receptor signaling.

    • Author(s)
      Sukenobu, N., Seya T., et al.
    • Journal Title

      J.Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 医科免疫学 改定第6版2005

    • Author(s)
      瀬谷 司, 小華和征志 他
    • Publisher
      南江堂(in press)
    • Related Report
      2004 Annual Research Report
  • [Book] 医学を学ぶための生物学2004

    • Author(s)
      瀬谷司 他
    • Total Pages
      510
    • Publisher
      南江堂
    • Related Report
      2004 Annual Research Report
  • [Publications] Hazeki, K, Seya et al.: "TLR-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and-independent pathways."Eur.J.Immunol. 33. 740-747 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue, N, Seya et al.: "Disruption of the mouse CD46 caused an accelerated spontaneous acrosome reaction in sperm."Molec.Cell.Biol.. 23. 2614-2622 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oshiumi, H., Seya et al.: "A novel adapter molecule that participates in Toll-like receptor-mediated interferon-beta induction"Nature Immunol. 4. 161-167 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oshiumi, H, Seya et al.: "Prediction of the prototype of the human Toll-like receptor gene family from the Pufferfish Fugu. rubripes genome"Immunogenetics. 54. 791-800 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeuchi, J., Seya et al.: "TGF-betal Maintains the Skin Homeostasis by Modulating Responsiveness of Langerhans cells Against Bacteria"Biochem.Biophys.Res.Commun. 306. 674-679 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uehori, J, Seya et al.: "Simultaneous blocking of human Toll-like receptor 2 and 4 suppresses myeloid dendritic cell maturation induced by Mycobacterium bovis bacillus Calmette-Guerin (BCG)-peptidoglycan (PGN)."Infect.Immun. 71. 4238-4249 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shingai, M, Seya et al.: "Receptor usage by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis."J.Gen.Virol. 84. 2133-2143 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsumoto, M, Seya et al.: "Subcellular localization of human Toll-like receptor 3 in human dendritic cells"J.Immunol. 171. 3154-3162 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oshiumi, H, Seya et al.: "Identification of the Toll-like receptor (TLR)-adapter that participates in TLR4-mediated interferon-beta induction."J.Biol.Chem. 278. 49751-49762 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akazawa T., Seya et al.: "A djuvant-mediated tumor regression and tumor-specific CTL induction are impaired in MyD88-deficient mice"Cancer Res.. 64. 757-764 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanabe, M, Seya et al.: "Up-regulation of a receptor for dsRNA, Toll-like receptor 3,in human myeloid dendritic cells via measles virus infection"Biochem.Biophys.Res.Commun. 311. 39-48 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Honda, K, Seya et al.: "Selective contribution of IFN-a/b signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection"Proc.Natl.Acad.Sci.USA. 100. 10872-10877 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Begum, N., A Seya et al.: "Mycobacterium bovis BCG Cell Wall-Specific Differentially Expressed Genes Identified by Differential Display and cDNA subtraction in Human Macrophages"Infect.Immun. 72. 937-948 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsumoto M., Seya et al.: "Minireview Toll-like receptor3:A Link between Toll-like reeptor, Intereferon and Virus"Microbiol Immunol.. 48(3). 147-154 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura, Y., Seya et al.: "A short consensus repeat-containing complement regulatory protein of Lamprey, which participates in cleavage of lamprey C3"J.Immunol.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 上堀淳二, 赤澤隆, 松本美佐子, 瀬谷司: "BCG細胞壁骨格による樹状細胞の活性化とTLR臨床免疫"臨床免疫. 40(3). 248-253 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 瀬谷司: "アジュバントを利用した樹状細胞の活性化と癌免疫療法への応用"現代医療 別冊. 35(8). 139-145 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 押海裕之, 松本美佐子, 瀬谷司: "Toll-like receptorと免疫療法"現代医療. 35(12). 149-154 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松本美佐子, 瀬谷司: "微生物成分を用いたヒト樹状細胞の制御:Toll-like receptorよにるPAMP認識とシグナル伝達"Molecular Medicine. 40(5). 528-534 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松本美佐子, 押海裕之, 瀬谷司: "線維芽細胞のTLR3を介するインターフェロン産生"臨床免疫. 44(3). 276-282 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松本美佐子, 押海裕之, 瀬谷司: "TLRを介したタイプイインターフェロン産生にかかわるアダプター分子TICAM-1"Molecular Medicine臨時増刊号 免疫2004. 40. 194-200 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 赤澤隆, 松本美佐子, 瀬谷司: "アジュバントを利用した樹状細胞の活性化と癌免疫療法への応用"現代医療. 35(8). 139-145 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 瀬谷司, 上堀淳二, 赤澤隆: "BCG細胞壁骨格(CWS)による樹状細胞活性化の分子機構"Annual Review 免疫. 216-223 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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