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Study of Cardiac Steroidogenesis

Research Project

Project/Area Number 15390249
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKumamoto University

Principal Investigator

YOSHIMURA Michihiro  Kumamoto University, Cardiovascular Medicine, Associate Professor, 大学院・医学薬学研究部, 助教授 (30264295)

Co-Investigator(Kenkyū-buntansha) OGAWA Hisao  Kumamoto University, Cardiovascular Medicine, Professor, 大学院・医学薬学研究部, 教授 (50177135)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2004: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2003: ¥7,300,000 (Direct Cost: ¥7,300,000)
Keywordsaldosterone / dehydroepiandrosterone / ACTH / Heart Failure / Hypertension / ACE / ACE2 / Angiotensin II / コルチゾール / CYP17 / CYP11B1 / CYP11B2 / 冠静脈洞
Research Abstract

In heart failure or hypertension, it has come to seem that not only circulating aldosterone but also tissue aldosterone has some pathophysiological meanings. In our laboratory, we continuously examined the study of cardiac Steroidogenesis and the relating hormones in humans. In our recently study, we found that aldosterone is secreted from the failing heart ; on the other hand, dehydroepiandrosterone(DHEA) is secreted from the control(healthy) heart in humans(Circulation 2004). In a sense, when the heart is healthy, it has the feature as zona reticularis of the adrenal gland ; however, when the heart condition is deteriorated, it appears the feature of zona glomerulosa. It is interesting to see the switching of the cascades to produce aldosterone or DHEA in relation to the heart conditions ; this is our big challenge of overlapping the concepts of the heart and the adrenal gland.
Furthermore, we recently clarified the ACTH secretion from the hearts(ventricles) of patients with hypertens … More ion(J Hypertens 2005). The amount of ACTH secreted from the ventricle was significantly correlated with the grade of blood pressure, suggesting a certain participation of cardiac ACTH to the pathophysiology of essential hypertension. Moreover, there was a positive correlation between cardiac ACTH secretion and cardiac aldosterone secretion, suggesting that, unlike the adrenal gland, ACTH may continue promoting synthesis of aldosterone in the heart. Thus, a new concept called cardiac Hypothalamus-Pituitary-Adrenal(HPA) system study was established in addition to the cardiac RAA system study.
Previously, we reported that aldosterone induces the gene expression of angiotensin-converting enzyme(ACE). On the other hand, we found a new action of aldosterone as for the inhibition of the ACE2 gene expression, which was via the mineralocorticoid receptor(MR). Augmentation of the ACE gene expression and inhibition of the ACE2 gene expression by aldosterone would contribute to the deformation of Angiotensin_<1-7> and formation of Angiotensin II, leading to worsening heart failure. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (13 results)

All 2005 2004 2003 Other

All Journal Article (10 results) Book (1 results) Publications (2 results)

  • [Journal Article] Adrenocorticotropic hormone (ACTH) is produced in the ventricle of patients with essential hypertension2005

    • Author(s)
      Mizuno Y, et al.
    • Journal Title

      J Hypertens 23(2)

      Pages: 411-416

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Adrenocorticotropic hormone(ACTH) is produced in the ventricle of patients with essential hypertension.2005

    • Author(s)
      Mizuno Y, Yasue H, Yoshimura M, Harada E, Fujii H, Nakamura S, Yamamoto N, Ogawa H, Nakao K.
    • Journal Title

      J Hypertens 23(2)

      Pages: 411-416

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hypertension Methods and Protocols - TaqMan real-time RT-PCR quantification : conventional and modified methods.2005

    • Author(s)
      Yoshimura M, Nakamura S, Ogawa H.
    • Journal Title

      Methods in Molecular Medicine(Human Press)

      Pages: 191-200

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart2004

    • Author(s)
      Nakamura S, et al.
    • Journal Title

      Circulation 110(13)

      Pages: 1787-1793

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction : a long-term follow-up analysis2004

    • Author(s)
      Suzuki S, et al.
    • Journal Title

      Circulation 110

      Pages: 1387-1391

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BNP as a biochemical marker of heart failure.2004

    • Author(s)
      Yoshimura M.
    • Journal Title

      Korean Circulation 34(4)

      Pages: 18-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Plasma levels of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction : a long-time follow-up analysis.2004

    • Author(s)
      Suzuki S, Yoshimura M, Nakayama M, Mizuno Y, Ito T, Nakamura S, Abe K, Yamamoto M, Sakamoto T, Saito Y, Nakao K, Yasue H, Ogawa H.
    • Journal Title

      Circulation 110(11)

      Pages: 1387-1391

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart.2004

    • Author(s)
      Nakamura S, Yoshimura M, Nakayama S, Ito T, Mizuno Y, Harada E, Sakamoto T, Saito Y, Nakao K, Yasue H, Ogawa H.
    • Journal Title

      Circulation 110(13)

      Pages: 1787-1793

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibitory effect of natriuretic peptide on aldosterone synthase gene expression in cultured neonatal rat cadiocytes2003

    • Author(s)
      Ito T, et al.
    • Journal Title

      Circulation 107

      Pages: 807-810

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.2003

    • Author(s)
      Ito T, Yoshimura M, Nakamura S, Nakayama M, Shimasaki Y, Harada E, Mizuno Y, Yamamuro M, Harada M, Saito Y, Nakao K, Kurihara H, Yasue H, Ogawa H.
    • Journal Title

      Circulation 107

      Pages: 807-810

    • NAID

      110002709609

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Methods in Molecular Medicine2005

    • Author(s)
      Yoshimura M, et al.
    • Publisher
      Human Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Ito T, et al.: "Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes"Circulation. 107. 807-810 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 吉村道博 他: "心不全フロンテイア(小室一成編)"メディカルレビュー社. 109-116 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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