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Gene expression and gene polymorphisms related with chole-pancreatic diseases

Research Project

Project/Area Number 15390237
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Metropolitan Foundation of Research on Aging and Promotion of Human Welfare

Principal Investigator

MIYASAKA Kyoko  Tokyo Metro Found Res Aging and Promotion of Human Welfare, Tokyo Metro Inst Gerontology, 東京都老人総合研究所, 研究副部長 (90166140)

Co-Investigator(Kenkyū-buntansha) OHTA Minoru  Tokyo Metro Found Res Aging and Promotion of Human Welfare, Tokyo Metro Inst Gerontology, Research Assistant, 東京都老人総合研究所, 助手 (70133634)
TAKIGUCHI Soichi  Kyushu Cancer Center, Dept of Clinical Research, Researcher, 臨床研究部, 研究員 (00280793)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,800,000 (Direct Cost: ¥14,800,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2003: ¥7,700,000 (Direct Cost: ¥7,700,000)
KeywordsSHIP2 / ALDH2 / gene polymorphism / pancreatic cancer / alcohol / 軽症糖尿病 / コレシストキニンA受容体 / 糖尿病 / SHIP-2 / 遺伝子ノックアウロマウス / 肥満 / 胆石 / インスリン
Research Abstract

We found positive associations of gene polymorphisms and chole-pancreatic disorders. The CCK-A receptor (AR) gene polymorphism (-81A/G, -128G1T) was associated with panic disorder, alcoholism, and obesity. The adrenalin beta 3R mutation (Trp64Arg) was associated with higher BMI, and ALDH2 mutation (Glu to Lys) was the risk of pancreatic cancer in the smokers. The ghrelin receptor polymorphism (177T/C) was a risk of Bulimia Nervosa. The CEL gene polymorphism was associated with alcoholic pancreatitis. The SHIP2 gene polymorphism was associated with glucose intolerance. However, we could not found polymorphisms of PAR2, Klotho, Cyp2A6, and Ghrelin, which had been reported in the Western counties.
The gene expression of CCK-AR was decreased in the gallbladder with gallstones. However, it is still unknown whether there were positive associations of CCK-AR polymorphism and the levels of CCK-AR gene expression.
We observed new phenotypes of CCK-ARKO mice. CCK-ARKO mice showed over-eating after the restraint stress, and they drank alcohol more than other genotypes, possibly due to the higher expression of dopamine 2R protein in the nucleus accumbens. The frequency of gallstone formation was increased in CCK ARKO mice, compared with wild-type mice, however, the sex difference was not clarified, yet.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (98 results)

All 2006 2005 2004 2003 Other

All Journal Article (79 results) Book (3 results) Publications (16 results)

  • [Journal Article] Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population.2006

    • Author(s)
      Miyasaka K
    • Journal Title

      J Neural Trasnmission In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of SH-2 containing inositol 5'-phosphatase 2(SHIP2) gene polymorphisms and impaired glucose tolerance2006

    • Author(s)
      Ishida S, Funakoshi A, Miyasaka K
    • Journal Title

      Pancreas In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differences in the appetite-stimulating effect of orexin, NPY, and ghrelin among young, adult, and old rats.2006

    • Author(s)
      Takano S, Kanai S, Hosoya H, Ohta M, Uematsu H, Miyasaka K
    • Journal Title

      Neuroendocrinology In press

    • NAID

      130005448633

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl2005

    • Author(s)
      Kitani K, Kanai S, Miyasaka K
    • Journal Title

      Biogerontology 6

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Stimualtory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A receptor2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Pancreas 30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence2005

    • Author(s)
      Shimokata, H, Ando F, Niino N, Miyasaka
    • Journal Title

      Ann Epidem 15

      Pages: 196-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Pancreas 30

      Pages: 1-5

    • NAID

      10016139528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Alcohol and Alcoholism 40

      Pages: 176-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carboxylester lipase gene polymorphism as a risk of alcohol induced pancreatitis2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Pancreas 30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Overeating after restraint stress in cholecystokinin-A receptor deficient mice2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Jpn J Physiol 55

      Pages: 285-291

    • NAID

      10018623962

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Sp-family of transcription factors regulates the human SHIP2 gene expression2005

    • Author(s)
      Ishida S, et al., Miyasaka K, et al.
    • Journal Title

      Gene 348

      Pages: 135-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] L-アラビノース摂取による骨格筋線維組成の変化2005

