Study of Cardiac Steroidogenesis
| Project/Area Number |
15390249
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
YOSHIMURA Michihiro Kumamoto University, Cardiovascular Medicine, Associate Professor, 大学院・医学薬学研究部, 助教授 (30264295)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Hisao Kumamoto University, Cardiovascular Medicine, Professor, 大学院・医学薬学研究部, 教授 (50177135)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2004: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2003: ¥7,300,000 (Direct Cost: ¥7,300,000)
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| Keywords | aldosterone / dehydroepiandrosterone / ACTH / Heart Failure / Hypertension / ACE / ACE2 / Angiotensin II / コルチゾール / CYP17 / CYP11B1 / CYP11B2 / 冠静脈洞 |
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| Research Abstract |
In heart failure or hypertension, it has come to seem that not only circulating aldosterone but also tissue aldosterone has some pathophysiological meanings. In our laboratory, we continuously examined the study of cardiac Steroidogenesis and the relating hormones in humans. In our recently study, we found that aldosterone is secreted from the failing heart ; on the other hand, dehydroepiandrosterone(DHEA) is secreted from the control(healthy) heart in humans(Circulation 2004). In a sense, when the heart is healthy, it has the feature as zona reticularis of the adrenal gland ; however, when the heart condition is deteriorated, it appears the feature of zona glomerulosa. It is interesting to see the switching of the cascades to produce aldosterone or DHEA in relation to the heart conditions ; this is our big challenge of overlapping the concepts of the heart and the adrenal gland.
Furthermore, we recently clarified the ACTH secretion from the hearts(ventricles) of patients with hypertens
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ion(J Hypertens 2005). The amount of ACTH secreted from the ventricle was significantly correlated with the grade of blood pressure, suggesting a certain participation of cardiac ACTH to the pathophysiology of essential hypertension. Moreover, there was a positive correlation between cardiac ACTH secretion and cardiac aldosterone secretion, suggesting that, unlike the adrenal gland, ACTH may continue promoting synthesis of aldosterone in the heart. Thus, a new concept called cardiac Hypothalamus-Pituitary-Adrenal(HPA) system study was established in addition to the cardiac RAA system study.
Previously, we reported that aldosterone induces the gene expression of angiotensin-converting enzyme(ACE). On the other hand, we found a new action of aldosterone as for the inhibition of the ACE2 gene expression, which was via the mineralocorticoid receptor(MR). Augmentation of the ACE gene expression and inhibition of the ACE2 gene expression by aldosterone would contribute to the deformation of Angiotensin_<1-7> and formation of Angiotensin II, leading to worsening heart failure. Less
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Plasma levels of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction : a long-time follow-up analysis.2004
Author(s)
Suzuki S, Yoshimura M, Nakayama M, Mizuno Y, Ito T, Nakamura S, Abe K, Yamamoto M, Sakamoto T, Saito Y, Nakao K, Yasue H, Ogawa H.
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Journal Title
Circulation 110(11)
Pages: 1387-1391
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart.2004
Author(s)
Nakamura S, Yoshimura M, Nakayama S, Ito T, Mizuno Y, Harada E, Sakamoto T, Saito Y, Nakao K, Yasue H, Ogawa H.
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Journal Title
Circulation 110(13)
Pages: 1787-1793
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.2003
Author(s)
Ito T, Yoshimura M, Nakamura S, Nakayama M, Shimasaki Y, Harada E, Mizuno Y, Yamamuro M, Harada M, Saito Y, Nakao K, Kurihara H, Yasue H, Ogawa H.
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Journal Title
Circulation 107
Pages: 807-810
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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