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Genetic analysis of measles viruses isolated in Japan and mechanism of transmission-role of antibodies induced by vaccination

Research Project

Project/Area Number 15390211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagahama Institute of Bio-Science and Technology (2004-2006)
Osaka Prefectural Institute of Public Health (2003)

Principal Investigator

ITOH Masae  Nagahama Institute of Bio-Science and Technology, Department of Bio-Science, Professor, バイオサイエンス学部, 教授 (10201328)

Co-Investigator(Kenkyū-buntansha) OKUNO Yoshinobu  Osaka Prefectural Institute of Public Health, Department of Infectious Disease, Senior researcher, 感染症部, 総括研究員 (30112064)
MIYAGAWA Hiromi  Osaka Prefectural Institute of Public Health, Department of Infectious Disease, Senior researcher, 感染症部, 主任研究員 (10346207)
HOTTA Hak  Kobe University Graduate School of Medicine, Division of Microbiology, Professor, 大学院医学系研究科, 教授 (40116249)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥4,200,000 (Direct Cost: ¥4,200,000)
Keywordsmeasles virus / vaccine / antibody / genome analysis / H gene / N gene / cell fusion / diversity / 多核巨細胞 / F遺伝子
Research Abstract

Nucleotide sequences of the H and N genes of measles viruses isolated in Japan since 1980s were determined and compared with those obtained from databases. By examining accumulation of the mutations and genetic development of the genes, the origin of each virus was assumed and the affect of antibodies acquired by vaccination on the rate of accumulation of the mutations was discussed.
Type D3 virus : Type D3 viruses were prevailing in the late 1980s and the early 1990s, which were replaced by Type D5 viruses and emerged again in 1997. Re-emerging D3 viruses originated from the Guam.USA/94 like strain and mutated into two lineages in Japan.
Type D5 virus : Type D5 viruses in the early 2000s were supposed to be the progenitor of type D5 viruses in the early 1990s and the most probable ancestor was the Palau.BLA/93 like virus. In 2007, the measles virus infection burst around Tokyo and is now spreading all over Japan. The isolated viruses from the epidemic belong to the different lineage of type D5 from that of type D5 viruses in the early 2000s, to the same lineage with MVi/Queensland.AU/37.03.
Type H1 virus : Type H1 viruses have been isolated in Japan since 1999. Type H1 viruses isolated in Japan could be divided into two groups and there is a possibility that two kinds of type H1 virus possessing different gene sequences invaded into Japan.
Isolates from vaccinated patients : H and N genes of the viruses from the vaccinated patients were compared with those of isolates from the same epidemic. We could not confirm the increased accumulation of mutations with the viruses isolated from vaccinated patients.
Diversity of measles virus : A strain of measles virus derived from a patient revealed not to be genetically single but to be a mixed population.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (36 results)

All 2007 2006 2005 2004 Other

All Journal Article (27 results) Patent(Industrial Property Rights) (3 results) Publications (6 results)

  • [Journal Article] Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia2006

    • Author(s)
      Torashima, T
    • Journal Title

      Eur. J. Neurosci. 24・2

      Pages: 371-380

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.2006

    • Author(s)
      Deng, L
    • Journal Title

      J. Gen. Virol. 87

      Pages: 1703-1713

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells.2006

    • Author(s)
      Ohgimoto, K
    • Journal Title

      Virus Res. 123・1

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Full-length sequence analysis o subacute sclerosingpan encephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE.2006

    • Author(s)
      Hotta, H
    • Journal Title

      Microbiol. Immunol. 50・7

      Pages: 525-534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference.2006

    • Author(s)
      Otaki, M
    • Journal Title

      Antiviral Res. 70

      Pages: 105-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia2006

    • Author(s)
      Torashima, T
    • Journal Title

      European Journal of Neuroscience 24・2

      Pages: 1703-1713

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] NS3 protein of Hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.2006

    • Author(s)
      Deng, L
    • Journal Title

      Journal of General Virology 87

      Pages: 1703-1713

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells.2006

    • Author(s)
      Ohgimoto, K
    • Journal Title

      Virus Research 123・1

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Full-length sequence analysis of subacute sclerosingpanencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE.2006

    • Author(s)
      Hotta, H
    • Journal Title

      Microbiology and Immunology 50・7

      Pages: 525-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference.2006

    • Author(s)
      Otaki, M
    • Journal Title

      Antiviral Research 70

      Pages: 105-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis.2006

    • Author(s)
      Nomura-Takigawa, Y
    • Journal Title

      J. Gen. Virol. 87

      Pages: 1935-1945

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent menner.2006

    • Author(s)
      Deng, L
    • Journal Title

      J. Gen. Virol. 87

      Pages: 1703-1713

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE.2006

    • Author(s)
      Hotta, H
    • Journal Title

      Microbiol. Immunol. 50・7

      Pages: 525-534

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis.2006

    • Author(s)
      Nomura-Takigawa, Y
    • Journal Title

      J Gen Virol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference.2006

    • Author(s)
      Otaki, M
    • Journal Title

      Antiviral Res (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CMV DNA detection from dried blood spot for diagnosing congenital CMV infection in Japan.2006