    • Author(s)
      菊沢歩, 田中紀子, 市川みね子, 宮坂京子
    • Journal Title

      日本栄養・食糧学会誌 58

      Pages: 51-57

    • NAID

      10020369621

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 遺伝子異常と胆石2005

    • Author(s)
      船越顕博, 宮坂京子
    • Journal Title

      臨床消化器内科 20

      Pages: 41-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 膵癌と性差2005

    • Author(s)
      船越顕博, 澄井俊彦, 宮坂京子
    • Journal Title

      性差と医療 2

      Pages: 61-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 膵癌と性差2005

    • Author(s)
      宮坂京子
    • Journal Title

      Bio Clinica

      Pages: 36-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl.2005

    • Author(s)
      Kitani K, Kanai S, Miyasaka K, Carrilo M-C, Ivy GO
    • Journal Title

      Biogerontology 6

      Pages: 1-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stimualtory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A receptor.2005

    • Author(s)
      Miyasaka K, Kanai S, Ohta M, Hosoya H.
    • Journal Title

      Pancreas 30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence2005

    • Author(s)
      Shimokata, H, Ando F, Niino N, Miyasaka K, Funakoshi A.
    • Journal Title

      Ann Epidem 15

      Pages: 196-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.2005

    • Author(s)
      Miyasaka K, Kawanami T, Shimokata H, Ohta S, Funakoshi A.
    • Journal Title

      Pancreas 30

      Pages: 1-5

    • NAID

      10016139528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice.2005

    • Author(s)
      Miyasaka K, Hosoya H, Takano S, Ohta M, Sekime A, Kanai S, Matsui T, Funakoshi A.
    • Journal Title

      Alcohol and Alcoholism 40

      Pages: 176-180

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sp-family of transcription factors regulates the human SHIP2 gene expression.2005

    • Author(s)
      Ishida S, Funakoshi A, Miyasaka K, Iguchi H, Takiguchi S.
    • Journal Title

      Gene 348

      Pages: 135-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carboxylester lipase gene polymorphism as a risk of alcohol induced pancreatitis2005

    • Author(s)
      Miyasaka K, Ohta M, Takano S, Hayashi H, Higuchi S, Maruyama K, Tando Y, Nakamura T, Funakoshi A.
    • Journal Title

      Pancreas 30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A. Overeating after restraint stress in cholecystokinin-A receptor deficient mice2005

    • Author(s)
      Miyasaka K, Kanai S, Ohta M, Hosoya H, Takano S, Sekime A, Sakurai C, Kaneko T, Tahara S, Funakoshi
    • Journal Title

      Jpn J Physiol 55

      Pages: 285-291

    • NAID

      10018623962

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stimualtory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A receptor2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Pancreas 30

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Pancreas 30

      Pages: 1-5

    • NAID

      10016139528

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Alcohol and Alcoholism 40

      Pages: 176-180

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sp-family of transcription factors regulates the human SHIP2 gene expression2005

    • Author(s)
      Ishida S, Funakoshi A, Miyasaka K, Iguchi H, Takiguchi S
    • Journal Title

      Gene 348

      Pages: 135-141

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CCK, orexinと脳腸相関2005

    • Author(s)
      宮坂京子
    • Journal Title

      Bio Clinica

      Pages: 36-40

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 胆汁酸研究の歩み「胆汁酸と膵外分泌」2005

    • Author(s)
      宮坂京子
    • Journal Title

      消化器病ネットワーク たんじゅうさん 4

      Pages: 26-26

    • Related Report
      2005 Annual Research Report
  • [Journal Article] コレシストキニンA受容体欠損モデル動物の、肥満、インスリン非依存性糖尿病、脂質代謝、胆石形成に対する大豆たん白質およびペプチドの改善効果2005

    • Author(s)
      宮坂京子
    • Journal Title

      大豆たん白質研究 8

      Pages: 108-112

    • NAID

      40007316047

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stimualtory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A receptor.2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Pancreas 30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence2005

    • Author(s)
      Shimokata, H, Ando F, Niino N, Miyasaka K, Funakoshi A
    • Journal Title

      Ann Epidem 15

      Pages: 196-201

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Pancreas 30

      Pages: 1-5

    • NAID

      10016139528

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sp-family of transcription factors regulates the human SHIP2 gene expression.2005

