| Project/Area Number |
15390348
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OKUBO Yoshiro Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (20213663)
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| Co-Investigator(Kenkyū-buntansha) |
SUHARA Tetsuya National Institute of Radiological Sciences, Molecular Imaging Center, Group Leader, 分子イメージング研究センター・分子神経イメージング研究グループ, グループリーダー (90216490)
SUZUKI Hidenori Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (30221328)
KAWARA Tokuhiro Tokyo Medical and Dental University, Depatment of Bioinfomatics, Research Associate, 大学院・保健衛生学研究科, 助手 (50234141)
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| Project Period (FY) |
2003 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Keywords | schizophrenia / PET / MRI・VBM / fMRI / Neurotropic factors / Peripheral benzodiazepine receptor / 末梢性ベンゾジアゼピン受容体 |
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| Research Abstract |
Using both morphological and functional neuroimaging techniques, we aimed to elucidate the progressive changes in the brain of patients with schizophrenia. One hundred twenty patients with schizophrenia aged 20 to 49 years, 60 males and 60 females, and 120 age and gender matched healthy controls were examined by magnetic resonance imaging(MRI). Voxel-based morphometry revealed that age-related decline in the brain morphology was larger in the patient group than in the control groups. This indicates the existence of progressive neuropathology in schizophrenia. Further, the difference in the brain morphology between the patient group and the control group were more prominent in male than in female. Thus, future research should take gender difference into account. Positron emission tomography with [11C[DAA1106 makes it possible to evaluate peripheral benzodiazepine receptors which reflect activated microglia and gliosis in the living human brain. We conducted [11C[DAA1106 PET study in a preliminary sample of patients with schizophrenia and controls. However, there was no statistical difference between groups.
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