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Development of real-time tracking radiotherapy method and its clinical application

Research Project

Project/Area Number 15390355
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

TAKAI Yoshihiro  Tohoku University, School of Medicine, Radiological Technology, Professor, 医学部, 教授 (50107653)

Co-Investigator(Kenkyū-buntansha) YAMADA Shogo  Tohoku University, Graduate School of Medicine, Radiation Oncology., Professor, 大学院・医学系研究科, 教授 (60158194)
NEMOTO Kenji  Tohoku University, Graduate School of Medicine, Radiation Oncology., Associate Professor, 大学院・医学系研究科, 助教授 (10208291)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2004: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsStereotactic Radiotherapy / Tumor tracking / Amorphous silicon X-ray sensor / Tracking radiotherapy / Gantry mounted fluoroscopy / Image-guided radiotherapy / Prostate cancer / Intensity modulated radiotherapy / アモルファスシリコンX線セン / ガントリー搭載X線透視装置 / アモルファスシリコンX線センサー
Research Abstract

We have developed to mount two sets of X-ray fluoroscopy with amorphous silicon X-ray sensors on the gantry of Clinac EX23 for image-guided radiotherapy as a cooperative work with Varian Medical Systems company. A new software for real-time tracking of a fiducial marker in a tumor using images obtained by the fluoroscopic system on the gantry of Linac. In this software, the color of a rectangle square for tracking a marker turns green when the marker tracking is successful, and once it fails to track the marker, the color turns red and the size of the square get bigger. Thus the condition of the tracking can be monitored at real time. The 3D coordinates of the fiducial marker can be calculated using this tracking system, and the coordinates is displayed simultaneously. In the treatment of intensity modulated radiotherapy (IMRT) for prostate cancer, intra- and inter-fractional errors were evaluated by this system. Motion of the prostate more than 1 mm was found in 33 % of all fractions of dose delivery, and re-positionings of the patients of these cases were done so that all cases can be treated with less than 1mm positioning error. In IMRT for prostate cancer, dose painting method to reduce the dose around the urethra became possible by using our new image-guided devices. We have treated 67 patients so far. Among them, the whole prostates were treated with 80Gy/40fr in 24 patients (no dose reduction group), and 5% dose reduction around the urethra was done in 43 patients. The rates of grade 1 acute adverse effect of GU tract were 46% (11/24) and 28% (12/43) for no dose reduction group and dose reduction group, respectively.
This new device and system developed by this research was found to be very useful for image guided radiotherapy which is very important technology to increase the local control rate and to reduce normal tissue damage.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (25 results)

All 2005 2004 Other

All Journal Article (20 results) Book (1 results) Publications (4 results)

  • [Journal Article] Evaluation of inter- and intrafraction organ motion during intensity modulated radiation therapy for localized prostate cancer measured by a newly developed on-board image-guided system.2005

    • Author(s)
      Britton K, Takai Y et al.
    • Journal Title

      Radiation Medicine 23

      Pages: 14-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Construction of a remote radiotherapy planning system.2005

    • Author(s)
      Ogawa Y, Takai Y et al.
    • Journal Title

      Int J Clin Oncol. 10

      Pages: 26-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dosimetric correlations of acute esophagitis in lung cancer patients treated with radiotherapy2005

    • Author(s)
      Takeda K, Takai Y et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys. 62

      Pages: 626-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection.2005

    • Author(s)
      Nemoto K, Takai Y et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys. 63

      Pages: 1290-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Construction of a remote radiotherapy planning system.2005

    • Author(s)
      Ogawa Y, Takai Y et al.
    • Journal Title

      Int J Crin Oncol 10

      Pages: 26-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dosimetric correlations of acute esophagitis in lung cancer patients treated with radiotherapy2005

    • Author(s)
      Takeda K, Takai Y et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 62

      Pages: 626-629

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Salvage radiation therapy for residual superficial esophageal cancer after endoscopic mucosal resection.2005

    • Author(s)
      Nemoto K, Takai Y et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 63