    • Author(s)
      Ishida S, Funakoshi A, Miyasaka K, Iguchi H, Takiguchi S.
    • Journal Title

      Gene 30(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Alcohol and Alcoholism 39

      Pages: 25-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Association of Cholecystokinin-A Receptor Gene Polymorphisms and Panic Disorder in Japanese2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Am J Med Genet 127B

      Pages: 78-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Histopathological difference between chronic pancreatitis amimal models and human chronic pancreatitis2004

    • Author(s)
      Suda H, Jimi A, Miyasaka K, Funakoshi A.
    • Journal Title

      Pancreas 28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor : A study of CCK-A, B, and AB receptor gene knockout mice2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      J Gastroenterol 39

      Pages: 319-323

    • NAID

      10012894041

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Physiological and pathological age-associated changes in diurnal rhythm of energy expenditure in rats.2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Arch Geriat Gerontol 39

      Pages: 83-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature.2004

    • Author(s)
      Nomoto S, et al., Miyasaka K
    • Journal Title

      Am J Physiol 287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 強度条件の異なる身体運動負荷が血漿中消化管ホルモンの変動に及ぼす影響。2004

    • Author(s)
      永松俊哉, 荒尾孝, 宮坂京子
    • Journal Title

      体力研究 102

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 肥満、糖尿病を自然発症するOLETFラットにおけるL-アラビノースの長期投与の効果2004

    • Author(s)
      関目綾子, 太田稔, 船越顕博, 宮坂京子
    • Journal Title

      消化と吸収 26

      Pages: 21-25

    • NAID

      10012957430

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] CCK-A受容体ノックアウトマウスにおけるストレス負荷時の摂食量の変動2004

    • Author(s)
      太田稔, 関目綾子, 金井節子, 宮坂京子
    • Journal Title

      消化と吸収 27

      Pages: 22-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 老化に伴う摂食低下におけるorexin, CCKの関与について-老化動物での検討2004

    • Author(s)
      宮坂京子, 高野紗恵子, 船越顕博
    • Journal Title

      消化と吸収 27

      Pages: 48-50

    • NAID

      10014495901

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 飲酒、喫煙と膵癌発症リスク2004

    • Author(s)
      船越顕博, 川波賢子, 宮坂京子
    • Journal Title

      消化と吸収

      Pages: 163-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] にがうりエキス酢のエネルギー代謝回転亢進と基礎代謝上昇効果2004

    • Author(s)
      宮坂京子 他
    • Journal Title

      老年消化器病 16

      Pages: 95-99

    • NAID

      130005447234

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 胆石、胆嚢機能と遺伝子2004

    • Author(s)
      船越顕博, 宮坂京子
    • Journal Title

      内科 95

      Pages: 313-318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 膵外分泌におけるnew concept2004

    • Author(s)
      宮坂京子
    • Journal Title

      胆と膵 25

      Pages: 804-805

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima Fatty (OLETF) rats.2004

    • Author(s)
      Shimazoe T, Nakamura S, Kobayashi K, Watanabe S, Miyasaka K, Kono A, Funakoshi A.
    • Journal Title

      Neuroscience 123

      Pages: 201-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population.2004

    • Author(s)
      Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Maruyama K, Niino N, Ando F, Shimokata H, Ohta S, Funakoshi A.
    • Journal Title

      Alcohol and Alcoholism 39

      Pages: 25-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of Cholecystokinin-A Receptor Gene Polymorphisms and Panic Disorder in Japanese2004

    • Author(s)
      Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Shirakawa O, Shimokata H, Funakoshi A.
    • Journal Title

      Am J Med Genet 127B

      Pages: 78-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Histopathological difference between chronic pancreatitis amimal models and human chronic pancreatitis.2004

    • Author(s)
      Suda H, Jimi A, Miyasaka K, Funakoshi A.
    • Journal Title

      Pancreas 28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: A study of CCK-A, B, and AB receptor gene knockout mice.2004

    • Author(s)
      Miyasaka K, Ohta M, Kanai S, Yoshida Y, Sato N, Nagata A, Matsui T, Noda T, Jimi A, Takiguchi S, Takata Y, Kawanami T, Funakoshi A.
    • Journal Title

      J Gastroenterol 39

      Pages: 319-323

    • NAID

      10012894041

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Physiological and pathological age-associated changes in diurnal rhythm of energy expenditure in rats.2004

