| Project/Area Number |
15390354
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TAMAKI Nagara Hokkaido Univ., Grad.School of Med., Prof., 大学院・医学研究科, 教授 (30171888)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Koichi Hokkaido Univ., Grad.School of Med., Lecturer, 大学院・医学研究科, 講師 (20210172)
KATOH Chietsugu Hokkaido Univ., Grad.School of Med., Associate Prof., 医学部, 助教授 (10292012)
北畠 顕 北海道大学, 大学院・医学研究科, 教授 (00124769)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 2003: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | emission tomography / blood flow / coronary artery disease / myocardium / endothelial function |
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| Research Abstract |
Assessment of coronary atherosclerosis plays a major role for dearly detection and management of patients with coronary artery disease. Positron emission tomography (PET) using O-15 labeled water permits quantitative assessment of myocardial blood flow, and therefore, this is valuable means for measurement of myocardial flow reserve and coronary endothelial function noninvasively. In the study of patients suspected with coronary artery disease, myocardial flow reserve was reduced not only in the areas with coronary stenosis but also in the remote areas in the patients having coronary risk factors. Multivariate analysis indicated that smoking and diabetes were the only independent variables which reduced myocardial flow reserve. In addition, coronary endothelial dysfunction was identified in patients with young healthy smokers and remote stage of Kawasaki disease. Moreover, such coronary endothelial dysfunction was reversible after smoking cessation. These data indicate that O-15 labeled water PET is feasible for early detection and management of coronary atherosclerosis in clinical setting.
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