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Integrated system of the tailor-made cancer treatment based on the expression profiling and bioinformatic analyses

Research Project

Project/Area Number 15390181
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionNagoya University (2004-2005)
Aichi Cancer Center Research Institute (2003)

Principal Investigator

TAKAHASHI Takashi  Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50231395)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Kiyoshi  Nagoya University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (20372112)
TOMIDA Shuta  Nagoya University, Graduate School of Medicine, Research Fellow, 大学院・医学系研究科, 研究機関研究員 (10372111)
MITSUDOMI Tetsuya  Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (70209807)
HIDA Toyoaki  Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (80250249)
YATABE Yasushi  Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (90280809)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥7,200,000 (Direct Cost: ¥7,200,000)
KeywordsExpression profiling / Microarray / Bioinformatics / Proteomics / Mass spectrometry / 発現プロファイリング
Research Abstract

In this study, we have carried out highly sophisticated genomics and proteomics analyses of surgically resected cases of lung cancer, which has been the number one cause of cancer deaths in Japan, in order to establish the foundation for the integrated system of the tailor-made cancer treatment. As a result, we were able to show the presence of expression-profile-defined heterogeneity of pulmonary adenocarcinomas, which appeared to be correlated well with the status of genetic alterations and postoperative clinical behaviors such as prognosis. Furthermore, the newly proposed classification could distinguish a subset of patients, which most likely benefit from adjuvant molecular targeted therapy against EGFR-mediated signaling. In addition, we were able to establish the foundation for future studies on the applied proteomics of blood specimens such as serum. These findings should aid further development of genomics and/or proteomics-based approach towards the tailor-made medicine to conquer this devastating illness.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (22 results)

All 2006 2005 2004 Other

All Journal Article (14 results) Patent(Industrial Property Rights) (2 results) Publications (6 results)

  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno, K., et al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.2005

    • Author(s)
      Hayashita, Y., et al.
    • Journal Title

      Cancer Research 65

      Pages: 9628-9632

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.2005

    • Author(s)
      Osada, H., et al.
    • Journal Title

      Cancer Research 65

      Pages: 10680-10685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.2005

    • Author(s)
      Osada, H., et al.
    • Journal Title

      Molecular Carcinogenesis 44

      Pages: 233-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Reduced expression of Dicer associated with poor prognosis in lung cancer patients.2005

    • Author(s)
      Karube, Y., et al.
    • Journal Title

      Cancer Science 96

      Pages: 111-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Gene expression-based, individualized outcome prediction for surgically treated lung cancer patients.2004

    • Author(s)
      Tomida, S., et al.
    • Journal Title

      Oncogene 23

      Pages: 5360-5370

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction.2004

    • Author(s)
      Endo, S., et al.
    • Journal Title

      J.Clin.Oncol. 22

      Pages: 811-819

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.2004

    • Author(s)
      Nakagawa, T., et al.
    • Journal Title

      Cancer Res. 64

      Pages: 4826-4832

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.2004

    • Author(s)
      Takamizawa, J., et al.
    • Journal Title

      Cancer Res. 64

      Pages: 3753-3760

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel approach to identifying markers of tissue-specific expression : Use of MGB in the differential diagnosis of lung tumors in patients with a history of breast cancer.2004

    • Author(s)
      Koga, T., et al.
    • Journal Title

      J.Mol.Diag. 6

      Pages: 90-95

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

    • Author(s)
      Takeuchi, T., et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

    • Author(s)
      Takeuchi, T., et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

    • Author(s)
      Takeuchi, T., et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small cell lung cancer with postoperative recurrence.

    • Author(s)
      Mitsudomi, T., et al.
    • Journal Title

      J.Clin.Oncol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺腺癌患者の術後予後を予想するための方法及び組成物2005

    • Inventor(s)
      高橋隆, 他
    • Industrial Property Rights Holder
      名古屋大学及び愛知県
    • Industrial Property Number
      2005-291588
    • Filing Date
      2005-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 肺腺癌患者の術後予後を予想するための方法及び組成物2005

    • Inventor(s)
      高橋 隆, 他
    • Industrial Property Rights Holder
      名古屋大学及び愛知県
    • Industrial Property Number
      2005-291588
    • Filing Date
      2005-10-04
    • Related Report
      2005 Annual Research Report
  • [Publications] Tomida, S., et al.: "Gene expression-based, individualized outcome prediction of surgically treated lung cancer patients."Oncogene. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Masuda, A., et al.: "Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by antimicrotubule agents in human lung cancers."Am.J.Pathol.. 163. 1106-1119 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Konishi, H., et al.: "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer."Oncogene. 22. 1892-1905 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Osada, H., et al.: "Reduced expression of class II HDAC genes are associated with poor prognosis in lung cancer patients"Int.J.Cancer. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Endo, S., et al.: "Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time RT-PCR."J.Clin.Oncol.. 22. 811-819 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwafuchi, H., et al.: "Phenotypic composition of salivary gland tumors ; an application of principle component analysis to tissue microarray data."Modern Pathol.. (in press).

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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