    • Author(s)
      Miyasaka K, Ichikawa M, Momose K, Araki A, Kobayashi M, Ichimaru Y, Funakoshi A.
    • Journal Title

      Arch Geriat Gerontol 39

      Pages: 83-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature.2004

    • Author(s)
      Nomoto S, Ohta M, Kanai S, Yoshida Y, Takiguchi S, Funakoshi A, Miyasaka K.
    • Journal Title

      Am J Physiol: Regul Integrative 287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain.2004

    • Author(s)
      Koda M, Ando F, Niino N, Shimokata H, Miyasaka K, Funakoshi A.
    • Journal Title

      Obes Res 8

      Pages: 1212-1216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Orexin-A does not stimulated food intake in old rats.2004

    • Author(s)
      Takano S, Kanai S, Hosoya H, Ohta M, Uematsu H, Miyasaka K.
    • Journal Title

      Am J Physiol; Gastrointestinal Physiol 287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima Fatty (OLETF) rats.2004

    • Author(s)
      Shimazoe T, Miyasaka K, et al.
    • Journal Title

      Neuroscicence 123

      Pages: 201-205

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of Cholecystokinin-A Receptor Gene Polymorphisms and Panic Disorder in Japanese2004

    • Author(s)
      Miyasaka K et al.
    • Journal Title

      Am J Med Genet 127B

      Pages: 78-80

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Histopathological difference between chronic pancreatitis amimal models and human chronic pancreatitis.2004

    • Author(s)
      Suda H, Jimi A, Miyasaka K, et al.
    • Journal Title

      Pancreas 28

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor. A study of CCK-A,B, and AB receptor gene knockout mice.2004

    • Author(s)
      Miyasaka K et al.
    • Journal Title

      J Gastroenterol 39

      Pages: 319-323

    • NAID

      10012894041

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature2004

    • Author(s)
      Nomoto S, Miyasaka K, et al.
    • Journal Title

      Am J Physiol : Regul Integrative 287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain2004

    • Author(s)
      Koda M, Ando F, Niino N, Shimokata H, Miyasaka K et al.
    • Journal Title

      Obes Res 8

      Pages: 1212-1216

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Orexin-A does not stimulated food intake in old rats.2004

    • Author(s)
      Takano S, Miyasaka K et al.
    • Journal Title

      Am J Physiol ; Gastrointestinal Physiol 287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats2003

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Mech Aging and Develop 124

      Pages: 183-190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lack of cholecystokinin (CCK)-A receptor enhanced gallstone formation : A study in CCK-A receptor gene knockout mice2003

    • Author(s)
      Sato N, Miyasaka K, et al.
    • Journal Title

      Dig Dis Sci 48

      Pages: 1944-1947

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bitter melon-malt venegar increases daily energy turnover in rats.2003

    • Author(s)
      Ichikawa M, et al., Miyasaka K
    • Journal Title

      J Nutr Sci Vitaminol 49

      Pages: 428-433

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats2003

    • Author(s)
      Sato N, et al., Miyasaka K
    • Journal Title

      Jpn J Phsyiol 53

      Pages: 443-449

    • NAID

      130005446792

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin and cholecystokinin receptors. A review article.2003

    • Author(s)
      Miyasaka K, Funakoshi A
    • Journal Title

      J Gastroenterol 38

      Pages: 1-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] コレシストキニン-A,B,AB受容体遺伝子ノックアウトマウスのエネルギー代謝2003

    • Author(s)
      宮坂京子 他
    • Journal Title

      消化と吸収 25

      Pages: 21-24

    • NAID

      50000825356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 沖縄特産にがうりエキス酢のエネルギー代謝回転亢進と基礎代謝上昇効果2003

    • Author(s)
      宮坂京子 他
    • Journal Title

      消化と吸収 26

      Pages: 103-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 胆石とコーヒー、緑茶2003

    • Author(s)
      船越顕博, 宮坂京子
    • Journal Title

      肝胆膵 46

      Pages: 139-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 肥満症2003

    • Author(s)
      船越顕博, 内村浩太郎, 宮坂京子
    • Journal Title

      日本臨床 61

      Pages: 479-484

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] コレシストキニン受容体の胃排出速度に及ぼす影響2003

    • Author(s)
      佐藤紀一, 船越顕博, 宮坂京子
    • Journal Title

      消化器科 37

      Pages: 225-229

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats.2003

    • Author(s)
      Miyasaka K, Ichikawa M, Kawanami T, Kanai S, Ohta M, Sato N, Ebisawa H, Funakoshi A.
    • Journal Title