      Pages: 1290-1294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of inter- and intrafraction organ motion during intensity Modulated radiation therapy for localized prostate cancer measured by a newly developed on-board image-guided system.2005

    • Author(s)
      Britton K, Takai Y et al.
    • Journal Title

      Radiation Medicine 23

      Pages: 14-24

    • Related Report
      2005 Annual Research Report
  • [Journal Article] イメージガイド放射線治療(IGRT)とIMRT、ART2005

    • Author(s)
      高井良尋
    • Journal Title

      治療学 39

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Construction of a remote radiotherapy planning system.2005

    • Author(s)
      Ogawa Y, Takai Y et al.
    • Journal Title

      Int J CIin Oncol. 10

      Pages: 26-29

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluation of inter- and intrafraction organ motion during intensity modulated radiation therapy for localized prostate cancer measured by a newly developed on-board image-guided system.2005

    • Author(s)
      Britton K, Takai Y et al.
    • Journal Title

      Radiation Medicine 23:1

      Pages: 14-24

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Image-guided radiotherapy - current and future state-2004

    • Author(s)
      Takai Y
    • Journal Title

      Proceedings of 10^<th> Varian European Users Meeting

      Pages: 8-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors.2004

    • Author(s)
      Wada H, Takai Y et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys. 58

      Pages: 1114-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a dual kV X-ray on-board imager for patient setup and dynamic tumor tracking.2004

    • Author(s)
      Takai Y, Mitsuya M, Yamada S et al.
    • Journal Title

      Proceedings of 10^<th> Varian European Users Meeting.

      Pages: 15-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high dose radiotherapy for small pulmonary or hepatic tumors.2004

    • Author(s)
      Wada H, Takai Y et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 58

      Pages: 1114-1120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Image-guided radiotherapy -current and future state-2004

    • Author(s)
      Takai Y.
    • Journal Title

      Proceedings of 10^<th> Varian European Users Meeting.

      Pages: 8-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 定位放射線療法の適応と長期予後2004

    • Author(s)
      高井良尋, 小藤昌志 他
    • Journal Title

      治療学 38

      Pages: 671-675

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of a dual kV X-ray on-board imager for patient setup and dynamic tumor tracking.2004

    • Author(s)
      Takai Y, Mitsuya M et al.
    • Journal Title

      Proceedings of 10^<th> Varian European Users Meeting.

      Pages: 15-19

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical feasibility of newly developed dual kV X-ray on-board imager ; IMRT for prostate cancer and SRT for early lung cancer.2004

    • Author(s)
      Takai Y, Britton KR et al.
    • Journal Title

      Proceedings of 10^<th> Varian European Users Meeting.

      Pages: 82-92

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 前立腺癌をめぐる最新動向:放射線が照射療法の新展開-強度変調照射法と線量増加-2004

    • Author(s)
      高井良尋, 山田章吾
    • Journal Title

      カレントテラピー 22

      Pages: 45-51

    • Related Report
      2004 Annual Research Report
  • [Book] PET診療から粒子線治療まで-ハイテクがん診療の最前線2004

    • Author(s)
      高井良尋 他
    • Total Pages
      261
    • Publisher
      先端機能画像医療研究センター
    • Related Report
      2004 Annual Research Report
  • [Publications] 高井良尋, 和田仁, 山田章吾: "第5章:肺癌の外科成績向上の戦略 6.定位放射線療法"先端医療シリーズ. 26「呼吸器外科の最先端」(印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wada H, Takai Y: "Univariate analysis of factors correlated with tumor control probability of three-dimensional conformal hypofractionated high-dose radiotherapy for small pulmonary or hepatic tumors"Int J Radiat Oncol Biol Phys. 58. 1114-1120 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nomiya T, Nemoto K, Takai Y, et al.: "Relationships between radiosensitivity and microvascular density in esophageal carcinoma : significance of hypoxic fraction"Int J Radiat Oncol Biol Phys. 58. 589-596 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高井良尋: "第11章:新しい放射線治療 1.定位放射線療法"先端医療シリーズ. 20「肺癌の最新医療」. 302-308 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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