| Project/Area Number |
15390241
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATA Masataka The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (80345214)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Yasunobu The University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部附属病院, 助教授 (70167609)
SAIURA Akio The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (70345221)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2004: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2003: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Keywords | stem cells / atherosclerosis / differentiation / smooth muscle cell / endothelial cells / mobilization / growth factor / artery |
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| Research Abstract |
Exuberant accumulation of smooth muscle cells plays a principal role in the pathogenesis of vascular diseases. It has been assumed that smooth muscle cells derived from the adjacent medial layer migrate, proliferate and synthesize extra cellular matrix. Although much effort has been devoted, targeting migration and proliferation of medial smooth muscle cells, no effective therapy to prevent occlusive vascular remodeling has been established. Recently, we reported that bone marrow cells substantially contribute to the pathogenesis of vascular diseases, in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis. It was suggested that bone marrow cells may have the potential to give rise to vascular progenitor cells that home in the damaged vessels and differentiate into smooth muscle cells or endothelial cells, thereby contributing to vascular repair, remodeling, and lesion formation. Our findings may provide the basis for the development of new therapeutic strategies for vascular diseases, targeting mobilization, homing, differentiation and proliferation of circulating vascular progenitor cells. Putative vascular progenitor cells would be used to generate biological artificial arteries to treat patients with severe atherosclerosis.
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