|Budget Amount *help
¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2005: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2004: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2003: ¥5,100,000 (Direct Cost: ¥5,100,000)
Objective : To study appropriate levels of physical exercise for health promotion, we examined anthropometric characteristics and lifestyle parameters along with mid-and post-race biological markers, including reactive oxygen species, of Japanese non-professional runners attending a two-day ultra-marathon race.
Subjects and Methods : We evaluated anthropometric characteristics and lifestyle parameters and baseline biomarkers of 202 (in 2002) and 186 (in 2003) Japanese amateur ultra-marathon runners. We also examined changes in biomarkers, including oxidant, anti-oxidant and muscle damage markers from baseline to mid-and post-race points. Furthermore, in 2004, we recruited 25 runners to explore biomarkers, including NK cell activity and parameters of glucose and lipid metabolism, not only at baseline, mid-race and post-race points but also at the points one day, three days and five days after the race.
Results : Ultra-marathon runners demonstrated desirable baseline biological markers. Oxidant biomarkers, including 8-OHdG and d-ROM, were elevated at the mid-race point ; however, those markers were decreased on the 2nd day. On the other hand, anti-oxidant markers, such as uric acid and bilirubin, and muscle damage indices, including GOT, LDH and CPK, were induced progressively at mid-race and post-race points.
Discussion : Ultra-marathon runners show a good health status according to baseline biological markers, providing strong evidence that regular aerobic exercise is beneficial to health along with other aspects of desirable lifestyle. Oxidant biomarkers were elevated at the mid-race point but were decreased on the 2nd day, which implies that adaptive mechanisms evolved during the 2nd day to repair oxidative DNA damage.