| Project/Area Number |
15390213
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
UENO Yasuhiro Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (30184956)
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| Co-Investigator(Kenkyū-buntansha) |
KOJO Shosuke Nara Women's University, Department of Food Science and Nutrition, Professor, 生活環境学部, 教授 (10108988)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2004: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2003: ¥9,400,000 (Direct Cost: ¥9,400,000)
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| Keywords | sudden infant death / lipid metabolism / carnitine / vitamin C / 脂質代謝異常 / 酸化ストレス |
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| Research Abstract |
This study was designed to elucidate the abnormal lipid metabolism on carnitine deficiency said to be one of the important factor of sudden infant death syndrome (SIDS), and to investigate the way of medical information in the future, we carried out the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania.
Following new information were obtained :
1)Establishment of the method to determine the quantity of total- and free-carinitine by enzyme assay, and quantitative analysis by LC-MS/MS.
2)About the role of water soluble vitamin, vitamin C, on the way of biosynthesis of carnitine.
3)Effect of carnitine deficiency induced by carnitine-like-materials on cell damage and apoptosis.
4)The way how to transmit of medical information to people, especially young generation, by the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania areas.
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