    • Author(s)
      Yamagishi, Y
    • Journal Title

      J med virol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.2006

    • Author(s)
      Tanaka, M
    • Journal Title

      Biochem Biophys Res Commun 340・3

      Pages: 792-799

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Isolation of influenza virus type AH3 from a traveler returning from Vietnam in July 2005 in Osaka, Japan.2005

    • Author(s)
      Kase, T
    • Journal Title

      Jap. J. Infect. Disease 58・6

      Pages: 395-396

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Isolation of influenza virus type AH3 from a traveler returning from Vietnam in July 2005 in Osaka, Japan.2005

    • Author(s)
      Kase, T
    • Journal Title

      Japanese Journal of Infectious Disease 58・6

      Pages: 395-396

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hepatitis C virus NS3 protein interacts with ELKS-d and ELKS-a, members of a novel protein family involved in intracellular transport and secretory pathways.2005

    • Author(s)
      Hidajat, R
    • Journal Title

      J Gen Virol 86・8

      Pages: 2197-2208

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Variation of the conserved neutralizing epitope in influenza B virus Victoria group isolated in Japan.2005

    • Author(s)
      Nakagawa, N
    • Journal Title

      J.Clin.Microbiol 43・8

      Pages: 4212-4214

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the Interleukin 8 promoter.2005

    • Author(s)
      Kadoya Hiroyasu
    • Journal Title

      Microbiol Immunol 49・3

      Pages: 265-273

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Suppression of hepatitis C virus replicon by RNA interference directed against the NS3 and NS5B regions of the viral genome.2004

    • Author(s)
      Takigawa Yuki
    • Journal Title

      Microbiol Immunol 48・8

      Pages: 591-598

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of interferon in an ISDR-independent manner.2004

    • Author(s)
      Taguchi Takashi
    • Journal Title

      J Gen Virol 85

      Pages: 959-969

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA.2004

    • Author(s)
      Tanaka-Taya Kyoko
    • Journal Title

      J Med Virol 73・3

      Pages: 465-473

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Influenza B virus victoria group with a new glycosylation site was epidemic in Japan in the 2002-2003 season.2004

    • Author(s)
      Nakagawa Naoko
    • Journal Title

      J Clin Microbiol 42

      Pages: 3295-3297

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Poor immune responses to influenza vaccination in infants.2004

    • Author(s)
      Kumagai Takuji
    • Journal Title

      Vaccine 22

      Pages: 3404-3410

    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 被験物質に対するプロープの結合親和性を測定する方法及びその利用2007

    • Inventor(s)
      長谷川慎, 川端隆司, 川瀬千晶, 伊藤正恵, 水上民夫
    • Industrial Property Rights Holder
      長浜バイオ大学
    • Filing Date
      2007-03-29
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 試料中のウイルスを検出する方法およびシステム2006

    • Inventor(s)
      水上民夫, 伊藤正恵, 長谷川慎, 西矢芳昭, 長屋寿, 白井伸明
    • Industrial Property Rights Holder
      関西文理総合学園, 滋賀県工業技術センター, 東洋紡株式会社, テクノサイエンス株式会社
    • Industrial Property Number
      2006-163071
    • Filing Date
      2006-06-13
    • Acquisition Date
      2007-02-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 試料中のウイルスを検出する方法2005

    • Inventor(s)
      水上民夫, 伊藤正恵, 長谷川慎, 西矢芳昭, 長屋寿, 白井伸明
    • Industrial Property Rights Holder
      長浜バイオ大学, 滋賀県工業技術センター, 東洋紡株式会社, テクノサイエンス株式会社
    • Filing Date
      2005-06-06
    • Related Report
      2005 Annual Research Report
  • [Publications] Taguchi, Takashi: "Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of interferon in an ISDR-independent manner."J.Gen.Virol.. 85(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ogata, Satoshi: "Identification of Hepatitis C Virus (HCV) Subtype 1b Strains That Are Highly, or Only Weakly, Associated with Hepatocellular Carcinoma on the Basis of the Secondary Structure of an Amino-Terminal Portion of the HCV NS3 Protein"J.Clin.Microbiol.. 41(7). 2835-2841 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Goto, Eiji: "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and 2 and has similar activity."J.Biol.Chem.. 278(17). 14657-14668 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Oka, Kiyomasa: "Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins."Microbiol.Immunol.. 47(6). 429-438 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi, Michiaki: "Enhancement of immunity against VZV by giving live varicella vaccine to the elderly assessed by VZV skin test and IAHA, gpELISA antibody assay."Vaccine. 21(25-26). 3845-3853 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kondo, Kazuhiro: "Recognition of a novel stage of betaherpesvirus latency in human herpesvirus 6."J.Virol.. 77(3). 2258-2264 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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