      Mech Aging and Develop 124

      Pages: 183-190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lack of cholecystokinin (CCK)-A receptor enhanced gallstone formation: A study in CCK-A receptor gene knockout mice.2003

    • Author(s)
      Sato N, Miyasaka K, Suzuki S, Kanai S, Ohta M, Kawanami T, Yoshida Y, Takiguchi S, Noda T, Takata Y, Funakoshi A.
    • Journal Title

      Dig Dis Sci 48

      Pages: 1944-1947

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bitter melon-malt venegar increases daily energy turnover in rats.2003

    • Author(s)
      Ichikawa M, Ohta M, Kanai S, Yoshida Y, Takano S, Ueoka T, Takahashi T, Kimoto K, Funakoshi A, Miyasaka K.
    • Journal Title

      J Nutr Sci Vitaminol 49

      Pages: 428-433

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats.2003

    • Author(s)
      Sato N, Kanai S, Takano S, Kurosawa M, Funakoshi A, Miyasaka K.
    • Journal Title

      Jpn J Phsyiol 53

      Pages: 443-449

    • NAID

      130005446792

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cholecystokinin and cholecystokinin receptors. A review article.2003

    • Author(s)
      Miyasaka K, Funakoshi A.
    • Journal Title

      J Gastroenterol 38

      Pages: 1-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 専門医のための消化器病学2005

    • Author(s)
      宮坂京子
    • Total Pages
      637
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Book] 臨床研修イラストライテッド消化器系マニュアル2005

    • Author(s)
      宮坂京子
    • Total Pages
      219
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Book] 臨床研修イラストレイテッド5、消化器系マニュアル2005

    • Author(s)
      宮坂 京子
    • Total Pages
      220
    • Publisher
      羊土社
    • Related Report
      2004 Annual Research Report
  • [Publications] Miyasaka K, Ichikawa M, et al.: "Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats"Mech Aging and Develop. 124. 183-190 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato N, Miyasaka K, et al.: "Lack of cholecystokinin(CCK)-A receptor enhanced gallstone formation : A study in CCK-A receptor gene knockout m"Dig Dis Sci. 48. 1944-1947 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ichikawa M, et al. Miyasaka K.: "Bitter melon-malt venegar increases daily energy turnover in rats"J Nutr Sci Vita. 49. 428-433 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato N, et al. Miyasaka K.: "Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats"Jpn J Phsyiol. 53. 443-449 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shimazoe T, et al. Miyasaka K.: "Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima Fatty(OLETF)rats"Neuroscience. 123. 201-205 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyasaka K, Yoshida Y, et al.: "Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population"Alcohol and Alcoholism. 39. 25-28 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyasaka K, Yoshida Y, et al.: "Association of Cholecystokinin-A Receptor Gene Polymorphisms and Panic Disorder in Japanese"Am J Med. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suda H, Jimi A, Miyasaka K, et al.: "Histopathological difference between chronic pancreatitis amimal models and human chronic pancreatitis"Pancreas. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyasaka K, Ichikawa M, et al.: "Physiological and pathological age-associated changes in diurnal rhythm of energy expenditure in rats"Arch Geriat Gerontol. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyasaka K, Ohta M, et al.: "Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor : A study of CCK-A, B, and AB receptor gene knockout mice"J Gastroenterol. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 宮坂京子, 金井節子他: "コレシストキニンーA,B,AB受容体遺伝子ノックアウトマウスのエネルギー代謝"消化と吸収. 25. 21-24 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 船越顕博, 宮坂京子: "胆石とコーヒー、緑茶"肝胆膵. 46. 139-145 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 船越顕博, 内村浩太郎, 宮坂京子: "肥満症"日本臨床. 61. 479-484 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 佐藤紀一, 船越顕博, 宮坂京子: "コレシストキニン受容体の胃排出速度に及ぼす影響"消化器科. 37. 225-229 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 船越顕博, 川波賢子, 宮坂京子: "飲酒、喫煙と膵癌発狂リス"医学のあゆみ. 208. 163-165 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 宮坂京子, 篠崎博嗣他: "ヒト遊離膵腺房からのアミラーゼ分泌:CCK-A,B受容体いずれもアミラーゼ分泌に関与しない"膵臓. 18. 91-92 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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